GENETIC NEUROCHEMICAL AUTOIMMUNE

OXIDATIVE STRESS OTHERS

CONTRIBUTION IMBALANCES RESPONSE

Decrease antioxidants in
Increase susceptibility Increase serotonin level GI difficulties
plasma Increase auto-antibodies
in the brain and altered
immune cells responses
Concomitantly found in patients with fragile
X syndrome, tuberous sclerosis and other Low level of dopamine Increase oxidate stress Food intolerance
genetic conditions

Low levels of IgA

Decrease GABA proteins and
Ex. Nucleotide polymorphism in
GABA receptors Allergic
MET Causing hyper-permeable
blood brain barrier,
apoptosis
neurodegeneration and Increase inflammatory
Changes in catecholaminergic,
demyelination cytokines Mitochondrial
peptidergic, and cholinergic
systems dysfunction

Defective
detoxification

PATHOPHYSIOLOGY OF AUTISM