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Bone- framework of the body -The principal minerals stored are calcium and
phosphorous.
Cartilages- reduce friction and serves as
model/precursor for bone formation. Blood cell production
- Cartilage provides firm yet flexible support Bone, cartilage, tendons, and ligaments of the
within certain structures, such as the nose, skeletal system are all connective tissues.
external ear, thoracic cage, and trachea.
Their characteristics are largely determined by the
composition of their extracellular matrix.
- Ligaments, strong bands of fibrous
The matrix always contains collagen, ground
connective tissue, hold bones together.
substance, and other organic molecules, as well as
Organ protection water and minerals.
-Not every part of our body is equally protected. Bone’s extracellular matrix- organic and inorganic
(flexible and able to bear weight).
-The most protected organs of the entire body
are the brain, spinal cord, and the organs on Cartilage’s extracellular matrix- collagen and
our chest. proteoglycans (good shock absorber).
The inorganic material consists primarily of a calcium -do not undergo mitosis
phosphate crystal called hydroxyapatite Ca10 (PO4) 6
(OH)2. Hydroxyapatite makes the bones hard and -secrete osteocalcin
strong.
-Ossification- the formation
The collagen and mineral components are responsible of new bone by osteoblasts.
for the major functional characteristics of bone.
OSTEOCYTES
If mineral in a long bone is reduced, collagen becomes -Osteocytes are cells that
the primary constituent, and the bone is overly flexible. maintain bone matrix and form
On the other hand, if the amount of collagen is reduced from osteoblast after bone
in the bone, the mineral component becomes the matrix has surrounded it.
primary constituent, and the bone is very brittle.
- account for 90–95% of bone
BRITTLE BONE DISEASE cells with a life span of up to
25 years
-Osteogenesis imperfecta
(imperfect bone formation) is
- produce the components
an inherited (genetic) bone needed to maintain the bone
disorder that is present at matrix
birth.
- Lacunae- houses within the
-a rare disorder caused by any one of a number of faulty
bone matrix where osteocytes
genes that results in either too little collagen formation, live.
or poor-quality collagen
-Canaliculi – cell extensions
- As a result, the bone matrix has decreased flexibility
of the lacunae
and is more easily broken than normal bone.
OSTEOCLASTS - bone-destroying cells
- break down bone
BONE CELLS
- Bone resorption- process of
bone repair and remodeling by
removing existing bone by
osteoclasts.
2|P age
TYPES OF BONE
Spongy
Compact
BASED ON SHAPE:
Long Bone
Short Bone
Flat Bone
Irregular Bone
COMPACT BONE/CORTICAL BONE
SPONGY AND COMPACT BONE -Compact bone, or cortical bone, is the solid, outer
layer surrounding each bone.
-Mature bone is called lamellar bone. It is organized -The functional unit of compact bone is osteon. It is
into thin, concentric sheets or layers, called lamellae. composed of concentric rings of matrix surrounding a
-Bone can be classified according to the amount of bone central canal.
matrix relative to the amount of space within the bone. -Central canals are lined with endosteum and contain
-Spongy bone has less bone matrix and more space blood vessels, nerves, and loose connective tissue.
than compact bone, which has more bone matrix and
less space.
SPONGY BONE
-No osteons.
3|P age
Epiphysis (pl. Epiphyses)
Articular cartilage
Medullary cavity
- Center of diaphysis
Bone Marrow
-In the fetus, the spaces within bones are filled with red
marrow. Just before birth the red bone marrow starts
to get converted to yellow marrow.
4|P age
-Where tendons and ligaments attach to bone, fibers of 1. intramembranous ossification
the tendon or ligament become continuous with those
of the periosteum. -Starts within embryonic connective tissue membranes
-Inner-most single cell layer of connective tissue that -CT membranes formed by mesenchymal cells
lines the internal surfaces of all cavities within bones. 2. endochondral ossification
-Membrane that lines medullary cavity. -Starts with a hyaline cartilage model.
Metaphysis -Forms most bones
-Located between epiphysis and diaphysis. -Similar to post-natal bone growth
-Contains the growth plate of the epiphysis known as
the epiphyseal plate.
INTRAMEMBRANOUS OSSIFICATION
Compact Bone
-Found in the harder outer shell of the bone organ. -Occurs when
osteoblasts begin to
Spongy Bone
produce bone within
- Found in the inner portions of bone and is identified by connective tissue.
the trabeculae and open spaces.
-This occurs primarily
in the bones of the
skull.
BONE DEVELOPMENT
Bone formation (ossification/osteogenesis; osteo-bone,
genesis-beginning) in the fetus follows two processes:
5|P age
STEPS IN INTRAMEMBRANOUS OSSIFICATION STEPS IN ENDOCHONDRAL OSSIFICATION
Osteoblasts from the periosteum lay down bone 4. Secondary ossification centers from
matrix to form an outer surface of compact epiphysis.
bone.
5. Original cartilage model is almost completely
Centers of ossification: locations in the membrane ossified and remaining cartilage is articular
where intramembranous ossification begins. The cartilage.
centers of ossification expand to form a bone by
gradually ossifying the membrane. Thus, the centers
BONE GROWTH
have the oldest bone, and the expanding edges the
youngest bone
BONE GROWTH IN WIDTH- APPOSITIONAL
Fontanels, or soft spots, are the larger, membrane- GROWTH
covered spaces between the developing skull bones
that have not yet been ossified. The bones eventually
grow together, and all the fontanels have usually closed -Bone growth occurs by the deposition of new bone
by 2 years of age. lamellae onto existing bone or other connective tissue.
ENDOCHONDRAL OSSIFICATION -As osteoblasts deposit new bone matrix on the surface
of bones between the periosteum and the existing bone
matrix, the bone increases in width, or diameter.
-Endochondral bone formation is bone formation within
a cartilage model. -The process is called appositional growth.
6|P age
BONE GROWTH IN LENGTH- ENDOCHONDRAL 18 to 23 years Bone of the lower limbs
GROWTH and os coxas become
completely ossified.
23 to 25 years Bone of the sternum,
-Growth in the length of a bone, which is the major clavicles, and vertebrae
source of increased height in an individual, occurs in the become completely
epiphyseal plate. ossified.
By 25 years Nearly all bones are
-This type of bone growth occurs through completely ossified.
endochondral ossification.
BONE REMODELING
7|P age
Classification of Bone Fractures -Calcium is a critical nutrient involved in many
physiological processes including:
Open (Formerly called a compound
fracture fracture) occurs when an open -Stimulation and regulation of skeletal and
wound extends to the site of the cardiac muscle contraction.
fracture or when a fragment of bone
protrudes through the skin. -Exocytosis of cellular molecules, including
Closed (Formerly called a simple fracture). If those important for neural signaling.
fracture the skin is not perforated, the
fracture is called a closed fracture PARATHYROID HORMONE (PTH)
Complicated If the soft tissues around a closed
fracture fracture are damaged. Goal: Increase the amount of calcium in the blood.
Incomplete Does not extend completely across
fracture the bone. - Secreted by the parathyroid gland
Complete The bone is broken into at least two (behind thyroid)
fracture fragments.
Greenstick An incomplete fracture on the - Increases formation and activation of
fracture convex side of the curve of the bone osteoclasts, the principal bone-
Hairline are incomplete fractures in which the reabsorbing cells.
fractures two sections of bone do not
separate; hairline fractures are
common in the skull. - Stimulates reabsorption of Calcium from
Comminuted is a complete fracture in which the urine in the kidney, reducing the amount of
fracture bone breaks into more than two Calcium excreted in the urine.
pieces—usually two major
fragments and a smaller fragment. - Indirectly increases Calcium uptake
Impacted One fragment is driven into the from the small intestine through the
fracture spongy portion of the other activation of calcitriol.
fragment.
Linear Run parallel to the length of the bone CALCITONIN
fractures
Transverse At right angles to the length of the Goal: Lower the amount of calcium in the blood.
fractures bone. -Secreted from C cells in the thyroid gland when blood
Spiral Take a helical course around the
calcium(2+) levels are too high.
fractures bone
Oblique Run obliquely in relation to the length -Rapidly lowers blood calcium levels by inhibiting
fractures of the bone. osteoclasts activity.
Dentate Have rough, toothed, broken ends.
fractures
Stellate Have breakage lines radiating from a
fractures central point.
8|P age
LONG BONES
SHORT BONES
FLAT BONES
Axial skeleton- consists of the bones of the skull, the -Complex in shape.
auditory ossicles, the hyoid bone, the vertebral column, -Do not fit readily into the other three
and the thoracic cage. (Midline bones) categories.
Appendicular skeleton consists of the bones of the -Ex. Vertebrae and facial bones
upper limbs, the lower limbs, and the two girdles.
9|P age
BONE MARKINGS/ SKELETAL TERMINOLOGY Process
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FACE (14) APPENDICULAR SKELETON
Zygomatic 2 Scapula 2
Palatine 2 Clavicle 2
Lacrimal 2
Humerus 2
Inferior nasal concha 2
Ulna 2
Unpaired Mandible 1
Radius 2
Vomer 1
Carpal bones 16
BONES ASSOCIATED WITH THE SKULL (7)
Metacarpal bones 10
AUDITORY OSSICLES (6)
Phalanges 28
Incus 2
Coxal bone 2
Stapes 2
LOWER LIMB (60)
Total 6
Femur 2
HYOID (1)
Tibia 2
Hyoid 1 Fibula 2
VERTEBRAL COLUMN (26) Patella 2
VERTEBRAL COLUMN (26) Tarsal bones 14
Metatarsals 10
Cervical vertebrae 7
Phalanges 28
Thoracic vertebrae 12
TOTAL GIRDLE AND UPPER LIMB 64
Lumbar vertebrae 5
TOTAL GIRDLE AND LOWER LIMB 62
Sacrum 1
TOTAL APPENDICULAR SKELETON 126
Coccyx 1
SKULL
Both the exterior and the interior of the skull have visible
ridges and lines. Most of these are locations where
head and neck muscles attach to the cranium.
CRANIAL SUTURES
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CRANIAL BONES Ethmoid bone
-Anterior portion
of cranium,
including medial
surface of eye
orbit and roof of
nasal cavity.
-Nasal conchae.
FACIAL BONES
Maxillae
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Lacrimal bones
Nasal bones
Vomer
-Attached to lateral
walls of nasal cavity.
Mandible
-Lower jawbone
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The paranasal sinuses are:
-Frontal
-Ethmoid
-Sphenoid
-Maxillary
HYOID BONE
-floating bone
VERTEBRAL COLUMN
-7 cervical vertebra
15 | P a g e
ATLAS:
-1st vertebra
-hold head
AXIS:
-2nd vertebra
-rotates head
The thoracic region curves -Allows spinal nerves to exit the spinal cord
posteriorly. -Provides a site for muscle attachment
The lumbar region curves -Provides movement of the head and trunk.
anteriorly.
16 | P a g e
Intervertebral foramina- are the locations where two
vertebrae meet. Each intervertebral foramen is formed
by intervertebral notches in the pedicles of adjacent
vertebrae.
Articular
facets
The Vertebra
prominens
(C7) is the
Vertebral body- the solid bony disk of each vertebra,
largest and
supports the body’s weight.
most inferior
Vertebral arch- protects the spinal cord. The vertebral vertebra in the
arch projects posteriorly from the body. neck region.
STERNUM:
-breastbone
-has 3 parts
-COCCYX
18 | P a g e
APPENDICULAR SKELETON
The appendicular skeleton allows movement of our
appendages and supports our weight in an upright
position.
Acromion process
SCAPULA:
-shoulder blade
CLAVICLE:
-collar bone
19 | P a g e
UPPER LIMB BONES The proximal end of the humerus has two prominent
landmarks
Humerus:
Greater tubercle
-upper portion of fore limb
- Laterally,
Ulna:
-larger
-forearm
Lesser tubercle
Radius:
- Anteriorly
- one of the two bones that
make up the forearm Deltoid tuberosity
-radius and the thumb are - site of attachment of the deltoid muscle
always on the same side
Capitulum
Carpals:
-location where the humerus articulates with the radius.
-wrist
Trochlea
Metacarpals:
-location where the humerus articulates with the ulna.
-hand
Lateral and Medial epicondyle
Phalanges:
-smooth rounded parts of the bone
-fingers
HUMERUS
HUMERUS
Greater
tubercle
Lesser
tubercle
20 | P a g e
Intertubercular Groove- between greater and lesser Radial tuberosity
tubercle
-lump of bone
Styloid process
Ulna
-more medial
Coronoid process.
Olecranon process
Radius
-shorter one
-more lateral
21 | P a g e
BONES OF THE WRIST AND HAND Ilium
Acetabulum
CARPAL BONES
COMPARISON OF THE MALE PELVIS TO THE
Proximal row- has 4 bones (scaphoid, lunate, FEMALE PELVIS
triquetrum, pisiform)
METACARPAL BONES
-bones 1-5
PHALANGES
PELVIC GIRDLE
22 | P a g e
PHALANGES
FIBULA
-smaller bone
of lower leg
TARSALS:
-ankle
23 | P a g e
Apex-pointed part, bottom part
24 | P a g e
TIBIA or shinbone- larger, always medial, major BONES OF THE FOOT
weight-bearing bone of the leg
FIBULA-always lateral
1.Talus
2.Calcaneus
3.Navicular
7. Cuboid
Mnemonic
25 | P a g e
arches extend from the heel to the ball of the foot, and FUNCTIONAL CLASSIFICATION OF JOINTS
a transverse arch extends across the foot.
SYNARTHROSIS:
-non-movable joint
AMPHIARTHROSIS:
DIARTHROSIS:
FIBROUS JOINT:
CARTILAGINOUS:
SYNOVIAL:
26 | P a g e
SYNOVIAL JOINT TYPES OF SYNOVIAL JOINTS
27 | P a g e
Pronation: rotation of the forearm with palms down
TYPES OF MOVEMENT
Flexion: bending
Extension: straightening
28 | P a g e