You’ll never look at toothpaste

the same way again…

Sensitivity
Gingivitis
Plaque Caries

Enamel
Erosion
Halitosis
Calculus Staining

Oral-B PRO-HEALTH ®

one toothpaste with the benefits of many.

Our first and only toothpaste with a breakthrough formulation of stabilised stannous fluoride and sodium
hexametaphosphate. This combination amplifies its plaque reduction, sensitivity, and acid erosion benefits.
15 years of research and over 100 clinical and scientific studies have helped validate this latest innovation.
 Contents

Plaque
> Advanced antiplaque benefits 4
Gingivitis
> Breakthrough gingivitis benefits 6
Sensitivity
> Advanced sensitivity benefits 10
Caries
> Proven caries benefits 14
Enamel Erosion
> Significant enamel erosion benefits 18
Staining
> Powerful stain removal & prevention benefits 22
Calculus
> Proven calculus benefits 24
Halitosis
> Long-lasting halitosis benefits 26

02
Introducing

PRO-HEALTH ®

Our breakthrough stabilised stannous fluoride formulation provides one toothpaste

with the benefits of many1

> Oral-B PRO-HEALTH® finally allows you

to experience the benefits of stannous
fluoride with this revolutionary stabilised
formulation2
> Until now, products with stannous fluoride
have not been able to deliver all of its

+
benefits without tradeoffs, due to instability
challenges2

+
A proven advanced technology with benefits
beyond standard fluoride1
> 0.454% stabilised stannous fluoride and
Sodium
hexametaphosphate sodium hexametaphosphate combined like
no other for the first time to create our
one-of-a-kind formulation2
> The benefits of stannous
Sodiumfluoride have long
been recognised.hexametaphosphate
Experience them now
with this formulation2
> Sodium hexametaphosphate’s benefits of
advanced calculus prevention and stain
prevention are well documented and
captured in this toothpaste2
Sodium hexametaphosphate is also referred to PRO-HEALTH®
sodium polymetaphosphate 03
 Advanced antiplaque benefits

How it works
3
Stannous fluoride is a powerful agent . Oral-B Pro-Health
formula helps control plaque/antiplaque benefits by
reducing bacteria

Why it matters
Reduces plaque bacteria

Inhibits plaque bacteria

Up to 33% reduction in plaque bacteria 12 hours postbrushing vs. negative control1

04 untreated after USE OF oral-b PRO-HEALTH

Bacteria associated with plaque and gum issues Plaque bacteria reduced
 PLAQUE

> Fights a broad spectrum of bacteria associated with plaque and

gum issues3
> Reduces >90% of salivary plaque bacteria with a single exposure of toothpaste*3

Controls Plaque Bacteria Growth3

> Provides sustained inhibition of bacterial metabolic activity
> Decreases plaque acid production
> Reduces bacterial adhesion and cohesion by reducing the thickness
and stickiness of plaque

*16 hours after single exposure in laboratory test.

Plaque and gingivitis studies conducted using North American formulation, Crest®
PRO-HEALTH® Toothpaste, which includes 1100 ppm fluoride, Oral-B PRO-HEALTH
formulation includes 1450 ppm fluoride.
PRO-HEALTH®
05
 Breakthrough gingivitis benefits

Breakthrough
How it works gum problem benefits
Stannous fluoride controls plaque accumulation
that can lead to gingivitis3

Inhibits plaque bacteria

Up to 33% reduction in plaque bacteria 12 hours post brushing vs. negative control1

untreated after USE OF oral-b PRO-HEALTH

Bacteria associated with plaque and gingivitis Plaque bacteria reduced

06
 GINGIVITIS

> Fights a broad spectrum of bacteria associated with plaque and gingivitis3
> Reduces >90% of salivary plaque bacteria with a single exposure of toothpaste*3

Controls plaque bacterial growth3

> Provides sustained inhibition of bacterial metabolic activity
> Decreases plaque acid production
> Reduces bacterial adhesion and cohesion by reducing the thickness
and stickiness of plaque

* 16 hours after single exposure in laboratory test.

Plaque and gingivitis studies conducted using North American formulation, Crest®
PRO-HEALTH® Toothpaste, which includes 1100 ppm fluoride, Oral-B PRO-HEALTH
formulation includes 1450 ppm fluoride.
PRO-HEALTH®
07
 Breakthrough gingivitis benefits

Why it matters
Significantly reduces gingivitis4

Reduces gingival inflammation by up to 21%4

2.2
Gingival inflammation

2.0
Reduces
gingival
1.8 21% inflammation4

1.6

1.4
Baseline 3 months 6 months n Negative control
n Oral-B PRO-HEALTH formulation*

Mankodi S et al. J Clin Periodontol. A randomized, double-blind, parallel-group gingivitis

study (n=130) for 6 months. Results based on Modified Gingival Index; higher scores
08 indicate more severe symptoms. p=0.001.
 GINGIVITIS

Reduces gingival bleeding by up to 57% 4

10

8
Gingival bleeding

Reduces
6 57% gingival
bleeding4
4

0
Baseline 3 months 6 months n Negative control
n Oral-B PRO-HEALTH formulation*

Mankodi S et al. J Clin Periodontol. A randomized, double-blind, parallel-group gingivitis study (n=130)
for 6 months. Results based on Gingival Bleeding Index; higher scores indicate more severe symptoms. p=0.001.

*Crest study product was a dentrifice containing 0.454% stabilised stannous fluoride PRO-HEALTH®
with sodium hexametaphosphate—the ingredients in the Crest Polyfluorite System. 09
 Advanced sensitivity benefits

How it works
Stannous fluoride blocks dentinal tubules to help
prevent dentinal hypersensitivity 5

> Fluid movement stimulates > Occluded tubules after stannous

nerves, causing pain fluoride treatment

untreated after USE OF oral-b PRO-HEALTH

Sensitivity occurs when hot, cold, osmotic, or Occluded tubules inhibit fluid movement and
10 tactile stimulus triggers fluid flow in tubules nerve stimulation
 SENSITIVITY

How it works differently

Oral-B PRO-HEALTH uniquely addresses the cause of sensitivity by occluding tubules5

> Potassium nitrate–based formulations work by anesthetising the nerve, leaving the root
cause of sensitivity unaddressed5

PRO-HEALTH®
11
 Advanced sensitivity benefits

Why it matters
Treats and helps prevent dentinal hypersensitivity

Up to 44% reduction in thermal sensitivity6 at week 8 vs. negative control

3.0

2.5
Schiff Air Index score

2.0
Reduces
1.5
44% thermal
sensitivity6
1.0

0.5

0.0
Baseline 4 weeks 8 weeks
n Negative control
n Oral-B PRO-HEALTH formulation*
12
 SENSITIVITY

Up to 2x greater tolerance to tactile sensitivity6 at week 8 vs. negative control

30

Greater
Yeaple Probe Index score

25
tolerance
20 2x to tactile
15
sensitivity6

10

0
Baseline 4 weeks 8 weeks n Negative control
n Oral-B PRO-HEALTH formulation*

Schiff T et al. J Contemp Dent Pract. A randomized, double-blind, parallel-group clinical trial
(N=90) for 8 weeks. Thermal sensitivity results based on Schiff Air Index. Tactile sensitivity
results based on Yeaple Probe Index. p<0.0001.

*Crest study product was a dentrifice containing 0.454% stabilised stannous fluoride PRO-HEALTH®
with sodium hexametaphosphate-the ingredients in the Crest Polyfluorite System. 13
 Proven caries benefits

How it works
Stannous fluoride provides anticaries benefit by fighting
the bacteria associated with caries and promotes
remineralisation1,7

Inhibits plaque bacteria

> Reduces streptococcus mutans, the bacteria commonly associated with caries1

untreated after USE OF oral-b PRO-HEALTH

14 Bacteria produce acids that can damage tooth surface Caries-causing bacteria reduced
 CARIES

Promotes remineralisation, strengthening tooth

> Helps treat early-stage caries by rebuilding minerals within the tooth’s surface1

Demineralisation

Remineralised

untreated after USE OF oral-b PRO-HEALTH

Demineralisation of enamel rods Remineralised tooth structure

S mutans studies conducted using North American formulation,

legend Acid Calcium Fluoride Crest PRO-HEALTH® Toothpaste, which includes 1100 ppm fluoride.
Oral-B PRO-HEALTH® formulation includes 1450 ppm fluoride.

PRO-HEALTH®
15
 Proven caries benefits

Why it matters
Provides overall protection against caries

Significant 2-year anticaries benefit with an early Oral-B PRO-HEALTH prototype

7.0 Up to

25% Greater
‡
Adjusted mean DMFS* score†

6.5 protection
vs 1100 ppm
fluoride
6.0 toothpaste8

5.5

5.0

0
2 years n 1100 ppm fluoride toothpaste
n Oral-B PRO-HEALTH prototype§
16
 CARIES

Adjusted mean DMFS score†

7
Comparable
6 ‡ ‡ protection
5 vs 2800 ppm
fluoride
4 toothpaste8
3

0
2 years
n 2800 ppm fluoride toothpaste
n Oral-B PRO-HEALTH prototype§

Stookey GK et al. Caries Res. A randomised, double-blind study (n=683) for 24 months.
Results based on visual-tactile and radiographic examinations. p=0.002.

* Decayed, missing, or filled surfaces.

† Adjusted means significantly different for an early Oral-B PRO-HEALTH prototype vs a standard
dentifrice (p<0.02) and the 2800 ppm vs a standard dentifrice (p<0.05).
‡ Significantly fewer caries relative to sodium fluoride group.
Crest study product was an early Oral-B PRO-HEALTH prototype containing 0.454% stabilised
§ 
PRO-HEALTH®
stannous fluoride with sodium hexametaphosphate—the ingredients in the Crest Polyfluorite System. 17
 Significant enamel erosion benefits

How it works
Stannous fluoride forms a protective layer that blocks
dietary acids from eroding enamel 1

> Enamel rods are at risk for erosion after repeated exposure to dietary acids over time

untreated untreated
Dietary acid molecules attack unprotected enamel rods Weakened enamel rods are vulnerable to mechanical
18 insult, such as chewing, abrasion, and tongue friction
 ENAMEL EROSION

> Stannous fluoride provides an effective barrier against dietary acid molecules

AFTER USE OF ORAL-B PRO-HEALTH AFTER USE OF ORAL-B PRO-HEALTH

Stannous fluoride molecules form a protective coating Stannous fluoride coating shields against dietary acid
attacks and helps protect against erosion

PRO-HEALTH®
19
 Significant enamel erosion benefits

Why it matters
Protects against enamel erosion

Significantly provides more protection against dietary acids1

50

42%
45

40
Less
Microns of enamel lost

35
enamel
30
loss*91
25

20

15

10
5

0 n Sodium fluoride control

n Oral-B PRO-HEALTH

20 * Significantly less enamel loss relative to sodium fluoride group. p<0.05.

 ENAMEL EROSION

Significantly reduced the loss of enamel†

-2.5
-2.5
Microns of enamel lost
Microns of enamel lost

-2 -2 Significant
Significant
reduction in
reduction in
-1.5-1.5 enamel loss
enamel loss
in situ in
in situ in
-1 -1 day 15
†

day 15
†

-0.5
-0.5
42%
42%
0
0 0 5 10 15
0 5 10 15
Days of product use n Sodium fluoride control
Days of product use
n Oral-B PRO-HEALTH

† In situ patients wore an intra-oral appliance containing enamel specimens.

‡ Significantly less reduction in enamel loss in situ. p<0.001.

PRO-HEALTH®
21
 Powerful stain removal and prevention benefit

How it works
Sodium hexametaphosphate chemically removes stains and forms a protective layer 10

> These processes are especially relevant given the high chromogen level from dead
bacteria and its potential to cause stains

Extrinsic stain removal Extrinsic stain prevention

untreated

after USE OF oral-b PRO-HEALTH after USE OF oral-b PRO-HEALTH

Sodium hexametaphosphate binds to free calcium, Sodium hexametaphosphate stays on tooth surface
22 disrupting the pellicle to chemically remove existing stains to prevent new stains from forming
 STAINING

Why it matters
Removes and prevents staining

Provides whitening with powerful stain removal efficacy11

3.5
Mean composite Lobene stain score

3.0
96%
2.5 Terézhalmy G et al. Am J Dent. A randomized,

2.0
Reduces double-blind, positive-controlled, parallel-group
trial (N=59) for 2 weeks. Efficacy was evaluated
1.5
stains11 based on Lobene examination on anterior teeth.
p<0.0001.
1.0

0.5

0
Baseline 2 weeks n Oral-B PRO-HEALTH formulation*

* Crest study product was a dentifrice containing 0.454% stabilised stannous fluoride
with sodium hexametaphosphate—the ingredients in the Crest Polyfluorite System.

Stain removal study conducted using North American formulation,

Crest PRO-HEALTH Toothpaste, which includes 1100 ppm fluoride. PRO-HEALTH®
Oral-B PRO-HEALTH formulation includes 1450 ppm fluoride. 23
 Proven calculus benefits

How it works
Sodium hexametaphosphate helps prevent plaque mineralisation12

untreated after USE OF oral-b PRO-HEALTH

Calcium and phosphate in saliva cause mineralisation Inhibits mineralisation of calcium and phosphate
of plaque post-prophylaxis and protects tooth surface from calculus formation
post-prophylaxis

24
 CALCULUS

Why it matters
Inhibits calculus formation

Offers significant calculus inhibition13

20
Up to 56% greater calculus inhibition13 vs.
56% up to 56%
Greater 0.3% triclosan/copolymer positive control
mean-amount of calculus

15 greater
tartar Schiff T et al. Compend Contin Educ Dent.
V-MI† adjustment

calculus
inhibition 13 A randomized, double-blind, parallel-group
study (N=80) for 6 months. Results based
10 inhibition13 on V-MI. p=0.0001.

0 n Oral-B PRO-HEALTH formulation*

Pre-prophylaxis 6 months
n Triclosan/copolymer positive control‡

† Volpe-Manhold Index.
‡ Positive control was a marketed, multibenefit calculus-control dentifrice.

Tartar inhibition study conducted using North American formulation,

Crest PRO-HEALTH Toothpaste, which includes 1100 ppm fluoride. PRO-HEALTH®
Oral-B PRO-HEALTH formulation includes 1450 ppm fluoride. 25
 Long-lasting halitosis benefits

How it works
Stannous fluoride gives the benefit of fresh breath by
reducing bacteria1

>S
 tannous fluoride reduces volatile sulfur compound(VSC)-producing bacteria—the
main cause of halitosis1

untreated after USE OF oral-b PRO-HEALTH

26 VSC–producing bacteria cause halitosis VSC–producing bacteria reduced
 HALITOSIS

Why it matters
Protects against bad breath

Helps achieve and maintain long-lasting fresh breath14

10
Nachnani S et al. J Dent Res. A randomized,
Long-lasting double-blind, two-treatment, parallel-design
8
halitosis
Mean hedonic score

clinical trial (N=71) for 3 weeks. Oral malodor

reduction14
49%
was assessed on a 9-point hedonic scale.
6 71% p<0.0001.

0
Baseline Week 1 Week 3
n Oral-B PRO-HEALTH formulation*
n Standard fluoride toothpaste

* Crest study product was a dentifrice containing 0.454% stabilised

stannous fluoride with sodium hexametaphosphate—the ingredients in the
Crest Polyfluorite System.

Halitosis study conducted using North American formulation, Crest

PRO-HEALTH Toothpaste, which includes 1100 ppm fluoride. PRO-HEALTH®
Oral-B PRO-HEALTH formulation includes 1450 ppm fluoride. 27
 References

1. Farrell et al. J Dent Res 2008; 87 Special Issue A#994.

2. Baig A, He T. A novel dentifrice technology for advanced oral health protection: a review of technical and
clinical data. Compend Contin Educ Dent. 2005;26(suppl 1):4-11.

3. Ramji N, Baig A, He T, et al. Sustained antibacterial actions of a new stabilized stannous fluoride dentifrice
containing sodium hexametaphosphate. Compend Contin Educ Dent. 2005;26(supp 1):19-28.

4. Mankodi S, Bartizek RD, Winston JL, et al. Anti-gingivitis efficacy of stabilized 0.454% stannous fluoride/
sodium hexametaphosphate dentifrice: a controlled 6-month clinical trial. J Clin Periodontol. 2005;32:75-80.

5. Walters PA. Dentinal hypersensitivity: a review. J Contemp Dent Pract. 2005;6:107-117.

6. Schiff T et al., Desensitizing effect of a stabilized stannousfluoride/sodium hexametaphosphate dentifrice.

Compendium 2005; 26(suppl 1);35-40.

7. Pfarrer AM, McQueen CM, Lawless MA, et al. Anticaries potential of a stabilized stannous fluoride/sodium
hexametaphosphate dentifrice. Compend Contin Educ Dent. 2005;26(suppl 1):41-46.

8. Stookey GK, Mau MS, Isaacs RL, et al. The relative anticaries effectiveness of three fluoride-containing
dentifrices in Puerto Rico. Caries Res. 2004;38:542-550.

28
 REFERENCES

9. Hooper SM, Newcombe RG, Faller R, et al. The protective effects of toothpaste against erosion by orange
juice: studies in situ and in vitro. J Dent. 2007;35:476-481.

10. Baig AA, White D, van der Mei H, et al. Hexametaphosphate dentifrice effects pellicle conditioning films.
J Dent Res. 2006;85(special issue). Abstract 694.

11. Terézhalmy G, Chaves E, Bsoul S, et al. Clinical evaluation of the stain removal efficacy of novel stannous
fluoride and sodium hexametaphosphate dentifrice. Am J Dent. 2007;20:53-58.

12. White DJ, Cox ER, Suszcynskymeister EM, et al. In vitro studies of the anticalculus efficacy of sodium
hexametaphosphate whitening dentifrice. J Clin Dent. 2002;13:33-37.

13. Schiff T, Saletta L, Baker RA, et al. Anticalculus efficacy and safety of a stabilized stannous fluoride/
sodium hexametaphosphate dentifrice. Compend Contin Educ Dent. 2005;26(supp 1):29-34.

14. Nachnani S, La S, Lee S, et al. Oral malodor reduction with 3-week use of 0.454% SnF2 dentifrice. J Dent
Res. 2008;87(special issue B). Abstract 2864.

PRO-HEALTH®
29
Notes

PRO-HEALTH®
 PRO-HEALTH
One toothpaste with the benefits of many.
®

Look at the toothpaste with breakthrough differences. PLAQUE ✔

GINGIVITIS ✔
Our first and only toothpaste formulated with stabilised SENSITIVITY ✔
stannous fluoride and sodium hexametaphosphate that CARIES ✔
protects all the key areas you check most.1,2
ENAMEL EROSION ✔
STAINING ✔
CALCULUS ✔
Inhibits plaque bacteria3 Significantly reduces enamel erosion1 HALITOSIS ✔
• Up to 33% reduction in plaque bacteria 12 hours • Up to 42% reduction in enamel loss vs.
post brushing vs. negative control1 benchmark toothpaste in situ9 in day 15

Significantly reduces gingivitis3 Powerful stain removal11 and prevention10

• Up to 21% reduction in gingival inflammation • Up to 96% reduction in staining within
2 weeks vs. baseline
• Up to 57% reduction in gingival bleeding4
vs. negative control at month 6
Significant calculus inhibition13
Reduces dentinal hypersensitivity5 • Up to 56% greater calculus inhibition13 vs.
0.3% triclosan/copolymer positive control
• Up to 44% reduction in thermal sensitivity6
• 2x greater tolerance to tactile sensitivity6 Long-lasting fresh breath14
at week 8 vs. negative control • Up to 71% halitosis reduction14 vs. negative
control at 3 weeks
Effective protection against caries1, 7
• Up to 25% greater protection vs. 1100ppm
fluoride toothpaste8 in a 2-year clinical study
(with an early Oral-B PRO-HEALTH prototype)