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Received February 25, 2020, accepted March 13, 2020, date of publication March 18, 2020, date of current version March 31, 2020.
Digital Object Identifier 10.1109/ACCESS.2020.2981670
ABSTRACT Cerebellar Ataxia (CA) is a neurological disease with the symptom of poor coordination of
movement and balance disorders. In clinical medicine, the heel-knee-shin test and the rapid alternating
movements test are important basis for assessing CA. Based on the above tests, this paper presents a
non-contact method and investigates the feasibility of this method for detecting CA. This body sensor
networks uses wireless devices operating in the C-band frequency range to capture data of both types of tests
without intrusiveness. The obtained data of tests contains massive useful information about human health
which is really significant to subjects. But the information can be so subtle that people ignore the value hidden
in it. So utility pattern mining (UPM) is used for the purpose of mining subjects’ activity pattern. We find that
the subjects’ activity pattern differs greatly in amplitude information. We extracted the amplitude information
that is helpful for analyzing the test’ results to determine whether the test is positive or negative. Then we
use different kind of algorithms to classify the data samples. Among them, support vector machine (SVM)
has the best classification effect on both tests. In the heel-knee-shin test, the coincidence rate (π ) is 98.7%,
the sensitivity (Se) is 98.9% and the specificity (Sp) is 98.5%. In the rapid alternating movements test, the π
is 99.4%, Se is 99.8% and Sp is 99%. The experimental results show that this technique has the potential
to open up new clinical opportunities for contactless and accurate CA monitoring in a patient-friendly and
flexible environment.
INDEX TERMS Cerebellar Ataxia, body sensor networks, C-band, pattern mining.
This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/
56730 VOLUME 8, 2020
J. Jin et al.: Activity Pattern Mining for Healthcare
cumbersome or require the subject to wear the appropriate In order to characterize multipath propagation, wire-
hardware device. This is expensive to test and is primarily less channels are usually modeled with Channel Impulse
suitable for use in a laboratory environment. The wireless Response (CIR). Under the assumption of linear time invari-
sensing technology used in this paper is sensitive enough to ance, CIR can be expressed as:
these characteristics of motor tasks and these characteristics XN
can be easily collected. Based on the technical characteristics h (τ ) = ai e−jθi δ(τ − τi ) (1)
i=1
involved in this research, and due to the accuracy of the
where ai , θi , τi are the amplitude attenuation, phase offset
research, in this study, we focused on the assessment of limb
and time delay of the i-th path, N is the total number of
motor function, with commonly used motor tasks including
propagation paths, and δ(τ ) is the Diclad pulse function.
the heel-knee-shin test and the rapid alternating movements
Each term in the formula represents the amplitude, phase,
test. These tasks have the following in common:
and delay of a propagation path in the time domain. Due to
• Movements that require action across limb joints
multipath propagation appears as frequency selective fading
• Repetition and rhythm in a manner that requires some
in the frequency domain, multipath propagation can also be
accuracy in stopping and starting
characterized by Channel Frequency Response (CFR). CFR
• The subject needs posture stability to perform these
contains the amplitude response and phase response. Under
actions
the condition of unlimited bandwidth, CFR and CIR are
From this body sensor networks, we can collect large
Fourier transforms of each other. Wireless channel in the
volumes of experimental data. These complex data contain
frequency domain is represented as a superposition of phase
rich environmental information and human activity pattern
and frequency of signals. The narrowband flat fading channel
information. Mining the characteristics of human activity
model can be expressed in the frequency domain as:
pattern from these data is essential for effective analysis of
test results. Utility pattern mining (UPM) is a vital task in Y =H ×X +N (2)
many applications, including e-commerce, finance, cross-
where Y represents the received signal vector, X represents
marketing, medical, and biomedical applications [9], [10].
the transmitted signal vector, N represents the noise signal
UPM considers the utility factors to find potentially useful
vector, and H represents the channel state matrix. So we can
patterns that can be utilized in real-world applications [11].
also get the channel state transition matrix:
However, each object is different in nature [12]. Finding out
the characteristics of the object is very important. By ana- y1 x1 h11 · · · h1M
lyzing the channel information of wireless signals, the key Y = ... X = ... H = ... ..
.
..
.
features of the activity are discovered. Then, we establish the
yN xN hN 1 ··· hNM
activity pattern and use different kind of algorithms to classify
the data. Results show that the derived pattern is reasonable, n1
and acceptable. This scheme provides an important basis for ..
N = . (3)
the diagnosis of Cerebellar Ataxia. nN
The structure of this paper is as follows: section II gives
the basic theory of the wireless channel information (WCI), The wireless communication technology uses a MIMO-
section III gives the system design, section IV gives the OFDM system. Therefore, the matrix H is a complex matrix
details of the experiment and analyzes the data, section V of n ∗ m ∗ 30, where n is the number of transmitting antennas,
provides data classification, section VI gives discussion and m is the number of receiving antennas, and 30 is the number
section VII gives the conclusion. of subcarrier information. Each wireless channel information
packet received in this system contains 30 subcarriers. The
II. WIRELESS CHANNEL INFORMATION amplitude and phase information of each subcarrier is given
In recent years, with the rapid development of wireless net- by
work devices and technologies, researchers have been able 6 H (i)
H (i) = k H (i)k ei (4)
to use wireless signals to sense and identify changes in
the environment. The idea of a wireless sensing system is where H (i)Hi represents channel state information of the
multipath propagation of wireless signals in indoor spaces, i-th subcarrier, k H (i)k represents amplitude information, and
including direct radiation, reflection, diffraction, and scatter 6 H (i) represents phase information.
propagation. This multipath propagation is hampered by inte- This technology is currently widely used in medical
rior walls, floors, furniture and other obstacles. In addition, fields [18]–[20], including the detection of some respira-
human behavior always changes the propagation path of tory [21] and neurological [22], [23] diseases. A large number
wireless signals which changes the characteristics of received of studies have shown that the system designed based on
wireless signal [13]–[15]. In particular, human motion can this technology has a good effect on detecting human life
cause multipath fading and Doppler shift, which indicates that features [24], [25]. This technology does not require the
the received signal contains rich environmental information subject to wear any hardware device. Instead, the device
about human behavior [16], [17]. performs the detection function only in a passive manner
C. PRE-PROCESSING
In both types of experiments, the amplitude information in
the wireless channel information is significantly different for
whether the test is positive or not. The phase information in
the wireless channel information is greatly disturbed by noise,
and phase-wrapping is prone to occur for these large-scale
actions, so it can’t reflect real human activity. In this study we
only extracted the amplitude information in the channel state
FIGURE 1. The logic flow of our system.
information. Then, we performed wavelet filtering on the
amplitude information. Wavelet filtering is chosen because
it uses a multi-resolution method, which can identify more
using a common commercial wireless device. More impor-
smoothly the non-stationary features of the signal, such as
tantly, this technology can effectively protect personal pri-
edges, spikes, breakpoints, etc. and wavelet filtering can
vacy [26]. Moreover, the technology is not affected by light
complete the de-correlation of the signal, which is more
conditions and has no blind spots, can usually work in line
conducive to de-noising than the time domain. The Hampel
of sight (LOS) and non-line of sight (NLOS) environments
filter algorithm is then used to identify and remove outliers in
and is non-invasive, robust. With the development of wire-
the data.
less technology, various wireless terminals are everywhere,
The comparison before and after filtering the amplitude
it makes the scheme based on this technology convenient and
information is shown in Figure 2.
low-cost.
After pre-processing the amplitude information, we basi-
cally filter out the noise in the signal and completely preserve
III. SYSTEM DESIGN the original signal.
A. SYSTEM FLOW
The basic idea of our system is to capture the behavioral
information of the subjects during the heel-knee-shin test D. CLASSIFICATION AND RESULTS ANALYSIS
and the rapid alternating movements test, and to classify After pre-processing, we remove a lot of noise and some
the captured behavioral information. The results of the clas- outliers, and retains relatively complete human behavior
sification can provide an important objective basis for our information. We classify the preprocessed data signals using
diagnosis. The system is divided into three parts, namely Decision Trees [27], KNN [28], and SVM [29] classifica-
data collection, preprocessing and finally the classification tion algorithms. The results of the classification can indicate
and result analysis. The architecture of the system is shown whether the subject’s test is positive or negative, provid-
in Figure 1. ing the clinician with a diagnostic basis and reducing the
workload.
B. DATA COLLECTION
During the test, we used a combination of a transmitter IV. EXPERIMENTS AND PERFORMANCE EVALUATION
antenna and three receiving antennas to transmit and receive A. EXPERIMENTAL DESCRIPTION
electromagnetic signals. Due to the different placement posi- According to DeJong’s The Neurologic Examination [30],
tions of the three receiving antennas, some receiving antennas the heel-knee-shin test and the rapid alternating movements
may be subject to large interference when capturing behav- test are common methods for diagnosing Cerebellar Ataxia.
ior information. Therefore, we must remove these signals In this research, we recruited 5 volunteers to participate in the
degraded by interference to prevent wrong information while test. In order to reflect the robustness and universality of this
analyzing and classification of data. In the heel-knee-shin system, and to demonstrate the authenticity of the test, both
test, the signal received by one antenna was greatly affected tests were performed in an ordinary indoor environment of
by environmental interference, while the other two received university. The test was divided into two groups: the healthy
signals were less disturbed. In the rapid alternating move- group and the Cerebellar Ataxia group. Each group of tests
ments test, the signals received by the three receiving anten- was repeated 20 times for 5 subjects to collect sufficient data
nas are less affected by environmental interference. In this samples for analysis. As this research involves the scien-
study, we selected all the subcarriers of the two receiving tific research of human body and the application of related
antennas as the input signal of the system for the heel-knee- technologies, in order to protect human life and health, safe-
shin test; for the rapid alternating movements test we used all guard human dignity, respect and protect the legitimate rights
the subcarriers of the receiving antennas as the input signal and interests of human subjects, the test must strictly abide
of the system. by the International Peace Convention ‘‘Industrial Guidance
Through this microwave sensing platform, we completed - The E6 standard clinical trials (ICH GCP guideline E6),
the data collection. After screening the subcarriers, we can the Helsinki Declaration (2002 edition), the Ministry of
get 12,000 subcarriers in the heel-knee-shin test. In the rapid Health ‘‘Human Medical Research Ethical Review Measures
alternating movements test, we can get 18,000 subcarriers. (Trial)’’ and other relevant provisions and agreements signed
B. EXPERIMENTAL SETUPS
The test uses a wireless device and a directional antenna,
and uses a C-band frequency based on the IEEE 802.11n
standard. In order to acquire electromagnetic wave signals,
FIGURE 2. The amplitude information: (a) The amplitude information
before filtering; (b) The amplitude information after filtering. the transmitter antenna is deployed as an access point (AP).
The receiving antenna is placed opposite the AP at a distance
of 1.2 meters. The distance between each receiving antenna is
TABLE 1. The details of the 5 subjects.
greater than half the wavelength of the operating frequency to
prevent mutual interference between the receiving antennas.
This microwave sensing platform is deployed in the 4.8GHz
to 5GHz frequency band divided by 5G in China, which is an
important part of 5th generation mobile networks, the latest
official document released by the MIIT(Ministry of Industry
and Information Technology). The subject was tested in the
middle of the transmitter antenna and the receiver antennas.
Because we found that the microwave sensing platform is
very sensitive to this location and can detect subtle human
with relevant international organizations. Therefore, the five activities, which is very beneficial for us to analyze the char-
volunteers we recruited were all healthy. The test of the Cere- acteristics of human activities. There was only one subject
bellar Ataxia group was simulated by healthy people. Under present when data was collected. During the test, the data
the relevant national regulations and the guidelines issued rate was 12 Mbits per second and the sampling rate was
by international organizations, we have conducted systematic set to 200 packets per second. According to the length of
training with the consent of the participants. The training the test, we select the appropriate amount of data packets
includes the following two aspects: 1. Review relevant med- transmission for each types of tests. The test environment
ical information to understand the symptoms of the disease is easy to deploy, data collection is non-invasive and can be
during the test; 2. View the medical videos of the relevant continuously monitored. The specific test scenario is shown
tests. According to medical data, patients with Cerebellar in Figure 3.
Ataxia will show corresponding symptoms when performing
two types of tests. During the heel-knee-shin test, the patient’s C. THE HEEL-KNEE-SHIN TEST
movements are slightly trembled. During the rapid alternating The procedure of the heel-knee-shin test is as follows: the
movements test, the patient’s movement showed symptoms subject lay supine, the lower limb is raised, and the heel is
of uneven rhythm. Subjects underwent extensive rigorous placed at the knee of the other lower limb, and then moved
training on the simulation of these symptoms prior to the test. down the leading edge of the tibia. This test is carried out
All subjects did not take any medication within a few hours in the case of opening eyes, and the normal person moves
prior to the test. And there is no alcohol abuse. The details of accurately. If the subject shakes when the legs moving down,
the 5 subjects are shown in Table 1. then the test is positive.
V. DATA CLASSIFICATION
Although we can distinguish between the healthy group
FIGURE 5. The variances of CFR information obtained during the rapid and the Cerebellar Ataxia group in the heel-knee-shin test
alternating movements test: (a) The raw CFR data recorded for the person and the rapid alternating movements test by observing the
without Cerebellar Ataxia; (b) Time history for the person without
Cerebellar Ataxia(c) The raw CFR data recorded for the person with
amplitude changes of the subcarriers and their spectrograms.
Cerebellar Ataxia; (d) Time history for the person with Cerebellar Ataxia. But we hope that through machine learning, classification
can be done more accurately and efficiently, and the newly
obtained data signal categories can be predicted. In this
comparison, we found that there are many long ‘recesses’ paper, we choose the Decision Tree classification algo-
on the y-axis in Figure 5(c). In order to further analyze rithm, K-Nearest Neighbor classification algorithm (KNN)
the experimental data, we compared the single subcarriers and SVM. Because a lot of research has shown that these
of the two groups. Here, we selected the 21th subcarrier algorithms have a good effect in human activity classification.
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2020.
JIAXIN JIN is currently with Xidian University. XIAODONG YANG (Senior Member, IEEE) has
published over 100 articles in peer-reviewed jour-
nals. His main research area is body area net-
works. He received the Young Scientist Award
from the International Union of Radio Science,
in 2014. He is on the editorial board of several
IEEE and IET journals. He has a global collabo-
rative research network in the related fields.