HAND/PERIPHERAL NERVE

Keeping the Finger on the Pulse: Cardiac

Arrhythmias in Hand Surgery Using Local
Anesthesia with Adrenaline
Uri Farkash, M.D.
Background: The wide-awake local anesthesia no tourniquet (WALANT) tech-
Amir Herman, M.D., Ph.D.
nique in hand surgery is gaining popularity. The authors aimed to prospec-
Tal Kalimian, M.D.
tively analyze the frequency and type of arrhythmias in patients undergoing
Ohad Segal, M.D. hand surgery under local anesthesia and to examine whether the addition of
Amir Cohen, M.D. adrenaline affects their incidence.
Avishag Laish-Farkash, M.D., Methods: Adult patients undergoing hand surgery under local anesthesia were
Ph.D. randomized into two groups: group 1, local anesthesia with lidocaine and tour-
Downloaded from http://journals.lww.com/plasreconsurg by BhDMf5ePHKbH4TTImqenVIiuKVF7qTxs6UC4BycYtGRf/dNOWuVs54Ttco+ZJu9w on 07/05/2020

Ashdod and Beer-Sheva, Israel
niquet; and group 2, local anesthesia with lidocaine and adrenaline (WALANT).
Patients with a history of arrhythmias were excluded. Patients were connected to
Holter electrocardiographic monitoring before surgery and up until discharge.
The records were blindly compared between the groups regarding types of ar-
rhythmias, and frequency and timing relative to injection and tourniquet inflation.
Results: One hundred two patients were included between August of 2018 and
August of 2019 (age, 59.7 ± 13.6 years; 71 percent women; 51 in each group). No
major arrhythmia (ventricular tachycardia, ventricular fibrillation, atrial fibrilla-
tion) or arrhythmia-related symptoms were recorded for either group. Minor
arrhythmias (including atrial premature beats, ventricular premature beats, and
atrial tachycardia) were recorded in 68 patients (66.6 percent), with no statistical
difference between the groups. There were three patients with minor arrhyth-
mias during inflation of the tourniquet. Patients in the adrenaline group had 2
percent sinus tachycardia during injection and 4 percent asymptomatic bradyar-
rhythmias. These findings do not require any further treatment.
Conclusions: The authors’ results show that hand operations using WALANT
technique in patients with no history of arrhythmia are safe and are not
arrhythmogenic; therefore, there is no need for routine perioperative continu-
ous electrocardiographic monitoring.  (Plast. Reconstr. Surg. 146: 54e, 2020.)
CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.

W
hile performing surgical procedures in
general, and in the hand in particular,
it is essential to have a bloodless surgical
field, to enable the surgeon to get the best view of
From the Hand Surgery Unit, the Department of Orthopedic
Surgery, and the Electrophysiology and Pacing Unit, Cardi-
ology Department, Assuta Ashdod University Hospital; and
the Faculty of Health Sciences, Ben-Gurion University of
the Negev.
Received for publication September 21, 2019; accepted
January 17, 2020.
The trial is registered under the name “Evaluation of Car-
diac Arrhythmias in Hand Surgery Using Local Anesthesia
With Adrenaline,” ClinicalTrials.gov identification num-
ber NCT04029610 (https://clinicaltrials.gov/ct2/show/
NCT04029610).
Copyright © 2020 by the American Society of Plastic Surgeons
DOI: 10.1097/PRS.0000000000006902
the surgical site. There are two options for achiev-
ing a bloodless surgical field in the hand. Tradi-
tionally, a tourniquet on the arm has been used to
create ischemia to the whole upper limb, thus pre-
venting blood flow to the surgical site. In recent
years, the wide-awake local anesthesia no tourni-
quet (WALANT) technique has gained popularity
Disclosure: The authors have no financial interest
to declare in relation to the content of this article.
By reading this article, you are entitled to claim
one (1) hour of Category 2 Patient Safety Credit.
ASPS members can claim this credit by logging
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54e www.PRSJournal.com
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 Volume 146, Number 1 • Cardiac Arrhythmias in Hand Surgery
among hand surgeons. In this technique, adrena-
line (epinephrine) is infiltrated to the surgical site
with the local anesthetic.
Adrenalin constricts the small blood vessels
and reduces bleeding during the surgical proce-
dure. It acts as a vasoconstrictor of capillaries and
is considered the vasoconstrictor of choice with
local anesthetics.1 Adrenaline also prevents tox-
icity by reducing the systemic absorption of local
anesthetics from the infiltrated field and by pro-
longing the duration of action and the intensity
of nerve block by local anesthetics. Adding vaso-
constrictors to the local anesthetics has commonly
been used in surgical procedures in the dental;
plastic; ear, nose, and throat; and gastroenterol-
ogy fields for many years. However, the dose of
local anesthetics and that of adrenaline used in
the WALANT technique, is severalfold larger than
that used in other surgical fields.
The beta-1 effects of adrenaline include
tachycardia and increased myocardial contractil-
ity,2 whereas the stimulation of alpha-1 receptors
might cause an increase in systemic and pulmo-
nary vascular resistance. The increase in myocar-
dial oxygen demand along with limited perfusion
might cause ischemia or infarction. The coronary
vasospasm might also precipitate acute myocar-
dial infarction in these patients. There are several
descriptions in the medical literature of cardiac
side effects with the use of lidocaine and adrena-
line in ear, nose, and throat and oral and maxillo-
facial operations, mostly arrhythmias, pulmonary
edema, and hypertension.3–6
To the best of our knowledge, there is no study
that examines systematically the prevalence and
clinical significance of cardiac arrhythmias during
hand surgery using the WALANT technique. The
purposes of this study are to prospectively check
for frequency and type of arrhythmias in patients
undergoing hand surgery under local anesthesia
and to compare blindly whether the addition of
adrenaline to local anesthesia affects their inci-
dence, type, and symptoms. Our results will help to
decide whether continuous electrocardiographic
monitoring is needed during WALANT operations.
PATIENTS AND METHODS
The study took place at Assuta Ashdod Univer-
sity Hospital, Israel, between August of 2018 and
August of 2019. The study was approved by the
hospital’s local ethics committee.
Consecutive adult patients who were scheduled
to undergo a hand surgical procedure under local
anesthesia in the outpatient surgical department
Copyright © 2020 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
of our hospital were invited to participate in the
study. Patients with a known medical history of car-
diac arrhythmias were excluded. After giving writ-
ten informed consent, patients were randomized
into two groups: group 1, local anesthesia with lido-
caine and arterial blockage on the arm; and group
2, local anesthesia with lidocaine and adrenaline.
Time of injection and the amount and type of
anesthetic used were recorded. The time of tour-
niquet inflation in group 1 was also recorded. In
addition to the routine monitoring (use of non-
invasive blood pressure gauge and oxygen satu-
ration), patients were connected to an external
continuous electrocardiographic cardiac Holter
monitor before the start of the surgical procedure
up until their discharge from the recovery room.
On completion of the monitoring, the results of
the Holter test were transmitted to the electro-
physiology unit and analyzed to detect arrhyth-
mias. The electrophysiologist was blinded to the
patient’s affiliated group and to the injected mate-
rial but was aware of the time of injection.
During the patient’s stay at the hospital, a
registration of the side effects reported by the
patients (palpitations, dizziness, chest pain, short-
ness of breath, presyncope, syncope, and the need
for resuscitation) was carried out. In patients in
whom arrhythmias were detected, the type of
arrhythmia and related symptoms were recorded.
Arrhythmias were divided into major ones (includ-
ing ventricular tachycardia, ventricular fibrilla-
tion, and atrial fibrillation) and minor ones (atrial
premature beats, ventricular premature beats,
atrial tachycardia, sinus tachycardia, and bradyar-
rhythmias). Each type of arrhythmia was further
characterized by its timing relative to the injection
of the drug (blindly) and to the time of start of
inflation of tourniquet (not blindly), to elucidate
the effect of adrenaline from the effects of pain or
stress caused by the injection itself and from the
pain or stress from inflating the tourniquet.
Statistical Analysis
Sample size was calculated for a 15 percent
incidence of arrhythmia in the adrenaline group
and a 0 percent incidence in the control group.
Power was set at 80 percent and alpha at 0.05.
The estimated sample size was 50 patients in each
group. Adding patients (10 percent) that might
drop off the study because of technical problems
with the Holter device, the final sample size was 55
patients in each group.
Continuous variables were represented by
means and standard deviation of the means, and
categorical variables were represented by absolute
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 Plastic and Reconstructive Surgery • July 2020

and relative frequencies. The Mann-Whitney test
or t test were used for comparisons of continu-
ous variables, whichever was appropriate, and the
chi-square test or Fisher’s exact test was used for
categorical variables, each when appropriate. The
level of statistical significance was set at p < 0.05 for
all analyses. All statistical analyses were performed
using IBM SPSS Version 22 (IBM Corp., Armonk,
N.Y.). All p values calculated are two-sided.
RESULTS
During the study period, 111 patients were
enrolled. Because of technical difficulties in the
Holter recordings, nine patients were excluded;
therefore, 102 patients were finally included in
the study.
Study Population
Baseline characteristics are listed in Table  1.
Average age of the patients was 59 years (range, 27
to 85 years), and 71 percent of them were women.
The surgical procedures were carpal tunnel release
in 56, trigger finger release in 31, release of both car-
pal tunnel and trigger finger in six, and excisional
biopsy (of a ganglion or other soft-tissue mass) in
nine patients. Fifty-one patients had the procedure
under local anesthesia with 2% lidocaine using a
tourniquet (group 1) and 51 patients had the proce-
dure using the WALANT technique with lidocaine
and 1:100,000 adrenaline (group 2).
The average amount of local anesthetic used
was 8.9 cc, ranging from 4 cc in single trigger fin-
ger release to 16 cc in combined carpal tunnel and
trigger finger release, with no statistical difference
between the groups. The total duration of Holter
monitoring was 96 ± 49 minutes. It was statistically
longer for the adrenaline group (105 ± 57 min-
utes versus 86 ± 38 minutes; p = 0.045); however,
the time of monitoring before drug injection was
comparable between the groups, as was the time
of monitoring after injection (Table 1).
Arrhythmias
The results are shown in detail in Table 2. No
major arrhythmia was recorded for either group.
None of the patients reported clinical symptoms
that could have been attributed to either arrhyth-
mias or cardiac ischemia or hemodynamic com-
promise during their stay at the hospital.
Overall, minor arrhythmias were recorded in
68 patients (66.6 percent), with no statistical dif-
ference between the groups. Regarding tachyar-
rhythmias, sinus tachycardia occurred in two
patients in the adrenaline group [one before
adrenaline injection and one during injection
(0.98 percent)]. Atrial tachycardia developed in
eight patients (7.8 percent) (four in each group):
there was homogenous distribution before and
after drug injection in three; in one patient, atrial
premature beats occurred only during inflation
of the tourniquet (nonadrenaline group); atrial
premature beats occurred in three patients dur-
ing drug injection (one in the adrenaline group
and two in the nonadrenaline group); and in one
patient in the adrenaline group, atrial premature
beats occurred only after drug injection. When
comparing the rate of arrhythmias occurring dur-
ing or after drug injection between the two groups
(i.e., drug-related arrhythmias), there were two
patients in each group (4 percent) (p = 1). Atrial
premature beats were recorded in 54 patients (53
percent) (25 patients in the adrenaline group and
29 patients in the nonadrenaline group; p = not

Table 1.  Baseline Characteristics of the Study Population

Overall Lidocaine plus Adrenaline
Characteristic (%) Tourniquet (%) (%) p
No. of patients 102 51 51
Age, yr 0.7
 Mean ± SD 59.7 ± 13.6 60.2 ± 14.6 59.1 ± 13.0
 Range 27–85 27–85 27–81
Male 30 (29) 13 (25) 17 (33) 0.514
Type of surgery 0.5998
 CTR 56 30 26
 TF 31 13 18
 TF and CTR 6 4 2
 Biopsy 9 4 5
Dose injected, cc 8.8 ± 2.5 8.8 ± 2.7 8.8 ± 2.3 0.8
Holter monitoring, min
 Total time 96 ± 49 86 ± 38 105 ± 57 0.045
 Time before injection 58 ± 42 50 ± 34 65 ± 47 0.07
 Time before tourniquet 58 ± 32 —
 Time after injection 41 ± 21 37 ± 19 45 ± 23 0.06
CTR, carpal tunnel release; TF, trigger finger.

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 Volume 146, Number 1 • Cardiac Arrhythmias in Hand Surgery

Table 2.  Side Effects and Arrhythmias in the Study Groups

Lidocaine plus
Characteristic Overall Tourniquet Adrenaline p
No. of patients 102 51 52
Side effects 0 0 0
Arrhythmias
 Major (no. of patients) 0 0 0 1
  AF 0 0 0
  VT 0 0 0
  VF 0 0 0
Minor (no. of patients) 68 37 31 0.293
 None 34 14 20
APBs 54 29 25 0.05518
 Homogenous distribution 22 8 14
 Only before injection 14 9 5
 During tourniquet 1 1 —
 During injection 7 5* 2*
 Only after injection 10 6 4
VPBs 38 22 16 0.305
 Homogenous distribution 17 10 7
 Only before injection 13 8 5
 During tourniquet 1 1 —
 During injection 2 1 1
 Only after injection 5 2 3
Atrial tachycardia 8 4 4 1
 Homogenous distribution 3 1 2
 Only before injection — — —
 During tourniquet 1 1 —
 During injection 3 2 1*
 Only after injection 1 — 1
Sinus tachycardia 2 0 2 0.495
 Homogenous distribution — — —
 Only before injection 1 — 1
 During tourniquet — — —
 During injection 1 — 1
 Only after injection — — —
Bradyarrhythmias 2 0 2 0.495
 Homogenous distribution — — —
 Only before injection — — —
 During tourniquet — — —
 During injection — — —
 Only after injection 2 — 2†
AF, atrial fibrillation; VT, ventricular tachycardia; VF, ventricular fibrillation; APBs, atrial premature beats; VPBs, ventricular premature beats.
*During injection and after injection in one patient.
†One patient with baseline first-degree atrioventricular block had Mobitz I second-degree atrioventricular block event (i.e., one dropped beat)
55 min after injection; another patient had five runs of sinus bradycardia up to 10 beats at 43 beats/min 5–10 min after injection.

significant). In most patients, atrial premature
beats were distributed homogenously throughout
the monitoring or only before injection (Table 2);
in one patient, atrial premature beats occurred
only during the start of tourniquet inflation (non-
adrenaline group); in seven patients, atrial pre-
mature beats occurred during drug injection (two
in the adrenaline group and five in the nonadren-
aline group); and in 10 patients, atrial premature
beats occurred only after drug injection (four in
the adrenaline group and six in the nonadrenaline
group). When comparing the rate of arrhythmias
occurring during or after drug injection between
the two groups (i.e., drug-related arrhythmias),
there were six in the adrenaline group (12 per-
cent) versus 11 in the nonadrenaline group (21.5
percent) (p = 0.26); ventricular premature beats
were recorded in 38 patients (37 percent) (16
patients in the adrenaline group and 22 patients
in the nonadrenaline group; p = not significant).
In most patients, ventricular premature beats
were distributed homogenously throughout the
monitoring or only before injection (Table 2); in
one patient, ventricular premature beats occurred
only during the start of tourniquet inflation (non-
adrenaline group); in two patients, ventricular
premature beats occurred during drug injection
(one in each group); and in five patients, ven-
tricular premature beats occurred only after drug
injection (three in the adrenaline group and two
in the nonadrenaline group). When compar-
ing the rate of arrhythmias occurring during or
after drug injection between the two groups (i.e.,
drug-related arrhythmias), there were four in the

57e
Copyright © 2020 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.

adrenaline group (7.8 percent) and three in the
nonadrenaline group (5.8 percent) (p = 1). Two
patients in the adrenaline group had recordings
of bradyarrhythmia: one patient with baseline
first-degree atrioventricular block had Mobitz I
second-degree atrioventricular block event with
one dropped beat 55 minutes after injection, and
the other patient had five runs of sinus bradycar-
dia up to 10 successive beats at 43 beats/minute, 5
to 10 minutes after drug injection.
DISCUSSION
The results of our study show that no major
arrhythmias (either ventricular tachycardia, ven-
tricular fibrillation, or atrial fibrillation) occurred
during the use of local anesthesia with adrenaline
during hand surgery procedures. Minor arrhyth-
mias, including atrial premature beats, ventricular
premature beats, and atrial tachycardia, occurred
at low rates either with or without adrenaline injec-
tion, with no statistical difference between the
groups. There were three patients with atrial pre-
mature beats, ventricular premature beats, or atrial
tachycardia events during inflation of the tourni-
quet, probably caused by the stressogenic effect of
the pain and pressure. Patients in the adrenaline
group had a 2 percent rate of sinus tachycardia dur-
ing injection and a 4 percent rate of asymptomatic
bradyarrhythmias (sinus bradycardia or Wencke-
bach type atrioventricular block) 5 to 55 minutes
after atrioventricular block injection. Patients with
these findings do not require any further treatment.2
The WALANT technique is gaining popularity
among hand surgeons worldwide. The technique
has many advantages, including no tourniquet
pain and no need for sedation; thus, there is no
need for preoperative blood tests, and the patient
maintains the ability to speak to the surgeon dur-
ing the procedure and has a shorter postoperative
recovery time in the surgery center.7,8 Concerns
regarding the cardiovascular risks of adding
adrenalin to the local anesthetics has motivated
us to perform this study.
Arrhythmias have been reported in 37.5 per-
cent of healthy patients who undergo multiple
dental extractions under local anesthesia with a
vasopressor agent.9 Neves et al.10 reported a 41
percent rate of arrhythmias during dental pro-
cedures in patients with coronary artery disease,
with no difference between the groups with or
without vasoconstrictor agents. In this study, it
was impossible to extract data about preanesthe-
sia electrocardiographic records; therefore, the
aforementioned data cannot be interpreted as
stemming from the use of a vasoconstrictor agent.
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Copyright © 2020 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Plastic and Reconstructive Surgery • July 2020
Barkin and Middleton,5 in an uncontrolled
study of a younger population (mean age, 34
years), reported that 36 of 225 patients (16 per-
cent) undergoing oral surgery under local anes-
thesia with adrenaline demonstrated arrhythmias
preoperatively or during surgery; most of them
were ventricular premature beats (32 patients),
and there were four heart blocks. In five cases,
the arrhythmias were serious enough to alter the
treatment plan: three were detected preopera-
tively, one was detected during injection, and one
was detected during surgery. The authors recom-
mended that adequate continuous monitoring is
justified in all dental patients. It should be men-
tioned that the reported “serious events” in those
five patients included seven ventricular prema-
ture beats within 30 seconds in one patient, with
no future cardiac intervention; eight ventricular
premature beats before treatment in a second
patient and a future uncomplicated procedure;
four ventricular premature beats per minute
before the procedure in a third patient; six ven-
tricular premature beats per minute for 3 minutes
in the fourth patient during and after injection
with spontaneous resolution but postponement
of the procedure; and ventricular premature
beat bigeminy before surgery in the fifth patient
caused by inappropriate codeine consumption
with future uneventful surgery.
In another uncontrolled study of 77 oral sur-
gery procedure in 65 patients, Hughes et al.6 per-
formed electrocardiography before injection of
0.8 to 8.8 ml lidocaine with 1:100,000 adrenaline,
and up to a few minutes after surgery (which lasted
3 to 48 minutes; average, 17.5 minutes). Operative
arrhythmia was found in 33 percent of patients
with known cardiovascular disease versus 17 per-
cent in those without cardiovascular disease, and
included clinically nonsignificant arrhythmias
(i.e., unifocal infrequent ventricular premature
beats, occasional atrial premature beats, nodal
escape rhythm, sinus arrhythmia, and wandering
pacemaker). In 10 percent of the procedures in
patients with a history of cardiovascular disease,
the ventricular premature beats were multifocal.
The incidence of arrhythmias increased with older
age and cardiovascular history and with duration
of the procedure. No consistent relationship was
found between quantity of anesthetics and devel-
opment of arrhythmias.
However, serious major arrhythmias were
sporadically described in young patients follow-
ing ear, nose, and throat and oral procedures:
Hema et al.1 described a case of hemodynamically
unstable ventricular tachycardia following the
 Volume 146, Number 1 • Cardiac Arrhythmias in Hand Surgery
use of intranasal adrenaline-soaked pledgets dur-
ing functional endoscopic sinus surgery that was
treated successfully with defibrillation. In this case
report, the authors mentioned that a large con-
centration of adrenaline was used; however, the
exact dose absorbed was not specified. Manani et
al.4 described another case of a first-event symp-
tomatic atrial fibrillation after local anesthesia
with 1.8  ml of 2% mepivacaine and 1:100,000
adrenaline in a 19-year-old healthy anxious dental
patient. The atrial fibrillation recovered spontane-
ously the following day, and a second attempt after
a stress reduction protocol11 in the same patients
was uneventful. Another case report describes a
28-year-old patient who developed excessive hyper-
tension, ventricular tachycardia, and pulmonary
edema after ear, nose, and throat surgery under
local anesthesia with lidocaine and adrenaline
(volume and concentrations were not reported).12
The authors suspected intravascular injection or
an excessive dose of adrenaline infiltration.
To the best of our knowledge, our study is the
first randomized controlled study that analyzed
the arrhythmogenic effect of adding adrenaline
to local anesthetics during hand surgery. This is
also the first study to continuously monitor and
compare the patient’s arrhythmia before injec-
tion versus after injection. The fact that each
patient served as their own control enabled us to
determine the vasoconstrictor-related arrhythmo-
genic effect. In addition, this is the first study to
examine the influence of the stressogenic effect
of tourniquet inflation on arrhythmia.
Adrenaline, with its potent vasopressor and
inotropic properties, is a mainstay of therapy in
critical care patients (e.g., during shock, cardiac
arrest). In these situations, the maximal bolus dose
is 0.2 mg/kg and the maximal infusion rate is 0.1
μg/kg per minute. This dose can cause ventricu-
lar arrhythmias.13 Maslov et al. used a rat model
with arterial and left ventricular catheters to inves-
tigate the dose-response relationship of the drug
in incremental doses of 0.05 to 0.5 μg/kg per
minute.14 Only an infusion rate of 0.2 μg/kg per
minute raised myocardial tissue epinephrine levels
sufficiently to increase heart rate but not contractil-
ity. Inotropic and lusitropic effects were significant
at the infusion rate of 0.3 μg/kg per minute. This
study implies that the need for higher doses to see
cardiac effects is likely attributable to a threshold
for drug accumulation in tissue; however, these
data cannot be directly translated to humans with-
out further investigation. The New York Heart
Association recommended in 1955 that no more
than 0.2  mg of adrenaline be used in any one
Copyright © 2020 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
session for dental surgery,15 and several authors
recommend restricting the amount of adrenaline
to 0.04 mg, especially in patients with cardiovascu-
lar disease (American Society of Anesthesiologists
class III and IV).11,16 This dose is the equivalent of
approximately two 1.8-ml cartridges of 1:100,000
epinephrine-containing local anesthetic. Our data
prove the safety of up to 16  ml of local anesthe-
sia containing adrenaline in a concentration of
1:100,000 in patients undergoing wide-awake local
anesthesia no tourniquet surgery.
There are several limitations to our study.
First, the Holter monitoring in the adrenaline
group was longer than in the control group.
Despite this fact, there was no statistical difference
between the groups regarding type and frequency
of arrhythmias. Longer monitoring could have
exposed more arrhythmias in the control group,
reducing even more the arrhythmogenic impact
of adrenaline compared to the control group;
second, there was a difference between the con-
centrations of lidocaine between the two groups.
This limitation was not translated into clinical dif-
ference. Third, although we used relatively higher
doses of adrenaline compared to the doses that are
frequently used in common plastic or dental pro-
cedures, there are upper extremity surgical proce-
dures using the WALANT technique where up to
50 cc of solution is used (e.g., ulnar nerve release
at the elbow). Our results cannot be applied to
procedures with higher doses of adrenaline, and
further study is needed to examine their safety
regarding arrhythmias.
CONCLUSIONS
Our results show that hand operations using
the WALANT technique in patients with no his-
tory of arrhythmia are safe and are not arrhyth-
mogenic. Therefore, there is no need for routine
perioperative continuous electrocardiographic
monitoring.
Uri Farkash, M.D.
Hand Surgery Unit
Assuta Ashdod University Hospital
7 Harefua Street
Ashdod, Israel
urifarkash@gmail.com
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Plastic and Reconstructive Surgery • July 2020
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