Bibliografía

1. Yanez-Mo M, Siljander PR, Andreu Z, Zavec AB, Borras FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colas E,
Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH,
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TA, O’Driscoll L, Olivan M, Oliveira C, Pallinger E, Del Portillo HA, Reventos J, Rigau M, Rohde E, Sammar M, Sanchez-
Madrid F, Santarem N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben
MH, De Wever O (2015) Biological properties of extracellular vesicles and their physiological functions. J Extracell
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2. Deatherage BL, Cookson BT (2012) Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet
underappreciated aspect of microbial life. Infect Immun 80(6):1948–1957
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involved in health and disease: basic science and clinical applications. Int J Mol Sci 14(3):5338–5366
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extracellular vesicles. Annu Rev Cell Dev Biol 30:255–289
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of ESCRT functions in exosome biogenesis, composi- tion and secretion highlights the heterogeneity of extracellular
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7. Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B,
Benaroch P, Hacohen N, Fukuda M, Desnos C, Seabra MC, Darchen F, Amigorena S, Moita LF, Thery C (2010) Rab27a and
Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 12 (1):19–30; sup pp 11–13
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methods of study. Bioscience 65(8):783–797
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11. Choi DS, Kim DK, Kim YK, Gho YS (2013) Proteomics, transcriptomics and lipidomics of exosomes and ectosomes.
Proteomics 13(10–11):1554–1571

12. Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brugger B, Simons M (2008) Ceramide
triggers budding of exosome vesicles into multivesicular endo- somes. Science 319(5867):1244–1247
13. Subra C, Laulagnier K, Perret B, Record M (2007) Exosome lipidomics unravels lipid sorting at the level of multivesicular
bodies. Biochimie 89(2):205–212
14. Vidal M, Sainte-Marie J, Philippot JR, Bienvenue A (1989) Asymmetric distribution of phospholipids in the membrane of
vesicles released during in vitro maturation of guinea pig reticulocytes: evidence precluding a role for
“aminophospholipid translocase”. J Cell Physiol 140(3):455–462
15. de Gassart A, Geminard C, Fevrier B, Raposo G, Vidal M (2003) Lipid raft-associated protein sorting in exosomes. Blood
102(13):4336–4344

12. Dubois L, Ronquist KK, Ek B, Ronquist G, Larsson A (2015) Proteomic profiling of detergent resistant membranes (lipid
rafts) of prostasomes. Mol Cell Proteomics 14(11):3015–3022
13. Llorente A, Skotland T, Sylvanne T, Kauhanen D, Rog T, Orlowski A, Vattulainen I, Ekroos K, Sandvig K (2013) Molecular
lipidomics of exosomes released by PC-3 prostate cancer cells. Biochim Biophys Acta 1831(7):1302–1309
14. Haraszti RA, Didiot MC, Sapp E, Leszyk J, Shaffer SA, Rockwell HE, Gao F, Narain NR, DiFiglia M, Kiebish MA, Aronin N,
Khvorova A (2016) High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell
sources. J Extracell Vesicles 5:32570
15. Kim CW, Lee HM, Lee TH, Kang C, Kleinman HK, Gho YS (2002) Extracellular mem- brane vesicles from tumor cells
promote angiogenesis via sphingomyelin. Cancer Res 62(21):6312–6317
16. Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S,
Poirot M, Record M (2010) Exosomes account for vesicle- mediated transcellular transport of activatable phospholipases
and prostaglandins. J Lipid Res 51(8):2105–2120
17. Xiang X, Poliakov A, Liu C, Liu Y, Deng ZB, Wang J, Cheng Z, Shah SV, Wang GJ, Zhang L, Grizzle WE, Mobley J, Zhang HG
(2009) Induction of myeloid-derived suppressor cells by tumor exosomes. Int J Cancer 124(11):2621–2633
18. Esser J, Gehrmann U, D’Alexandri FL, Hidalgo-Estevez AM, Wheelock CE, Scheynius A, Gabrielsson S, Radmark O (2010)
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote
granulocyte migration. J Allergy Clin Immunol 126(5):1032–1040, 1040 e1031–e1034
19. Altadill T, Campoy I, Lanau L, Gill K, Rigau M, Gil-Moreno A, Reventos J, Byers S, Colas E, Cheema AK (2016) Enabling
metabolomics based biomarker discovery studies using molecular phenotyping of exosome-like vesicles. PLoS One
11(3):e0151339
20. Palomo L, Casal E, Royo F, Cabrera D, van-Liempd S, Falcon-Perez JM (2014) Considerations for applying metabolomics
to the analysis of extracellular vesicles. Front Immunol 5:651
21. Royo F, Palomo L, Mleczko J, Gonzalez E, Alonso C, Martinez I, Perez-Cormenzana M,

Castro A, Falcon-Perez JM (2017) Metabolically active extracellular vesicles released from hepatocytes under drug-
induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes.
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22. Fontana S, Saieva L, Taverna S, Alessandro R (2013) Contribution of proteomics to under- standing the role of tumor-
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23. Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borras FE, Breakefield X, Budnik V, Buzas E,
Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM,
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Nolte-’t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE,
Sanchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW,
Vazquez J, Vidal M, Wauben

28. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H,

Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE,
Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont- Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK,
Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K,
Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK,
Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D (2015) Tumour exosome integrins determine organotropic
metastasis. Nature 527(7578):329–335

29. Taverna S, Fontana S, Monteleone F, Pucci M, Saieva L, De Caro V, Cardinale VG, Giallombardo M, Vicario E, Rolfo C, Leo
GD, Alessandro R (2016) Curcumin modulates chronic myelogenous leukemia exosomes composition and affects
angiogenic phenotype via exosomal miR-21. Oncotarget 7(21):30420–30439