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11. This is not part of the HELLP syndrome. 14. Which of these are mainly responsible for the pathogenesis of
a. Hemoconcentration hypertension during pregnancy?
b. Hemolysis a. Increased blood volume
c. Elevated SGPT b. Sodium retention
d. Thrombocytopenia c. Increased heart rate and cardiac output
H – hemolysis (inc LDH) d. Vasospasm of vessels and endothelial damage
12. For pregnancies with severe preeclampsia less than 34wks, in 15. In which situation is Preeclampsia considered mild?
which situation is immediate delivery indicated? a. BP: 140/90mmHg; liver enzyme elevated
a. Reversed diastolic flow in the umbilical artery b. BP: 150/100mmHg; all labs normal
b. Intrauterine growth restriction c. BP: 140/80mmHg; with IUGR
c. Eclampsia d. BP: 130/90mmHg; HELLP syndrome
d. Severe oligohydramnios
Pregnancies ≥ 34wks of gestation complicated by severe preeclampsia is best
managed by delivery after maternal stabilization Classification of Preeclampsia:
16. A 20-year old sought consult for her first prenatal care. AOG: 18 weeks. FHT 140s. BP 150/100. 24hour urine protein is 500mg. Classify the
hypertensive disorder.
A. Gestational hypertension
B. Preeclampsia
C. Chronic Hypertension
D. Chronic Hypertension with superimposed preeclampsia
Convulsions Eclampsia (seizures that cannot be attributed to other causes in a woman with pre-eclampsia)
Magnesium sulphate – given for 24h to control convulsions
TREATMENT FOR ECLAMPSIA
1. Control of convulsions using an intravenously administered loading dose of magnesium sulfate, followed either by a continuous infusion of magnesium sulfate or by an
intramuscular loading dose and periodic intramuscular injections.
2. Intermittent intravenous or oral administration of an antihypertensive medication to lower blood pressure whenever the diastolic pressure is considered dangerously high.
3. Avoidance of diuretics and limitation of intravenous fluid administration.
4. Delivery (definitive cure for pre-eclampsia)
18. A 28 y/o G2 was admitted due to elevated BP. AOG: 32 weeks. Initial labs revealed LDH and SGPT with decreased platelet count. Give the
most appropriate management.
A. give platelet transfusion until the count becomes normal.
B. give antihypertensives and repeat the lab every 3 days.
C. give MgSO4 then proceed with delivery
D. give MgSO4, antihypertensives then deliver after steroid therapy
20. A pre-eclamptic woman whose BP remained elevated beyond 3 months postpartum should be classified as having
A. preeclampsia with severe features
B. preeclampsia mild
C. chronic hypertension
D. chronic hypertension with superimposed preeclampsia
21. G1P0 PU 14 weeks AOG developed fever, headache and body 22. What is the AOG in weeks with the highest risk of fetal
malaise. She developed multiple vesicular lesions all over her body transmission of varicella infection?
the following day. The MOST common cause of mortality of this A. <13
disese is secondary to: B. 13-20
A. renal failure C. 20-26
B. pneumonia D. 26-30
C. infected lesions
D. anemia EXPOSURE RISK BASED ON AGE OF GESTATION
< 13 weeks 0.4%
Diagnosis: Varicella/Chicken pox (basis: fever, headache, body malaise, vesicular 13 – 20 weeks Highest risk
lesions)
Most common cause of mortality: Pneumonia > 20 weeks None
23. G3P2 consulted because of flu-like symptoms and multiple vesicular lesions all over her body with accompanying itchiness. Which of the
following is not a recommended management?
A. Advised bed rest and vitamin C
b. Request for chest Xray
c. Acyclovir
D. vaccination
Diagnosis: Varicella/Chicken pox
VACCINATION
Non pregnant: 4 to 8 weeks apart
NOT recommended for pregnant and within a month following each vaccine dose
Not secreted in breastmilk
Recommended during Contraindicated during Post-partum and Breastfeeding
Pregnancy Pregnancy
Influenza Varicella Non pregnant: give 4-8wks apart; Not secreted in breastmilk
MMR (Measles, Mumps, MMR - Pregnancy is avoided 1 month after vaccination; Measles vaccine - can
Rubella) be given during postpartum breastfeeding
Measles only
HPV Can be given to breastfeeding women
28. A G3P2 PU 12 weeks consulted because of painless solitary ulcer noted on the labia majora. On examination, the ulcer has smooth base with
red firm border with inguinal lymphadenopathy. What is the diagnosis?
A. herpes genitalis
B. donovanosis
C. syphilis
D. granuloma inguinale
29. A G1P0 PU 38 weeks came in labor. She has fever for 2 days with o Has been recommended to decrease HIV prenatal
multiple painful ulcers at the labia majora. What is the BEST transmission for patients with 1000 copies/mL of HIV RNA
management? load at 38 weeks
A. rupture the bag of waters IV Zidovudine
B. await spontaneous delivery o As loading dose prior to CS followed by 2 more hours of
C. give Oxytocin to hasten delivery continuous maintenance therapy
D. immediate CS
31. Which of the following is NOT DERIVED from the
Diagnosis: Herpes (Herpes = multiple ulcers vs Syphilis = Solitary) MULLERIAN DUCTS?
See also #28 for basis of diagnosis a. Fallopian Tubes
Highest transmission during peripartum, therefore A, B, and C are not advised. b. Ovary
c. Uterus
NEONATAL TRANSMISSION d. Upper Vagina
Intrauterine 5%
Peripartum 85% Structures/Parts of the Mullerian ducts are:
(During labor and delivery) Fallopian Tube
Postnatal 10% Uterus
Cervix
PERIPARTUM SHEDDING PROPHYLAXIS Upper Vagina
Acyclovir and Valacyclovir suppression at 36 weeks will decrease the
number HSV outbreak at term 32. A G1P0 PU * weeks AOG was diagnosed to have a Mullerian
CS is RECOMMENDED for women with ACTIVE GENITAL lesions or Anomaly, Which of the following modalities is done INITIALLY to
prodromal symptoms SCREEN for an associated RENAL ANOMALY?
CS is NOT recommended for ACTIVE lesions in NON GENITAL area a. Renal Sonography
No evidence that external lesions causes ascending infection in PPROM b. Intravenous Pyelography
No absolute duration of membrane rupture beyond which the fetus will c. Magnetic Resonance Imaging
benefit from CS delivery d. Computed Tomography
Breastfeeding is allowed as long as there is no breast lesions
Di ko mahanap yung RATIO neto, pero nasa samplex sya.
30. Which of the following is recommended for HIV infection during 33. What uterine anomaly ARISES from a COMPLETE LACK OF
pregnancy? FUSION resulting in SEPARATE HEMIUTERI, CERVICES and
A. rupture the bag during the active phase of labor VAGINAS?
B. deliver the baby by forceps extraction a. Bicornuate Uterus
C. vaccinate for pneumonia and tetanus b. Septate Uterus
D. methylergonovine to prevent atony c. Uterine Didelphys
d. Arcuate Uterus – MILD deviation from normally developed
For HIV infection: uterus.
CS and pneumococcal, HepB, HepA, Tdap and Influenza vaccines are
recommended.
Avoid Artificial rupture, methergine administration. BICORNUATE/SEPTATE UTERUS UTERINE DIDELPHYS
UTERUS 2 2
MANAGEMENT DURING PREGNANCY
CERVIX 1 2
Serum creatinine, hemogram, and bacteriuria screening
Plasma HIV RNA quantification – “viral load”, CD4+ T-lymphocyte count,
and antiretroviral resistance testing 34. In a woman diagnosed to have a BICORNUATE UTERUS,
Serum hepatic aminotransferase levels which of the following complications is LEAST LIKELY to occur?
HSV-1 and -2, cytomegalovirus, toxoplasmosis, and hepatitis C serology a. Ectopic Pregnancy
screening b. Miscarriage
Chest radiograph c. Malpresentation
Tuberculosis skin testing – Purified protein derivative (PPD) or interferon d. Preterm birth
– gamma release assay
Pneumococcal, hepatitis B, hepatitis A, Tdap, and Influenza vaccines There is an increased incidence of Pre-term delivery (miscarriage?), Abnormal Fetal
Sonographic evaluation to establish gestational age. Lie (Malpresentation) and CS delivery.
PRENATAL HIV TRANSMISSION (PREVENTION) 35. A 16 year old consulted because of PRIMARY AMENORRHEA
Highly active antiretroviral therapy or HAART and cyclic abdominal pain. Which of the following is the MOST
o Reduced perinatal HIV transmission LIKELY diagnosis?
Avoid artificial rupture of membranes, invasive fetal monitoring a. Longitudinal Vaginal Septum
Avoid forceps or vacuum extraction b. Imperforate Hymen
Methergine and other ergot adversely interact with antiretroviral drugs c. Unicornuate Uterus
causing vasoconstriction d. Bicornuate Uterus
o Do NOT administer
CS
Imperforate Hymen
-is NOT ENCOUNTERED in Pregnancy (assumed that the patient is not 41. A Primigravid came in for consult due to PRURITIC PAPULES.
pregnant cause she is just 16 year, and just came for consult due to the amenorrhea Thee were noted within her STRIAE, face, palm & sole, but
and cyclic abdominal pain). SPARING her PERIUMBILICAL AREA. What is the Diagnosis?
-It’s common presentation is PRIMARY AMENORRHEA and a. Eczema of Pregnancy
HEMATOCOLPOS (accumulation of menstrual blood in the vagina due to intact b. PUPP
hymen) c. Pemphigoid Gestationis
d. Cholestasis of Pregnancy
Longitudinal Vaginal Septum, Unicornuate and Bicornuate Uterus are all UTERINE
MALFORMATION, and is discovered at CS or manual exploration of uterine cavity Pemphigoid Gestationis -starts as PRURITIC PAPULE > Plaque > BULLAE; It has
after delivery. Abdominal lesion involving the Umbilicus.
36. Which of the following is NOT A COMMON associated symptom PUPP looks like Pemphigoid Gestations that has not blistered (so PRURITIC PAPULE).
of a RETROFLEXED INCARCERATED UTERUS? Rash affects the Abdomen, Proximal Thigh, but has UMBILICAL SPARING.
a. Pelvic Pressure
b. Abdominal Pain 42. Elsa, G2P1 on her second trimester of pregnancy developed
c. Vaginal Bleeding Scaly, Dry, Thickened RED PATCHES on her EXTREMITIES and
d. Urinary Retention NECK. On further lab work-ups, the serum IgE were elevated. What
is the diagnosis?
Accoding to the TRANS, Symptom of RETROFLEXED INCARCERATED UTERUS are: a. Prurigo of Pregnancy
Abdominal Discomfort (Abdominal Pain, Pelvic Pressure?) b. Pruritic Folliculitis of Pregnancy
Inability to void normally (Urinary Retention) c. PUPP
d.Eczema of Pregnancy
37. A 5x6 cm BARTHOLIN’S CYST was noted in a Gravida 2 Para
1, Term, in labor. Which of the ff is NOT THE APPROPRIATE
MANAGEMENT? Prurigo of Preg - Pruritic RED PAPULES; Extensor surface and Trunk.
a. Allow Labor to continue Pruritic Folliculitis - small RED PAPULES; Sterile Pustules on Trunk.
b. Cesarean Section PUPP - Erythematous PRURITIC PAPULES/ Plaques on Abdomen and Thigh
c. Vaginal Delivery ECZEMA OF PREG - Dry, RED SCALY PATCHES on Flexor Extremities, Neck and
d. Needle Aspiration of the Cyst Face.
38. Which of the following conditions will NOT ALLOW a An ELEVATED IgE is also seen in ECZEMA of PREG ONLY! It is not seen in the other
spontaneous vaginal delivery? 2 AEP Dermatoses.
a. Extensive Venereal Warts
b. Cystocoele 43. Which of the following MEDICATIONS CAN BE GIVEN to
c. Rectocoele women with ATOPIC ERUPTION of PREGNANCY?
d. Uterine Anteflexion a. Oral Corticosteroids
b. Oral Antihistamine
Extensive Venereal Warts is cause by HPV, which can be transmitted (vertical c. Topical Corticosteroids
transmission) to the child through NSD. Therefore, we deliver a child from a mother d. All of the Above
with venereal warts through CS.
LOW TO MOD
39. Which of the following pregnancy specific dermatoses is Topical Corticosteroids
associated with ABNORMALLY ELEVATED SERUM BILE AND Oral Antihistamine
HEPATIC AMINOTRANSFERASE LEVEL? SEVERE
a. Intrahepatic Cholestasis of Pregnancy Topical Corticosteroid (Ultrapotent and Short Course)
b. Pemphigoid Gestationis Oral Corticosteroid, Cyclosporine, Narrow Band UVB (Occasionally
c. PUPP required)
d.Eczema of Pregnancy
INTRAHEPATIC CHOLESTASIS vs. ECZEMA OF PREGNANCY 44. Pregnancy DOES NOT exert much influence on the course of
Intrahepatic Cholestasis of Pregnancy Breast Cancer
Both Serum Bile and Hepatic Aminotransferase are ELEVATED. a. True
Eczema of Pregnancy b. False
Elevated Bile Acid, but up to expected for normal pregnancy
NORMAL AMINOTRANSFERASE. *Nakalagay mismo sa trans.
Pemphigoid Gestationis
Elevated IgG against collagen XVII (BP 180) 45. A primigravid on her First Trimester came in for follow-up with
PUPP - Unknown cause a Pap Smear result of CIN I. What is the next best thing to do?
a. Colposcopy
40. What is the GOLD STANDARD procedure in diagnosis b. Conization
PEMPHIGOID GESTATIONIS? c. Curettage
a. KOH Smear d. LEEP
b. Immunofluorescent Skin Tissue Staining
c. Gram Staining Management of women with CIN1/LSIS (low-grade squamous Intraepithelial lesion):
d. Tzank Smear 1. PAP SMEAR
1. COLPOSCOPY
IMMUNOFLUORESCENT SKIN TISSUE STAIN - GOLD STD; Since the pathology of 1. if with POSITIVE HPV TEST
Pemphigoid Gestationis is that maternal IgG works against Collagen XVII (BP180), 2. if with NO HPV TEST
which is found in the Basement Membrane of the Skin, you have to perform 2. REPEAT COTESTING
Immunofluor. Skin test Stain to demonstrate the reaction of IgG and collagen in the 1. If NEGATIVE HPV TEST
skin. *Since Papsmear lang ginawa, and NO HPV TEST… COLPOSCOPY is the best
answer. (SOURCE IS GYNE TRANS on CIN and CERVICAL CA)
KOH - to demonstrate Fungal morphology
Gram Stain - to demonstrate Bacterial Morphology Conization, Curettage and LEEP can be done if the result of COLPOSCOPY is
Tzank Smear - Used to demonstrate Multinucleate Giant Cells of Herpes, Varicella, INADEQUATE.
CMV.
46. A multigravida currently on her 20th week AOG sought consult 51. Which of the following is TRUE of hyperemesis gravidarum?
due to vaginal bleeding. On examination, the cervix was converted A. It is very common in pregnancy up until the 16th week
to a 3x3 fungating mass with smooth and pliable parametria. What of gestation
is the next BEST thing to do? B. It can cause weight loss, dehydration and hypokalemia
A. Pap Smear C. It is more likely to trigger hospitalization in obese patients
B. Cervical Biopsy D. It is more common if carrying a male fetus
C. Curettage
D. Radical hysterectomy Mild to moderate nausea and vomiting are especially common in
pregnant women until approximately 16 weeks
Endocervical curettage should NOT be performed during pregnancy to avoid Severe unrelenting nausea and vomiting—hyperemesis gravidarum—is defined
risk of hemorrhage and membrane rupture variably as being sufficiently severe to produce weight loss, dehydration,
Colposcopically directed Biopsies are used liberally to assess any ketosis, alkalosis from loss of hydrochloric acid, and hypokalemia
suspicious lesions. obese women are less likely to be hospitalized (Williams Obstetrics 24th ed)
And for unknown reasons—perhaps estrogen-related—a female fetus
increases the risk by 1.5-fold (Williams Obstetrics 24th ed)
47. A primigravid at 10 weeks AOG came in at the emergency room
because of an on and off abdominal pain. She had an ultrasound done
4 weeks ago with a finding of a left adnexal mass measuring 6x6cm. 52. Which of the following is the MOST commonly observed finding
On PE, her abdomen was soft but with tenderness on the left lower of appendicitis in pregnancy?
quadrant, FHT of 140bpm. What is the MOST likely diagnosis? A. Fever
A. Ovarian torsion B. Anorexia
B. Acute appendicitis C. Nausea and vomiting
C. Ruptured ectopic pregnancy D. Persistent abdominal pain and tenderness
D. Fecal stasis
Anorexia, nausea and vomiting that accompany normal pregnancy are also
The two most common complications of any ovarian mass are torsion and common symptoms of appendicitis
hemorrhage. Torsion usually causes acute constant or episodic lower abdominal pain Persistent abdominal pain and tenderness – most reproducible findings
that frequently is accompanied by nausea and vomiting. (Williams Obstetrics 24th ed)
57. Which labarotory result will give the diagnosis of overt DM Women diagnosed with GDM or DM ( during pregnancy) should be screened
during pregnancy? for Type 2 DM using 75 gram OGTT at 6-12 weeks postpartum
A. FBS 135 mg/dl with polydipsia
B. HgbA1C 6.0% with polyphagia
C. RBS 190 mg/dl with polyuria 62. To meet the increased need for the thyroid hormones during
D. 50 OGCT 140 mg/dl with polyhydramnios pregnancy, which of the following is TRUE?
A. Increase in both TRH and TSH
B. Increase in uterine clearance of iodide
C. Thyroid gland hyperplasia
D. All of the above
59. A 35 year old G5 had her 50 gram oral glucose challenge test.
AOG: 18 weeks Result = 140 mg/dl. What is the NEXT step? 64. A 29 y/o primigravid at 8 weeks is diagnosed with
A. Monitor the capillary blood glucose 3x a day hyperthyroidism. Pertinent PE: BP 100/70 PR 89 RR 19cpm; FHT
B. Start her on diabetic diet 160’s. Which of the following is the MOST appropriate treatment at
C. Request for a 100 gram OGTT this time?
D. Repeat the OGCT at 24-28 weeks A. Propylthiouracil
B. Methimazole
screening for gestational diabetes should be performed between 24 and C. Propanolol
28 weeks age of gestation D. A & C
a 50-g oral glucose challenge test is followed by a diagnostic 100-g oral
glucose tolerance test if results exceed a predetermined plasma glucose
concentration.
Plasma glucose level is measured 1 hour after a 50-g glucose load without
regard to the time of day or time of last meal.
Determine plasma sugar after hour –
o if 130 - 140mg/dl: do 100 grams OGTT after 8- 14
hours fasting
PTU and Methimazole does not have any difference when it comes to efficacy.
60. A 40 year old G3 with overt DM asked you on when is the best PTU – for 1st trimester (patient is at 8 weeks)
date to deliver her baby. Her last 2 pregnancies were delivered via Methimazole – 2nd trimester onwards (Methimazole is teratogenic at 1st trimester)
caesarean section. Current AOG is 36 weeks. The BEST answer is
A. 37 weeks
B. 38 weeks 65. What is a life threatening condition associated with poorly
C. 39 weeks controlled hyperthyroidism that may be precipitated by labor &
D. 40 weeks delivery?
A. Preeclampsia
Labor is induced at 39 weeks among patients with GDM requiring insulin B. Thyroid storm
C. Hypothyroidism
D. Atrial Fibrillation
an acute, life-threatening, hyper-metabolic state A. Reticulocyte count
Patients typically present with a fever as high as 40 0C, marked tachycardia, B. Bone marrow iron
prostration, and severe dehydration C. Serum iron
precipitating factors are labor, cesarean section, or infection D. Serum Ferritin
up to 25% mortality rate, despite aggressive, and appropriate, medical
management “When pregnant women with moderate iron deficiency anemia are given adequate
iron therapy, a hematological response is detected by an elevated reticulocyte count.
The rate of increase of hemoglobin concentration or hematocrit is typically slower
66. Which of the following is a fetal/neonatal effect of a maternal than in nonpregnant women due to the increasing and larger blood volumes during
elevated TSH and low T4? pregnancy.” (Williams Obstetrics 24th ed)
A. Goitrous Hyperthyrotoxicosis
B. Neonatal Hypothyroidism
C. Intellectual impairment 72. G2P1 PU 37 weeks previous CS, is for repeat CS at 39 weeks.
D. Motor paralysis However, haemoglobin was 9 gms/dL. What is the BEST treatment
for her?
Maternal hypothyroidism may impair fetal neuropsychological development. A. Ferrous sulphate
B. Ferrous gluconate
C. Ferrous fumarate
67. What are the MOST common causes of anemia during D. Iron sucrose
pregnancy?
A. Iron deficiency, Acute blood loss If a woman cannot or will not take oral iron preparations, then parenteral therapy is
B. Iron deficiency, Sickle cell disease given. Although both are administered intravenously, ferrous sucrose has been
C. Folate deficiency, Acute blood loss shown to be safer than iron-dextran
D. Folate deficiency, Sickle cell disease
“The two most common causes of anemia during pregnancy and the puerperium are 73. Which of the following condition/s is/are associated with
iron deficiency and acute blood loss.” (Williams Obstetrics 24th ed) thrombocytopenia during pregnancy?
A. Severe preeclampsia
68. What is the total requirement during a normal pregnancy? B. Amniotic fluid embolism
A. 100 mg C. Systemic Lupus Erythematosus
B. 300 mg D. All of the above
C. 1000 mg
D. 3000 mg “Thrombocytopenia in obstetrics is seen often with severe preeclampsia syndrome;
massive hemorrhage with transfusions; consumptive coagulopathy from placental
In a typical singleton gestation, the maternal need for iron averages close to 1000 abruption, sepsis syndrome, or amnionic-fluid embolism; hemolytic anemias;
mg. systemic lupus erythematosus and antiphospholipid antibody syndrome; or
300 mg - fetus and placenta hypoplastic or aplastic anemia. Other causes include viral infections, exposure to
500 mg - maternal hemoglobin mass expansion various drugs, and allergic reactions.” (Williams Obstetrics 24th ed)
200 mg - shed normally through the gut, urine, and skin.
(Williams Obstetrics 24th ed)
74. What is the MOST appropriate INITIAL treatment for a
pregnant woman with ITP?
69. G2P2 diagnosed to havean acute antepartum pyelonephritis and A. Systemic corticosteroids
she developed anemia on work up. What is the cause of anemia? B. Azathioprine
A. Decreased erythropoietin production C. Rituximab
B. Increased red cell destruction due to endotoxemia D. Laparoscopic splenectomy
C. Dilution secondary to intravenous hydration
D. Decreased iron stores Primary treatment includes IVIG or corticosteroids. Prednisone, 1
mg/kg daily, is given to suppress the phagocytic activity of the splenic
“ Anemia often accompanies acute pyelonephritis but is due to acute endotoxin- monocyte-macrophage system.
mediated erythrocyte destruction. With normal erythropoietin production, red In pregnant women with no response to corticosteroid or IVIG therapy,
cell mass is restored as pregnancy progresses.” (Williams Obstetrics 24 th ed) open or laparoscopic splenectomy may be effective.
70. During pregnancy, majority of iron requirement will be 75. In a primigravid, term, cephalic, in labor, diagnosed with ITP,
distributed to the – what is the manner of delivery?
A. Fetus A. Vaginal delivery
B. Placenta B. Caesarean delivery
C. Hemoglobin mass
D. Gastrointestinal tract “Because of the low incidence of severe neonatal thrombocytopenia and morbidity,
fetal platelet
300 mg - fetus and placenta determinations and cesarean delivery are not recommended for women with ITP.”
500 mg - maternal hemoglobin mass expansion (Williams Obstetrics 24th ed)
200 mg - shed normally through the gut, urine, and skin.
The route of delivery is the single most significant risk factor for the development of
uterine infection.
Vaginal delivery: membrane rupture, prolonged labor, multiple cervical examination
CS: prolonged labor, membrane rupture, multiple cervical examinations, internal fetal
monitoring
77. Thyrotoxicosis may occur in a H-mole. This is due to the Incomplete abortion bleeding that follows partial or complete placental
thyrotrophin effect of which hormone? separation and dilatation of the cervical os
A. hCG
B. FSH
C. LH 82. What is the MOST frequent associated condition with abruption
D. hPL placenta?
A. Multifetal pregnancy
The thyrotropin-like effects of hCG frequently cause serum fT4 levels to be elevated B. Smoking
and TSH levels to be decreased. C. Hypertension
D. Hydramnios