Houston Methodist Medical

Further research is needed to determine whether the same mechanisms [of TNT that
translocate SARS-CoV-2] operate in animal and human brains," said a biochemist at the
Houston Methodist Medical Institute. said Margolzata Kloc, who was not a collaborator on the
study. "This can be a very difficult task because TNT is a short-lived construct and it's difficult to
see it in action." Solutions need to be mapped. Also, because TNTs are composed entirely of
actin, there are few biomarkers for these small structures, making them difficult to study and
difficult to distinguish from other actin-based protrusions. As a result, TNT-mediated viral
transmission in vivo is simply "not well documented," she explains Tiwari. The only in vivo study
of TNT that Tiwari is aware of was in the eye.

Nath also notes that it is unclear whether viral entry into the brain is actually an important part of
the pathology of COVID-19. Although the virus is detectable in brain tissue, the levels
detectable in neurological samples are small compared to levels detectable in lung tissue, so it
may not be the cause of the neurological symptoms of COVID-19. . "This small amount of virus
cannot explain the pathology," he says.