RIMBERIO CO

DRUG-INDUCED DISEASES
EXERCISE NO. 5 FOR MIDTERM
RIMBERIO CO

GROUP 2
Abubakar, Mohajirah

Alison, Purity Mae

Relos, Jessa Mae

Tagotilla, Honey Riel
PRACTICE
EXERCISE:

1. Classify the kind of disease each type

of drug can induce.
2. Explain how each drug induces
disease formation.
3. Give the precautionary measures to
be undertaken when using a
particular drug to avoid disease
formation.
 Therapeutic Type of Disease
Name of Drug Toxic Effect Precautionary Measures
Classification Induced

If you are using this medicine

This drug can harm without a prescription, do not use
Group of Neuromuscular your kidneys, ears, and
it to treat deep wounds, puncture
1. Neomycin wounds, serious burns, or raw
antibiotics blockade nervous system, areas without first checking with
including your brain your health care professional. Do
not use this medicine in the eyes.

Chloroquine should not be used

can cause pathologic in patients who have psoriasis,
Antimalarials ocular damage unless porphyria (rare disorders that
Cardiomyopathy affect the skin and nervous
2. Chloroquine and strict prescribing and
Disease screening guidelines are
system), retina damage, or visual
amebicides field changes, whether or not they
followed. have been linked to 4-
aminoquinoline exposure

Nitrofurantoin should be used

This drug causes in caution with patients with
peripheral neuropathy anaemia, diabetes mellitus,
Interstitial Lung
3. Nitrofurantoin Antibiotics (including optic electrolyte imbalance,
Disease debilitating conditions and
neuritis), which may be
severe and irreversible. vitamin B (particularly folate)
deficiency.
 Therapeutic Type of Disease Precautionary
Name of Drug Toxic Effect
Classification Induced Measures

This drug can harm your Do not donate blood or

kidneys, ears, and sperm while you are
nervoMajor toxicities of taking this medicine and
Immunomodula thalidomide are birth for at least 4 weeks after
4. Thalidomide defects, sensorimotor your last dose. You must
tory agents Teratogenisis
peripheral neuropathy,

not share this medicine

somnolence, rash, fatigue, with anyone, even
and constipation someone who has similar
us system, including your symptoms
brain

Cephaloridine has been

shown to produce both
oxidative and
Antibiotics/ mitochondrial respiratory
Cephaloridine should not
be used in patients with
5. Cephaloridine Beta lactam Nephrotoxicity/ injury in renal cortex in
high levels of urea and

antibiotic Retinopathy patterns of dose (or
creatinine.
concentration) and time

that are consistent with
pathogenicity.
 Therapeutic Type of Disease
Name of Drug Toxic Effect Precautionary Measures
Classification Induced

Penicillin V and G can have Penicillins should be used with

adverse effects, including
nausea, vomiting, diarrhea,
rash, abdominal pain, and
Beta-lactam urticaria. In addition,
6. Penicillin Fulminant Penicillin G can have other
antibiotic
Myocarditis adverse reactions, including injection into or near major
muscle spasms, fever, chills, peripheral nerves or blood
muscle pain, headache,
tachycardia, flushing,
tachypnea, and hypotension
caution in individuals with
histories of significant allergies
and/or asthma. Care should be
taken to avoid intravenous or
intra-arterial administration, or
vessels, since such injections
may produce neurovascular
damage.

To keep the medicine as germ-

free as possible, do not touch
Anemia, Aplastic / the applicator tip to any
Antibiotic and is chemically induced. Blood surface (including the eye).
7. Chloramphenicol in the class of Cell Count. Blood After using chloramphenicol
Blood dyscrasias

antimicrobials Platelets. Bone Marrow eye ointment, wipe the tip of
Diseases / chemically the ointment tube with a clean

tissue and keep the tube tightly
induced
closed.
 Therapeutic Type of Disease
Name of Drug Toxic Effect Precautionary Measures
Classification Induced

Nausea, vomiting,
diaphoresis, and tinnitus are
the earliest signs and Protective equipment: Wear
symptoms of salicylate protective eyeware, gloves,
Nonsteroidal toxicity. Other early and clothing. Avoid inhaling
8. Acetyl salicylic symptoms and signs are
antiinflammator gases, fumes, dust, mist,
acid Renal Disease vertigo, hyperventilation,
y drugs (NSAIDs) tachycardia, and
vapor, and aerosols. Avoid

contact with skin, eyes, and

hyperactivity. As toxicity
progresses, agitation, clothing.
delirium, hallucinations,
convulsions, lethargy, and
stupor may occur.

It can effect of loss of If you are taking isoniazid by

appetite nausea or vomiting mouth and it upsets your
stomach, take it with food.
Antituberculosis numbness, tingling,
Antacids may also help.
9. Isoniazid motor-dominant burning, or pain in hands
agents and feet unusual tiredness
However, do not take

neuropathy aluminum-containing antacids

or weakness yellow eyes or
within 1 hour of taking
skin Rare Blurred vision or isoniazid.
loss of vision
 Therapeutic
Type of Disease
Name of Drug Classificatio Toxic Effect Precautionary Measures
Induced
n

Animal studies give clear Griseofulvin may increase the effects

evidence that it causes a of alcohol. If taken with alcohol it may
variety of acute and chronic also cause fast heartbeat, flushing,
Antifungal toxic effects, including liver increased sweating, or redness of the
10. Griseofulvin and thyroid cancer in face. If you have these symptoms, do
agents neuropathy
rodents, abnormal germ cell

not drink alcoholic beverages while

maturation, teratogenicity, you are taking this medicine, unless
and embroyotoxicity in you have checked first with your
various species doctor.

Using this medicine while you are

pregnant can harm your unborn baby.
Use an effective form of birth control
to keep from getting pregnant. If you
Phenytoin toxicity is rarely
Anticonvuls fatal, but can cause
think you have become pregnant while
11. Phenytoin Hypersensitivity using the medicine, tell your doctor
ants neurologic symptoms

phenomena ranging from nystagmus to
right away. Do not use this medicine if

you or your child are also using
ataxia to coma. delavirdine (Rescriptor®). Using these
medicines together may cause
unwanted effects.
 Therapeutic Type of Disease
Name of Drug Toxic Effect Precautionary Measures
Classification Induced

It can effect drowsiness This medicine may make your

increase in heart rate skin more sensitive to sunlight.
Use a sunscreen, hat, and
irregular heartbeat
protective clothing when you are
irritability mood changes
12. Furosemide Diuretics outdoors. Avoid sunlamps and
Adverse Reaction muscle cramps


numbness, tingling, pain,
tanning beds. Make sure any
doctor or dentist who treats you
or weakness in the hands,
knows that you are using this
feet, or lips rapid medicine.
breathing seizures

Serious skin rashes

include: Steven-Johnson
Syndrome, which causes Stay out of direct sunlight,
Antibiotics that aching joints and muscles, especially between the hours of
10:00 a.m. and 3:00 p.m., if
target bacteria redness, blistering, and
possible. Wear protective
13. Sulfonamide skin peeling. Toxic
causing Hepatic disease
epidermal necrolysis
clothing, including a hat. Apply a

sun block product that has a skin
infections causes difficulty in
protection factor (SPF) of at least

swallowing; peeling, 15
redness, loosening, and
blistering of the skin.
 Therapeutic Type of Disease
Name of Drug Toxic Effect Precautionary Measures
Classification Induced

Take this medicine exactly as

Common short-term directed by your doctor. Do not
prednisone side effects take more of it, do not take it
include nausea, weight more often, and do not take it for
14. Prednisone Corticosteroids gain and headaches. a longer time than your doctor
Osteoporosis


More serious side effects ordered. To do so may increase
include fetal toxicity, the chance for unwanted effects.
allergic reactions and Take this medicine with food or
high blood pressure milk to avoid stomach irritation.

Isolate spill or leak area in all

Non-narcotic Phenylbutazone toxicity directions for at least 50 meters (150
most commonly results in feet) for liquids and at least 25
analgesic, a non- meters (75 feet) for solids. SPILL:
adverse GI effects,
steroidal anti- Increase the immediate
including oral, esophageal,
15. inflammatory drug, an gastric, cecal, and right
precautionary measure distance, in
Equine glandular the downwind direction, as
Phenylbutazone ntirheumatic drug, a dorsal colonic ulcerations,
necessary. FIRE: If tank, rail car or
gastric disease and accompanying protein-

peripheral nervous tank truck is involved in a fire,
losing enteropathy, ISOLATE for 800 meters (1/2 mile) in
system drug, a hypoproteinemia, all directions; also, consider initial
metabolite and an EC leukopenia, and anemia. evacuation for 800 meters (1/2 mile)
in all directions. (ERG, 2020)
QUESTIONS:
1. What are the different factors or tactics that enhance drug
toxicity risks?

There are a number of variables that can affect the probability of

medication toxicity risk, but the most crucial is the patient's age. Patients
who are very young or very elderly are more susceptible to these reactions
than patients of other ages. Some example of factors also include the
prevalence of illness states, the pharmacokinetic and pharmacodynamic
properties of medications, the impact of disease on drug metabolism,
prescriber concerns such the prescription of many pharmaceuticals by
different prescribers, and poor prescriber knowledge
QUESTIONS:
2. How do adverse drug reactions differ from side effects and
contradictions?

Side effects and adverse drug reactions are both unintended responses to a medication, but they're
different from each other. Side effects are more predictable than ADRs, and side effects can be
beneficial or harmful. Side effects are the unintended, but predictable symptoms that can develop while
taking a medication. They may happen at normal doses, or they may occur when taking medicines for
the wrong condition. Some medications may cause weight loss as a side effect. But more often, they can
be harmful or unpleasant. Adverse effects are any undesired effects or outcomes caused by a
medication. The term adverse drug reaction specifically refers to unwanted or undesirable effects of a
medication that occur during usual clinical use, and so excludes overdose. The harm resulting from
adverse effects can be direct physical harm or toxicity, but an adverse effect can also be a secondarily
harmful effect, for example, effects that cause adverse outcomes such as increased risk of
noncompliance with the medication. Contraindications are symptoms or conditions that make a
particular treatment or procedure inadvisable. When a patient has these symptoms or conditions, the
contraindicated drug should not be used for this patient.
QUESTIONS:
3. How can you prevent the formation of drug-induced
diseases?

Steps that could help to prevent a drug-induced disease include the

following:
Always inform your doctor if you suffer from any illness or take any other
medication including a nutritional supplement before you are prescribed a
medication.
Inform your doctor if you have suffered from any previous allergic reaction
to a drug or any other substances like food ingredients.
Take the medication only as prescribed by the doctor. Stick to the dose,
duration of treatment as well as other structions like taking it after meals.
QUESTIONS:
4. Make a listing of drugs that can induce disease.

DISEASE DRUGS CAN INDUCE DISEASE

Rofecoxib
Fenfluramine
Cardiovascular system: corticosteroids
tERFENADINE

penicillin
sulfonamides
Skin: Hydralazine
chloroquine

Isoniazid
Theophylline
Brain and Nerves: Haloperidol
Benzodiazepines
QUESTIONS:
5. To what government agency are you going to make a report
on noted drug-induced diseases?

Food and Drug Administration (FDA)

Timely reporting by consumers, health professionals, and FDA-regulated
companies allows the agency to take prompt action. The agency evaluates
each report to determine how serious the problem is, and, if necessary,
may request additional information from the person who filed the report
before taking action.
RIMBERIO CO

THANK YOU