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The herpes simplex virus, also known as 

HSV, is a viral infection that causes genital


and oral herpes. Many people live with asymptomatic HSV, which means they have the
virus without ever having an outbreak or active episode of herpes.
Herpes simplex viruses -- more commonly known as herpes -- are categorized into two
types: herpes type 1 (HSV-1, or oral herpes) and herpes type 2 (HSV-2, or genital
herpes). Most commonly, herpes type 1 causes sores around the mouth
(gingivostomatitis) and lips (herpes labialis) (sometimes called fever blisters or cold
sores). HSV-1 can cause genital herpes, but most cases of genital herpes are caused
by herpes type 2. In HSV-2, the infected person may have sores around the genitals or
rectum. Although HSV-2 sores may occur in other locations, these sores usually are
found below the waist.
Transmission
Herpes simplex type 1, which is transmitted through oral secretions or sores on the skin,
can be spread through kissing or sharing objects such as toothbrushes or eating
utensils. In general, a person can only get herpes type 2 infection during sexual contact
with someone who has a genital HSV-2 infection. It is important to know that both HSV-
1 and HSV-2 can be spread even if sores are not present.
Drug of choice
The antivirals ( oral, intravenous and topical) acyclovir, valacyclovir, famciclovir and
pensiclovir are well established treatments for both HSV-1 and HSV-2. They all act by
interfering with the viral DNA polymerase and hence, viral genome replication.

Herpes zoster, also known as shingles, is caused by the reactivation of the varicella-
zoster virus (VZV), the same virus that causes varicella (chickenpox). Primary infection
with VZV causes varicella. Once the illness resolves, the virus remains latent in the
dorsal root ganglia.
The dorsal root ganglia lie in the intervertebral foramina. The intervertebral foramen
(also called neural foramen, ) is a foramen between two spinal vertebrae. 
Shingles itself is not contagious. It can't spread from one person to another.

Most cases of shingles last three to five weeks. The first sign is often burning or tingling
pain; sometimes it includes numbness or itching on one side of the body. Somewhere
between one and five days after the tingling or burning feeling on the skin, a red rash
will appear.
Some individuals develop shingles after several decades because of virus reactivation.
It is caused by decline of cellular immune response.
Up to one third of infected individuals will clinically reactivate VZV in their lifetimes,
usually in their elderly years when immunity is naturally senescing, or when immunity is
suppressed by disease or iatrogenic cause.
Mode of transmission
A person is not infectious before the blisters appear or after the rash has crusted over.
For disseminated zoster, transmission occurs through airborne and droplet
transmission, in addition to contact with fluid in the blisters of the rash. Disseminated
zoster is likely as infectious as varicella.
Drugs of choice
Herpes zoster is usually treated with orally administered acyclovir. Other antiviral
medications include famciclovir and valacyclovir.

Generally, to sum up this herpes simplex virus and herpes zoster virus
Oral herpes is caused by herpes simplex 1 and Genital herpes is caused by herpes
simplex 2. Mode of transmission: oral secretions and sores in the skin thru kissing or
sharing object. It is important to know that both HSV-1 and HSV-2 can be spread even
if sores are not present. The condition we call shingles is caused by herpes zoster.
Mode of transmission: we have the disseminated zoster virus thru airborne and droplet
transmission also can be with contact with fluid in the blisters of the rash Herpes zoster
is the same viral infection that causes chicken pox, and the herpes zoster virus can live
in the body for years after the case of chicken pox is gone and re-emerge as the painful
blisters of shingles.

Both antiviral drugs used in HSV and shingles, which is acyclovir.


human papillomavirus/ hpv
HPV infection is a viral infection that commonly causes skin or mucous membrane
growths (warts).
Warts are contagious. Warts can also spread when someone touches something that
already touched a wart.
Mode of transmission
HPV infection occurs when the virus enters your body, usually through a cut, abrasion
or small tear in your skin. The virus is transferred primarily by skin-to-skin contact.
Genital HPV infections are contracted through sexual intercourse, anal sex and other
skin-to-skin contact in the genital region. Some HPV infections that result in oral or
upper respiratory lesions are contracted through oral sex.
Commonly called sexually transmitted infection (STI)
Drug of choice
Imiquimod is in a class of medications called immune response modifiers. Commonly
prescribed solutions for HPV Imiquimod, which works by increasing the activity of the
body's immune system.
Imiquimod is an immunomodulator, a drug that interacts with the immune system.
Through boosting the immune system, imiquimod may help the body fight off cancer
cells.
Vaccines are available
Three HPV vaccines—9-valent HPV vaccine (Gardasil 9, 9vHPV), quadrivalent HPV
vaccine (Gardasil, 4vHPV), and bivalent HPV vaccine (Cervarix, 2vHPV)
CDC recommends routine vaccination of preteens at ages 11 or 12 years. The
vaccination series can be started at age 9 years. HPV vaccine may be given at the
same time as other vaccines.
HPV vaccination is administered as:
A two-dose series (0, 6-12 months) for most persons who initiate vaccination at ages 9
through 14 years except immunocompromised persons
A three-dose series (0, 1-2, 6 months) for persons who initiate vaccination at ages 15
through 45 years, and for immunocompromised persons initiating vaccination at ages 9
through 26 years; three-dose schedule also applies to adults initiating vaccination at
ages 27 through 45 years.
HPV vaccines should be administered intramuscularly 
The 9-valent HPV vaccine protects against HPV types 16 and 18, which cause about
66% of cervical cancers and most other HPV-attributable cancers in the United States,
and five additional cancer-causing types, which account for about 15% of cervical
cancers. It also protects against HPV 6 and 11, which cause most anogenital warts.

Everyone through age 26 years should get HPV vaccine if they were not fully
vaccinated already. HPV vaccination is not recommended for everyone older than age
26 years.

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