ANTIPSYCHOTICS

aka:majort
ranqui
li
zer
s

▪ Zy
prexa(
olanzapi
ne)
i
fmaybackgr oundkasamga
anti
psychotics,si
guronapansinmonamay Saanpobaitosil
aginagamit?
??
i
bat-i
banggener ati
onssil
a..l
ikef
ir
st Remembermopabay ungterm nat
inna
generati
on(typical
)andnewgener at
ion "psy
chosi
s".
.janposil
aginagamit.
.
(at
ypical
)..
Saschizophreni
a,maydalawangkl
aseng
Bakit? symptoms: posi
ti
veatnegati
vesymptoms.
Ganitopokasey an,sabawatgener at
ionng
drugsnag- iiba/i
ni-
improv eitongmgamga Mahalaganamal amanmoangpi nagkai
ba
manuf acturer s/
pharmaceut i
calcompani es, ngdalawangsy mptomsna' t
okaseangmga
angmgasi de-eff
ectspongmgaf i
rst anti
psychoti
csaymasef f
ecti
vesamga
generati
on( old)aymar ami atsobr ang posit
ivesymptoms( especi
all
ydel
usionsat
discomfor tangnai dudulot,that'
swhyang hal
luci
nati
ons)compar edsanegati
ve
mganewgener ati
onsayi mpr ov
edat symptoms..
nabawasanangmgasi de- effects(
whichi s
good).Per oangpr obl
ema, masmahal ang POSI TI
VE(TypeI )
mganewgener ati
oncompar edsaol d -
agitati
on
generati
onnapsy chdrugs. .kayay ungiba, -
delusions
maspi nipil
i pari
ny ungmgaol dgenerations -
halluci
nati
ons
kasesilay ungmasmur a.. -
paranoia(suspici
ons)
-
bizzarebehavior(l
ikecat
atoni
a)
FI
RSTGENERATI ON(typi
cal)
▪ Haldol(haloperi
dol
) Negat i
ve(Ty peII
)
▪ Thorazine(chlor
promazine) -anhedonia: i
nabil
i
tytofeelpl
easure
▪ Stel
azine(tri
fl
uoperazi
ne) -al
ogia:pov ert
yofspeech.
▪ Loxit
ane( l
oxapine) -apathy:l
ackoff eeli
ng,emotion,i
nter
estor
▪ Proli
xi
n( f
luphenazine) concern.
-avol
iti
on:lackofmot iv
ation
NEW GENERATI ON( at
ypi
cal
) -fl
ataffect
: absenceoffacialexpr
essi
on
▪ Clozari
l(clozapine)
▪ Risperdal(ri
speridone) note:
betweenthet
wo,angconfi
rmat
ory
▪ Seroquel (
quet i
apine) symptom poayangposi
ti
vesymptoms.
▪ Abili
fy(ari
piprazole)
NOTES -i
topoangsi
de-
eff
ectsngmga
1.neur
ol ept
icsangol dnamesngmga anti
psy
chot
icdr
ugs(perohi
ndi
lahat
).
.
anti
psychoti
cs. .t
inat
awagdinposi
l
ang
majort
r anquil
izers.
. note:
commonnanagkakar oonngEPSang
mgacl i
entnanagti
-t
akengtypi
cal
(fi
rst
2.angpri
mar yMoA( modeofact
ion)ng generat
ion)ant
ipsy
choti
cs.
.
mgaant i
psychot
icsayi-
decr
easeang
dopamine.. TORTICOLLI
S
cont
ract
edposi
ti
onoft
heneck
3.NMS( neur
olept
icmal i
gnantsy
ndrome)
angdelikadongadversereacti
onngboth OCCULOGYRICCRISI
S
typi
calatatypi
calanti
psychoti
cs.
.perokung cont
ract
edposi
ti
onoftheey
esupwar
d
i
tatanongkungkani nomascommonang
NMS, mascommonpoi tosamganagt i
- TARDI VEDYSKI NESIA
takengt ypi
calant
ipsychoti
cs.
. nangyay ar
epoangt ar
divedyski
nesiasa
l
ong- t
erm napag- gamitnganti
psychoti
cs.
.
4.clozapineaypwedengmag-causeng attr
eat mentpodi toaykail
angani-
stopat
agranulocytosi
s(sev
erel
ylowWBC).. pali
tan(substi
tute)angdrugnanagko-
causenet o.
.
5.chl
orpromazi
newast
hev
eryFI
RST
anti
psychot
icdr
ug. Signs:l
i
psmacki ng,r
epeti
ti
vechewi
ng,
rapideyebl
i
nking,inv
olunt
arymovement
s
ANTI
PSYCHOTI
CSI
DE-
EFFECTS ofthefi
ngers,
etc.

angisasamganaapektuhankapagnagt
i- St
udyTi
p:hindimonakail
angani-
memori
ze
takeangcl
ientngmganeurol
epti
csayang l
ahatngs/s..sabi
kongaanghanapi
nmo
kanil
ang"
extrapy
rami
dalsyst
em." l
angyungmgakey wor
ds.
.hal
imbawa:

angextr
apyramidal
syst
em poaypartng 1.satardiv
edy ski
nesi
a,r
emembert heword
ner
voussystem nanagr
i-
regul
atengmga "t
ardy"(
ibigsabi hi
naylat
eordelay
)..si
nce
muscleref
lexes.
. nagkakaroonl angpongtardi
vedyskinesi
a
salat
er( l
ong-term)napaggamitng
Tandaanmonaangat i
ngmgar efl
exesay anti
psychotics..
i
nv oluntarykayakapagnaapekt uhanang
extrapyramidal syst
em aynagkakaproblema PSEUDOPARKI NSONISM
ri
nsaat inginvolunt
arymov ements,dahi
lan -shuffl
ing/f
esti
nati
nggait
,dr
ool
ing,mask-
paramagkakar oonngt remors,aki
nesia, l
ikefacies,
brady ki
nesia,akathi
sia,et
c. -coar
sepi l
l
-rol
l
ingmov ement
softhethumb
andfingerswhileatr
est.
.
EPS(
ext
rapy
rami
dal
side-
eff
ect
s)
note:
ifpamilyarkasasaki tnaparkinson's
di
sease,paranggani t
or inpoang
nangyayar
esakani la..angpi nagkaibalang
i
s,angcausengpseudopar ki
nsonism ay
gamotathindi saki
t/disorder..

AKATHI SIA
uncontrol
labl
eurgetomov eandasenseof
rest
lessness..
i
nabili
tytositsti
l
lorrest(
ibi
gsabi
hin,
hindi
sil
amapakal ikayahi
ndisi
lamaka-
upo).

AKI
NESI
A–absenceofmov
ement

BRADYKI
NESI
A–sl
owedmov
ement

NOTES
1.tandaanmonat r
eat
mentsaEPSi st
o
STOPorLOWERTHEDOSEorpal it
an
(SUBSTITUTE)angant
ipsychot
icdrugna
nag-causengprobl
ema..

2.maymgadr ugspotayonabi
nibi
gaypar
a
ma-tr
eatangEPS,atkai
l
anganmor i
nit
ong
aral
i
n..

ant
i-
EPSdr ugs
▪ Aki
neton( Bi
periden)
▪ Cogenti
n( Benztropi
ne)
▪ Art
ane(Tr i
hexyphenidyp)
▪ Benadry
l (Di
phenhy dr
amine)
▪ Symmet rel(
Armant adi
ne)