Transport Phenomena in Bioprocess

Systems Reporting Topic:

Heat Transfer Group 8

Presented by:
Ray Anthony Comia
Daniel David Harris
Famela Clarice Paghasian
 Larissa
Content of Report
1 2 3

Heat transfer and Design/Working Sample Word

its role in Equations Problems related
biochemical involved for heat to the topics
engineering/ transfer in discussed.
bioreactos bioreactors
What is Heat
Transfer?
Heat transfer is defined as
the process in which the
molecules are moved from
the region of higher
temperature to lower
temperature.

In bioreactors, heat can be

either added or removed from
a microbial fluid.
Use of Heat in Biological Reactors
Supply of heat to bioreactors
in order to:
Kill foreign organisms by
sterilizing the feed to the
bioreactor
Reach and maintain the desired
operating temperature for
optimum substrate conversion.
Dry the cell sludge/biomass
Removal of heat from
bioreactors because:
Too much heat is produced
during subtrate conversion,
which will cause the bioreactor
temperature/conditions to
exceed its optimum value.
 Ways to Transfer heat to
and from the bioreactor
Water Circulation through an Coils inserted in a Flow through a
external jacket larger vessel heat exchanger

 Ways to Transfer heat to

and from the bioreactor
Evaporation or condensation Passing water through hollow Through the hollow draught tube
baffles in the bioreactor for airlift bioreactors
 Importance of Heat
Transfer in Bioreactors
Cultivation Regulation Control

It allows for Temperature must be Bioreactors are

cultivation of regulated to obtain highly dependent on
organisms in tightly reliable and temperature control
controlled consistent data

temperatures for

optimal growth

Working 1.) Rate of Heat Transfer (Q)

Equations
Where:
Q = heat transferred (W)
U = overall heat transfer coefficient (W
m-2 K-1)
A = heat transfer area (m2)
ΔT = log mean temperature (K)
 2.) Overall resistance to Heat
Working Trasnfer (1/U)

Equations

Where:
ho = outside film coefficient
hi = inside film coefficient
hof = outside fouling film coefficient
hif = inside fouling film coefficient
hw = wall heat transfer coefficient =
k = thermal conductivity of the wall
x = wall thickness

Working
Equations
Units for film coefficients:
W/(m^2.K)
Note: equation is not applicable for
thick-walled tube where a correction
factor must be used
hw = wall heat transfer coefficient =
2.) Overall resistance to Heat
Trasnfer (1/U)
Where:
ho = outside film coefficient
hi = inside film coefficient
hof = outside fouling film coefficient
hif = inside fouling film coefficient
k = thermal conductivity of the wall
x = wall thickness
 3.) Nusselt Number (Nu)
Working The ratio of the convective to
conductive heat transfer
Equations coefficients.
Used to determine the inside (hi)
and outside (ho) film coefficients,

Where:
k, a, b = constants
Re = Reynolds number
Pr = Prandtl number
 3.) Nusselt Number (Nu) (Cont'd)
Working Reynolds number is the ratio of

Equations inertial forces to viscous forces

Where: Prandtl number is the ratio of the

fluid kinematic viscosity to thermal
Dt = vessel diameter (m)
diffusivity
Di = impeller diameter (m)
= density (kg m-3)
= viscosity (kg m-1 s-1)
= kinematic viscosity (m2s-1)
k = thermal conductivity (W m-1 K-1)
h = convective heat transfer coefficient
(W m-2 K-1)
Cp = specific heat (J kg-1 K-1)
Alpha = thermal diffusivity (m2 s-1)
V = velocity (m s-1)
N = impeller speed (Hz) Note: Equation is only applicable to

Newtonian fluids in turbulent flow
 Paisley
Results 25

Project Findings from 20

Quantitative Methodology
15

10

Supported by data from Beal and 5

Harlow Research, January 2025

Visualize complicated and dense information 0

with graphs and charts. These are visual aids Item 1 Item 2 Item 3 Item 4 Item 5
that help add more context to the topic you
are discussing.
 Larissa
Word Problem #1