Know more about your patient’s immune response status

Patients with inflammatory diseases are common on many hospital wards whereby it is important to quickly differentiate between the various possible
conditions. One of the prime objectives is to distinguish between inflammations caused by infections and those that are not. One also has to determine
the pathogen responsible and the status of the immune response in case of infection. Haematological inflammation parameters, part of the blood count
available on Sysmex XN analysers, provide early information about the inflammatory reaction of patients’ immune systems and so support the diagnosis
and monitoring of these conditions.

A 23-year old man with an intermittent fever visited his physician three days after the initial onset of fever. The man reported the
following symptoms: shortness of breath, productive cough, abdominal pain, diarrhoea, night sweats and malaise. Considering
the man’s symptoms, a complete blood count with WBC differential analysis was performed. The results of the Sysmex XN-Series
analyser revealed leucopenia with a relative in­crease in neutro­phils. The neutrophils showed an increased activation and there were
slightly increased anti­body-synthesizing lymphocytes; the results indicated an early response of the innate immune system to an
active infection by intracellularly located bacteria.

INFECTION/
INFLAMMATION
Sysmex offers a practical solution
A combination of novel diagnostic inflammation parameters are readily available from a routine labo­ratory test, together with the
complete blood count. The parameters quantify and characterise the activa­tion status of white blood cell subpopulations, such as:
n Immature granulocytes (IG)

n Activated neutrophils (NEUT-RI, NEUT-GI)

n Activated lymphocytes (RE-LYMP, AS-LYMP)

These diagnostic inflammation parameters provide additional information about the activation of the immune response and help
Know more. clinicians monitor inflammatory conditions in details. More information on the individual parameters is found overleaf.
Decide with confidence.
Act faster.
 The diagnostic inflammation parameters support differentiation between the different types of immune response, such as early innate, adaptive cell-mediated and humoral immune response. This information
may help identify the stage of an infection. Furthermore they can support the management of inflammatory diseases and differentiation between inflammation and infections, as well as different pathogenic
causes of infection (e. g. bacterial, viral).
Cell populations and/
or their characteristics
Total reactive lymphocytes
Antibody-synthesizing
lymphocytes*
Granularity of neutrophils
Reactivity of neutrophils
Immature granulocytes
Your benefits
n Theparameters in the table are available from
a routine blood laboratory test together with a
Description Immunological Parameter Unit complete blood count and quickly provide an initial
interpretation indication of the patient’s immune response status.
This includes activated B and Increased in innate and RE-LYMP# Cells/L n Sysmex’s
haematological inflammation parameters
T lymphocytes recognised adaptive cell-mediated support an early diagnosis so that targeted treat­-
by an increased fluorescence immune response RE-LYMP% % ment can be started, changed or modified faster.
intensity compared to that (as a percentage of all WBC)
n Monitoringpatients with inflammatory diseases
of common lymphocytes.
and the success of their therapy helps to avoid the
These are exclusively activated Increased in innate and AS-LYMP# Cells/L overuse of antibiotics.
B lymphocytes recognised by adaptive humoral immune
the markedly increased fluo­- response  S-LYMP%
A %
rescence intensity compared to (as a percentage of all WBC) Benefit from more background information in our freely
that of common lymphocytes. accessible white papers:
A measure of the cytoplasmic Increased in early innate NEUT-GI: Scatter Intensity (SI) www.sysmex-europe.com/whitepapers
granularity of the neutrophil immune response Neutrophil Granularity Intensity
population, representing their
response to inflammatory
processes.
A measure of the fluorescence Increased in early innate NEUT-RI: Fluorescence Intensity (FI)
intensity of the neutrophil immune response Neutrophil Reactivity Intensity
population, representing their
metabolic activity.
The total of metamyelocytes, Indicates the severity IG# Cells/L
myelocytes and promyelocytes of the early innate immune
are counted as a single pop­- response IG% %
u­lation, separately from the (as a percentage of all WBC)
common neutrophils.

* When antibody-synthesizing lymphocytes (AS-LYMP) are present, they are also included in the total reactive lymphocytes (RE-LYMP).

ZE001504.EN.R.02/18
You will find your local Sysmex representative’s address under www.sysmex-europe.com/contacts www.sysmex-europe.com/xn