These populations have been the victims of a vast process of relocation of manufacturing

companies to the southern United States, but especially to Mexico and China, as the
document B, which is an article from Brookings published the 15 october 2019,talking about
the role of despair in America’s opioid crisis, shows. The decline in manufacturing
employment, which was only relative between the early 1960s and 2000, accelerated with
the entry of China into the World Trade Organization (WTO) in 2001, at the behest of Bill
Clinton and George W. Bush.