Drugs name References Dose Prescription Dose Information

Pembrolizumab 200 mg IV infusion every 200 mg IV 100 ml 0,9% NaCl

(additional drug 21 days (or every 3 weeks infusion every 21 over 30 mins using a
for the cycle 2) for four cycles) days (or every 3 low protein binding
weeks for four 0,2 to 5 micrometre in
cycles) line or add on filter
PEMEtrexed 500 mg/m2 IV infusion 500 mg/m2 IV 100 ml 0,9% NaCl
infusion over 10 min
The recommended
dose of pemetrexed is
500 mg/m2
administered as an i.v.
infusion over 10
minutes on day 1 of
each 21 day
CARBOplatin [AUC] 5 mg/mL/min every [AUC] 5 500 ml glucose 5%
3 weeks for four cycles mg/mL/min every over 30 mins
3 weeks for four
cycles
Palonosetron 0,25 mg IV 0,25 mg IV Infuse over 30
seconds beginning
approximately 30 min
before the start of
chemotherapy)
Dexamethasone 8 mg IV 8 mg IV Dexamethasone was
administered 30
minutes prior to
chemotherapy
treatment on Day 1
and in the morning on
 Days 2 through 4.
Aprepitant 125 mg orally 125 mg orally The recommended
dose of Aprepitant is
125 mg hour prior to
chemotherapy
treatment (Day 1) and
80 mg orally once
daily in the morning
on Days 2 and 3.