Name of Intern: SHANE NICOLE B.

PAMPELLONA School: CEU Manila Date: April 11,

2023

Herbanext Virtual Internship Program – Intern’s Kits

Activities Supplement Preparation Activity

Activity #2 Labels Clues Name of Use in the

the formulation
Ingredient

Identify the 3 x 5g – 152E Used as an Tawa-tawa Contains the

ingredients and its antithrombocytopenic (Euphoria active
use. (Spray dried Extract) hirta) spray ingredient
dried extract

5g – 152P Used as an Tawa-tawa Excipient

antithrombocytopenic (Euphoria
(Powdered part) hirta)
powder

3 x 5g – 221 Brand: Starch 1500® Pregelatiniz Binder

ed Starch

4 x 10g – 124 A sugar alcohol from Mannitol Filler

mannose

5g - 132 Highly processed Maltodextrin Diluent

polysaccharide (by partial
hydrolysis of corn, wheat,
or potato starch) often
used as an excipient in
spray drying

1 gram – 216 CAS No. 557-04-0 Magnesium Lubricant

(divided to 4) stearate

25 pcs Hard ☺ Describe Capsule No.

Gelatin the size __
Capsule (HGC)

Siever #1 Perforated screen 0.90 mm

(diameter)

Siever #2 Mesh wire Mesh No. 5

Formulation Instruction

Supplement Formulation 1

Needs: 5g – 152P, 5g – 221, 10g 124 + water

Supplement Formulation 2

Needs: 5g – 152E, 5g – 221, 10g 124 + water

 Supplement Formulation 3

Needs: 5g – 152E, 5g – 221, 10g 124 + 70% or higher Ethanol

Supplement Formulation 4

Needs: 5g – 152E, 5g – 132, 10g 124 + 70% or higher Ethanol

1. Procedures:
a. Wet Granulation
b. Drying
c. Dry granulation
2. Prepare a Formulation sheet that includes the ingredient and quantities to be used, and
the procedure. (Fill in table below)
3. Take a picture of your finished product (10 capsules each for Formulation 1 & 4 ONLY and
granules formed from ALL Formulations) and prepare a label for the immediate packaging material*.

Name of Intern: SHANE NICOLE B. PAMPELLONA School: CEU Manila Date: April 11,
2023

Supplement Formulation 1
Ingredient Name Quantity (Amt. in the formulation) %

Tawa-tawa (Euphoria hirta) 5g 16.53

powder

Pregelatinized Starch 5g 16.53

Mannitol 10 g 33.06

Magnesium stearate 0.25 g 0.83

Distilled water 10 mL 33.06

Procedure:

1. Mix the active constituent and all the other excipients in a mortar.

2. Add 10 mL of water.

3. Blend all the active ingredients using a pestle to create a damp mass.

4. Sift the damp mass through a no. 10 mesh sieve.

5. The materials are then dried in an oven for about an hour.

6. When the constituents have dried, mill the materials through a no. 5 mesh sieve.

7. The materials formed are thus ready for punch method.

Pictures
Name of Intern: SHANE NICOLE B. PAMPELLONA School: CEU Manila Date: April 11,
2023

Supplement Formulation 2
Ingredient Name Quantity (Amt. in the formulation) %

Tawa-tawa (Euphoria hirta) spray 5g 16.53

dried extract

Pregelatinized Starch 5g 16.53

Mannitol 10 g 33.06

Magnesium stearate 0.25 g 0.83

Distilled water 10 mL 33.06

 Procedure:

1. Mix the active constituent and all the other excipients in a mortar.

2. Add 10 mL of water.

3. Blend all the active ingredients using a pestle to create a damp mass.

4. Sift the damp mass through a 10-mesh sieve.

5. The materials are then dried in an oven for about an hour.

6. When the constituents have dried, mill the materials through a no. 5 mesh sieve.

Pictures

Name of Intern: SHANE NICOLE B. PAMPELLONA School: CEU Manila Date: April 11,
2023

Supplement Formulation 3
Ingredient Name Quantity (Amt. in the formulation) %

Tawa-tawa (Euphoria hirta) spray 5g 19.80

dried extract

Pregelatinized Starch 5g 19.80

Mannitol 10 g 39.60

Magnesium stearate 0.25 g 0.99

70% ethyl alcohol 5 mL 19.90

 Procedure:

1. Mix the active constituent and all the other excipients in a mortar.

2. Add 5 mL of 70% ethanol.

3. Blend all the active ingredients using a pestle to create a damp mass.

4. Sift the damp mass through a 10-mesh sieve.

5. The materials are then dried in an oven for about an hour.

6. When the constituents have dried, mill the materials through a no. 5 mesh sieve.

Pictures

Name of Intern: SHANE NICOLE B. PAMPELLONA School: CEU Manila Date: April 11,
2023

Supplement Formulation 4
Ingredient Name Quantity (Amt. in the formulation) %

Tawa-tawa (Euphoria hirta) spray 5g 19.80

dried extract

Maltodextrin 5g 19.80

Mannitol 10 g 39.60

Magnesium stearate 0.25 g 0.99

70% ethyl alcohol 5 mL 19.90

Procedure:

1. Mix the active constituent and all the other excipients in a mortar.

2. Add 5 mL of 70% ethanol.

3. Blend all the active ingredients using a pestle to create a damp mass.

4. Sift the damp mass through a 10-mesh sieve.

5. The materials are then dried in an oven for about an hour.

6. When the constituents have dried, mill the materials through a no. 5 mesh sieve

7. The materials formed are thus ready for punch method.

Pictures
Name of Intern: SHANE NICOLE B. PAMPELLONA School: CEU Manila Date: April 11,
2023

Additional Activity:
Given:
During Granule Density Testing, 25 g of granules has an initial volume of 40 mL and 35 mL
after 1250 taps.
Calculate:
a) Amount that can fit inside the Hard Gelatin Capsule using the bulk density of the granules and
the volume of the HGC. (how much granules in mg).
b) Flow property (Hausner Ratio)

Calculations & Answers:

a) Bulk density
40 mL−35 mL
=0.125 g∨125 mg
40 mL

b) Flow property (Hausner Ratio)

ρT
ρB

35 mL
=0.875
40 mL
Name of Intern: SHANE NICOLE B. PAMPELLONA School: CEU Manila Date: April 11,
2023

Herbanext Virtual Internship Program – Intern’s Kits

Activities Cosmetics Preparation Activity

A. Ingredients
Labels Clues Ingredient’s
Use
Identification
Name

Identify the C-121 10g; A type of acrylic acid. Carbomer Thickener

ingredients and
its use. C-122 10g; a naturally derived Lecithin Emulsifier
emulsifier made from a
detergent plus
vegetable-based oil

C-123 1 mL; potent antimicrobial Eucalyptus Antimicrob

EO from E. globulus globulus ial

C-124 10 mL; commonly used to Glycerin Humectant

retain moisture of the
formulation

C-125 20 mL; CAS No. 208126-53- 8 Caprylic/ Binder

Capric
triglycerides

Formulation Instruction:
Cosmetics Product 1 – Gel Sanitizer (20 mL)

Needs: C-121, C-123, C-124, 70% Alcohol c/o by intern

1. Research for a procedure for making Alcohol/Sanitizer Gel using the available
ingredients. 2. Prepare a Formulation sheet that includes the ingredient and quantities to
be used, and the researched procedure. (Fill in table below)
3. Take a picture of your finished product and prepare a label for the immediate
packaging material*.

Ingredient Name Quantity (Amt. in the formulation) %

Carbomer 1 mL 2.25
10 g x = 7.14 mL
1.4 g

Eucalyptus globulus 0.05 mL 7.88

5 gtts x = 0.25 mL
1 gtts

Glycerin 10 mL 3.15
Distilled water; 70% ethyl alcohol 200 mL; 100 mL 63.01; 31.51

Procedure:

1. In a large beaker, add 200 mL of distilled water.

2. Place the beaker in the greaves mixer, then add 10 grams of carbomer gradually until it
thickens.

3. Once the mixture thickens, add 10 mL of glycerin.

4. Add 1 mL of Eucalyptus oil.

5. Remove the beaker from the greaves mixer and add 100 mL of 70% ethyl alcohol then mix.

6. A clear gel sanitizer consistency is achieved. Transfer the gel to its proper container.

7. Label for packaging.

Pictures
Name of Intern: SHANE NICOLE B. PAMPELLONA School: CEU Manila Date: April 11,
2023

Formulation Instruction:
Cosmetics Product 2 – Cream with EO. (5-10g)

Needs: C-122, C-123, C -125, Water c/o by intern

1. Research for a procedure for making a cream using the available ingredients. 2. Prepare
a Formulation sheet that includes the ingredient and quantities to be used, and the
researched procedure. (Fill in table below)
3. Take a picture of your finished product and prepare a label for the immediate
packaging material**.
Reminder: Please take extra precaution whenever heating is done.

Ingredient Name Quantity (Amt. in the formulation) %

Lecithin 10 g 24.84

Eucalyptus globulus 0.25 mL 0.62

Caprylic/capric triglycerides 20 mL 49.69

Distilled water 10 mL 24.84

Procedure:

1. Prepare the oil phase by putting the ingredients into the beaker.

2. Pipette a 10-mL distilled water and disperse it into the powder ingredients for the hydration
of aqueous phase ingredients.

3. To accelerate the former step, apply heating.

4. Perform vigorous agitation to form the emulsion.

5. Transfer the formulation into an appropriate container. Label for packaging.

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