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Analysis and Detection of COVID-19 Cases On Chest X-Ray Images Using A Novel Architecture Self-Development Deep-Learning
Analysis and Detection of COVID-19 Cases On Chest X-Ray Images Using A Novel Architecture Self-Development Deep-Learning
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Analysis and detection of COVID-19 cases on chest X-ray images using a novel
architecture self-development deep-learning
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2021 IEEE International Biomedical Instrumentation and Technology Conference (IBITeC) | 978-1-6654-4179-7/21/$31.00 ©2021 IEEE | DOI: 10.1109/IBITeC53045.2021.9649156
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2021 IEEE International Biomedical Instrumentation and Technology Conference (IBITeC) | 978-1-6654-4179-7/21/$31.00 ©2021 IEEE | DOI: 10.1109/IBITeC53045.2021.9649327
ISBN: 978-1-6654-4179-7
ii
WELCOME MESSAGE FROM DEAN
Firstly, let us thank Allah Almighty, who has given us His blessings and mercies so we can gather
today, in good health and spirits.
On behalf of the Faculty of Industrial Technology, Universitas Islam Indonesia (UII), I welcome our
speakers and participants.
The development of technology has become very rapid with the advent of Industry 4.0, and almost all
aspects of our lives have been influenced by it.
In the field of health, technology and information systems have become vital tools to discuss. The
demands of the health community must be followed by the development of the technology used. Healthcare
technology is one of the technologies most affected by global regulations. Because technology is the only
instrument to generate added value, mastery and the ability to create technology becomes a crucial problem.
Also, the application of information technology in the field of health is believed to provide various
benefits for health care providers. With the support of these technologies, the benefits that can be obtained include
the availability of accurate and comprehensive patient health information so that professionals can provide the
best possible treatment.
To develop health technology, scientific meetings are needed as a means for sharing, disseminating, and
communicating between practitioners, researchers, government agencies, non-governmental institutions, and
industry.
On this occasion, the Electrical Engineering Department, Faculty of Industrial Technology, Universitas
Islam Indonesia held The International Biomedical Instrumentation and Technology Conference, IBITeC 2021.
This seminar is the second conference organized by the Electrical Engineering Department and co-organized by
Diponegoro University (UNDIP) and Universiti Teknologi Malaysia (UTM). We hope this activity can provide a
change of knowledge for researchers, practitioners, students, and lecturers to improve their abilities.
To our speakers and all those who support the seminar, we thank you for your cooperation in conducting
this seminar. Finally, our congratulations on attending the seminar. Hopefully, what we achieve here will benefit
institutions and society as a whole.
Dean,
iii
WELCOME MESSAGE FROM CONFERENCE CHAIR
Assalamu’alaikum. All praise is for Allah, who guided us to do good deeds and gave us the health bounty.
On behalf of the 2nd International Biomedical Instrumentation and Technology Conference (IBITeC) 2021
Committee, I would like to welcome you to this biannual conference held by the Department of Electrical
Engineering, Faculty of Industrial Technology, Universitas Islam Indonesia, Yogyakarta. This conference is co-
sponsored by IEEE Communication Society Indonesia Chapter, and co-organized by the Center for
BioMechanics, Bio-Materials, Bio Mechatronics, and Bio Signal Processing (CBIOM3S) of Diponegoro
University (UNDIP), Universiti Teknologi Malaysia (UTM), and UII IEEE Student Branch. The goal of this
conference is to facilitate researchers, practitioners, students, and lecturers around the world to publish, explore
and share their latest research in Biomedical Engineering and related fields in Biomedical Sensors Development,
Biomedical and Informatics, Biomedical Imaging, Internet of Things (IoT) and Healthcare Information System
with its associated topics. This year’s theme is “The Empowerment of Healthcare Technology to Achieve
Universal Health Coverage.”
The committee is delighted with the positive response of researchers to this conference. We received 50
submissions from Germany, France, Portugal, Morocco, Malaysia, Vietnam, China, India, Pakistan, Iraq, and our
own Indonesia. The papers were peer-reviewed by our reviewers from several countries to maintain the quality of
this conference. The acceptance rate of the 2nd IBITeC 2021 is 58%. All accepted and presented papers will be
forwarded for consideration to be published in the IEEE Xplore Digital Library and indexed by Indexing Service
Partners (Scopus, INSPEC, Semantic Scholar, EBSCO, and others that are available/eligible).
We are grateful for the contributions of our invited speakers. We will have three keynote speakers that
we believe could spread the new insight for biomedical engineering disciplines to follow the industry 4.0 needs.
The organization of a conference is very much a team effort. I want to thank all committees, editorial team, event-
organizer, reviewers, and other parties who have carried a vast and complicated workload. The 2nd IBITeC 2021
strives to offer plenty of opportunities, especially networking. Authors and participants have the chance to meet
and interact with each other to share and transfer their knowledge in similar fields. We hope that you can benefit
from this conference during discussions and, most importantly, networking among our peers. We hope that this
conference will be unforgettable moments and experiences. Thank you. Wassalamu’alaikum.
Firdaus, Ph.D
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TABLE OF CONTENTS
COPYRIGHT STATEMENT
TITLE PAGE
WELCOME MESSAGE FROM DEAN v
WELCOME MESSAGE FROM CHAIR
AUTHORS INDEX
Quaternion-based AHRS with MEMS Motion Sensor for Biomedical Applications
Stress Effect on Attention Level Detection Using Neurosky Mindwave Headset
Cortical Functional Connectivity by Partial Directed Coherence In Relation To
Create Thinking: A Case Study
Study of effect of silver nanoparticles on the electrical excitability of hippocampal
neuronal network based on “Voltage Threshold Measurement Method”
Texture Analysis of Ultrasound Images to Differentiate Pneumonia and Covid-19
Green Synthesis of Silver Nanoparticles using Citrus aurantifolia (Bangladeshi
Lemon Leaf) Extract and Its Antibacterial Activity
Preparation and Evaluation of Folic Acid-TPGS Polymeric Micelle as a Quercetin
Anticancer Drug Carrier
Characterization of Silver Resistive Electrode as Heating Module for Portable
Thermocycler Device
Hip Joint Implant Loading During Routine Activities of Elderly Indonesian
Optimization of Insole Shoe for Diabetic Mellitus Type 2 Using Finite Element
Analysis
Analysis and detection of COVID-19 cases on chest X-ray images using a novel
architecture selfdevelopment deep-learning
A Review on Opportunities and Challenges of Machine Learning and Deep
Learning for Eye Movements Classification
Fetal Heart Rate Detection Algorithm fromNoninvasive Fetal Electrocardiogram
Performance Improvement of Breast Cancer Diagnosis based on Mammogram
Images using Feature Extraction and Classification Methods
Classification of Markerless 3D Dorsal Shapes in Adolescent Idiopathic Scoliosis
Patients Using Machine Learning Approach
Combating Bias in COVID-19 Disease Detection Using Synthetic Annotations on
Chest X-Ray Images
A Hybrid Risk Assessment Kit by Using Observing and Instrument Methods
The Statistical Analysis of Urodynamic Parameters with Different Stress Urinary
Incontinence
Pressure Ulcer Prediction, Prevention and Assessment Using Biomedical System
Design
GGB Color Normalization and Faster-RCNN Techniques for Malaria Parasite
Detection
Computer-Aided Design for Analyzing the Influence of Single Radius on Flexion
Angle of Artificial Knee Joint
Performance Evaluation of a New Dry-Contact Electrode for EEG Measurement
Conceptual Design of Bionic Foot for Transtibial Prosthesis
A Computational Stress Analysis of Active Prosthetic Hand “Asto Hand V4” for
the Loaded Hook Position
Experiment on Deep Learning Models for COVID-19 Detection from Blood
Testing
Effect of Chest X-Ray Contrast Image Enhancement on Pneumonia Detection using 142
Convolutional Neural Networks
Classification of the Degree of Dehydration in Diarrhea Using the Naïve Bayes 148
Algorithm
vi
----- CONFERENCE PAPERS-----
vii
AUTHOR INDEX
2021 IEEE International Biomedical Instrumentation and Technology Conference (IBITeC) | 978-1-6654-4179-7/21/$31.00 ©2021 IEEE | DOI: 10.1109/IBITeC53045.2021.9649053
viii
Maheza Irna Mohd Sali 7
Minh Bao Pham 59
Mohammed Alfaqawi 93
Mouna Ben Mabrouk 93
Muhammad Ainul Fikri 65
Norhana Jusoh 33
Norjihada Izzah Ismail 33
Norlaili binti Mat Safri 13
Nunung Nurul Qomariyah 88, 136
P. K. Fergiawan 52
P. W. Anggoro 52, 114
Paulus Insap Santosa 65
Puspa Inayat binti Khalid 13
Quoc Tuan Nguyen Diep 59
R. Novriansyah 114, 124
Rania Al-Ashwal 7
Rayhan Ammarsyah 40
Retno Paras Rasmi 77
Rifky Ismail 46, 114, 124, 130
Rilo Berdin Taqriban 46
Rizki Nurfauzi 109
Roshida binti Abdul Majid 13
Rui Azevedo Antunes 1
Saeful Bahri 24
Saif Abdulmohsin A 99
Sasa Cukovic 83
Shihab Uddin Al Mahmud 29
Siti Fatimah Ibharm 33
St´ephane Davai 93
Suatmi Murnani 77
Sunu Wibirama 65
Suprijanto 24
Syafwendra Syafril 7
T. Prahasto 124
Trung Nghia Tran 59
Xiao-Ying Lü 19
Yan Huang 19
Yudan Whulanza 40
Zeena Sh Saleh Biomedical 104
Zhi-Gong Wang 19
Zubair Ahmed Ratan 29
Analysis and detection of COVID-19 cases on chest
X-ray images using a novel architecture self-
development deep-learning
Hoang Nhut Huynh Quoc Tuan Nguyen Diep Minh Bao Pham
2021 IEEE International Biomedical Instrumentation and Technology Conference (IBITeC) | 978-1-6654-4179-7/21/$31.00 ©2021 IEEE | DOI: 10.1109/IBITeC53045.2021.9649263
Abstract— The recent ongoing pandemic coronavirus disease The COVID-19 identification now relies on the Real-time
2019 (COVID-19) is growing increasingly out of control reverse transcriptase polymerase chain reaction (RT-PCR)
globally, posing a severe threat to human health. The use and serological testing [6]. In low-middle income countries,
of artificial intelligence (AI) in predicting COVID-19-positive the shortage of required material and specialized personnel to
individuals becomes a promising tool that may enhance the perform these tests mainly leads to widely spreading disease
existing diagnosis modality. Algorithms in supporting in common. On the other hand, RT-PCR is time-consuming,
classifications for chest X-ray images face challenges in terms has poor sensitivity, high false-positive rates [6]-[12].
of dependability. With this aim, a convolutional neural Computed tomography (CT) scan and X-ray of the chest are
network (CNN) model FASNet is proposed to identify chest
also used to diagnose and identify the COVID-19 infected
X-ray images of three distinct conditions: pneumonia,
COVID-19, and normal (or healthy) cases. The FASNet model
individuals [6], [11], [12]. These techniques are hospital-
consists of four convolution layers and two fully connected accepted techniques for diagnosing COVID-19 patients.
layers. The pre-trained deep learning models were used and However, these techniques required specialized personnel to
included in our self-development FASNet CNN model. In the perform, assess, and interpret the images. This work needs
first convolutional layer, the size of the kernel 1×1 is used on experience and is difficult for applying with the naked eye.
each pixel as a fully connected connection with the aim of Hence, an alternative method to support the diagnosis of
reducing the channel depth and number of parameters of the COVID-19 is an urgent and crucial need.
model. The early- stopping class and dropout layer are used
The use of artificial intelligence (AI) to assess, and
to limit the number of neural connections and prevent
overfitting. The dataset for this study was derived from an interpret the medical diagnosis images for COVID-19 patients
open-source collection of 6,432 images for training and testing. is a promising method [6]. Moreover, it can be a practical tool
As the result, our approach successfully detected COVID-19 in tracking the coronavirus’s spread, identifying high-risk
infected individuals, pneumonia, and healthy ones with a patients, adequately analyzing patients’ previous data, and
98.48% accuracy. This promising preliminary results lead us to predicting the risk of death [13]. Thus, many studies have
expect that the FASNet model can be used in further focused on CT images and X-ray images using machine
development research to assist in diagnosing COVID-19. learning (ML) and deep learning (DL) [14]-[23][21].
The result with FASNet model has a high correlation in
comparison with other popular models such as ResNet50V2 and
The chest X-ray imaging may play an important role in a
MobileNetV2. rapid clinical assessment, as the machine is normally already
Keywords—chest X-ray image, COVID-19, CNN, deep available in the clinical unit. In comparison with CT scanner
learning, FASNet imaging, X-ray imaging is a faster, easier, cheaper, less
harmful, and digital type result. Using chest X-ray imaging
I. INTRODUCTION
can early identify the COVID-19 infected individuals and
Since early December 2019, the ongoing coronavirus separate out other respiratory disease ones.
disease 2019 (COVID-19) has created an unprecedented
situation all over the world. Following the large-scale In this paper, a self-development convolutional neural
COVID-19 out-break this year, especially in low-middle network (CNN) model was proposed to categorize chest X-
income countries, the COVID-19 pandemic causes the ray images for healthy, pneumonia, and COVID-19 patients in
national medical systematic collapse by the lack of resources order to aid clinical diagnosis and reduce misinterpret. The
and the high demand of the intensive care units simultaneously transfer learning technique and a dense neural network were
[1]-[6]. The COVID-19 mainly damages the respiratory employed in our model. Instead of training an utterly new
system then may cause damage to other systems. neural network, this technique allowed the use of lower-level
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weighting for optimizing higher-level weights to compensate max-pooling and a non-linear ReLU activation layer. The
for the absence of input data, and save computation time. With result is (7, 7, 128).
a view towards contributing a little effort to averting the 4) Fourth convolutional layer: The output was upgraded
COVID-19 pandemic if our CNN model can perform well in in the fourth layer, increasing the number of convolution
categorizing chest X-ray images of groups: COVID-19,
filters to 256 while keeping the max-pooling and non-linear
pneumonia, and normal (healthy). This work was designed to
allow the prediction can be made using chest X-ray images of ReLU activation layer the same as the previous layers,
any size. The public datasets of chest X-ray images were converting the feature output to (2, 2, 512). This output map
applied for testing and evaluating the model. Our model also is fed into the linear layer and used for feature extraction.
benchmarked the performance of pre-trained CNNs with the 5) Fully connected layer: At this layer, the feature map
popular CNN models i.e. ResNet50V2 and MobileNetV2. Our flattens with the value 2,048 and then integrating it with the
CNN model also can detect the location of COVID-19 damage final linear layer with 512 nodes. Softmax activation is used
zones in chest X-ray image. to categorize three layers of pictures in FasNet's final output
size - COVID-19, pneumonia, and normal.
II. FASNET AND FRE-TRAINED CNN MODEL
The FASNet model includes a total of trainable 1,752,003
A. FASNet model parameters and 0 non-trainable parameters.
Our novel CNN network was designed to classify better B. Pre-Trained CNN model
the individuals with COVID-19, pneumonia, and normal from
24 pre-trained models are used to train with our FASNet
their chest X-ray images after challenging and experimenting
for the first time to detect subjects infected with COVID-19,
with hundreds of parameters (e.g. dense layer, filter,
pneumonia, and normal (healthy). Fig. 2 and Fig. 3 show the
convolution layer, normalizations, and max pooling). We
accuracy and the training time of these 24 models after one
experimented with hundreds of parameters to build this
epoch, respectively. Two models ResNet50V2 and
network: dense layer, filter, convolution layer, normalizations,
MobileNetV2 achieved the most outstanding performance
and max pooling. The proposed CNN network was named
among the 24 models as shown in Fig. 2 and Fig. 3.
“FASNet” which “FAS” stands for “Faculty of Applied
Science”. FASNet is made up of four convolutional layers and
a fully connected linear layer as shown in Fig. 1.
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accuracy of COVID-19 detection. This is not our primary gradient-based optimization method for stochastic objective
objective in this research; instead of being able to diagnose functions. This optimizer method is selected because of its
and avoid mishandling COVID-19 instances properly. To straightforward to implement, computationally efficient, less
overcome this difficulty, the data was re-organized in order to time-consuming, and requires little memory to process [26].
balance the three cases and ensure that the number of images Pre-trained models are deployed on Keras library, Tesla P100
in each case is almost equal. This work helps to increase GPUs, and 25 GB of RAM powered by Google Colab
COVID-19 cases detection while also balancing overall Notebooks [27].
accuracy.
TABLE III. THE PARAMETERS FOR PROCESSING DATASET
Parameters Value
Input shape images (150, 150, 3)
Batch size 32
Dropout 0.50
Number of epochs 20
Optimizer Adam
Metrics Accuracy
Fig. 4. Representative chest X-ray images from Kaggle database. Image
size is of (224, 224).
Step 3: Reduce the number of dimensions by flattening.
Table I shows the distribution of images in dataset for
Step 4: Dense layer
training, validation, and testing with FASNet. Table II shows
the parameters for enhancing dataset. The dense layer is a neural network layer that is connected
deeply, which means each neuron in the dense layer receives
TABLE I. DISTRIBUTION OF CHEST X-RAY IMAGE DATASET input from all neurons of its previous layer. Dense layer does
Number of chest X-ray images the below operation on the input and return the output :
Patient case
Training Validation Testing Total (1)
Normal 1250 400 200 1850
where is the bias and = ReLU(Z).
COVID-19 1250 300 232 1782
Step 5: The non-linear ReLU function is used because it
Pneumonia 2000 500 300 2800
does not activate all of the neurons simultaneously, which
means that the neurons will only be deactivated if the linear
TABLE II. THE PARAMETERS FOR PROCESSING DATASET transformation output is less than zero. The softmax function
Parameters Value is used in the final layer to classify three cases: COVID-19,
pneumonia, and normal (healthy) [27]:
Rotation range 30
∑
(2)
Width shift range 0.20
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• True positive (TP): number of correctly identified COVID-
19 and pneumonia X-ray images;
• True negative (TN): number of correctly identified
healthy X-ray cases;
• False positive (FP): number of incorrectly identified
healthy X-ray cases;
• False negative (FN): number of incorrectly classified
COVID- 19 and pneumonia X-ray images.
In addition, other evaluation indicators as shown in Eqs.
(3)-(6): Fig. 6. Confusion matrix of train data of ResNet50V2
• Precision (PRE): is also known as the percentage of Fig. 6 shows the confusion matrix of train data of
positive predictive value; ResNet50V2 model with “0” is COVID-19, “1” is normal, “2”
is pneumonia.
• The f1-score is defined as the harmonic mean of
precision and sensitivity B. MobileNetV2 model
• Recall: It is the ratio of correctly predicted positive
observations to all observations in actual class.
!"#!$
(3)
!"#%"#%$#!$
!"
& ' ()( * (4)
!"#%"
Accuracy 0.94 66
Accuracy 0.92 66
Fig. 8. Confusion matrix of train data of MobileNetV2
Macro avg. 0.93 0.92 0.92 66
Fig. 8 shows the confusion matrix of train data of
Weighted avg. 0.93 0.92 0.92 66
MobileNetV2 model with “0” is COVID-19, “1” is normal,
“2” is pneumonia.
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C. FASNet model weights of model were reset at the beginning of each fold run.
Table VII show the result for the FASNet model's testing. The results are shown in Table VIII.
TABLE VII. RESULT WITH TESTING DATA TABLE VIII. CLASSIFICATION PERFORMANCE WITH TESTING DATASET
ResNet50V2 100 94 80
V. DISCUSSION
The time consumption for diagnosis of COVID-19
infection is a critical requirement for limiting the disease's
global spread. The chest X-ray imaging has played a crucial
role in the diagnosis of COVID-19 [6], [11], [12]. Our work
supports the importance of chest X-rays and offers a FASNet
model that can predict the COVID-19 infected individuals and
Fig. 10. Classification results of FASTNet model separate out those pneumonia or healthy persons.
Fig. 9 shows the confusion matrix of train data of FASNet In our model, the first convolutional layer is designed with
model with “0” is COVID-19, “1” is normal, “2” is the size of the kernel 1×1 is used on each pixel as a fully
pneumonia. As shown in the results, FASNet model with a connected connection with the aim of reducing the channel
simpler architectural design is able to outperform better than depth and number of parameters of the model. The early-
the other pre-trained models in terms of detection of COVID- stopping class and dropout layer are used to limit the number
19 from 10% images in validation dataset. The result for the of neural connections and prevent overfitting.
FASNet model show the accuracy rate is 98.48%. To verify
the accuracy of the FASNet model, new testing data from a The dataset is usually imbalanced because of fewer
completely different dataset was used [29]. The results are COVID-19 images than pneumonia and healthy pictures for
depicted in Fig. 10 with a high correlation between the actual training, the model may identify pneumonia and healthy
label (represents the subject's original state) and predicted subjects rather than COVID-19. In this scenario, the overall
label (represents the model's categorization). accuracy becomes high but does not represent the accuracy of
COVID-19 detection. This will cause the accuracy will be
D. Comparison of grading performance of models imbalanced as in other research. To overcome this problem,
To benchmark FASNet model with ResNet50V2 and the data was re-organized in order to balance the cases and
MobileNetV2, the training using different epochs were ensure that the number of images in each case is almost equal.
conducted. The parameters setting was used as in Table III. To This work helps to increase COVID-19 cases detection while
avoid data overfitting concerns during the training phase, the also balancing overall accuracy.
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