(13): 01:27:04 5-Alpha Reductase & Saw Palmetto; Curcumin

The discussion pertains to dihydrotestosterone and its negative impact on hair

maintenance and growth, specifically its ability to abbreviate the anagen
phase. Therefore, the hair will experience a reduced duration of growth.
Secondly, this can be attributed to the existence of androgen receptors in the
stem cell niche region. The process effectively reduces the size of the follicle
and stem cell niche, thereby decreasing the population of cells responsible for
generating additional hair proteins. This reduction can potentially lead to the
complete elimination of these cells. Consequently, any intervention that
reduces the activity of 5 alpha reductases and subsequently lowers DHT
levels can help sustain or prolong the anagen phase of hair growth while also
preventing the onset of the telogen phase.

Saw palmetto, an extract derived from salt palmetto berry, has the potential to
inhibit 5-alpha reductase. There were no observed side effects. When
administered at a daily dosage of approximately 300 milligrams, it has been
observed to promote hair retention and potentially stimulate the growth of new
hair follicles. The treatment in question lacks efficacy in reversing hair loss.
Although it may not be highly efficacious, the product in question boasts a
relatively low cost and widespread availability in the market [32].

Certain herbal compounds exhibit potent biological effects that promote hair
growth, albeit through synergistic interactions among them. The majority of
supplements containing herbal compounds typically comprise a combination
of five, ten, or more ingredients, rendering it exceedingly challenging to
discern the efficacious components and optimal dosages. It has been