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increase in IGF-1 levels and promoting hair growth.

The efficacy of topical


caffeine application has been found to be comparable to that of minoxidil
application while avoiding the potential side effect of reduced blood pressure.
Caffeine-containing ointments and creams are considered to be a favorable
choice for promoting healthy hair. The administration of this therapy may be
conducted thrice weekly, while the degree of caffeine concentration in various
ointments exhibits significant variation. The majority of research conducted on
the potential benefits of caffeine for enhancing the stem cell niche has been
carried out in vitro or in a laboratory setting. When evaluating the cost, side
effects, and efficacy of minoxidil and caffeine, it appears that caffeine may be
a more favorable option. As opposed to minoxidil, caffeine was found to lack
any associated adverse effects. Caffeine has been observed to not only
stimulate insulin-like growth factor 1 (IGF-1), but also to exhibit potential in
reducing apoptosis, a naturally occurring phenomenon of cell death in the hair
stem cell niche [28].

References

28. Völker, J.M., et al., Caffeine and Its Pharmacological Benefits in the
Management of Androgenetic Alopecia: A Review. Skin Pharmacology and
Physiology, 2020. 33(3): p. 153-169.

(11): 01:21:06 IGF-1: Growth Hormone & Sermorelin; Insulin


Sensitivity: Myo-Inositol

One of the key methods for promoting hair growth involves elevating IGF-1
levels through the utilization of growth hormones. Sermorelin, a peptide, has
been found to increase growth hormone levels by stimulating its secretion.

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