WRITTEN WORK 1.

Literature Review

1. Search for five (5) research journal articles of research journals and articles about the science project you want to work on. Choose a
reliable site like Google scholar to look for articles. Never use Wikipedia.
2. Make a summary of the research findings on the above articles using the format indicated below.
3. Submit the summary and the copies of the article through the Google classroom.

Tentative Research Title: Human Genetics

Variables: IV
DV

Author/s Title of article Name of Research Year of Publication Problem/s or
Journal objectives
Robert Plomin The new Human genetics 2018 To discuss early attempts
Sophie von Stumm genetics of intel to find the inherited genetic
differences that account for
the substantial heritability
of intelligence, and a twist
of fate involving GWAS on
years of education, before
discussing the results of
recent large GWAS on
intelligence.
To focus on genome-wide
polygenic scores (GPSs) for
intelligence that aggregate
the effects of thousands of
DNA variants associated
with intelligence across the
genome
Finding/s Source/
Bibliography
entry
Robert, P. and
Genetic association
Sophie, V.(2018)
studies have confirmed
a century of The new genetics
quantitative genetic
research showing that of intelligence.
inherited DNA The new
differences are
responsible for genetics of
substantial individual intelligence - Pub
differences in
intelligence test scores. Med -
NIHpubmed.ncbi
A reachable objective
shared with all complex
.nlm.nih.gov › ...
traits in the life
sciences is to close the
gap between the 10%
variance in intelligence
scores explained by
GPSs (Genome wide
polygenic score)and
the SNP heritability of
intelligence of about
25%. A more daunting
challenge is to break
through the ceiling of
25% SNP(Single
nucleotide
 Polymorphisms)
heritability to reach the
50% heritability
estimated by twin
studies.

finch, ruvkun The Genetics of Genomics and 2001 The purpose of this The metabolic Caleb, E. and
aging Human genetics review is to outline rate, insulin Ruvkun, G.
signaling, and free
the prospects of a (September,
radicals have
unifying mechanism emerged from 2001). The
in the very different Genetics of
genetics of aging approaches to aging.
aging in annurev.genom.
nematodes and 2.1.435
mammals. These
findings hint that
the genetic
control of life span
was already
developed
in the common
ancestor of
modern animals
so that
subsequent
evolution
of life spans was
mediated by
quantitative
changes in the
control of
metabolism
through insulin
and the
production of free
radicals.
John L Hopper, Human genetics 1982(first 1. introduce a test of the For Jhon, L., and
Extensions to
JD Mathews publication) assumption of small pedigrees it Mathews.
multivariate multivariate normality will be feasible to
normal models (October
and methods for the extend our model
for pedigree detection of to allow for the 1983).Extensions
analysis outlying families and detection of major to multivariate
outlying individuals. 2. gene normal models
introduce a method for effects as for pedigree
the estimation of described for analysis.
effects of measured nuclear families.
Extensions to
genetic markers as For pedigrees
variance components, a where this multivariate
flexible parameterization approach will be normal models
to limited by for pedigree
estimate effects of computing costs, analysis
shared family the study suggest
environment 3. to have a that major gene
method to allow for the effects might be
ascertainment of suspected from
pedigrees through the pattern of
probands. outlying
individuals within
pedigrees. The
dominance may
provide indirect
evidence for the
segregation of a
small number of
major genes.
K. Paige Harden using genetics Biology 2020 K. Paige,
for social science To describe the main The rapidly
tools of statistical
H.(2020)Using
increasing
availability of genetics for
genetics, discuss some genetic data now social science.
of the underlying
allows scientists to Using genetics
assumptions and
implications of these unravel the for social science
tools, and illustrate their genetic
| Nature Human
current use in the social underpinnings of
sciences with concrete individual Behaviourwww.n
examples differences in ature.com › ... ›
social, behavioural review articles ›
and health article
outcomes.
Although not
without caveats,
the current
workhorses of
statistical genetics
(e.g.,GWAS, LD
score regression,
polygenic scores)
are useful for
social scientists
whose primary
interests lie in
understanding
effects of
environments,
such as parenting,
policies or
interventions, that
might lead to or
entrench
inequalities.
Genetic effects
influence most
dimensions of
individual
differences that
social scientists
care about, and
genetic differences
between people
are tightly
interwoven with
environmental
differences that
social scientists
study.
Carmencita D. Genetics and Human Genetics 2016 The Philippines Carmencita,
1. To know the still faces many D.(2016) The
Padilla genomic challenges in the
Demographics genetics and
medicine in and Health delivery
of services and the genomic medicine
the Philippines Indicators of the in the
conduct of genetic
country and genomic Philippines.Geneti
2. To know the research. Although cs and genomic
Health one of the active medicine in the
Expenditures and countries in
Philippines - NCBI -
Financing Southeast
Asia with regard to NIHwww.ncbi.nlm.
3. To know the nih.gov › pmc ›
genetics, the
Future of Medical
country still has a articles ›
Genetic and shortage of PMC5023934
Genomic geneticists and
Services in the genetic
Philippines. counselors.
Difficulties
4.
exist for continued
research and
integration of
health care
services into the
public health
system due to
limited
resources.
Geographical,
cultural, and
financial barriers
must be overcome
by the country in
order to realize
this
goal.
Author/s Title of article Discussion/ Entries Source/ Bibliography entry
Juan Pablo Kaski Pedigree A pedigree tree can show and identify relatives who have a risk of Juan, P.(2006)Pedigree
analysis inheriting a disease. It can be a great way to show various diseases analysisPedigree Analysis - an
from a member to another. overview | ScienceDirect
Topicswww.sciencedirect.com ›
topics › medicine-and-dentistry

Kara Rogers Pedigree, Women are represented in circles while the male is represented Kara, R.(n.d)Pedigree, definition,
definition, inboxes. Pedigree can be either x-linked or autosomal. breeding, symbolpedigree |
breeding, Definition, Breeding, & Symbols |
symbol Britannicawww.britannica.com › ...
› Genetics & Evolution

None Biology A pedigree is a diagram that depicts the blood relationships of N.A(2010)Pedigree and modes of
family members, as well as which individuals express the trait or inheritance.Pedigrees and Modes of
disorder under study. Construction of a pedigree is often the first Inheritance - Biology Encyclopedia
step in the identification of a gene variant that causes a ...http://www.biologyreference.co
particular disease or trait. m › Oc-Ph