OUTCOME READINESS ASSESSMENT

SEMI FINALS
MODULE 4 PHARMACOLOGY – PHARMACOKINETICS 15%

INSTRUCTION: Highlight the correct answer

1.A branch of Pharmacology that deals with the study of the fate and
disposition of drugs in the body:
a.pharmacodynamics – study of the biochemical and physiologic effects of
drugs in biological systems and the mechanisms by which these effects are
produced. “what the drug does to the body”
b.pharmacokinetics
c. pharmacotherapeutics – study of rational use of drugs in the
management of disorders
d.toxicology – the branch of science concerned with the nature,effects and
detection of poisons
2.Which of the ff. is an example of a drug acting directly through receptors?
a. Protamine binds stoichiometrically to heparin anticoagulants
b.Andrenergic beta blockers for thyroid hormone – induced tachycardia
c.Epinephrine for increasing heart rate and blood pressure
d. Mannitol for subarachnoid hemorrhage
Rationale: A drug that acts directly through receptors has the ability to
produce a response is termed as EFFICACY (intrinsic activity) this varies
with the type of response measured.
3.Synthesis of diacylglycerol as a secondary messenger is commonly
results of:
a.stimulation of alpha -1 receptors
b.inhibition of beta -1 receptors
c.stimulation of beta -2 receptors
d.stimulation of alpha -2 receptors
Rationale:
Q=alpha1 – Gq linked : secondary messengers (DAG,IP3) = increase of
calcium
I=alpha2 – presynaptic (autoreceptor) : Gi : decrease of cAMP
S=beta1-Gs : increase cAMP - heart
S=beta2 and beta3-Gs : increase cAMP – sm muscle; lipolysis
4.Which of the ff. are the reasons for formulating pro.drugs
I. improve bioavailability of the drug
II. Decrease the cost of the drug
III. Promotes site-specific delivery of the drug,
a. I and II
b. AOTA
c. I and III
d. I
Rationale: Prodrugs are medications that becomes into an active form once
metabolized, unlike the other drugs that are already in active form then
once it undergone metabolism process it will turn in its inactive form and
ready to be excreted in our body. Prodrugs helps improve a medication’s
effectiveness. They may also be designed to avoid certain side effects or
toxicities. Prodrugs are important for developing new medications. Certain
medications only work because they’re a prodrug.
5.The intensity of the pharmacologic action of the drug is MOST dependent
on?
a. concentration of the drug at the receptor sites
b. onset of action – the length of time it takes for a medicine to start to work
c. protein binding – enhances or detect from a drug’s performance
d.volume of distribution – a pharmacokinetic parameter representing an
individual drug’s propensity to either remain in the plasma or redistribute to
other tissue compartments.
6. Which of the ff. describes an agonist?
a.any substance that brings about a change in biologic function through its
chemical action
b.a specific regulatory molecule in the biologic system where a drug
interacts
c. a drug that binds to a receptor and stimulates cellular activity
d. a drug that binds to a receptor and inhibits or opposes cellular activity
7. If 10mg of naproxen sodium produces the same analgesic response as
100mg ibuprofen, it signifies that:
a. Naproxen is more efficacious that is ibuprofen
b. Naproxen is more potent than ibuprofen
c. Naproxen is a full agonist, and ibuprofen is a partial agonist
d. Naproxen is a better drug to take for pain relief than ibuprofen
8.Drugs with a narrow therapeutic window means that the drug is:
a. less potent
b. more potent
c. less safe
d. more safe
9.For Items 9-10

100 A C E

%of maximum effect 80

60
B D
40

20

Log Dose
Graph: Irreversible/ Non competitive

The figure presents a comparison between log-dose-response curves of

drugs tested in an vitro system
Which of the ff. statements are true?
I. A,C, and E have equal efficacy
II. B is more potent than A
III. C and E has the same ceiling dose
IV. C is produced when A is given with its competitive antagonist

a. I,II,III,IV
b. I,IV
c. II,III
d. I,III,IV
Rationale: When Curve A was given an antagonist you can observed that
Curve B was shifted down from that momentum you can tell that it was
already given an antagonism because of the Curve B. Then Curve C was
produced an agonist at higher dose + non competitive antagonist.
10. Which of the curves depicts the log dose response curve of the drug C
when a fixed dose of an irreversible antagonist is given concomitantly.
a. CURVE A
b.CURVE B
c. CURVE D
d. CURVE E

For 11-12

Response (%) 100 A C

80

60 B

40

20

Log 10 Dose
Which of the ff. statements are true?
I. Drug A is more efficacious than Drug C
II. Drug B is the least efficacious
III. Drug C is equally efficacious as Drug B

a. I only
b. II only
c. I and II
d. I,II, III
Rationale: Drug B has the lowest efficacy as given in the measurement in
the graph, since drug A and C has an equal value.
12. Arrange the drugs in increasing potency
a. A<B<C
b.C<B<A
c.B<C<A
d.A=C<B
Rationale: in measuring or arranging the drugs with their potency always
remember that the drug that is closest to the value 0 is the most potent
drug.
13.Which direction would a partial agonist shift the dose response curve
when compared to a full agonist
a.to the left
b. to the right
c.down
d.up
14.Four identical experiment animals were treated with a mg of the ff.
toxins (Refer to the choices below with their corresponding LD50) Which
toxic would most likely cause death to animals)
a. Toxin EF(LD50=5mg/kg)
b. Toxin GH(LD50=1500mg/kg)
c.Toxin AB(LD50 =8000mg/kg)
d.Toxin CD(LD50=0.00001mg/kg)
Rationale: The drug that has the lowest LD50 is the most toxic
 OUTCOME READINESS ASSESSMENT
SEMI FINALS
MODULE 4 PHARMACOLOGY – PHARMACOKINETICS 15%

INSTRUCTION: Highlight the correct answer

For numbers 1-3

F(minimum toxic conc.)

concentration

Log time E
B dOA C
MEC(minimum effectiveconc)
Onset offset

TIME
1.What refers to the horizontal distance between time 0 and the time that
the dose-response curve hit point B.
a.minimum toxic concentration
b.lag time
c.minimum effective concentration
d. duration of action
2.Which of the ff. statements is/are incorrect?
(please refer the graph)
I. A represents tmax while D represents Cmax
II. The gap between B and C represents the duration of action
III. The higher the E is,the more dangerous the drug is
IV. If a drug goes beyond point F it already surpassed the maximum
effectiveconcentration
a. II only
b. I,III,IV
c. I, IV
d. I,III
3.The graph is mostly likely a dose-response curve of a drug
administered: (please refer the graph)
a.IV as infusion
b.IV as bolus loading dose
c.IV as infusion with loading dose combined
d.Orally as an intermediate-release product
Rationale: 1 -IV admin
2 -immediate
3- delayed
concentration

TIME
4.Identify the pharmacokinetic plot for a delayed release formulation
a.1
b.2
c.3
5.Two drugs that act on the same tissue or organ through independent
receptors in effects in opposite directions known as
a.physiologic antagonism - different receptors aka functional
b.irreversible -binds permanently
c.competitive antagonism – binds to the same site as the agonist but
does not activate it,thus block the agonist’s action
 d.chemical antagonism – drug that counters the effects of another by
binding the agonist drug.
6.A drug was shown to reverse the action of a particular
neurotransmitter. It appears to interact directly with the neurotransmitter
and not at all with the neurotransmitter’s receptor’s receptors. Which of
the ff. BEST describes the drug?
a.chemical antagonism
b.physiologic antagonism
c.pharmacologic antagonism – a drug that binds without activating its
receptor and thereby prevents activation by an agonist.
d.partial agonist -drugs that bind to and activate a given receptor, but
have only partial efficacy at the receptor to a full agonist
7.Which of the ff. describes the action of Protamine against Heparin?
a.Physiologic antagonism
b. Competitive antagonism
c.Irreversible antagonism
d.chemical antagonism
8.Which of the ff.drugs will cross the cell membranes easily?
I.Polar drugs
II.Non polar drugs
III. Lipophilic drugs
IV.Hydrophilic drugs
a.I and IV
b.II and III
c.II and IV
d.I and III
Rationale: Like dissolves Like
9.According to Fick’s Diffusion Equation, the rate of transport of a drug by
passive diffusion is:
a. independent of the concentration gradient
b.indirectly proportional to the membrane surface
c.inversely proportional to the membrane thickness
d.inversely proportional to the partition coefficient
Rationale:
Firck’s Diffusion Equation:
Dependent of the concentration gradient
Directly proportional to the membrane thickness
Directly proportional to the partition coefficient
10. All of the ff. statements regarding drug transport are true EXCEPT.
a.high molecular weight drugs diffuse across a cell membrane more easily
than low molecular weight drugs.
b.drugs bound to proteins do not easily cross cell membranes
c.lipohilic drugs cross cell membrane more easily than hydrophilic drugs
d.drugs maybe transported by passive diffusion,carrier-mediated,
paracellular or vesicular transports
Rationale:Drug+ Proteins”unbound/free” [Drug – Protein bound drug]
11.Which of the ff. dosage forms would be absorbed the FASTEST in the
gastrointestinal tract?
a.capsule
b.tablet
c.solution
d.suspension
12.Which of the ff is not correct(FALSE)?
a.decrease disintegrant,increase rate of bioavailability
b.increase retention time in GIT: increase amount of drug absorbed
c.retard drug dissolution: reduced drug absorbed
d.increased solubility: increase rate of absorption
13.Which of the ff. forms of a drug favorably absorbed:
I.Non-ionized
II.Water soluble
III.Ionized
IV.Lipid soluble
a. I and IV
b. I and II
c. II and III
d. III and IV
Rationale: always remember this mneumonic
LUNA = Lipophilic,Unionized,Nonpolar,Absorbed
HIPE= Hydrophilic,Ionized,Polar,Excreted
14.According to the pH partition hypothesis, a weak, acidic drug will not be
absorbed from the small intestine because:
a.the drug will exist primarily in the unionized, more lipid soluble form
b.the drug will exist primarily in the ionized, more water soluble form
c. weak acids are more soluble in an acid medium
d.the ionic form of the drug facilitates absorption. – it should be excretion
15.Decreased oral absorption of a drug due to high stomach pH would
result to:
a.decreased gastric toxicity of the drug
b.decreased bioavailability of the drug
c.increased bioavailability of the drug
d.increase clearance of the drug
Rationale Activity #2
Adventist Medical Center College
Department of Pharmacy
Outcome Readiness Assessment
Activity #2
Module 2 Pharmacognosy and BioChem15%
Instructions: Highlight the correct answer.

Situation 1: [For items 1-5] See Figure Below

I . Plasma drug concentration – time curve
II. Linewaeaver-Burk Plot
III. Michaelis -Menten Kinetics
IV. Vapor pressure – composition curve
V. Sigmoidal curve

I. Plasma drug concentration – time curve

II. Lineweaver – Burk Plot

III. Michaelis Menten Kinetics

IV. Vapor pressure – composition curve

 V. Sigmoidal Curve

1.Identify the diagram that shows the actual body exposure to drug after the administration of a
certain dose of the drug.
A. IV
B. II
C. III
D. I
Rationale: Plasma drug concentration time curve -is used to determine the systemic
bioavailability of a drug from a drug product. (Highlighted sentence gives you clue what
kind of curve was being asked)
2. Which diagram shows how an enzyme can cause kinetic rate enhancement of a reaction and
explains how reaction rates depend on the concentration of enzyme and substrate?
A. IV
B. III
C. I
D. II
Rationale: Michaelis -Menten Kinetics - describes how reaction velocity varies
w/substrate concentration. V=Vmax[S]/Km+[S]
Where: V= rate of enzyme catalyze reaction
Vmax=Maximum velocity
[S]=substrate concentration
Km=Michaelis-menten constant
[S]= required to reach ½ Vmax measure of the substrate affinity to the enzyme.
(Highlighted sentence gives you clue what kind of curve was being asked)
3. Which diagram demonstrates the Michaelis – Menten Kinetics
A. I
B. III
C. IV
D. I
4. Which diagram demonstrate Raoult’s Law?
A.IV
B. II
C. I
D. III
Rationale: Vapor pressure – composition curse is also known as Raoult’s Law.
5.Which diagram demonstrates enzyme cooperativity? The curve results from cooperation
between subunits. The binding of a substrate to one active site in a molecule increases
likelihood that the substrate will bind to other active sites.
A.III
B.I
C. IV
D.V
Rationale: A sigmoidal curve starts out with a low slope, increases the slope to an
inflection point, then levels off as it approaches a maximum value.

Situation 2: [For items 6-10]: Catalysts alter the rate of chemical reactions. Enzymes act
as catalysts in biochemical reactions, employing different catalytic strategies, such as:
I. Promotion of a reaction that is immeasurably slow at neutral pH.
II. Achievement of high absolute rate of reaction, suitable for integration with other rapid
physiological processes.
III. Attainment of a high degree of specificity.
IV. Utilization of the free energy associated with the hydrolysis of ATP
Instruction: Identify the mechanism or catalytic strategy employed by the following enzymes.
6. Trypsin
A. II
B. III
C. IV
D. I
7.Carbonic anhydrase
A.IV
B. III
C.II
D. I
8.Restriction endonucleases
A. III
B. II
C. IV
D. I
9. Chymotrypsin
A.IV
B.III
C.II
D.I
10.Myosins
A. II
B. I
C. III
D. IV
Situation 3: [For items 11-15] Vitamins are molecules that cannot be made by the body
and therefore, must be obtained form the diet . These are excreted daily and subject to
turnover. Example of these are:
I. Vitamin E
II. Vitamin K
III. Biotin
IV. Riboflavin
 V. Vitamin A
VI. Vitamin D
Identify the vitamin that is described.

11.It is non polar vitamin; mixture of tocopherols; serves as an antioxidant in biomembranes,

protecting these and embedded proteins against oxidative attack of free radicals and peroxides.
A. V
B. I – vitamin E
C. III
D. IV
12. It is made by the gut bacteria; the bacterial source can supply most or all of the needs of a
normal healthy adult; it serves as a cofactor in carboxylation reactions.
A. II – Vitamin K
B. VI
C. I
D. III
13. It serves as a cofactor in numerous biochemical index reaction, where its ability to accept
and donate electrons one at a time quite valuable.
A. I
B. II
C. V
D. IV -Vitamin B2 (Riboflavin)
14. Vitamin that is required for the clotting of blood.
A. III
B. I
C. VI
D.II – Vitamin K
15. This vitamin is really three separate but chemically related compounds : retinol, retinal, and
retinoic acid . When converted to the retinal form they serve as an essential cofactor for the
protein rhodopsin, which is responsible for vision in rod cells.
A. II
B.VI
C. V – Vitamin A
D. III
Additional Info: Most poisonous vitamin is Vitamin A

Rationale for activity 1.

12. Given pKa NH2 of 9.8, pKa COOH 2.09, and pKa of 3.86, calculate the
isoelectric pH of aspartic acid.
A. 5.96
B. 2.98
C. 6.84
D. 5.26
Solve for the Isoelectric pH
Non-ionizable pI=pk1+pk2/2
Acidic pI=ave. of 2lower pka
pI =pk1+pk2/2
Basic pI= ave. of 2 higher pka
pI=pKr+pK2/2
Solution
pI=2.09+3.86/2
=2.98
13.Level of protein organization characterized by multiple secondary units.
A. Secondary
B. Supersecondary -between secondary and tertiary
C.Tertiary
D. Quaternary
14. Which is the catalytic site model, where the substrate induces a
conformational change in the enzyme?
 A. Lock and Key model – absorption specifity ex. glucokinase
B. Hill Equation Model
C. Quaternary Structure
D. Induced Fit Model- group specifity ex.Hexokinase

20 essential amino acids

Amino Acids with Non polar groups

Alkyl R group
Alanine
Valine
Leucine
Isoleucine
Proline
Aromatic Group
Phenylalanine
Tryptophan
S-Containing
Methionine

Outcome Readiness Assessment

Activity 3
Module 3 Practice of Pharmacy 17.5%
Rationale
Instructions: Choose the BEST answer. Highlight your answer
1. MCDL
a. 1450
b. 1550
c. 1600
d. 1650
Rationale: M=1000, C=100, D=500, L=50
2.The patient was prescribed with a drug to be administered at 20mg/kg/day every
12hours, what will be the daily dose of the patient weighing 50kg?
a.500mg
b.1000mg
c.250mg
d.2000mg
Rationale:
Given: 50kg, 20mg/kg/day
Solution: 50kg/20kg/dayx1day/24hrsx12hrs = 500mg
3.Concentration expression most commonly used for suspensions?
a. %w/v
b.%v/v - alcohol
c.%w/w
d.ppm – heavy metal concentration
e.mg%

4.mg% is equivalent to
a.gram/liter
b.gram/deciliter
c.mg/dl
d.meq/100ml
5.A physician places a patient on a daily dose of 48units of U-80 insulin. How many mL
should the patient inject daily?
a.0.4ml
b.0.6mL
c.4mL
d.2.6mL
Rationale: U-80 insulin = 48units
80units/1m = 48/x = 0.6mL
6. A patient presented himself on a clinic complaining of a cough that won’t go away.
Upon interviewing him, you have learned that he has smoked 20 sticks of cigarette a
day for 17 years. What is the patient pack history?
a. 17 pack years
b. 20 pack years
c. 10 pack years
d.16 pack years
Rationale: 20sticks/20x17years
7. Compute for the required volume of water to make 2.35g of atropine sulphate
(E=0.13) isotonic. Use White Vincent method.
a. 33.94 mL
b. 36.42 mL
c. 4.33 mL
d. 30.16mL
Rationale:
White Vincent
mL = wt x E value x 111.1
=2.35g x 0.13 x 111.1
=33.94mL

Sprowl’s method
mL= 0.3 x E value x 111.1
 = 0.3 x 0.13 x 111.1
= 4.33mL
8. How many liters of a mouthwash can be prepared from 100mL of cinnamon flavor if
its concentration is to be 0.5% (v/v)
a. 10L
b. 15L
c. 20L
d. 18L
Rationale:
C1V1=C2V2
100mL(100%) = (0.5%) (V2)
V2 = 20000 mL = 20L
9.At what number is degrees Fahrenheit and degree Celsius the same?
a. -24
b. -40
c. 0
d. 7
F= (C x 9/5)+32
C= (F-32)x5/9
Assume F=C
C = (C x 9/5 ) +32
C-9/5 C=32
5-9/5 C =32
-4/5 C /-4/5 =32/-4/5
C=-40
10. Van’t Hoff equation
a. P= nRT
b. P= VRT
c.P= MRT
d.P= CVRT
rationale: derived from Ideal Gas LAw
11. Which of the ff. is the Morse Equation? – osmotic pressure
a. 𝝅= n/kg of solvent x 0.08205 x T
b. 𝝅 = n x 0.08205 x T x 2.203

c. 𝝅 = kg of solution x 0.08205 x T

d. 𝝅 = n x kg of solvent x 0.08205 x (T1-T2)

12. What mass of NaCl should be added in 100mL of 5.0%(w/v) dextrose monohydrate
( E= 0.16) isotonic solution?
a. 250mg
b. 2.20g
c. 0.9g
d. 100mg
Rationale: NaCl Eq.method 5% dextrose in 100mL prep
 5g/100mL x 100mL = 5g dextrose
 5g dextrose x 0.16 = 0.8g NaCl
 Isotonic solution = 0.9% NaCl
0.9g / 100ml x 100ml = 0.9g NaCl
 Mass of NaCl to be added
0.9g-0.8g=0.1g (100mg)
13. If 500mL of a 1:200 (v/v) solution were diluted to 800mL. what would be the ratio
strength (v/v)?
a. 1:800
b. 1:300
c. 1:320
d. 1:250
e. 1:500
Rationale:
Formula to be used: C1V1=C2V2
(1/200) (500mL) = C2 (800mL)
C2 =1/3200
14. For numbers 14-15
An in-patient was ordered with 300mg tablet that contains Levodopa/Carbidopa
250mg/25mg. The following dosing regimen: ½ tablet at 7am ¼ +1/8 tablet at 11 am, ¼
+1/2 tablet at 3pm, ½ tablet at 7pm, ¼ +1/8 at 11pm.
What is the total dose of levodopa/carbidopa to be administered to the patient per day?
a. 593.75mg/59.375mg
b. 625mg/62.5mg
c. 587.5mg/50mg
d. 656.26mg/68.75mg
Rationale: You can start by converting the fractions into decimal points
½ =0.5 , ¼ = 0.25 , 1/8 = 0.125
Then you can itemized them by multiplying them to the given dose.
250mg/25mg x 0.5 = 125mg/12.5mg x 3 375/ 37.5
250mg/25mg x 0.25 = 62.5mg/6.25mg x 3 187.5/ 18.75
250mg/25mg x 0.125 = 31.25mg/3.125mg x 2 62.5/6.25
Multiply by how many times it is administered then add all the results given by the
computations
375/37.5 + 187.5/18.75+62.5/6.25 = 625mg/62.5mg
15.How many tablets will be used to compound the order?
a. 3
b. 5
c. 2
d. 4
Rationale: You need 625mh/62.5mg per day, the order was 300mg, you need to use 3
tablets to complete the order
16.The physician ordered an infusion of NSS 500mL in 3 hours using a 15gtts/mL set.
With ½ hours remaining, you discover that only 150mL is left in the bag. At what rate in
gtts per minute will the infusion be reset?
a. 10gtts/minute
b. 5gtts/minute
c. 25gtts/minute
d. 20gtts/minute
Rationale: 150mLx 15gtts/mL = 2250gtts/30mins = 75gtts/min
17. The serum creatinine of a 65-year old female weighing 150lbs was 1.5mg/dL what is
the creatinine clearance?
a.94.6mL/minute
b.104.3mL/minute
c.40.2mL/minute
d.27.3mL/minute
Rationale: ClCr= (140-age) (wt in kg) / 72 x SCr
= (140-65) (68.18kg) / 72 x 1.5mg/dL
= 47.02 mg/dL (if male)
= 47.02 x 0.85 = 40.2mg/dL if FEMALE

18.What is the % v/v of a solution of 800g liquid (spec. gravity = 0.8) in water to make
4000mL?
a.20%
b.40%
c.25%
d.80%
Rationale: % V/V
800g Liq (S.G. = 0.8)
0.8 = 800g Liq / V
VLiq = 800g Liq /0.8
V Liq =1000mL
1000mL/4000mL = x / 100ml
X = 25%
19.Calculate the specific gravity of the gravity of the mixture 800mL glycerin, s.g. 1.25,
900mL water, 2000mL alcohol, s.g. 0.81
a.0.705
b.0.687
c.0.951
d.0.864
Rationale: mixture
800mL x 1.25 =1000g Glycerin
900mL x 1= 900g Water
2000mL/3700mL x 0.81 = 1620mg Alcohol / 3520g
SG: 3520/3700mL = 0.951

20.How many mg potassium (MW=39) are there in 4L of a solution that is 3mEq/L?

a. 117mEq
b.468mEq
c.53 mEq
d.38mEq
Rationale :
mg= mEq x FW/valence
= 3mEq x 39/1 x 4L
=468mEq

Outcome Readiness Assessment

Activity 3
Module 4 Practice of Pharmacy 17.5%

Instructions: Choose the BEST answer. Highlight your answer

1. How many mEq of Na are present 250cc NSS (Na=23,Cl=35)
a.23mEq
b.15mEq
c.53mEq
d.38mEq
 Rationale: mEq= mg/FW x valence
= 2250mg/58 X 1
= 38.79 mEq

2.A formula for an antifungal shampoo contains 2%(w/v) of ketoconazole. How many
grams of ketoconazole would be needed to prepare 25L of the shampoo.
a.5
b.50
c.500
d.5000
Rationale: 2g/100mL X 25000mL =500g
3.How many 1-fluidonce bottles of Lagundi syrup can be prepared from 5 gallons of the
syrup?
a.740
b.640
c.460
d.470
Rationale :1gal = 3785mL , 1floz= 29.57mL
5gal X 3785mL/1gal X 1floz/100mg = 640floz

4.The dose of acetaminophen for infants less than 3 months of age is 10mg/kg body
weight to be taken 3-4 times a day. What is the volume per dose of acetaminophen oral
drops 100mg/mL should be given to a child weighing 11 lbs?
a. 0.5mL
b. 1.5mL
c. 2 mL
d. 2.5mL
Rationale: 111lbs X 1kg/2.2lbs X 10mg/1kg X 1mL/100mg = 0.5mL
5. The adult dose of a drug is 300mg. What would be the approximate dose for a 6
year-old child weighing 60-lb? ( use youngs rule)
a. 87.5mg
b. 100mg
c. 150mg
d. 200mg
e. 250mg
Rationale : Young’s Rule = age/age+12 X adult dose
= 6/6+12 X 300
= 100mg

6. A patient weighing 120lbs was administered 2.1grams of a drug that was intended to
be dosed at 30mg/kg. What can you say about the dose administration?
a.Underdose
b.Overdose
c.Correct
d.Insufficient information
Rationale: 120lbs x 1Kg/2.2lbs = 54.5kg
2.1g Drug
(2100mg drug/54.5kg = 38.5 OVERDOSE)

7.How many grams of 1% hydrocortisone cream must be mixed with

0.5%hydrocortisone cream if one wishes to prepare 80g of a 0.6% w/w preparation?
a. 12g
b. 16g
c. 20g
d. 24g
e. 36g
1 0.6 0.1part
0.5 0.4part
TOTAL = 0.5parts
0.1part/0.5part = X/80g
X = 16g of 1% HC
8. A patient was prescribed with Cefuroxime oral suspension (125mg/mL) to be taken in
doses of 2tsp 3 times a day for 4 days and 1tbsp 2 a day for 2 days. How many mL of
the suspension should be dispensed to cover the entire regimen?
a.180
b. 18
c. 1.8
d. 200
e. 20
1 tsp = 5mL
1tbsp = 15mL

2tspx5mL/1tsp = 10mLx3/day x 4days

X1= 120mL

1tbsp x 15mL/1tbsp = 15mL x 2/day x 2days

X2 = 60ml + 120ml = 180mL

9. Calculate the volume in wine gallons represented by 175 proof gallons of 70% v/v
alcohol?
a.125
b.135
c.145
d.150

P.G = WG x % / 50 %
Formula derivation
PG x 50%/% = WG
175 x 50% / 70% = WG
125 = WG

10. 75g of proteins is equivalent to

a.100kcal
b.200kcal
c.300kcal
d.400kcal

anhydrous 4kcal/g
hydrous 3.4kcal/g
protein 4kcal/g
fats 9kcal/g
alcohol 5.6kcal/g
total = 4 x 75 = 300kcal

11. An ointment formulation requires 80g of emulsifier blend with tween 40 and span 20.
If the HLB requirement is 12.3, how many grams of each emulsifier should be used?
(HLB tween 40 = 15.6 Span 20= 8.6)
a.46.5g Span 20 and 23.3 g Tween 40
b.23.3g Span 20 and 46.5 g Tween 40
c.42.3g Span 20 and 37.7 g Tween 40
d.37.7g Span 20 and 42.3 g Tween 40

TWEEN 40
15.6 3.7
12.3
SPAN 20
8.6 3.3/7 PARTS

TWEEN 40 = 3.7 parts/7parts x Xg/80g = 42.3g

SPAN 20 = 3.3parts/7parts x Xg/80g =37.7g

12. For numbers 12-13

Rx
Coal Tar Solution 5mL
Salicylic acid 5%
Urea 5%
Triamcinolone 0.25g
Alcohol 30mL
Propylene glycol qs 120mL

How many ml of Triamcinolone injection (40mg/mL) should be used to prepare 250mL

of this formula?
a.12.5ml
b.13mL
c.16.7mL
d.19mL
13. Approximately how much of the preparation can be made from 100ml of
triamcinolone (40mg/mL)
a.300L
b.1900L
c.1200mL
d.2L
e.2500ml
14. The patient was prescribed with 125mg/5mL one tbsp. bid for 7 days. The available
preparation of the medication is 35-ml bottle, how many bottles are needed to complete
the whole regimen?
a.4 bottles
b.1 bottle
c. 3bottles
d. 6 bottles
15. You are directed to weigh 10g of a substance so as to limit the error to 0.1%.
calculate the maximum potential error. In terms of grams that you would not be
permitted to exceed?
a. 0.01gram
b. 0.1gram
c.0.02gram
d.1 gram

RATIONALE FOR 12,-15

12. 0.25G/120ML x Xg/250mL = 0.52g or 520mg needed to prepare 250mL
13. 40mg/1mL = 520mg/ XmL = 13mL
13mL/250mL = 100mL/ X = 1923mL or 2L (roundoff)
14. 1tbsp = 15mL x BID = 30mL
30mL x 7days/35mL = 6bottles
15. Maximum potential error
%error x quantity desired
0.1%(0.001 x 10gram = 0.01g)

16. The purpose of the Pharmacy and Therapeutics Committee are the ff.
a. Advisory and educational
b. Advisory and planning
c. Educational and planning
d. Dispensing and Inventory
17.Wich of the ff. is written in the Subscription – instruction to the rph?
a. Mix and make ointment
b. Take it after a meal - Transcription
c. Clarithromycin 125mg/5mL – Inscription
d. Rx - superscription
17.Which of the ff. medications prescribed is used for its inotropic effect?
a. lanoxin – BN : digoxin
b. Plavix - Clopidogrel
c. actilyse - thrombolytic
d. isoproterenol
18. Which of the ff. FDA approved tall man lettering is appropriate?
a. dopAMINE and dobutamine
b.DOpamine and Dobutamine
c.doPamine and doBUTamine
d.DOPamine and DOBUTamine
19.ADHD stands for?
a. Attention Deficiency Hyperactivity Disorder
b. Attention Deficit Hyperactivity Disorder
c. Attention Deficiency Hyperactivity Disease
d. Attention Deficiency Hyperkinetic Disorder
e.Attention Deficiency Hyperkientic Disease
20. PhilPSP stands for?
a. Philippine Professional Standards for Pharmacists
b. Philippine Professional Standards of Practice
c. Philippine Practice Standards for Pharmacists
d. Philippine Pharmaceutical Science Program
e. Philippine Practice Standards for Professionals