Generic/ Brand Classification Mechanism of Action Consideration/ What to Observe/ Look Adverse Effect

Celecoxib Pharmacologic Inhibits the enzyme Assess range of motion, degree of CNS: dizziness,
classification:  cyclooxygenase COX-2. This enzyme is swelling, and pain in affected jointsheadache, insomnia
-2 (COX-2) inhibitor required for the before and periodically throughout CV: HF, MYOCARDIA
Dosage: synthesis of therapy. L
500 mg./ BID Therapeutic prostaglandins. Assess patient for allergy to INFARCTION, STROK
classification:  anti- Has analgesic, anti- sulfonamides, aspirin, or NSAIDs. E, THROMBOSIS,
inflammatory inflammatory, and Patients with these allergies should not
edema, hypertension
antipyretic properties. receive celecoxib. Assess patient forDerm: EXFOLIATIVE
Pregnancy risk category C skin rash frequently during therapy. DERMATITIS, STEVE
Discontinue at first sign of rash; may be
NS-JOHNSON
life-threatening. Stevens-Johnson
SYNDROME, TOXIC
syndrome may develop. Treat EPIDERMAL
symptomatically; may recur once NECROLYSIS, rash
treatment is stopped. F and E: hyperkalemia
GI: GI BLEEDING,
Lab Test Considerations:  abdominal pain,
May cause ↑ AST and ALT levels. diarrhea, dyspepsia,
May cause hypophosphatemia, flatulence, nausea
hyperkalemia, and ↑ BUN.