DRUG NAME MECHANISM OF INDICATION/ ADVERSE NURSING RESPONSIBILITIES

ACTION CONTRAINDICATION EFFECT

GENERIC: NSAID that exhibits INDICATION: Body as a Whole: Assessment & Drug Effects
Celecoxib antiinflammatory, Back pain,
analgesic, and Relief of S&S of osteoarthritis and peripheral edema. Therapeutic effectiveness is
BRAND NAME: antipyretic activities. rheumatoid arthritis. Treatment of acute Increased risk of indicated by relief of joint pain.
Celebrex Unlike ibuprofen, pain and primary dysmenorrhea. cardiovascular Lab tests: Periodically monitor Hct
inhibits prostaglandin Reduction of polyp formation in events. GI: and Hgb, liver functions, BUN and
CLASS: synthesis by inhibiting familial adenomatous polyposis (FAP), Abdominal pain, creatinine, and serum electrolytes.
CENTRAL NERVOUS cyclooxygenase-2 ankylosing spondylitis diarrhea, Monitor closely lithium levels when
SYSTEM AGENT, (COX-2), but does not Reduces or eliminates the pain of the two drugs are given
dyspepsia,
ANALGESIC, NSAID, inhibit cyclooxygenase- rheumatoid and osteoarthritis. concurrently.
flatulence, nausea.
CYCLOOXYGENASE-2 1 (COX-1). Monitor closely PT/INR when used
INHIBITOR, CONTRAINDICATION: CNS: Dizziness, concurrently with warfarin.
ANTIPYRETIC headache, Monitor for fluid retention and
Severe hepatic impairment; insomnia. edema especially in those with a
PHARMACOLOGIC: hypersensitivity to celecoxib; asthmatic Respiratory: history of hypertension or CHF.
Selective patients with aspirin triad; advanced Pharyngitis,
cyclooxygenase-2 (COX- renal disease; concurrent use of rhinitis, sinusitis, Patient & Family Education
2) inhibitor diuretics and ACE inhibitors; anemia; URI. Skin: Rash.
pregnancy (category D) in third Avoid using celecoxib during the
DOSAGE: trimester; lactation. third trimester of pregnancy.
400 mg Promptly report any of the
200 mg following: unexplained weight gain,
edema, skin rash.
ROUTE: Stop taking celecoxib and promptly
PO report to physician if any of the
following occurs: S&S of liver
dysfunction including nausea,
fatigue, lethargy, itching, jaundice,
abdominal pain, and flulike
symptoms; S&S of GI ulceration
including black, tarry stools and
upper GI distress.
Do not breast feed while taking this
drug.