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Production Technology Work?

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Fight against COVID-19?

https://www.tandfonline.com/doi/full/10.1080/14712598.2020.1752177 Will plant-made

biopharmaceuticals play a role in the fight against COVID-19?

https://www.researchgate.net/profile/Yogesh-Pawar-10/publication/
340809680_AIJR_Preprints_Reconsidering_Traditional_Medicinal_Plants_to_Combat_COVID-19/links/
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COVID-19.pdf Reconsidering traditional medicinal plants to combat COVID-19

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Compounds and Their Modes of Action Against Coronavirus Infection

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Natural Therapeutics Against the COVID-19 Pandemic

https://www.mdpi.com/2223-7747/10/2/352 COVID-19 Crisis: How Can Plant Biotechnology Help?

Plant-based Vaccines Technology

Plants as Catalyst in Surviving Pandemic

Plant-based vaccines are a technology with proven viability, which have led to promising results for
candidates evaluated at the clinical level, meaning this technology could contribute towards the fight
against COVID-19.

The production of immune complexes (ICs) in plants is another approach that renders highly
immunogenic agents

Pure antigens produced in plants have been assessed with promising results in schemes where a
conventional vaccine is used as a priming agent and the plant-made antigen is administered by the oral
route as boosting [106]. Exploring these schemes will be useful to achieve the best immune profile
against SARS-CoV-2 in terms of safe and long-lasting protective immune responses. In fact, the potential
of using prime-boosting schemes through different immunization routes has been proven as an
efficacious approach to achieve the desired immune profiles

The development of vaccines based on transplastomic lines or edible plant species transformed at the
nuclear level and intended to result in oral vaccines (especially boosting agents to provide mucosal
immunity) are considered long term goals. However, they have special importance given their low cost
and potential to serve as effective boosting agents, which could lead to attractive immune profiles
characterized by proper humoral response in the mucosal compartments and long-lasting protection,
especially for the elderly. In parallel to these developments, the production of monoclonal antibodies in
plants will provide another strategy to generate alternatives to the convalescent plasma transfusion, in
which plant-made antibodies will constitute a low cost and safer intravenous treatment for critically ill
patients.

As the COVID-19 epidemic advances, the exploitation of plant-made vaccines is a promise to generate
low cost, easy to administer, and safe/effective vaccines to fight against this pandemic.

Plant biotechnology offers potential solutions to this pandemic through the development of low-cost
vaccines and antibodies useful for therapy, prophylaxis, and diagnosis. The technology to produce plant-
made biopharmaceuticals is already established; two examples of these are: a therapeutic enzyme that
has entered the market and the influenza vaccines that are currently under clinical trials with
encouraging results. Thus far, some companies have started developing anti-COVID-19 antibodies and
vaccines. In particular, plant-made antibodies might be timely produced and approved for human use in
the short term, while the development of vaccines will take longer time (clinical evaluations could be
concluded by the end of 2021); nonetheless, the candidates obtained will be valuable tools for future
outbreaks

Nearly 80% of the people are dependent on traditional plants for their primary health (according to a
WHO report).

Ayurveda or the traditional Indian system of medicines has described the use of plants, which have a
number of compounds and secondary metabolites that are useful for drug formulations.

Plants as Catalyst in Surviving Pandemic

- Studies have shown plant-based vaccines and antibodies to combat COVID-19

- Plant essential oils: Possible COVID-19 therapeutics
- Weed Plant Act as Vaccine against Plant and COVID-19 Diseases: Enriched Agriculture Health
Development Socioeconomy Sciences Technology Communication Application
- WHO is working with research institutions to select traditional medicinal plant products which
can be investigated for clinical efficacy and safety for COVID-19 treatment.
- documented 1230 uses of 491 plants in treatments of mild COVID-19 symptoms as listed by
WHO.
- Notably, 61.9% of interviewed people used plants for preventing or treating COVID-19