A foaming idea…

PROTEOL APL

PROTEOL OAT … for controlling

ORAMIX CG110
bubbles!
ORAMIX NS10

ORONAL LCG/E OD
 PROTEOL OAT

PROTEOL APL Challenge!

Smoothness & gentle
Fruity sensation : of oat for a foam
Protecting skin with a respectful to skin ORONAL LCG/E OD
gentle touch of beauty!
Suitable for even the
most sensitive skin…

… ask for more

ORAMIX CG110
ORAMIX NS10
Ultra gentle solubilizing
and cleansing agent
making all your Naturally foaming !
formulas “green” with
pleasure

C/4426/GB/01/november 2009 2
 PROTEOL APL
Sodium Cocoyl Apple Amino Acids

Softness in all its forms,

PROTEOL APL boosts and expands the foam

to the skin's delight!

C/4426/GB/01/november 2009 3
 PROTEOL APL
KEY POINTS

 Abundant foam texture

 Does not irritate the eyes

 Gentle on the skin

 Biodegradable

C/4426/GB/01/november 2009 4
 PROTEOL APL
ABUNDANT FOAM TEXTURE
1- Foam texture
Visualization of the microscopic structure of the foam: expansion of the foam in an inward radial
flow turbine (3,000 revs/min) for 2 min – solution at 0.1% a.m. in hard water – 40°C/ pH7

PROTEOL APL generates a thick foam, produced through the

formation of small, tightly packed bubbles.
Lasting foam stability!

Microscopic structure of the

foam

T: 10 minutes T: 30 minutes
A 10 minutes A 30 minutes
Photos x 15

C/4426/GB/01/november 2009 5
 PROTEOL APL
ABUNDANT FOAM TEXTURE
2- Abundant foam
Evaluation of foaming ability: Ross-Miles test (ISO 696-1975) – distilled water and hard water at
30°C, calcareous and soil – 1% a.m. –pH7
Evaluation of the foaming ability of PROTEOL APL with SLES (SLES (9/10) / co-surfactant (1/10)) –
10% a.m. – hard water and soil – pH 7

PROTEOL APL alone or in a combination generates an

abundant foam, even in extreme conditions!

Foaming ability of
PROTEOL APL alone
Foaming ability of
Foam volume
(mL)
PROTEOL APL in a 450 Foam volume
(mL)
700
combination 400
408
600 350
596
500 548 300

462 262
250
400 444 242
200

300 150

262
200
   Distilled water 100

50   
 Hard water and
100
  10   0
0 soil SLES SLES + Sodium SLES +
SLES Sodium Lauroyl PROTEOL APL Lauroyl Glutamate PROTEOL APL
Glutamate C/4426/GB/01/november 2009 6
 PROTEOL APL
DOES NOT IRRITATE THE EYES
1- Evaluation of the irritant effect of PROTEOL APL
HET-CAM in vitro test (application of a diluted product on an egg chorioallantoic membrane) (The
HET-CAM method results are similar to the results produced by the Draize test (in vivo method)
for doses 10 times higher)

PROTEOL APL can be used in formulation up to 10% of the

commercial product

Eye irritation index

HET-CAM irritation index

12 irritant
SLES
10
Moderately irritant
8

Slightly irritant
4

2
Non-irritant
PROTEOL APL
0
0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9
% a.m.

C/4426/GB/01/november 2009 7
 PROTEOL APL
GENTLE ON THE SKIN
1- Clinical evaluation: measurement of transepidermal water loss
(TWL)
In vivo test: application of an occlusive patch for 48 hrs on 16 volunteers – Doses tested: SLES at
7% a.m. / SLES + PROTEOL APL (7%/ 3% a.m.) – Measurement of TWL 2 hrs and 24 hrs following
removal of the patch – TWL measured between the area treated for 48 hrs in the occlusive patch
test and an untreated area

PROTEOL APL has an anti-drying effect that respects the skin

barrier. In combination with SLES, it reduces transepidermal
water loss (TWL)

Transepidermal water loss 2 hrs 24 hrs

0

-5

-10

-15

-15
-20
-19.1
-25
-21.4
SLES SLES
-30
PROTEOL APL
TWL (g/m2/hr) -35 -31.8
SLES SLES
PROTEOL APL

C/4426/GB/01/november 2009 8
 PROTEOL APL
ENVIRONMENTAL DATA

Biodegradability

 95% (28 days)

Aquatic toxicity

 On Daphnia: CE50 (48 hrs): 45mg/l

 On algae: CE50 (72 hrs): 76mg/l
 On fish: CL50 (96 hrs) >100mg/l

These results indicate a normal level of toxicity which is significantly reduced given the
rapid biodegradability

C/4426/GB/01/november 2009 9
 PROTEOL APL
FORMULATION INFORMATION

Anionic surfactant

 Appearance: clear liquid

 Dry extract: 28-32%

 Formulation pH:
o Alone, from pH 5.5
o In combination with SLES, from pH 5.0

 Ideal for all types of cleansing

foaming, white and transparent formulas

 Dosage: 10%
C/4426/GB/01/november 2009 10
 PROTEOL APL
SUGGESTED FORMULA

A Aqua/ water Qsp 100% Creamy foaming gel

SEPINOV EMT10 0.5% 7014
Aqua 5.0%
B CAPIGEL 98 3.0%
ORONAL LCG /E OD 11.0%
PROTEOL APL 6.5%
C Methylchloroisothiazolinone
0.08%
& methylisothiazolinone
Parfum / Fragrance 0.1% Appearance slightly yellow clear gel

pH 7.1-7.2

Viscosity at AT 10,000 – 15,000 mPa.s BROOKFIELD LV3

speed 6
Viscosity after 1 month at 1,000 – 2,000 mPa.s BROOKFIELD LV2
45°C speed 6

Viscosity uptake at AT 10,000 – 15,000 mPa.s BROOKFIELD LV3

(after 1 month at 45°C) speed 6
Stability M1 at AT and 45°C
M1 in thermal cycles –5 / +40°C
C/4426/GB/01/november 2009 11
 PROTEOL APL
SUGGESTED FORMULA

A Sodium laureth sulfate 21.0% Gentle foam

PROTEOL APL 5.0% 6970
SEPICIDE HB 0.3%

B Parfum / Fragrance 0.1%

Aqua / Water Qsp 100%
Imidazolidinyl urea 0.2%
Lactic acid 0.15%

Appearance clear colorless

pH approximately 6

Viscosity at AT < 50 mPa.s Brookfield LV 2

Stability Stable at AT / 40°C / 4°C

Sepicide HB : Phenoxyethanol & Methylparaben & Ethylparaben &

Propylparaben & Butylparaben

C/4426/GB/01/november 2009 12
 PROTEOL APL
SUGGESTED FORMULA

SOLAGUM AX 1.00%
A SEPINOV EMT10 1.00% Passion Jelly
Aqua/ water
PROTEOL APL
Qsp 100%
3.0%
7159
Sodium Lauryl Ether Sulfate 15.40%
Methyl chloroisothiazolinone 0.08%
& methyl isothiazolinone
B
Polyethylene 1.00%
Coco Nucifera 1.00%
Parfum / Fragrance 0.40%
Appearance Orange liquid
Colorant Qs
pH at M1 AT 7.1

Viscosity at M1 AT 6,100 mPa.s BROOKFIELD LV3 speed 6

Viscosity after 1 month at 5,600 mPa.s BROOKFIELD LV3 speed 6

45°C
Viscosity uptake at AT 6,400 mPa.s BROOKFIELD LV3 speed 6
(after 1 month at 45°C)

Solagum AX : Acacia senegal gum & Xanthan gum Stability M1 at AT and 45°C
Sepinov EMT10 : Hydroxyethyl acrylate & sodium acryloyldimethyl taurate
copolymer C/4426/GB/01/november 2009 13
 PROTEOL OAT
Sodium Lauroyl Oat Amino Acids

PROTEOL OAT challenge:

offer an elastic, unctuous foam with original

surfactant properties

C/4426/GB/01/november 2009 14
 PROTEOL OAT
KEY POINTS

 Abundant foam texture

 Minimal delipidation, gentle cleanser

 Biodegradable

C/4426/GB/01/november 2009 15
 PROTEOL OAT
ABUNDANT FOAM TEXTURE
1- Surfactant profile: Foaming ability
Evaluation of foaming ability: Ross-Miles test (ISO 696-1975) – distilled water and hard water at
30°C, calcareous and soil – 1% a.m.

PROTEOL O.A.T has greater foaming ability than conventional

ionic surfactants, notably in difficult conditions

Foaming ability
Foam volume (mL)
700

615
600

500 500 500

500
420
400

300
250
 Distilled water
200

 Hard water and

100
      soil
0
PROTEOL OAT SLES SLS
C/4426/GB/01/november 2009 16
 PROTEOL OAT
ABUNDANT FOAM TEXTURE
2- Surfactant profile: foam structure and stability
PROTEOL OAT foam microscopic structure
Comparison of foam elasticity produced with PROTEOL OAT and SLES: rheology study (oscillation
protocol) / foam generated by mechanical agitation

 Thick lamellar structure in a stable and unctuous foam

 Rich foam, unctuous texture: Air bubbles trapped within the
foam creating significant cohesion between them

PROTEOL OAT foam

microscopic structure
Foam elasticity comparison

Modulus of elasticity G’
9 (Pa)
8
7
6 PROTEOL OAT
5
4
Stability after 2 3
SLES
min 2
1
0
Stability after 15 0 200 400 600 800 1000 1200 Time (s)
min C/4426/GB/01/november 2009 17
 PROTEOL OAT
MINIMAL DELIPIDATION, GENTLE CLEANSER
1- Surfactant profile: Wetting power & cleansing action
Evaluation of wetting power: SEPPIC in-house method 57CO002 – measurements at 25°C for doses
at 0.1% a.m.
Evaluation of cleansing action: SEPPIC in-house method 57CO007 – measurement against Isoprolyl
Myristate stained using a lipophilic colorant – 10% a.m.

PROTEOL OAT: gentle cleanser for skin and mucous membranes.

Unlike anionic SLES and NaLS, it is non-delipidating.

Wetting power Cleansing action

Cleansing action
Time (s)
(µL/MIP/g a.m. AT)
70 600

60
60
500

50

45
400

40

300
30

200
20

10 100

0 0

PROTEOL OAT SLES PROTEOL OAT SLES NaLS

C/4426/GB/01/november 2009 18
 PROTEOL OAT
MINIMAL DELIPIDATION, GENTLE CLEANSER
2- Clinical evaluation: measurement of transepidermal water loss
(TWL)
In vivo test: application of an occlusive patch for 48 hrs on 15 volunteers – solutions tested at 10%
d.e. / control: distilled water – TWL measured 1 hr and 24 hrs after removal of the patch

PROTEOL OAT respects the skin barrier and, compared to the

control solution, does not significantly alter transepidermal
water loss

Transepidermal water
Control PROTEOL OAT SLES
loss
1 hr 24 hrs 1 hr 24 hrs 1 hr 24 hrs
0

-1.3
-5
-2.1
-5.1
-6.1
-10

-15

-20 -17.8

-25 -22.8
TWL (g/m2/hr)
C/4426/GB/01/november 2009 19
 PROTEOL OAT
ENVIRONMENTAL DATA

Biodegradability

 95% (28 days)

Aquatic toxicity

 On Daphnia: CE50 (48 hrs): 2.9mg/l

 On algae: CE50 (72 hrs): 36mg/l
 On fish: CL50 (96 hrs) >93mg/l

These results indicate a normal level of toxicity which is significantly reduced given the
rapid biodegradability

C/4426/GB/01/november 2009 20
 PROTEOL OAT
FORMULATION INFORMATION

Anionic surfactant

 Appearance: clear liquid

 Dry extract: 28-32%

 Formulation pH:
o Alone, from pH >7.0
o As co-surfactant, formulation at pH>5.0

 Ideal for all types of cleansing,

foaming, white, transparent and non-fragrant formulas

 Dosage: 10%
C/4426/GB/01/november 2009 21
 PROTEOL OAT
SUGGESTED FORMULA

Facial foam
PROTEOL OAT 10.00%
"Good Morning"
A ORAMIX CG110 3.00% 6855
SEPICIDE HB 0.5%
Parfum/Fragrance 5.0%
Aqua/Water Qsp 100%
Imidazolidinyl urea 0.03%
B SEPITONIC M3 1.00%
Tromethamine Qs
Colorant Qs
Appearance Clear blue

pH 6.5

Viscosity at AT < 50 mPa.sBROOKFIELD LV2 speed 6

Stability > M1 at AT and 40℃

Oramix CG110 : Caprylyl/Capryl Glucoside

Sepicide HB : Phenoxyethanol & methylparaben & ethylparaben &
propylparaben & butylparaben
Sepitonic M3 : Magnesium aspartae & zinc gluconate & copper gluconate
C/4426/GB/01/november 2009 22
 ORAMIX CG110
Caprylyl/Capryl Glucoside

Ultra-gentle solubilizing and cleansing agent

making all your formulas "green" with

pleasure

C/4426/GB/01/november 2009 23
 ORAMIX CG110
KEY POINTS

 Solubilizing agent validated by ECOCERT

 Foam booster

 Gentle cleanser
 Biodegradable

C/4426/GB/01/november 2009 24
 ORAMIX CG110
GREEN SOLUBILIZING AGENT
1- Evaluation of solubilizing properties
Measurement of the quantity of solubilized substance (in g) per 10g of solubilizing agent
(water qsp 100g) after three months' stability at ambient temperature – Comparison with
ethoxylated hydrogenated castor oil

ORAMIX CG110 has equivalent solubilizing properties to

ethoxylated hydrogenated castor oil

ORAMIX PEG-40 hydrogenated

CG110 castor oil

ESSENTIAL OILSS
Bergamot 1.5 1.5
Eucalyptus 2.5 3
Lavender 1 2
Orange 0.5 1.5
Pine 2 3
Rosemary 2 1
Sage 3 1.5

FRAGRANCES
“Chypre” note 3 0.5
“Cologne” note 2.5 0.5
“Floral” note 2.5 2
C/4426/GB/01/november 2009 25
 ORAMIX CG110
BOOSTS FOAM VOLUME
1- Influence of the solubilizing agent on foam volume
Measurement of foam volume in hard water and soil with SLES 10% a.m. and of co-surfactant
3% D.E.

ORAMIX CG110, used as a solubilizing agent in foaming

formulas, boosts foam formation. Its action is greater than that
of ethoxylated hydrogenated castor oil!

Foaming ability
Foam volume (mL)
300

248
250

200 184
166
150

100

50

0
SLES 10% a.m. SLES 10% a.m. + SLES 10% a.m. +
PEG-40 hydrogenated ORAMIX CG110 3%
castor oil 3% d.e. d.e. C/4426/GB/01/november 2009 26
 ORAMIX CG110
GENTLE CLEANSER
1- Surfactant profile: Wetting power & cleansing action
Evaluation of wetting power: SEPPIC in-house method 57CO002 – measurements at 25°C for doses
at 0.1% a.m.
Evaluation of cleansing action: SEPPIC in-house method 57CO007 – measurement against Isoprolyl
Myristate stained using a lipophilic colorant

ORAMIX CG110 has similar cleansing properties to those of

SLES, while maintaining excellent dermatological compatibility.

Wetting power
Cleansing action
Time (s) Cleansing action (µL/MIP/g a.m. AT)
250
600

500
200
200 500

150 400

100 300

60
50
200 156 160

100
0

ORAMIX CG110 SLES

0

ORAMIX CG110 SLES NaLS

C/4426/GB/01/november 2009 27
 ORAMIX CG110
SAFETY / TOLERANCE

Excellent skin tolerance: gentle, respects skin balance

RBCA test (in vitro): measurement of protein-denaturing ability

Patch test (in vivo): on 20 volunteers – ORAMIX CG110 tested at 10% d.e.

 Little denaturing and non-irritant

C/4426/GB/01/november 2009 28
 ORAMIX CG110
ENVIRONMENTAL DATA

Biodegradability

 93% (28 days)

Aquatic toxicity

 On Daphnia: CE50 (48 hrs): 35mg/l

 On algae: CE50 (72 hrs): 37mg/l
 On fish: CL50 (96 hrs) >170mg/l

These results indicate a normal level of toxicity which is significantly reduced given the
rapid biodegradability

C/4426/GB/01/november 2009 29
 ORAMIX CG110
FORMULATION INFORMATION

 Non-ionic surfactant
 Appearance: fluid liquid
 Dry extract: 58-62%

 Compatibility:
o with all surfactants regardless of the type
 Mainly used as surfactant
 Numerous applications in the hygiene and toiletry sector
 Dosage: 15%

C/4426/GB/01/november 2009 30
 ORAMIX CG110
FORMULATION INFORMATION

 Solubilizing agent for perfumes, lipophilic active agents in an

aqueous medium…
 Increases the whiteness of cream gels

 Increases the hydrophily of the O/W emulsifying

system in order to improve stability
 Fluidifies cream gels or emulsions to encourage sprayability

C/4426/GB/01/november 2009 31
 ORAMIX CG110
SUGGESTED FORMULA

moisturizing cleanser
Aqua/Water Qsp100% Sublime Mousse
A Chlorphenesin 0.20%
7039B
Methyl paraben 0.30%
Ethyl paraben 0.20%
Oramix CG110 10.00%
Parfum/ fragrance 0.40%
B Aquaxyl 2.00%
Colorant Qs
Lactic acid Qs pH=6.5
Appearance Pale green clear gel
pH 6.45
Viscosity at AT <250 mPa.s BROOKFIELD LV2 speed 6

Viscosity after 1 month at <250 mPa.s BROOKFIELD LV2 speed 6

45 C
Viscosity uptake at AT <250 mPa.s BROOKFIELD LV2 speed 6
(after 1 month at 45 C)
Stability > M1 at AT and 45 C
Aquaxyl : Xylitylglucoside & Anhydroxylitol & Xylitol > M1 in thermal cycles –5 / +40 C

C/4426/GB/01/november 2009 32
 ORAMIX CG110
SUGGESTED FORMULA

Crystal clear ultra-soft

Aqua/Water Qsp100%
mousse
A MONTANOV S 1.00%
soap-free
SOMEPON T25 30.00%
ORAMIX CG110
Methylchloroisothiazolinone &
10.00%
0.08% 6932
B Methylisothiazolinone
Parfum/ fragrance 0.30%

Appearance Colourless clear liquid

pH 6.53
Viscosity at AT <50 mPa.s BROOKFIELD LV2 speed 6

Viscosity after 1 month at <50 mPa.s BROOKFIELD LV2 speed 6

45 C
Viscosity uptake at AT <50 mPa.s BROOKFIELD LV2 speed 6
(after 1 month at 45 C)

Montanov S : Coco-glucoside & Coconut alcohol

Somepon T25 : Sodium Methyl Cocoyl Taurate
C/4426/GB/01/november 2009 33
 ORAMIX NS10
Decyl Glucoside

Naturally foaming!

C/4426/GB/01/november 2009 34
 ORAMIX NS10
KEY POINTS

 Exceptional foam for a non-ionic surfactant

 Reduces the total active material of the formulas

 APGs easy to thicken

 Safety / Tolerance
 Biodegradable

C/4426/GB/01/november 2009 35
 ORAMIX NS10
EXCEPTIONAL FOAM FOR A NON-IONIC SURFACTANT
1- Surfactant profile: Foaming & wetting ability
Evaluation of foaming ability: Ross-Miles test (ISO 696-1975) – distilled water and hard water at
30°C, calcareous with 0.25% reconstituted sebum – 1% a.m.
Evaluation of wetting power: SEPPIC in-house method 57CO002 – measurements at 25°C for
doses at 0.1% a.m.

 Foam volume identical to that of conventional anionic

surfactants with good foam stability
 Gentle cleanser

Foaming ability and

foam stability

Foam volume (mL)

Wetting power
600
493
500 467
427
400 433 426 433
388
300 SLES 50 sec
200  Distilled water
192 ORAMIX NS10 1 min
100
     Hard water and
soil Cocamidopropyl betaine 2 min
0
ORAMIX NS10 SLES

T=30 s T=5 min

C/4426/GB/01/november 2009 36
 ORAMIX NS10
REDUCES TOTAL A.M. IN FORMULAS

As a surfactant, ORAMIX NS10 reduces the quantity of a.m. of

formulas without affecting performance.
Other advantages: easy to thicken, formulation cost effective

Foaming ability
Foam volume
(mL)
500
Shampoo 1: 8% a.m.
400
ORAMIX NS 10: 2% a.m.
300 Other surfactants: 6% a.m.
200
Shampoo 2: 10% a.m.
100
ORAMIX NS10: /
0
Shampoo 1 Shampoo 2
Other surfactants: 10% a.m.

C/4426/GB/01/november 2009 37
 ORAMIX NS10
APGs EASY TO THICKEN

A formulation with ORAMIX NS10 is easily thickened than a

formulation with other APGs on the market (example with
Decyl polyglucoside)

Viscosity for alkyl polyglucosides (mPa.s)

ORAMIX NS10 Decyl polyglucoside
10% d.e. 10% d.e.

Di alkyl polyglycol ether 2% 600 50

non-ionic surfactants Talloweth-60 myristyl glycol 2% 400 50
PEG120 methyl glucose dioleate 2% 200 0
Seteareth methyl glucose dioleate 2% 1900 200
Acrylates C10-30 alkylacrylates crosspolymer
1800 100
0.3%
Synthetic polymers
Carbomer 940 0.5% 3600 200

Sepigel 305 4% 3000 50

Carboxy methyl cellulose 0.8% 1300 1000
Natural polymers Xanthan gum 0.3% 1300 1000
Carrageenan 1% 1100 /
C/4426/GB/01/november 2009 38
 ORAMIX NS10
SAFETY / TOLERANCE

Good ocular tolerance profile

HET CAM test (in vitro)

 Non irritant at 0.1% a.m.

 Moderately irritant at 0.5% a.m.

Excellent skin tolerance: gentle,

respects skin balance
RBCA test (in vitro): measurement of protein-denaturing ability
24 hr patch test (in vivo): on 11 volunteers – ORAMIX CG110 tested at 10% d.e.
Anti-drying effect (diffusion cell method/in vitro): simulated water diffusion
through the corneal layer following skin cleansing with a surfactant solution

 Little denaturing and non-irritant

 Behavior similar to that of the skin. It does
not dry the skin and respects skin balance
C/4426/GB/01/november 2009 39
 ORAMIX NS10
ENVIRONMENTAL DATA

Biodegradability

95% (28 days)

Aquatic toxicity

 On Daphnia: CE50 (48 hrs): 35mg/l

 On fish: CL50 (96 hrs) >8.1mg/l

These results indicate a normal level of toxicity which is significantly reduced given the rapid
biodegradability

C/4426/GB/01/november 2009 40
 ORAMIX NS10
FORMULATION INFORMATION

 Non-ionic surfactant
 Appearance: fluid liquid
 Dry extract: 53-57%

 Compatibility:
o with all surfactants regardless of the type
 Crystallizes at T<10°C / little heat required to solubilize the
crystals
 Numerous applications in the hygiene and toiletry sector
 Specially recommended for specific hair products: dying, perming,
straightening (Compatible with highly alkaline media (reducers) or highly
oxidant media with acid pH (fixatives))
 Dosage: 15%

C/4426/GB/01/november 2009 41
 ORAMIX NS10
SUGGESTED FORMULA

2in1 MOISTURIZING shower gel

ORAMIX NS10 10.00%

SLES 28% 35.00%

6552A
A Amonyl 380BA 15.00%
Diethylhexyl malate 1.00%
Aqua/ water Qsp 100%
Parfum/ Fragrance 0.40%
B SEPICIDE HB 0.50%
Imidazolidinyl urea 0.30%
Styrene copolymer 2.00%
C Aqua/ water 8.00%

Appearance Highly opaque smooth gel

pH approximately 5.5
Viscosity at AT 11,000 mPa.s BROOKFIELD LV2- speed
6
Stability Stable at AT and 40 C
Stable during centrifuging

Amonyl 380BA : Cocamidopropyl Betaine

C/4426/GB/01/november 2009 42
 ORONAL LCG/E OD
PEG-40 Glyceryl Cocoate and Sodium Coceth Sulfate

Suitable for even the most sensitive skin…

… ask for more

C/4426/GB/01/november 2009 43
 ORONAL LCG/E OD
KEY POINTS

 Excellent ocular tolerance

 Excellent skin tolerance

 Ultra gentle cleansing base

C/4426/GB/01/november 2009 44
 ORONAL LCG/E OD
EXCELLENT OCULAR TOLERANCE
1- Test in vitro
Irritant effect evaluated in a HET-CAM test – dose tested: 1% a.m.

Ocular tolerance significantly superior to that obtained with

other surfactants considered to be "gentle" and frequently
used on the market (anionic or amphoteric surfactants)

Eye irritation index

HET-CAM irritation index
12 irritant

10
Moderately irritant

Cocamidopropyl hydrosultaine
Sodium methyl cocoyl taurate

8 Sodium lauroyl sarcosinate

Sodium cocoyl isethionate

Cocamidopropyl betaine
Na / Mg laureth sulfate

Alkyl ether carboxylate

6
ORONAL LCG E/OD

Slightly irritant

2
Non-irritant

0
C/4426/GB/01/november 2009 45
 ORONAL LCG/E OD
NO OCULAR IRRITATION IN VIVO
2- Clinical evaluation
Raw material tested alone and diluted at 3%
15 volunteers: 7 Vol. on non-sensitive eyes – 8 Vol. on sensitive eyes
Application time - 30 min.
Clinical examination by an ophthalmologist and volunteer experience

ORONAL LCG E/OD applied at 3% in dilution is very well

tolerated by the eyes

1 2
The clinical examination did not reveal any
signs of irritation.
Application did not cause stinging of the
eyes.
1- Right eye: simulated make-up removal
2- Left eye: simulated shampoo application

C/4426/GB/01/november 2009 46
 ORONAL LCG/E OD
EXCELLENT SKIN TOLERANCE
1- Clinical evaluation
Raw material tested alone and diluted at 10% and 20%
FINN CHAMBER occlusive patch test – skin surface covered - 50mm2
2 groups of 20 volunteers: 20 Vol. to normal skin – 20 Vol. to sensitive skin
Results interpreted after 48 hrs application

ORONAL LCG E/OD is particularly recommended for cleansing

of sensitive skin.

ORONAL LCG E/OD at the 2 concentrations

tested, was shown to be non-irritant in both
groups of volunteers!

C/4426/GB/01/november 2009 47
 ORONAL LCG/E OD
EXTREMELY GENTLE CLEANSING BASE
1- Surfactant profile: Wetting power & cleansing action
Evaluation of wetting power: SEPPIC in-house method 57CO002 – measurements at 25°C for doses
at 0.1% a.m.
Evaluation of cleansing action: SEPPIC in-house method 57CO007 – measurement against Isoprolyl
Myristate stained using a lipophilic colorant

ORONAL LCG E/OD = ultra-gentle cleansing agent. Combines

ideal wetting and cleansing properties for sensitive skin

Wetting power
Cleansing action
Time (min)
6

Cleansing action (µL/MIP/g a.m. AT)

55 600

500
4 500

3
400

2
300

11 160
200
141
0

ORONAL LCG E/OD SLES

100

0
ORONAL LCG E/OD SLES LSNa
C/4426/GB/01/november 2009 48
 ORONAL LCG/E OD
EXTREMELY GENTLE CLEANSING BASE
2- Surfactant profile: Foaming ability
Evaluation of foaming ability: Ross-Miles test (ISO 696-1975) – hard water at 30°C and standard
soil – ORONAL LCG E/OD at 10% d.e. (dilution 1/10)
Boost foam volume of cleansing bases and maintain excellent ocular tolerance: combination of
ORONAL LCG E/OD and surfactant (5% d.e./5% d.e.) / distilled water

ORONAL LCG E/OD in combination with a surfactant: foam

volume boosted and excellent ocular tolerance

Foaming ability
Combination with
a surfactant
Foam volume (mL)
450 Foam volume (mL)
500 12 HET-CAM
400 432 irritation
450
index
350 392 400
10

302
350
314
300
8

257
300
250

200
241 250 6

193
200
150 4
150
90 T=30 s
100 100 73 2
50 73 T=5 min 50

0 0 0

ORONAL LCG ORONAL LCG ORONAL LCG ORONAL LCG

Distilled Hard water Hard water E/OD ALONE E/OD / disodium E/OD / decyl E/OD / Alkyl ether
water and soil cocoamphodiacetate glucoside carboxylate
C/4426/GB/01/november 2009 49
 ORONAL LCG/E OD
FORMULATION INFORMATION

Non-ionic/ anionic surfactant

 Appearance: colourless thick liquid

 Dry extract: 48-52%

 Compatibility:
o Anionic, non-ionic and amphoteric products
 Can be used in formulations with pH ranging from 5 to 8
 Ideal for all types of transparent cleansing formulas
 Particularly recommended for cleansers for sensitive skin
 Dosage: 40%

C/4426/GB/01/november 2009 50
 ORONAL LCG/E OD
SUGGESTED FORMULA

EXTRA GENTLE bath / shower gel

ORONAL LCG E/OD 10.00%

A Sodium cocoamphodiacetate 13.00% for kids

Parfum/ Fragrance 0.10% 6856
SEPICIDE HB 0.50%
Aqua/ water 20.00%
B CAPIGEL 98 4.50%
Aqua/water Qsp100%
Imidazolidinyl urea 0.30%
Colorant Qs
c NaOH Qs

Appearance Red clear liquid

pH 7
Viscosity at AT 1,600 mPa.s BROOKFIELD LV speed 6

Stability Stable at AT/40/+4 C

C/4426/GB/01/november 2009 51
 ORONAL LCG/E OD
SUGGESTED FORMULA

LIPACIDE C8G 1.00% Cleansing facial gel for

A Sodium hydroxide 48% 0.35% sensitive skin
Aqua/ water 20.00%
B
SIMULSOL 220 3.00% Preservative-free
Aqua/ water 10.00%
CAPIGEL 98 5.00% 6760A
C Aqua/water 10.00%
ORONAL LCG E/OD 20.00%
Parfum / fragrance 0.10%
Glycerine 5.00%
Aqua/ water Qsp100%
D Sodium Hydroxide qs pH=9.0
Lactic acid qs pH=5.5
Colorant Qs

Appearance Bluish gel

pH approximately 5.5
Viscosity at AT 500cps BROOKFIELD LV2-speed 6

Stability Stable at AT/40/+4 C

Lipacide C8G : Capryloyl Glycine

Simulsol 220 TM : PEG-200 glyceryl stearate
Capigel 98 : Acrylates copolymer

C/4426/GB/01/november 2009 52
 Choose your foam!
ORONAL
PROTEOL APL PROTEOL OAT ORAMIX CG110 ORAMIX NS10 LCG/E OD
Without Available without Without Without Without
preservative paraben preservative preservative preservative

PEG-40 Glyceryl
Sodium Cocoyl Sodium Lauroyl Caprylyl / Capryl Decyl Glucoside Cocoate and Sodium
INCI NAME Apple Amino Acids Oat Amino Acids Glucoside Coceth Sulfate

Non-ionic /
IONIC anionic anionic non-ionic non-ionic
anionic
CHARACTER

Slightly coloured Slightly coloured Solubilizing agent Enables reduction

Colourless and
GALENIC and odorless and odorless Enables foam
of active material
odorless
formulation formulation in formulas !
ADVANTAGE volumes formulation

FOAMING +++ +++ ++ +++ +

ABILTY

EASE OF +++ +++ ++ +++ ++

THICKENING
Light and creamy Ultra-gentle
foam for a gentle Foam respectful cleanser :
Green solubilizer Gentle cleanser
fruity touch to skin excellent ocular &
SPECIFICITIES skin tolerance

28-32% 28-32% 58-62% 53-57% 48-52%

DRY EXTRACT

C/4426/GB/01/november 2009 53
Comments

The only guaranteed analytical specifications are those featuring in the test report provided upon delivery of the products.

SEPPIC* does not provide any implicit, special or legal guarantees other than the limited guarantee described above, for the products mentioned in this document. Without prejudice to
the aforementioned provisions, SEPPIC* does not provide any guarantees as to the fair and merchantable quality of the products or their fitness for a particular purpose. Use and/or sale
of the products, alone or along with other goods, are the customer's responsibility. The data contained in this document is provided free of charge for information purposes; it is based on SEPPIC*'s current state of knowledge of the products and is given in good
faith. This information is provided for technically competent individuals using it at their own risk. Given that the use of this information is outside the control of the company
SEPPIC*, SEPPIC* does not provide any implicit or special guarantees and declines all responsibility as to the use of this information. In particular, customers must ensure that they do not contravene existing patents.

* SEPPIC being: According to country:

SEPPIC S.A. SEPPIC UK Ltd SEPPIC ITALIA Srl

22 Terrasse Bellini 50 Salisbury Road Via Quarenghi 27
Paris La Défense PO Box 338 – Hounslow 20151 Milan
92806 Puteaux Cedex TW4 6SH – ENGLAND ITALY
FRANCE
Tel.: +33 (0) 1 42 91 40 00 Tel.: +44 208 577 8800 Tel.: +39 02 380091 10
Fax: +33 (0) 1 42 91 41 41 Fax: +44 208 570 2106 Fax: +39 02 38009140

Head Office SEPPIC Inc. SEPPIC China

75, quai d’Orsay 30, Two Bridges Road, suite 210 Room 510 Jin Tai Building
75007 PARIS Fairfield, New Jersey 07004 – 1530 58 south Mao Ming Road
FRANCE USA Shanghai 200020 CHINA
Tel.: +1 973 882 5597 Tel.: +86 (21) 64 66 01 49
Fax: +1 973 882 5178 Fax: +86 (21) 64 66 11 09

SEPPIC Brazil SEPPIC GmbH SEPPIC Asia Singapore

Especialidades Químicas von-der-Wettern-STR.27 120 Lower Delta Road # 13 – 11
Comércio e Importação Ltda 51149 COLOGNE Cendex Centre
Rua Líbero Badaró, 182 GERMANY Singapore 169208
State SP – SAO PAULO Tel.: +49 (0) 2203-898 3020 SINGAPORE
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Tel.: +55 11 3242 3911 Fax: +65 6278 8193
www.seppic.com
Fax: +55 11 3105 8605
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