Drug Study OR RLE

Holy Angel University
School of Nursing and Allied Medical Sciences

NCM-109RLE / Second Semester, SY 2022 – 2023
Name: Vannesa Tarifa Date: 02 - 21- 23

Section: NU 202 Clinical Instructor: Ms. Jenn Manabat Quintela
DRUG STUDY
NAME OF DRUG
MECHANISM OF ACTION INDICATION CONTRADICTION ADVERESE EFFECT NURSING RESPONSIBILITY
(GENERIC & BRAND NAME)
Generic Name: Ranitidine • Ranitidine is a competitive Treatment and Hypersensitivity, Cross- • Headache BEFORE:
Hydrochloride inhibitor of histamine H2- prevention of sensitivity may occur; • Assess the patient for
• Malaise
receptors. The reversible heartburn, acid some oral liquids contain epigastric or abdominal pain
Brand Name: inhibition of H2-receptors in ingestion, and sour alcohol and should be • Dizziness and frank or occult blood in
Zanta gastric parietal cells results in stomach avoided in patients with • Somnolence the stool, emesis, or gastric
known intolerance aspirate.
Dosage: 50 mg q 8hrs
a reduction in both gastric • Insomnia • Assess geriatric and
acid volume and
• Vertigo debilitated patients routinely
concentration. It has some
antibacterial action against • Stomach pain for confusion. Report
promptly.
H. Pylori. • Drowsiness
• To reduce the amount of acid DURING:
in the stomach, or a different • Administer over at least 5
class of drugs called proton min. Rapid administration
pump inhibitors, which inhibit may cause hypotension and
the secretion of stomach arrhythmias.
acid, such as Prilosec
(omeprazole). AFTER:
• Ranitidine may cause false-
positive results for urine
protein, test with
sulfosalicylic acid.
• Administer with meals or
immediately afterward at
bedtime to prolong the

effect.

DRUG STUDY
NAME OF DRUG
(GENERIC & MECHANISM OF ACTION INDICATION CONTRADICTION ADVERESE EFFECT NURSING RESPONSIBILITY
BRAND NAME)
Generic Name: • When administered • Intravenous • Hypersensitivity • Drowsiness Before:
Lidocaine intramuscularly or ventricular • Advanced AV • Dizziness Nervousness • Assess patient’s condition
intravenously, Lidocaine arrhythmias block • (Mucosal use) Decreased or before therapy and
Brand Name: suppresses the • Intramuscular absent gag reflex reassess regularly
Xylocaine automaticity and self-injected or • Bradycardia thereafter to monitor drug’s
spontaneous when IV is • Hypotension effectiveness.
Dosage: 3mg/kg IVF depolarization of the unavailable • Burning sensation
q8 ventricles during during transport • Muscle twitching During:
diastole by altering the to local facilities. • Restlessness • Monitor vital signs and
flux of sodium ions • Local infiltration • Euphoria notify the
across the cell or mucosal or • Vomiting • physician of
membrane with little or topical aesthetic • abnormalities.
no effect on the heart. • Patch used • Monitor for
Locally, it produces when pain is • possible adverse drug
local anaesthesia effect present due to • reactions.
by inhibiting the post-herpetic • Monitor CNS function.
transport of ions across neuralgia • Monitor blood levels and
the neural membranes.
report abnormal results.
Thus, initiation and
conduction of normal
After:
nerve impulses is • Assess for renal and

prevented. urinary status.
• If signs of overdose occur,
stop the infusion
immediately and monitor
the patient closely.

DRUG STUDY
NAME OF DRUG
MECHANISM OF
(GENERIC & INDICATION CONTRADICTION ADVERESE EFFECT NURSING RESPONSIBILITY
ACTION
BRAND NAME)
Stimulates motility of • Relief of • Allergy to • Restlessness Before:
Generic Name: upper GI tract without symptoms of metoclopramide • Drowsiness • Observe 15 rights in drug
Metoclopramide stimulating gastric, biliary, acute and • GI haemorrhage • Fatigue administration.
or pancreatic secretions; recurrent diabetic • Mechanical • Lassitude • Assess for allergy to
Brand Name appears to sensitize gastroparesis obstruction or • Insomnia metoclopramide.
Reglan, Maxolon tissues to action of • Short-term perforation • Extrapyramidal • Assess for other
acetylcholine; relaxes therapy for adults • Pheochromocytoma reactions contraindications.
Dosage: pyloric sphincter, which, with symptomatic • Epilepsy • Parkinsonism like • Keep diphenhydramine injection
10-15 mg PO when combined with GERD who fail to • Previously detected reactions, readily available in case
up to 4 effects on motility, respond to breast cancer • Akathisia extrapyramidal reactions occur
times/day 30 accelerates gastric conventional • (50 mg IM). Have phentolamine
Lactation • Dystonia
minutes before emptying and intestinal therapy. • Fluid overload • Myoclonus readily available in case of
each meal and transit; little effect on • Prevention of • hypertensive crisis.
at bedtime for gallbladder or colon
Renal impairment • Dizziness
nausea and •
2-8 weeks motility; increases lower Decreased • Transient hypertension
vomiting During:
oesophageal sphincter absorption of • Nausea
associated with • Monitor BP carefully during IV
pressure; has sedative emetogenic
digoxin from the • Diarrhea
stomach administration.
properties; induces cancer • Monitor for extrapyramidal
release of prolactin. • Increased toxic and
chemotherapy. reactions and consult physician if
immunosuppressive
• Prophylaxis of effects of they occur.
postoperative cyclosporine. • Monitor diabetic patients.
nausea and
vomiting when • Increased • Give direct IV doses slowly over

nasogastric neuromuscular 1-2 minutes.
suction is blocking effect of • For IV infusion, give over at least
undesirable. succinylcholine 15 minutes.
• Facilitation of
small bowel After:
intubation when • Dispose of used materials
tube does not properly.
pass the pylorus • Educate patient about side
with conventional effects.
maneuvers • Instruct to report involuntary
• Stimulation of movement of the face, eyes, or
gastric emptying limbs, severe depression, severe
and intestinal diarrhea.
transit of barium • Instruct patient to take drug
when delayed exactly as prescribed.
emptying • Instruct not to use alcohol, sleep
interferes with remedies or sedatives; serious
radiologic sedation could occur.
examination of • Do proper documentation.
the stomach or
small intestine.
• Unlabelled uses:
Improvement of
lactation;
treatment of
nausea and
vomiting of a
variety of
etiologies:
hyperemesis
gravidarum,
gastric ulcer,
anorexia nervosa

DRUG STUDY
NAME OF DRUG
(GENERIC & MECHANISM OF ACTION INDICATION CONTRADICTION ADVERESE EFFECT NURSING RESPONSIBILITY
BRAND NAME)
Generic Name: • Cefazolin inhibits cell wall • It may reduce • Allergic to cefazolin, any • Difficulty breathing, Before:
Cefazolin biosynthesis by binding the incidence of other cephalosporin wheezing. • It is important that
penicillin-binding proteins certain (Ceclor), cefadroxil • Fever or chills, sore medication should be
Brand Name: which stops peptidoglycan postoperative (Duricef), or cephalexin throat given exactly as
Kefzol synthesis. Penicillin- infections. (Keflex)], penicillins, or any • Pain or difficulty directed.
binding proteins are • Cefazolin other drugs passing urine. • Before administering
Dosage: bacterial proteins that help eliminates • Kidney, liver, or • Redness, blistering, cefazolin, look at the
1 mg IVTT q8 to catalyse the last stages bacteria that gastrointestinal disease peeling or loosening solution closely. It
of peptidoglycan cause many (especially colitis). of the skin, including should be clear and free
synthesis, which is kinds of • Pregnant, plan to become inside the mouth. of floating material.
needed to maintain the infections, pregnant, or are breast • Seizures
cell wall. including lung, feeding (convulsions) During:
• Exerts its bactericidal skin, bone, joint, • Severe or watery • Watch for seizures;
effect by inhibiting stomach, blood, diarrhea notify physician
bacterial cell wall heart valve, and • Skin rash, itching. immediately if patient
synthesis. urinary tract • Stomach pain or develops or increases
infections. cramps seizure activity.
• Swollen joints. • Monitor signs of
• Unusual bleeding or pseudomembranous
bruising colitis, including
• Unusual weakness or diarrhea, abdominal
tiredness pain, fever, pus or
mucus in stools, and
other severe or
prolonged GI problems
(nausea, vomiting,
heartburn). Notify
physician or nursing
staff immediately of
these signs.
• Monitor signs of allergic
reactions and
anaphylaxis, including
pulmonary symptoms
(tightness in the throat
and chest, wheezing,
cough dyspnea) or skin
reactions (rash, pruritus,
urticaria). Skin reactions
may indicate serious
hypersensitivity
reactions (Stevens-
Johnson syndrome).
Notify physician or
nursing staff
immediately if these
reactions occur.
After:
• Instruct patient to notify
physician of signs of
superinfection, including
black, furry overgrowth
on tongue, vaginal
itching or discharge,
and loose or foul-
smelling stools.
• Instruct patient and
family/caregivers to
report other
troublesome side effects
such as severe or
prolonged skin
problems (rash, hives,
itching) or GI problems
(nausea, vomiting,
diarrhea)

DRUG STUDY
NAME OF DRUG
NURSING
(GENERIC & BRAND MECHANISM OF ACTION INDICATION CONTRADICTION ADVERESE EFFECT
RESPONSIBILITY
NAME)
• Enhances action of • Preprocedural • Hypersensitivity to • Nausea Before:
Generic Name: gamma aminobutyric acid sedation. midazolam. • Vomiting • Check the dx order.
Midazolam (GABA) one of the major • Aids in the • Acute narrow angle • Headache • Observe for the 12
inhibitory induction of glaucoma • Hiccoughs rights of drug
Brand Name: neurotransmitters in the anaesthesia and • Concurrent use of potent • Laryngospasm administration.
Dormicum brain. as part of CYP3A4 inhibitors • Dyspnoea • Resuscitative
• Acts on glycine receptors balanced • Hallucination equipment, oxygen
Dosage: and produces a muscle- anaesthesia must be available.
• Drowsiness
15 mg/tab half tablet PO relaxing effect. Almost all • Ataxia • Obtain v/s before
c minimal sip of water 2q the pharmacologic effects, administration.
prior to OR • Rash
including sedation,
• Paradoxical • Assess level of
anxiolysis, anterograde consciousness.
IV: Inject 2.5 mg for 2 reactions
amnesia, and
mins anticonvulsant effect, can • Amnesic
episodes During:
are explainable through its • Administer with
action on GABA receptors. minimal sip of water if
oral.
• Dispense directly into
mouth (oral)
• Monitor BP, PR and
RR continuously
during IV
administration.
• Oxygen and
resuscitative
equipment should be
immediately
available.
After:
• Dispose of used
materials properly.
• Educate patient
about side effects.
• Instruct to report
involuntary
movement of the
face, eyes, or limbs,
severe depression,
severe diarrhea.
• Instruct patient to
take drug exactly as
prescribed.
• Instruct not to use
alcohol, sleep
remedies or
sedatives; serious
sedation could occur.
• Do proper
documentation.

Drug Study OR RLE

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Holy Angel University

School of Nursing and Allied Medical Sciences

Name: Vannesa Tarifa Date: 02 - 21- 23

bedtime to prolong the

Name: Vannesa Tarifa Date: 02 - 21- 23

nerve impulses is • Assess for renal and

Name: Vannesa Tarifa Date: 02 - 21- 23

vomiting when • Increased • Give direct IV doses slowly over

Name: Vannesa Tarifa Date: 02 - 21- 23

Name: Vannesa Tarifa Date: 02 - 21- 23

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