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NPTEL » Spectroscopic Techniques for

Pharmaceutical and Biopharmaceutical

Industries

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Week 12

Mass Spectroscopy

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Quiz: Week 12 : Assignment 12

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Week 12 :
Assignment 12
The due date for submitting this assignment has
passed.
Due on 2022-10-19, 23:59 IST.

Assignment submitted on
2022-10-18, 21:51 IST
1) Which of the following techniques can be 1 point
used to distinguish between the give two isomers?

I. Mass spectroscopy
13
II. C NMR
1
III. H NMR

III
II
I, II, III
None of the above

Yes, the answer is correct.

Score: 1
Accepted Answers:
I, II, III

2) Reference compound used in NMR 1 point

spectroscopy is?

Silane
Tetramethylsilane
Dimethylsilane
Trimethylsilane

Yes, the answer is correct.

Score: 1
Accepted Answers:
Tetramethylsilane

3) One of the following compounds gives 3 1 point

signals in NMR spectroscopy?

CH3–COOH
CH3 – CH2 – NH2
CH3 – O – CH3
CH3 – CH2 – Cl

Yes, the answer is correct.

Score: 1
Accepted Answers:
CH3 – CH2 – NH2

4) How many Hertz does 1 ppm corresponds 1 point

to a PMR spectrometer operating at a radio frequency
of 60 MHz and 100 MHz?

60 Hz, 100 Hz
10 Hz, 60Hz
66 Hz, 6 Hz
10 Hz, 60 Hz

Yes, the answer is correct.

Score: 1
Accepted Answers:
60 Hz, 100 Hz

5) How many signals do you expect to see in 1 point

the 1H NMR spectra of 2-Bromopropane (CH3)2CHBr
and 1-Bromopropane CH3CH2CH2Br?

2; 3
3;2
1;2
1;3

Yes, the answer is correct.

Score: 1
Accepted Answers:
2; 3

6) Mass spectrometer separates ions on the 1 point

basis of

Mass
Charge
Molecular weight
Mass to charge ratio

Yes, the answer is correct.

Score: 1
Accepted Answers:
Mass to charge ratio

7) A PMR spectrometer operates at 300MHz. 1 point

Find the value of the magnetic field. Given gN=5.585
and BN =5.05 ×10-27 JT-1

7.05 T
6.38 T
7.58 T
5093 T

Yes, the answer is correct.

Score: 1
Accepted Answers:
7.05 T

8) The mass spectrum of acetone 1 point

(CH3COCH3) shows major peaks at m/z = 58, 43 and
15. What can be deduced from these data?

The parent ion is observed, and fragmentation

involves cleavage of two C–C bonds.
The parent ion is not observed
The parent ion is observed, and fragmentation
involves loss of CO
The parent ion is observed, and fragmentation
involves cleavage of a C–C bond

Yes, the answer is correct.

Score: 1
Accepted Answers:
The parent ion is observed, and fragmentation
involves cleavage of a C–C bond

9) Which of the following cannot be used as 1 point

an analyser in MS?

Ion trap
TOF
ESI
Quadrupole

Yes, the answer is correct.

Score: 1
Accepted Answers:
ESI

10)But-2-yne has the structure H3C–C≡C– 1 point

CH3. Major peaks in the mass spectrum of but- 2-yne
appear at m/z = 54, 39 and 27. Which of the following
is inconsistent with these data?

But-2-yne fragments by loss of two methyl

groups
+ The highest mass peak corresponds to [C4H6]
But-2-yne fragments by loss of a methyl group
But-2-yne fragments by cleavage of a C–C
bond

Yes, the answer is correct.

Score: 1
Accepted Answers:
But-2-yne fragments by loss of two methyl groups

11)The mass spectrum of CH3NO2, shows 1 point

major peaks at m/z 61, 46, 30 (base peak) and 15.

Which statement is inconsistent with above data?

The parent ion is observed

The parent ion is observed
[NO]+ is a fragment ion
[NO2]+ is not formed as a fragment

No, the answer is incorrect.

Score: 0
Accepted Answers:
The parent ion is observed

12)What is δ value of aldehyde proton in 1 point

PMR spectrum?

1–2
4–5
7–8
9–10

Yes, the answer is correct.

Score: 1
Accepted Answers:
9–10

13)Correct order chemical shift of proton is? 1 point

CH3F < CH3I < CH3Br < CH3Cl

CH3I < CH3Br < CH3Cl < CH3F
CH3I < CH3F < CH3Br < CH3Cl
CH3F > CH3I > CH3Br > CH3Cl

Yes, the answer is correct.

Score: 1
Accepted Answers:
CH3I < CH3Br < CH3Cl < CH3F

14)The 1H NMR of below given compound 1 point

should have four signals. Predict the splitting pattern
(singlet, doublet, doublet of doublets, etc) for each
signal.

Singlet, doublet, triplet, doublet

Doublet, doublet, singlet, doublet of triplet
Doublet, doublet, doublet of triplet
Singlet, doublet, triplet

No, the answer is incorrect.

Score: 0
Accepted Answers:
Doublet, doublet, singlet, doublet of triplet

15)How many peaks will be observed in the 1 point

proton NMR spectrum of (CH3)2CHCOO(CH3)?

4
5
1
3

No, the answer is incorrect.

Score: 0
Accepted Answers:
3