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Citation

Jesus Ruiz, Marta Hernández, Ana Juanes, Raimon Milà-Villarroel. The impact of integranted
pharmaceutical care in multidisciplinary teams on health outcomes: Systematic Review and Meta-Analysis.
PROSPERO 2021 CRD42021227736 Available from:
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021227736

Review question
Does pharmaceutical care in a multidisciplinary setting reduce the risk of hospital care?

Searches
Sources to be searched: MEDLINE (PubMed), Cochrane, WOS (Web of Science), Scopus, CINAHL

Language restrictions: English

Types of study to be included

Randomized clinical trials

Condition or domain being studied

Multidisciplinary team interventions with the participation of the hospital or primary care pharmacist.

Participants/population
The study population will be chronic adult patients cared for by a multidisciplinary team with a pharmacist
involved.

Intervention(s), exposure(s)
Multidisciplinary team interventions

Comparator(s)/control
Control group will included the standard of care

Main outcome(s)
The most important outcome is hospital admission. This outcome is defined by admission of a patient to
hospital or assistance in an emergency department.
Measures of effect
Odds ratios

Additional outcome(s)
Quality of life
Measures of effect
Standard mean

Data extraction (selection and coding)

We will select the studies by titles first and then by abstracts.

Three reviews authors will identify potential studies.

If there is any doubt, external reviewer will decide if the study is to be included or not.

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International prospective register of systematic reviews

Two review authors will extract data independently.

Risk of bias (quality) assessment

Two review authors will independently assess the risk of bias in included studies by the analysis of the
quality of the studies with the NIH tool - Quality Assessment of Controlled Intervention Studies.

Strategy for data synthesis

We will provide a narrative synthesis of the findings from the included studies, structured around the type of
intervention, target population characteristics, type of outcome and intervention content. We will provide
summaries of intervention effects for each study by calculating odds ratio for drop outs risk of hospital
admission and or standardised mean differences for Quality of Life. For all outcomes, trial results will also be
combined using a random effects model to test robustness to model choice.

Analysis of subgroups or subsets

None

Contact details for further information

Jesus Ruiz
jrzrms@gmail.com

Organisational affiliation of the review

Hospital Sant Creu i Sant Pau

Review team members and their organisational affiliations

Dr Jesus Ruiz. Hospital Sant Creu i Sant Pau
Dr Marta Hernández. School of Health Science Blanquerna, Ramon Llull University, Padilla 326-332,
Barcelona, Spain.
Dr Ana Juanes. Hospital Santa Creu i Sant Pau, Barcelona, Spain
Dr Raimon Milà-Villarroel. School of Health Science Blanquerna, Ramon Llull University, Padilla 326-332,
Barcelona, Spain.

Type and method of review

Intervention, Meta-analysis, Systematic review

Anticipated or actual start date

01 May 2020

Anticipated completion date

01 March 2021

Funding sources/sponsors
None

Conflicts of interest
Language
English

Country
Spain

Stage of review
Review Ongoing

Subject index terms status

Subject indexing assigned by CRD

Subject index terms

Humans; Outcome Assessment, Health Care; Patient Care Team; Pharmaceutical Services

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International prospective register of systematic reviews

Date of registration in PROSPERO

04 February 2021

Date of first submission

04 January 2021

Details of any existing review of the same topic by the same authors
None

Stage of review at time of this submission

Stage Started Completed

Preliminary searches Yes No

Piloting of the study selection process Yes No

Formal screening of search results against eligibility criteria No No

Data extraction No No

Risk of bias (quality) assessment No No

Data analysis No No

The record owner confirms that the information they have supplied for this submission is accurate and
complete and they understand that deliberate provision of inaccurate information or omission of data may be
construed as scientific misconduct.
The record owner confirms that they will update the status of the review when it is completed and will add
publication details in due course.

Versions
04 February 2021
04 February 2021

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