PROSPERO

International prospective register of systematic reviews

A systematic review and meta-analysis of esophagogastrectomy versus total gastrectomy

for Siewert type II and III gastroesophageal malignancies
Xiang Dong, Mahir Gachabayov, Tracy Weigel

Citation
Xiang Dong, Mahir Gachabayov, Tracy Weigel. A systematic review and meta-analysis of
esophagogastrectomy versus total gastrectomy for Siewert type II and III gastroesophageal
malignancies. PROSPERO 2018 CRD42018089464 Available from:
http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018089464

Review question
To investigate the effectiveness of esophagogastrectomy versus total gastrectomy for the treatment of
Siewert type II and III gastroesophageal malignancies.

PICOS:
P (population): adults older than 18 years of age, with Siewert type II and type III gastroesophageal junction
cancer.
I (intervention): patients undergoing esophagogastrectomy.
C (comparator): patients undergoing total gastrectomy.
O (outcome): short-term (overall morbidity and mortality including anastomotic leaks, lymph node harvesting,
margin status, post-operative SSI, pneumonia, LOS, operating time); long-term (overall survival, disease-free
survival, recurrence rate).
S (setting): both inpatient and outpatient.

Searches
MEDLINE, Google Scholar; PubMed; EMBASE; The Cochrane Library; CINAHL; Scopus; and Web of
Science will be searched for relevant literature.
Both experimental and observational studies will be eligible for inclusion, conducted in both inpatient and
outpatient settings.

Types of study to be included

Both experimental and observational studies will be included.

Condition or domain being studied

Esophageal cancer, gastric cancer, or adenocarcinoma of the gastroesophageal junction, Siewert type II or
type III.

Participants/population
Adult patients older than 18 years of age with esophageal and gastric cancer, Siewert type II and III, being
treated at a medical center.

Intervention(s), exposure(s)
Esophagogastrectomy.

Comparator(s)/control
Total gastrectomy.

Primary outcome(s)
Long-term survival.

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Timing and effect measures

Five years.

Secondary outcome(s)
Quality of life and short-term outcomes (post-operative).

Timing and effect measures

Thirty days.

Data extraction (selection and coding)

Two independent researchers will search the literature and will select relevant papers for inclusion, and will
then extract data onto predefined Excel spreadsheets. Any inconsistencies will be resolved by the senior
authors.

Risk of bias (quality) assessment

All included papers will be assessed for selection, attrition, performance, detection, reporting, and publication
biases.

Strategy for data synthesis

For continuous variables, point estimated for standardized mean differenced and standard errord will be
calculated. For dichotomous variables, odds ratios with 95% confidence intervals will be calculated. In cased
in which continuous variables are reported as median and interquartile ranged, mean and standard deviation
will be estimated using Hozo's formula. Statistical heterogeneity will be assessed using the I² and ?²
statistics, and if it is found to be greater than 50%, a random-effects model will be utilized for the meta-
analysis. In addition, Egger's test will be employed to assess for publication bias.

Analysis of subgroups or subsets

None planned.

Contact details for further information

Xiang D Dong
xddong@hotmail.com

Organisational affiliation of the review

Westchester Medical Center / New York Medical College
www.westchestermedicalcenter.com

Review team members and their organisational affiliations

Assistant/Associate Professor Xiang Dong. Westchester Medical Center / New York Medical College
Dr Mahir Gachabayov. Westchester Medical Center
Dr Tracy Weigel. Westchester Medical Center / New York Medical College

Anticipated or actual start date

01 March 2018

Anticipated completion date

01 January 2019

Funding sources/sponsors
Not applicable

Conflicts of interest

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International prospective register of systematic reviews

None specified.

Language
English

Country
United States of America

Stage of review
Review_Ongoing

Details of final report/publication(s)

Subject index terms status

Subject indexing assigned by CRD

Subject index terms

Digestive System Surgical Procedures; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction;
Gastrectomy; Humans; Neoplasms; Stomach Neoplasms; Treatment Outcome

Date of registration in PROSPERO

05 March 2018

Date of publication of this version

05 March 2018

Details of any existing review of the same topic by the same authors
No reviews on this topic have been previously published.

Stage of review at time of this submission

The review has not started

Stage Started Completed

Preliminary searches No No

Piloting of the study selection process No No

Formal screening of search results against eligibility criteria No No

Data extraction No No

Risk of bias (quality) assessment No No

Data analysis No No

Versions
05 March 2018

PROSPERO
This information has been provided by the named contact for this review. CRD has accepted this information in good
faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration
record, any associated files or external websites.

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International prospective register of systematic reviews

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