PROSPERO

International prospective register of systematic reviews

To enable PROSPERO to focus on COVID-19 submissions, this registration record has undergone basic
automated checks for eligibility and is published exactly as submitted. PROSPERO has never provided peer
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published records should be treated as any other PROSPERO registration. Further detail is provided here.

Citation

Willemax Gomes, Eduardo Campos, Tércio Barros, Lucas Santos, André Costa, Alessandro Zagatto. Effects
of Beta-alanine Supplementation on Performance in the Repeated Sprint Abilty (RSA) test: A Systematic
Review and Meta-analysis. PROSPERO 2020 CRD42020214234 Available from:
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020214234

Review question
What is the effect of beta-alanine supplementation on the performance of the RSA test?

Searches
The searches will be done on PubMed; Scoups; Web of Science; SPORTDiscus; Google Scholar;

The search terms ‘beta alanine’ linked with ‘repeated sprint ability’.

There will be no language restrictions. There will be no restriction on the year of publication.

The searches will be re-run just before the final analyzes and further studies retrieved for inclusion.

Types of study to be included

Double-blind, randomized controlled trials with crossover design or counterbalanced.

Condition or domain being studied

Beta-alanine supplementation and RSA test performance.

Participants/population
Inclusion Criteria: Healthy humans’ males and females, of any age or activity level;

Exclusion Criteria: Studies conducted on clinical populations, or diseased; Studies conducted on animals;

Intervention(s), exposure(s)
Repeated sprint ability

Comparator(s)/control
Chronic ingestion (>1day) of beta-alanine supplementation compared to placebo without fatigue state

Main outcome(s)
Total work done, best (fastest sprint time or highest power output – usually corresponding to the initial sprint
– recorded/achieved during the repeated sprint ability (RSA) test) and last sprint performances during
repeated
Measures of effect
Mean, standard deviations, effect size and confidence intervals.

Additional outcome(s)
None
Measures of effect
None

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International prospective register of systematic reviews

Data extraction (selection and coding)

A three stage approach will be used to screen potential studies, i.e. title/abstract; full-text screen and full text
appraisal. Data will be extracted using a pre-piloted and standardised form, and include information related
to study design; participant characteristics; dosing strategy and duration; participant retention; primary study
outcomes and results; All screening, selection and data extraction procedures will be independently
undertaken by two members of the review team, and final outcomes from each procedure will be agreed
through discussion, or third party mediation if required.

Risk of bias (quality) assessment

The risk of bias will be accessed through a form analysis, funnel plot and the heterogeny levels.

Strategy for data synthesis

We will use a correction strategy (Hedge's) to combine the values of the crossover and parallel studies. A
fixed effect will be used when the variables are in the same classes or random when there are
methodological differences.

Analysis of subgroups or subsets

If necessary, subgroup analyzes will be made when the data refer to similar conditions.

Contact details for further information

Willemax dos Santos Gomes
willemaxsantos@gmail.com

Organisational affiliation of the review

Federal University of Pernambuco

Review team members and their organisational affiliations

Professor Willemax Gomes. Federal University of Pernambuco
Professor Eduardo Campos. Federal University of Pernambuco
Professor Tércio Barros. University of Pernambuco
Professor Lucas Santos. Federal University of Pernambuco
Professor André Costa. Federal University of Pernambuco
Professor Alessandro Zagatto. São Paulo State University

Type and method of review

Intervention, Meta-analysis, Systematic review

Anticipated or actual start date

02 November 2020

Anticipated completion date

02 April 2021

Funding sources/sponsors
Federal University of Pernambuco - UFPE

Conflicts of interest
Language
English

Country
Brazil

Stage of review
Review Ongoing

Subject index terms status

Subject indexing assigned by CRD

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International prospective register of systematic reviews

Subject index terms

MeSH headings have not been applied to this record

Date of registration in PROSPERO

13 November 2020

Date of first submission

13 October 2020

Stage of review at time of this submission

The review has not started

Stage Started Completed

Preliminary searches No No

Piloting of the study selection process No No

Formal screening of search results against eligibility criteria No No

Data extraction No No

Risk of bias (quality) assessment No No

Data analysis No No

The record owner confirms that the information they have supplied for this submission is accurate and
complete and they understand that deliberate provision of inaccurate information or omission of data may be
construed as scientific misconduct.
The record owner confirms that they will update the status of the review when it is completed and will add
publication details in due course.

Versions
13 November 2020

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