Patient-reported improvement

50%

45%
After Tx1
40% After Tx2

Percen tage of Pa tients

35%

30%

25%

20%

15%

10%

5%

0%
0% 1-25% 26-50% 51-75% 76-100%
Percent age of i m provem ent

Patient-reporte d improvement

80%

70% After Tx1

After Tx2
60%
Perc e nt ag e of Pa tie nt s

50%

40%

30%

20%

10%

0%
0% 1-25% 26-50% 51-75% 76-100%
Perc e n t a ge of improve m e n t