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Ocular effects of systemic drugs

Amiodarone Chloroquines Digitalis Sildenafil ( Viagra ) Steroids Interferon Ethambutol Topiramate


(topomax)

Use Antiarrhythmic  Malaria  Erectile dysfunction  Hepatitis C TB Seizures


 SLE  Raynaulds  Leaukemia
 RA  Lymphoma

Ocular 1. Vortex 1. Vortex Chromatopsia 1. chromatopsia 1. 2ry cataract Retinopathy Dose related Acute bilateral
effects keratopathy keratopathy ( yellow with {blue tinge} (systemic) = cotton wool Optic Acute
whorl like overdose) 2. 2ry Glaucoma spots and neuropathy congestive
pigment 2. Bull’s eye 2. ischemic optic (Local) haemorrhages glaucoma
deposits maculopathy neuropathy
rarely affects {rare}
vision Follow up
with VA-
2. Optic color-OCT-
neuropathy
field –
Amsler is
essential

(Cilio-choroidal effusion with anterior displacement of iris lens diaphragm)


Mechanism of acute congestive glaucoma with topiramate

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