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It is a way of supplying all the nutritional needs directly into blood stream
bypassing gastrointestinal tract.
It is administered outside the digestive tract, intravenously.
Indications
Usual fluid volume is 1.5 - 2.5L over a 24 hours period for most people.
Actual infusion depends on:
a. Site of infusion; and
b. Patient’s fluid and nutrient requirements.
Composition:
1. Carbohydrate
- Dextrose provides the carbohydrate content of PN, up to 75% of the total
energy of the solution. It provides 3.4 kcal/g.
- Glucose is the body’s main source of energy.
- Concentration is 12.5% (maximum for peripheral introduction) to 25% (total
parenteral nutrition)
- Restricted in ventilator patients because oxidation of glucose produces more
carbon dioxide than does oxidation of fat.
2. Protein
- Mixture of essential and non-essential amino acids
- Concentration 3.5 – 15%
- Quantity of amino acids depends on patients estimated requirements and
hepatic and renal function.
3. Fat
- Lipid emulsion is a soluble form of fat that allows it to be infused safely into
the blood.
- Safflower and soybean oil with egg lecithin used as an emulsifier.
- Isotonic
- Significant source of calories.
- Usual dose is 0.5 to 1 g/kg/day to supply 20- 30% of total kcal requirement.
- IV fat contraindicated for severe hepatic pathology, hyperlipidemia or severe
egg allergies.
- Used cautiously with atherosclerosis, blood coagulation disorders.
4. Micronutrients
- Standard multi-vitamin and trace mineral preparations added to parenteral
solutions to meet micronutrient needs.
5. Electrolyte
- It is dictated by patient’s blood chemistry values and physical assessment
findings.
2 Ways of Access:
Sites of Delivery
1. Central
- Superior vena cava, right atrium, or inferior vena cava
- Access:
Percutaneous central catheter
Hickman line
Broviac line
Groshong line
PICC line
Portacath
- Indications:
Longer-term use
Short-term use when peripheral solution cannot meet full nutritional
needs or if peripheral route not available
2. Peripheral
- Any other veins
- Access: ✓peripheral cannula ✓midline catheter midclavicular catheter
- Indication: ✓ short-term use (<10-14days)
3. Intra-dialytic
- Administered during hemodialysis
- Access:
Venous port of hemodialysis tubing (into AV shunt)
- Indication:
Malnourished hemodialysis patients who are unable to maintain weight
and oral / enteral nutrition is not possible or has failed.
Equipment
Intravenous Access Device
Intravenous Giving Set
Light Protective Covering
Administration Reservoir Containing PN Solution
Infusion Pump
Syringes for Additives
Initial Considerations
TPN should start slowly so that the body has time to adapt to both glucose load
and the hyperosmolarity of the solution, and to avoid fluid overload.
A pump controls the infusion rate of the TPN solution.
1. Start with 1 liter of TPN solution during the first 24 hours (or use 42 cc/hr as a
typical start rate).
2. Increase volume by 1 liter each day until the desired volume is reached.
3. Monitor blood glucose and electrolytes closely.
4. Pump administer TPN at a steady rate.
5. Don’t attempt to catch up if administration gets behind.
1. Continuous
- Infuses for 24 hours continuously.
- This is the most common type of regimen in the hospital setting.
- Infusion rates usually range between 40 – 150 ml/h. Choice of Nutrition
Regimen
- Advantages:
a. Allows the lowest possible hourly infusion rate to meet nutrient requirements.
b. Better control of blood glucose levels due to continuous carbohydrate input. 3.
May result in better utilization of nutrients.
- Disadvantages:
a. Physical attachment to the pump (may affect quality of life)
b. Higher risk of biliary stasis (if no oral/enteral intake)
c. Promotes continuous high insulin levels, which may increase risk of fatty liver.
2. Cyclic / Intermittent
- It is commonly used in long-term parenteral nutrition
- The patient is fed for 12 - 18 hours during the night and fasts during the day
or given only on some days of the week. This gives the longterm TPN patient
freedom from the machinery to lead a less restricted life during the day.
- It helps prevent hepatotoxicity that can develop with long-term TPN and the
fasting period allows essential fatty acids to be released from fat stores.
- Used for home patients
- Advantages:
a. Allows greater patient mobility (may improve quality of life)
b. Mimics physiological feeding / fasting pattern, which may help to prevent
accumulation of fat in the liver and sludge in the biliary system.
- Disadvantages:
a. Compared with continuous nutrition, a higher infusion rate is required to
provide the same volume of feed. This may be less well-tolerated, with a
higher risk of problems such as:
b. Fluid overload (and frequent urination during infusion, inconvenient especially
at night)
c. Electrolyte Fluctuations
d. Unstable blood glucose levels
PN Infusion Rate
All patients require individual assessment for determining the rate of delivery of
nutritional support, which depends on the patient’s nutritional requirements and
medical condition.
Typical infusion rates vary between 40-150 ml/h, but cyclic infusions may be
delivered at rates as high as 300 ml/h.
Purposes of Monitoring:
What should be Monitored, and the Frequency of Monitoring will depend on Factors
such as:
Areas of Monitoring:
1. Anthropometry
2. Biochemistry / Hematology
3. Liver tests
4. Iron studies
5. Lipid studies
6. Vitamins, minerals and trace elements
7. Indicators of protein status
8. Clinical assessment and monitoring:
9. Nutritional assessment
10. Dietary intake
Common Problems
1. Line problems
- Blocked intravenous line
- Suspected line infection
2. Blood vessel problems
- Phlebitis
- Thrombosis
- Line displacement
3. Formulation problems
- Stability problems
- Drug – nutrient interactions
4. Intolerance
- Allergic reaction to parenteral nutrition infusion ❑ Nausea or vomiting ❑
Appetite problems
- Constipation
5. Metabolic Abnormalities
- Re-feeding syndrome
- Overfeeding
- Dehydration
- Fluid overload
- Abnormal biochemistry
TPN Procedures
CVP Catheter
Equipment
Manometer
Intravenous Access Device
Transducer
Insertion Sites
CVP Recording
Using a manometer:
Steps:
Using a Transducer
Steps:
Interpreting Measurements
1. The normal range for CVP is 5-10cm H2O (2- 6mmHg) when taken from the mid-
axillary line at the fourth intercostal space.
2. Many factors can affect CVP, including vessel tone, medications, heart disease
and medical treatments.
3. A CVP measurement should be viewed in conjunction with other observations
such as pulse, blood pressure and respiratory rate and the patients response to
treatment.
Potential Complications
The patient does not have to work as hard to breathe – their respiratory muscles
rest
Helps the patient get adequate oxygen and clears carbon dioxide
Preserves a stable airway and preventing injury from aspiration
Air is delivered in patients with compromised ventilation
Oxygenate the different organs of the body
Expel the carbon dioxide in the lungs
Provide comfortable breathing pattern to patients experiencing shortness of
breath
To breathe for patients who are seriously compromised ventilation such as in
comatose, brain damaged, or patients with spinal cord injuries (Links to an
external site.).
1. Infections– A foreign object such as the endotracheal tube in the trachea makes
the patient more susceptible to bacteria entering the lungs. This is treated with
the use of antibiotics.
2. Pneumothorax –This is the condition when the lung/s collapses. It is a
complication when the lungs are damaged because of gets over-expansion. If
this happened, a chest tube is inserted on the collapsed lung to allow it to re-
expand and seal the leak.
3. Lung damage – The air forced in the lungs can increase the risk for injury.
4. Side Effects of medications– Intubated patients are most of the time given
sedatives to allow easier ventilation of the machine. These medications keep the
patient calm and sleepy.
5. Maintenance of Life– The ventilator sometimes serves as the only reason why
the patient is alive. Organs fail because the body is dying, this includes the lungs.
1. Tidal Volume (TV) – Air that the client receives per breathing. Percentage in the
mechanical ventilator is adjusted depending on client’s needs (40-100%). The
normal value of tidal volume is ½ L or 500 ml.
2. Fraction of inspired oxygen (FiO2) – the oxygen concentration delivered to the
client. ABG is usually determined before adjusting FiO2 levels. It is adjusted from
40%-100%.
3. Peak Flow Rate (PFR) – The peak flow rate is the maximum flow delivered by
the ventilator during inspiration. Peak flow rates of 60 L per minute may be
sufficient, although higher rates are frequently necessary.
4. Back-up Rate (BUR) – for spontaneous or time mode ventilator, back-up rate is
set so that the client may receive a minimum number of breaths per minutes if
the client fail to breath. If the client’s breathing rate is slower, it will cycle inhale /
exhale pressure at the set rate. The usual setting for BUR ranges from 12-22
breaths per minute, depending on the physician’s order.
5. Pressure end-expiratory pressure (PEEP) – is exerted during the expiration
phase of ventilation, which improves oxygenation by enhancing gas exchange
and preventing atelectasis. Not all clients with mechanical ventilator is attached
to PEEP. A typical initial applied PEEP is 5 cmH2O. However, up to 20 cmH2O
may be used in patients undergoing low tidal volume ventilation for acute
respiratory distress syndrome (ARDS)
6. Continuous positive airway pressure (CPAP) – used for spontaneously breathing
clients. Positive airway pressure is introduced during the respiratory cycle.
7. Sensitivity- used to describe the ventilator’s responsiveness to the patient’s
breathing effort. Sensitivity adjusts the level of negative pressure required to
trigger the ventilator. With assisted ventilation, the sensitivity typically is set at -1
to -2 cm H2 O.
Alarms are designed to warn nurses that there is something wrong either to the
patient or to the mechanical ventilator. But sometimes, alarms can give nurses
apprehensions especially if the alarm is non-stop and we don’t know how to
troubleshoot the problem.
So as a nurse, how will you manage if there’s an alarm? First, assess the patient
if he/she is in distress. Identify the alarm whether high pressure or low pressure.
Some mechanical ventilators have their own indicators and shows the cause of
the alarm, so it’s important to check your machine as well.
1. Low Pressure alarm
- Low pressures alarm may indicate leak in the patient’s tube, disconnection of
the tube, or the patient stops to breath.
- What are your interventions for low pressure alarm?
a. Check the tube connections.
b. Reconnect patient to the ventilator.
c. Replace leaking tubes by manually ventilating the patient.
d. Auscultate patient’s lung fields for bilateral lung sounds.
e. Monitor respiratory rate and breathing patterns.
f. Evaluate cuff pressure. Reinflate if needed.
2. High Pressure alarm
- High pressure alarm may indicate displacement of the ET tube, increased
secretions, obstruction in the tube, bronchospasms, or the patient is coughing
or biting the tube.
a. Assess your patient.
b. Auscultate lung fields for secretions. This should be done at least every 2
hours or more.
c. Suction secretions as needed. Oxygenate patient manually before suctioning.
d. If patient is biting the tube, provide bite block.
e. Sedate patient if necessary especially when patient is fighting the vent. Make
sure this is ordered by the attending physician or hospitalist on duty.
f. Monitor pulse oximeter continuously if cardiac monitor and pulse oximeter
devices are present.
Bundles of care for VAP should be strictly observed by the Critical Care Nurses
or nurses in any department.
- Strict hand washing. The best way to prevent cross-contamination of any
disease is hand washing.
- Oral hygiene. Nurses should always perform oral care to patient attached to
mechanical ventilator. Know your hospital policies regarding your standard
oral hygiene procedures.
- Initiate closed suction system. Change the system at least every 72 hours or
as indicated/needed.
- Avoid pressure ulcers. Turn patient to sides every 2 hours or as needed.
Apply cream or ointment to bony prominences or as indicated by the
physician.
- Elevate head of bed >30 degrees. Always observe aspiration precaution.
- Assess patient daily for extubation readiness. Early extubation can greatly
prevent VAP.
- Daily interruption of sedation.
Procedure
TPN: https://www.youtube.com/watch?v=IGnwzdRe7KQ
References
Hinkle, J.L. & Cheever, K.H. (2018). Brunner & Suddarth's Textbook of Medical-Surgical
Nursing (14th ed.). Philadelphia: Wolters Kluwer.
Ignatavicius, D.D., Workman, M.L., & Rebar, C.R. (2018). Medical-Surgical Nursing:
Concepts for Interprofessional Collaborative Care (9th ed.). St. Louis: Elsevier.
Lewis, S.L., Dirksen, S.R., Heitkemper, M.M., Bucher, L., & Harding, M.M. (2017).
Medical-Surgical Nursing: Assessment and Management of Clinical Problems (10th
ed.). St. Louis: Elsevier.