MEDICATIONS AFFECTING THE REPRODUCTIVE SYSTEM (AFFECTING THE LABOR AND DELIVERY)

DRUG NAME CLASSIFICATI MECHANISMS OF ACTION INDICATION CONTRAINDICATI ADVERSE EFFECT NURSING RESPONSIBILITIES
ON ON
GENERIC saline laxatives work by increasing the Bowel preparation - Known Cardiac: BEFORE:
NAME: osmotic pressure within the before hypersensiti - Heart 1) Assess the patient's medical history,
sodium intestines, leading to the colonoscopy, vity or condition including kidney function, heart conditions,
phosphate rectal retention of water in the sigmoidoscopy, or allergy to - hypotensi and any known allergies to medications or
bowel, which ultimately other medical sodium on laxatives.
stimulates bowel procedures. phosphate GI : 2) Review the patient's current medications to
BRAND NAME: movements. They are or any of the - Nausea check for any potential interactions or
commonly used for short- Relief of laxative and contraindications.
OTC term relief of constipation constipation in components Vomiting 3) Ensure the patient understands the bowel
and to empty the bowels specific . - Abdomin preparation process, including the need to
ACTUAL DOSE, before certain medical circumstances al drink plenty of clear fluids during and after
ROUTE, AND procedures. when other - Kidney Discomfo the procedure.
FREQUENCY: methods are not disease or rt
suitable. impaired DURING:
15 mL PO once kidney Hepatic: 1) Assess the patient's medical history,
daily This may be given function - People including kidney function, heart conditions,
to you to help with and any known allergies to medications or
empty your bowels - Heart kidney laxatives.
before your conditions issues 2) Review the patient's current medications to
delivery. are at a check for any potential interactions or
higher contraindications.
risk of 3) Ensure the patient understands the bowel
kidney preparation process, including the need to
damage drink plenty of clear fluids during and after
the procedure.

AFTER:
1) Continue to monitor the patient's fluid and
electrolyte status, especially if they have
any risk factors for dehydration or
electrolyte imbalances.
2) Encourage the patient to drink clear fluids
and follow any specific instructions given by
the healthcare provider regarding post-
procedure care.
3) Provide support and education to the
patient regarding post-procedure recovery
and any necessary follow-up care.
DRUG NAME CLASSIFICATI MECHANISMS OF ACTION INDICATION CONTRAINDICATI ADVERSE EFFECT NURSING RESPONSIBILITIES
ON ON
GENERIC Analgesics Relief of moderate - Hypersensiti RESPIRATORY BEFORE:
NAME: to severe pain, vity EFFECTS: 1) Assess the patient's pain level and medical
such as - Respiratory - Respirato history, including any known allergies,
Pethidine postoperative pain Depression ry respiratory conditions, or concurrent
or pain during labor - Pregnancy Depressi medications.
BRAND NAME: and delivery. - concurrent on 2) Determine if the patient has any
Use of MAO CNS: contraindications to pethidine use.
Meperidine Inhibitors - Sedation 3) Review the patient's medication history, as
- Dizziness pethidine may interact with other
ACTUAL and medications.
DOSE, ROUTE, Lighthea
AND dedness DURING:
FREQUENCY: - Confusio 1) Monitor the patient's respiratory rate, blood
n and pressure, and level of sedation regularly to
50 mg to 150 Cognitive detect any signs of respiratory depression or
mg IM Q4-5hr Impairme adverse effects.
PRN for pain nt 2) Ensure adequate pain relief and assess the
patient's pain score to titrate the dose as
GI: necessary.
- Nausea 3) Encourage patients to change positions
and regularly and provide interventions to
Vomiting prevent constipation.
- Constipat
ion AFTER:
CARDIAC: 1) Continue to monitor the patient's vital signs
- Hypotens and respiratory status.
2) Observe for any adverse reactions,
ion
particularly respiratory depression or signs
SKIN:
of allergic reactions.
- Itching
3) Implement measures to manage
and Rash
constipation, such as increased fluid intake,
BLADDER
dietary fiber, and possibly laxatives as
EFFECTS:
prescribed.
- Urinary
retention
DRUG NAME CLASSIFICATI MECHANISMS OF ACTION INDICATION CONTRAINDICATI ADVERSE EFFECT NURSING RESPONSIBILITIES
ON ON
GENERIC Oxytocic’s Pitocin acts on oxytocin - Induction of - Hypersensiti - Uterine BEFORE:
NAME: receptors in the uterine labor vity hyperstimulat 1) Assess the patient's medical history,
muscles. When administered - Augmentati - Abnormal ion including any contraindications or risk
Synthetic intravenously, it binds to on of labor fetal - Fetal distress factors that may affect the use of Pitocin.
oxytocin these receptors, leading to - Control of position or - Uterine 2) Confirm that the fetus is in an appropriate
increased uterine postpartum presentation rupture position for vaginal delivery and assess the
BRAND contractions. This results in bleeding - Fetal - Water fetal heart rate.
NAME: the initiation or strengthening distress intoxication 3) Ensure that adequate facilities and staff are
of labor, making it useful for - Cephalopelv - Postpartum available to monitor both the mother and
Pitocin labor induction or ic hemorrhage the baby during Pitocin administration.
augmentation. disproportio
ACTUAL n Cardiovascular DURING:
DRUG
DOSE, CLASSIFICATI MECHANISMS OF ACTION INDICATION CONTRAINDICATI ADVERSE EFFECT NURSING RESPONSIBILITIES
1) Continuously monitor the mother's vital
- Placenta Effects
NAME AND
ROUTE, ON ON signs, uterine contractions, and fetal heart
previa or
GENERIC
FREQUENCY B complex Folic acid is a precursor to the - Prevention - Known Gastrointestinal BEFORE:
rate throughout labor.
vasa previa - Hypotension
: NAME: vitamin active form of the vitamin and hypersensiti
- Certain
System:
- Increased
1)
2) Assess
Adjust thethePitocin
patient's medical
infusion history
rate and to
according
Folic acid called folate. Once ingested, treatment of vity. nutritional status to identify potential
the patient's response and ensure it does risk
medical
10 unit IM folic acid is converted into its folate - Methylmalo  heart
Nausearate factors for folate deficiency.
not cause excessive uterine
active form in the body. Folate conditions 2) Determine the appropriate
after delivery deficiency nic acidemia  Bloating hyperstimulation or distressdosage of folic
to the baby.
ofBRAND
placenta is essential for the synthesis - During and  Gas acid based on the patient's specific
3) Provide emotional support to the mother, needsas
NAME: of DNA and RNA, as well as pregnancy homocystin  Abdominal and medical condition.
Pitocin-induced contractions can be more
Folvite for the metabolism of certain - Certain uria: Folic cramps intense than natural labor.
amino acids. It is particularly medical acid may  Loss of DURING:
important during periods of conditions worsen appetite 1) Advise patients to take folic acid as
AFTER:
ACTUAL rapid cell division and growth, these rare 1) prescribed
Monitor theand at the
mother andrecommended
baby closely during
DOSE, such as pregnancy and metabolic Cardiovascular dosage.
the postpartum period for any signs of
ROUTE, infancy. By providing an disorders. System: 2) Monitor patients
complications, for signs
such of improvement
as excessive bleeding.
AND adequate supply of folate, 2) in conditions
Educate related about
the mother to folate deficiency,
signs of
FREQUENC folic acid supports these  hypertension such as anemia
postpartum or neuraland
hemorrhage tube defects
when to seek
Y: critical processes in the body. during pregnancy.
immediate medical attention.
3)
3) For
Offerpregnant women,
breastfeeding emphasize
support, the may
as Pitocin
Allergic Reactions: importance of taking folic acid early
also stimulate milk letdown after delivery. in
pregnancy to prevent neural tube defects
in the developing fetus.
 Skin rash
 Itching
AFTER:
 Swelling 1) Educate patients about the importance of
(angioedema maintaining a balanced diet rich in folate
) sources, such as leafy greens, fruits, and
 Difficulty fortified foods.
breathing (in 2) Encourage patients to follow up with their
severe healthcare provider regularly to monitor
cases) their progress and assess the
effectiveness of folic acid supplementation.
Cognitive Effects:
 cognitive
decline.
 DRUG CLASSIFICAT MECHANISMS OF ACTION INDICATION CONTRAINDICATI ADVERSE EFFECT NURSING RESPONSIBILITIES
NAME ION ON
GENERIC corticosteroid it exerts its effects by binding - Dermatitis - Hypersensiti Skin Reactions: BEFORE:
NAME: s to glucocorticoid receptors in Psoriasis vity - Thinning of 1) Assess the patient's medical history,
the skin cells. This binding - Other - Skin the Skin especially regarding any known allergies
betamethas leads to the modulation of Inflammato Infections CNS EFFECTS: or sensitivities to medications or other
one gene expression and inhibits ry Skin - Rosacea - Hypothalami corticosteroids.
dipropionat the production of inflammatory Conditions and Perioral c-Pituitary- 2) Perform a thorough skin assessment to
e substances, such as Dermatitis Adrenal determine the extent and nature of the
prostaglandins and cytokines. (HPA) Axis skin condition that requires treatment.
BRAND The reduction in inflammation Suppression
NAME: helps alleviate symptoms DURING:
associated with various skin Digestive Issues: 1) Instruct patients to apply the medication
Diprolene conditions. - nausea, only as directed by their healthcare
bloating, gas, provider and to avoid using it on infected
ACTUAL and or open skin areas.
DOSE, abdominal 2) Advise patients to avoid covering the
ROUTE, cramps. treated skin area with airtight dressings
AND unless specifically instructed by a
FREQUEN healthcare professional.
CY: 3) Caution patients against using the
medication for prolonged periods or on
extensive skin areas to reduce the risk of
systemic side effects.
4) Monitor the patient for any signs of skin
irritation or adverse reactions during the
course of treatment.

AFTER:
1) Educate patients about the proper use
and potential side effects of the
medication.
2) Emphasize the importance of
compliance with the prescribed treatment
plan and the need to follow up with their
healthcare provider as scheduled.

(AFFECTING REPRODUCTIVE TRACT)

DRUG CLASSIFICAT MECHANISMS OF ACTION INDICATION CONTRAINDICATI ADVERSE EFFECT NURSING RESPONSIBILITIES
NAME ION ON
GENERIC Estrogens Estradiol binds to estrogen 1) Hormone 5) Pregnancy 1) Nausea BEFORE:
NAME: receptors in various tissues, Replacem 6) Breast 2) Breast 1) Patient Assessment: Conduct a thorough
including the uterus, ovaries, ent Cancer or Tenderness assessment of the patient's medical
estradiol breast tissue, and bones. Therapy Estrogen- 3) Headache history,.
Upon binding, it influences (HRT) Dependent 4) Breakthrough 2) Pregnancy Test: If the patient is of
BRAND gene expression and cellular 2) Contrace Tumors Bleeding childbearing age and not currently
NAME: activities in these tissues, ption 7) Active Liver Cardiovascular pregnant, a pregnancy test may be
Estrace regulating a wide range of 3) Osteopor Disease Effects: recommended
physiological processes in the osis - risk of heart 3) Breast and Pelvic Examination: In certain
female body. Estradiol plays a Preventio attack cases, a breast and pelvic examination
ACTUAL crucial role in the development n and - stroke may be conducted before starting
DOSE, and maintenance of female Treatment skin effects: hormone replacement therapy with
ROUTE, reproductive organs, bone 4) Hypoestro - increased estradiol.
AND health, and other aspects of genism sensitivity
FREQUEN female physiology. or DURING:
CY: darkening - Medication Administration: Administer
of certain estradiol as prescribed, following the
10 to 20 areas recommended dosage and route.
mg IM CNS: - Monitoring: Monitor the patient for any
every 4 - Mood signs of adverse effects, especially
weeks changes during the initial period of therapy.
- Headache Regular check-ups and follow-up visits
Gastrointestinal are important to evaluate the patient's
Issues response to treatment.
- bloating,
gas, or AFTER:
indigestion 1) Patient Education: Provide the patient
. with information on the proper use of
estradiol, including dosage instructions,
potential side effects, and the importance
of adherence to the prescribed regimen.
2) Breast Health: Encourage patients to
perform regular breast self-examinations
and report any breast abnormalities to
their healthcare provider.
3) Vaginal Bleeding: Instruct patients to
report any unusual or persistent vaginal
bleeding to their healthcare provider
DRUG CLASSIFICAT MECHANISMS OF INDICATION CONTRAINDICATI ADVERSE EFFECT NURSING RESPONSIBILITIES
NAME ION ACTION ON
GENERI Fertility Drugs Cetrorelix is a Assisted Hypersensitivity: It Reproductive System: BEFORE:
C NAME: gonadotropin-releasing Reproductive is contraindicated - Ovarian 1) Patient Assessment: Conduct a comprehensive
DRUG hormone (GnRH)
CLASSIFIC MECHANISMS OF ACTION Technology INDICATION in patients with a
CONTRAINDICATI Hyperstimulation
ADVERSE EFFECT NURSINGassessment of the patient's medical history,
RESPONSIBILITIES
cetrorelix
NAME ATION antagonist. GnRH is a (ART): It is used known ONallergy or Syndrome including any known allergies, current
GENERIC Progestin hormone produced
Desogestrel primarilyinworks
the byin IVF
Desogestrel is hypersensitivity to
- Pregnancy (OHSS)
- Irregular BEFORE:medications, and reproductive health.
BRAND
NAME: hypothalamus
inhibiting that
ovulation, which is procedures
indicated tofor thecetrorelix
- or other
History of - Ovarian Cyst
Menstrual 2)1) Pregnancy Test: Confirm
Patient Assessment: the patient's
Conduct a comprehensive
s
NAME: stimulates
the release the release
of eggs fromofthe prevent
prevention of GnRH antagonists. Thrombosis Formation
Bleeding pregnancy
assessment status
of thebefore starting
patient's cetrorelix
medical history,
Cetrotide
desogestr other hormones
ovaries. called the premature
It also thickens pregnancy. It is - Breast GI EFFECTS:
- Headache 2) therapy
Pregnancyto ensure that the the
Test: Confirm patient is not
patient's
el gonadotropins
cervical mucus, (follicle-
making it more ovulation
used in and Cancer or - Nausea,
- Breast vomiting, pregnant.
pregnancy status before starting desogestrel
stimulating
difficult hormone
for sperm or the improve
to enter the
combination with Estrogen- or abdominal
Tenderness therapy to ensure that the patient is not
ACTUAL
BRAND FSH and
uterus. luteinizing
Additionally, chances of
an estrogen Dependent pain.
Cardiovascular DURING: pregnant.
DOSE,
NAME: hormone oralters
desogestrel LH) from the ofsuccessful
the lining component in Tumors CNSEffects:
EFFECTS: 1)3) Medication Administration:
Venous Thrombosis Risk: Administer
Assess thecetrorelix
patient's
ROUTE, pituitary
the uterus,gland.
making These
it less fertilization
combined andoral - Headache
- heart attack as prescribed,
risk factors forfollowing the recommended
venous thrombosis, such as a
AND
Kariva hormonestoare
receptive responsible
a fertilized egg, embryo
contraceptive Dizziness
and stroke dosage
history and instructions
of blood for use. Itor
clots, immobility, is other
typically
FREQUE for controlling
thus reducing the thechance of implantation.
pills (COCs). Cardiovascular Effects:
GI effects: given as a subcutaneous
conditions that may increase injection.
the risk.
NCY:
ACTUAL menstrual cycle and the
pregnancy. - changes in blood
- bloating, 2) Monitoring: Monitor the patient for any signs of
0.25
DOSE, mg release of eggs from the pressure. DURING:adverse effects, especially injection site
nausea,
per
ROUTE, ovaries (ovulation). vomiting, or 1) reactions
Medication and symptoms related
Administration: to ovarian
Administer
injection
AND hyperstimulation syndrome (OHSS) during IVF
desogestrel as prescribed
diarrhea can
repeated
FREQUE occur, but they 2) procedures.
Monitoring: Monitor the patient for any signs of
injections
NCY: adverse effects, especially during the initial
are not
every 24 common. AFTER: period of therapy. Regular check-ups and
hours
1 tab (75 1) Patient Education:
follow-up visits areProvide
important thetopatient
evaluatewiththe
Cardiac effects:
mcg) once information on the proper use of cetrorelix,
patient's response to the contraceptive method
- Hypertension
daily including injection techniques and potential side
AFTER: effects.
2)1) IVF Procedure
Patient Follow-Up:
Education: ProvideDuring IVF with
the patient
procedures,
information closely monitoruse
on the proper theofpatient's
desogestrel,
response
includingto ovarian
dosage stimulationpotential
instructions, and adjust the
side
dosage of cetrorelix as needed to prevent
effects, and the importance of adherence to the
premature
prescribedovulation.
regimen.
3)2) OHSS
Venous Monitoring:
Thrombosis Ovarian hyperstimulation
Prevention: Educate the
syndrome is a lifestyle
patient about potentialmodifications
complication that of IVF
can
procedures.
reduce the risk Nurses shouldthrombosis,
of venous be vigilant for signs
such as
and symptoms of OHSS, such as
maintaining physical activity and avoiding abdominal
pain, bloating,
prolonged and breathing difficulties, and
immobility.
3) report
RegularanyMenstrual
concerns Review:
promptlyIntopatients
the healthcare
team.
experiencing irregular bleeding, a review of the
menstrual pattern is important to assess any
potential issues or concerns.
DRUG CLASSIFICA MECHANISMS OF INDICATION CONTRAINDIC ADVERSE EFFECT NURSING RESPONSIBILITIES
NAME TION ACTION ATION
GENERI ergot Ergotrate works by - Postpart - Hyperse GI EFFECTS: BEFORE:
C NAME: alkaloids directly stimulating the um nsitivity - Nausea and 1) Patient Assessment: Conduct a comprehensive
smooth muscles of the Hemorrh - Hyperte Vomiting assessment of the patient's medical history, including
Ergonovi uterus, leading to age nsion REPRODUCTIVE SYSTEM any known allergies, current medications, and obstetric
ne uterine contractions. It - Uterine EFFECTS: history.
constricts the blood Bleeding - Uterine 2) Blood Pressure Measurement: Check the patient's
BRAND vessels in the uterus, - Cramps blood pressure to ensure it is within an acceptable
NAME: which helps to reduce CARDIAC: range before administering ergotrate.
bleeding after childbirth - Hypertension
Ergotrate or during specific - Chest Pain DURING:
medical procedures. SKIN: 1) Medication Administration: Administer ergotrate as
ACTUAL - Severe Allergic prescribed, following the recommended dosage and
DOSE, Reactions route. It is typically given orally or by injection.
ROUTE, 2) Monitoring: Continuously monitor the patient's uterine
AND contractions and bleeding, especially when using
FREQUE ergotrate for postpartum hemorrhage or during medical
NCY: procedures.

0.2 mg AFTER:
IM 1) Postpartum Care: In cases of postpartum hemorrhage,
immediat ensure close monitoring of the patient's recovery,
ely including monitoring blood loss, vital signs, and uterine
following tone.
delivery 2) Blood Pressure Monitoring: Regularly check the
of patient's blood pressure, especially if they have a
placenta history of hypertension or are at risk of developing high
blood pressure.
3) Severe Allergic Reactions: Be prepared to recognize
and manage severe allergic reactions, such as
anaphylaxis, if they occur
DRUG NAME CLASSIFICA MECHANISMS OF INDICATION CONTRAINDICATIO ADVERSE EFFECT NURSING RESPONSIBILITIES
TION ACTION N
GENERIC ovulatory Ergotrate works by Postpartum - Hypersensitivi GI EFFECTS: BEFORE:
NAME: stimulants directly stimulating the Hemorrhage: It is ty - Nausea and 1) Patient Assessment: Conduct a
smooth muscles of the used to control - Hypertension Vomiting comprehensive assessment of the patient's
clomiphene uterus, leading to uterine excessive bleeding REPRODUCTIVE medical history, including any known
contractions. It constricts after childbirth SYSTEM EFFECTS: allergies, current medications, and obstetric
BRAND the blood vessels in the when other - Uterine history.
NAME: uterus, which helps to measures have - Cramps 2) Blood Pressure Measurement: Check the
reduce bleeding after failed to stop the CARDIAC: patient's blood pressure to ensure it is
Clomid childbirth or during bleeding. - Hypertensio within an acceptable range before
specific medical n administering ergotrate
ACTUAL procedures. Uterine Bleeding: - Chest Pain
DOSE, Ergotrate may be SKIN: DURING:
ROUTE, AND used to help control - Severe Allergic 1) Medication Administration: Administer
FREQUENCY: uterine bleeding Reactions ergotrate as prescribed, following the
during certain recommended dosage and route. It is
50 mg orally gynecological typically given orally or by injection.
once a day for procedures. 2) Monitoring: Continuously monitor the
5 days. patient's uterine contractions and bleeding,
especially when using ergotrate for
postpartum hemorrhage or during medical
procedures.

AFTER:
1) Postpartum Care: In cases of postpartum
hemorrhage, ensure close monitoring of the
patient's recovery, including monitoring
blood loss, vital signs, and uterine tone.
2) Blood Pressure Monitoring: Regularly
check the patient's blood pressure,
especially if they have a history of
hypertension or are at risk of developing
high blood pressure.
3) Severe Allergic Reactions: Be prepared to
recognize and manage severe allergic
reactions, such as anaphylaxis, if they
occur.