IX.

DRUG STUDY

Doctor’s Mechanism of
Drug Order Actions Indications Contraindications Effects Nursing Considerations

Generic Name: Dosage: Glyxambi GLYXAMBI is a 1. Severe renal Therapeutic Effects: Independent:
combines 2 combination of impairment, end-
Empagliflozin and 10 mg 1. lower blood sugar 1. Check for
anti- empagliflozin and stage renal disease, or
Linaliptin levels in patients with hypersensitivity
hyperglycemic linagliptin dialysis
type 2 diabetes
agents with indicated as an 2. Identify the right
Frequency: 2. History of serious mellitus.
complementary adjunct to diet and patient by asking her/his
Brand Name: hypersensitivity
mechanisms of exercise to name.
1 tab OD reaction to
action to improve glycemic
Glyxambi empagliflozin,
Route: improve control in adults Side Effects: 3. Instruct patient and
linagliptin. family to report other
glycemic with type 2
Oral control in diabetes mellitus 1. Cough, sore throat troublesome side effects.
3. Any of the
Therapeutic patients with when treatment 2. Inflamed nose or
excipients in Dependent:
Class: type 2 diabetes: with both throat
GLYXAMBI such as
empagliflozin, a empagliflozin and 3. Upper respiratory
Antihyperglycemi anaphylaxis, 1. Verify with doctor’s
sodium-glucose linagliptin is tract infections
c drug angioedema, order.
co-transporter appropriate. 4. Itching, skin rash
exfoliative skin
(SGLT2) Empagliflozin is 5. Increased thirst 2. Communicate
conditions, urticaria,
inhibitor, and indicated to reduce and urination abnormal effects and
or bronchial
linagliptin, a the risk of risks of the medication to
hyperreactivity Adverse Effects:
dipeptidyl cardiovascular the doctor.
Pharmacologic
Class: peptidase-4 death in adults 1. Urinary Tract Collaborative:
(DPP-4) with type 2 Infection
Sodium-glucose inhibitor. diabetes mellitus 1. Refer to dietitian for
co-transporter 2 and established 2. Nasopharyngitis counseling specific to
inhibitor + cardiovascular individual dietary
3. Upper respiratory
dipeptidyl disease. However, customs.
tract infection
peptidase-4 the effectiveness of
inhibitor GLYXAMBI on
reducing the risk of
cardiovascular
death in adults
with type 2
diabetes mellitus
and cardiovascular
disease has not
been established.

Doctor’s Mechanism of
Drug Order Actions Indications Contraindications Effects Nursing Considerations
Generic Name: Dosage: Rosuvastatin Indicated to: Active liver disease, Therapeutic Effects: Independent:
selectively and including
Rosuvastatin 10 mg competitively - Treat high blood unexplained, Rosuvastatin is used 1. Obtain dietary history,
inhibits 3- pressure persistent elevations together with diet to especially with regard
Brand Name: hydroxy-3- (hypertension). of serum lower blood levels of consumption .
methylglutaryl - Used to lower the transaminases; "bad" cholesterol
Crestor Frequency: coenzyme A risk of stroke in myopathy. Severe (low-density 2. Emphasize the
(HMG- certain people with renal impairment lipoprotein, or LDL), importance of follow up
1 tab OD to increase levels of
CoA) reductase, heart disease. (CrCl <30 mL/min). exams to determine
the rate-limiting - Diabetic Pregnancy and "good" cholesterol
Therapeutic Route: effectiveness and to
enzyme in Nephropathy in lactation (high-density
Class: lipoprotein, or HDL), monitor side effects.
Oral cholesterol - Type 2 Diabetes
synthesis. It mellitus and
Antilipemic Agent 3. Instruct patient to take
increases the - Heart Faiure to lower triglycerides
number of -Hepatic (a type of fat in the medications as directed
hepatic LDL Impairment blood) and not skip doses or
Pharmacologic receptors on double up on missed
Class: the cell surface, doeses.
thereby
HMG-CoA enhancing the Side Effects: Dependent:
reductase uptake and
catabolism of 1. Blurred vision 1. Verify with doctor’s
inhibitors (statins)
LDL. It also 2. chest pain, order.
decreases discomfort, tightness,
apolipoprotein 2. Communicate
or heaviness
B, triglyceride abnormal findings to the
3. difficult, burning,
and increases doctor.
HDL or painful urination
concentrations 4. dry mouth Collaborative:
5. fast, irregular,
1. Consult a dietician for
pounding, or racing
advice that meets your
heartbeat or pulse
personal dietary
preferences.
Adverse Effects:

Blood and lymphatic

system disorders:
Rarely,
thrombocytopenia.
Gastrointestinal
disorders: Abdominal
pain, constipation,
nausea. General
disorders and
administration
site conditions:
Asthenia.
Hepatobiliary
disorders: Rarely,
pancreatitis,
hepatitis,
jaundice.Immune
system disorders:
Hypersensitivity (e.g.
angioedema).
Musculoskeletal and
connective tissue
disorders: Rarely,
 arthralgia, muscle
rupture, Lupus-like
syndrome

Doctor’s Mechanism of
Drug Order Actions Indications Contraindications Effects Nursing Considerations

Generic Name: Dosage: Promotes bowel 1. Constipation 1. Contraindicated in Therapeutic Effects: Independent:
evacuation by patients on low
Magnesium 240 mL 2. Acid Indigestion It works by causing 1. Explain the use of
causing osmotic sodium diet.
Citrate water to be retained pharmacological agents
retention of
2. Avoid use in with the stool. as ordered.
Brand Name: fluid, which
Frequency: patients with renal This increases the
distends colon 2. Assess the amount,
failure number of bowel
and stimulates
Citroma OD peristaltic 3. Avoid use in movements and frequency, and type of
activity. patients ith softens the stool so it drugs taken in patients
Therapeutic Route:
electrolyte is easier to pass.
Class: 3. Assess the patient’s
Oral abnormalities
Side Effects: allergies and previous
Laxatives
4. Avoid use with reactions to medications
Stomach cramps
myasthenia gravis. before administering
Dizziness
Pharmacologic Dependent:
Class: Upset stomach
1. Verify with doctor’s
Diarrhea order.
Stimulant Laxative
Adverse Effects: 2. Communicate
Abdominal cramping abnormal findings to the
Diarrhea doctor.
Electrolyte imbalance
Hypermagnesemia
Gas formation
Nausea/vomiting
Collaborative:

Refer to dietitian for

counseling specific to
individual dietary
customs.