Serious neurological conditions following pertussis immunization: an ... https://pubmed.ncbi.nlm.nih.

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Review Pediatr Rehabil. 2002 Jul-Sep;5(3):177-82. doi: 10.1080/1363849021000054031.

Serious neurological conditions following pertussis

immunization: an analysis of endotoxin levels, the
vaccine adverse events reporting system (VAERS)
database and literature review
David A Geier 1 , Mark R Geier

Affiliations
PMID: 12587565 DOI: 10.1080/1363849021000054031

Abstract
The purpose of this study was to determine the potential risks for the development and outcome
of serious neurological illnesses following whole-cell DTP vaccination and also to determine if the
switch to using acellular DTaP vaccine in the US has had any effect on the incidence rate of
serious neurological illnesses following vaccination. This study used the Limulus amebocyte lysate
(LAL) endotoxin assay to determine the levels of endotoxin in various commercially available
whole-cell and acellular DTaP vaccines, analysed the Vaccine Adverse Events Reporting System
(VAERS) database to determine the clinical effects of the use of whole-cell DTP and acellular DTaP
vaccines in the US and reviewed recently published pertinent studies that analysed the incidence
rates of serious neurological illness following whole-cell DTP and acellular DTaP vaccines. The
results indicated that whole-cell DTP vaccine contained high levels of endotoxin and was
statistically significantly more reactogenic than acellular DTaP vaccine. The presence of bias in the
VAERS database was not borne-out. The recommendation by the American Academy of
Paediatrics to use acellular DTaP vaccine for the entire childhood vaccination schedule beginning
in 1996 and the absence of the availability of whole-cell DTP in the US beginning in 2001 seems
well justified based upon the results of this study.

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