Scribd Logo
Upload

Welcome to Scribd!

  • Figure 9.3

    Uploaded by

    tranquoctuan0204
    8 views1 page
    Elevated levels of pyruvate activate the enzyme pyruvate dehydrogenase (PDH), the first component of the PDH complex, maximally. Calcium ions strongly activate PDH phosphatase, which stimulates PDH enzyme activity. This calcium activation of the PDH complex is particularly important in skeletal muscle, where calcium release during muscle contraction stimulates energy production by the PDH complex. Although the PDH complex is regulated by phosphorylation and dephosphorylation by its kinase and phosphatase enzymes, it is also inhibited by its end products, NADH and acetyl CoA.

    Original Description:

    hadfh

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Elevated levels of pyruvate activate the enzyme pyruvate dehydrogenase (PDH), the first component of the PDH complex, maximally. Calcium ions strongly activate PDH phosphatase, which stimulates PDH enzyme activity. This calcium activation of the PDH complex is particularly important in skeletal muscle, where calcium release during muscle contraction stimulates energy production by the PDH complex. Although the PDH complex is regulated by phosphorylation and dephosphorylation by its kinase and phosphatase enzymes, it is also inhibited by its end products, NADH and acetyl CoA.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    8 views1 page

    Figure 9.3

    Uploaded by

    tranquoctuan0204
    Elevated levels of pyruvate activate the enzyme pyruvate dehydrogenase (PDH), the first component of the PDH complex, maximally. Calcium ions strongly activate PDH phosphatase, which stimulates PDH enzyme activity. This calcium activation of the PDH complex is particularly important in skeletal muscle, where calcium release during muscle contraction stimulates energy production by the PDH complex. Although the PDH complex is regulated by phosphorylation and dephosphorylation by its kinase and phosphatase enzymes, it is also inhibited by its end products, NADH and acetyl CoA.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    • Thus, if pyruvate concentrations are

    elevated, E1 will be maximally


    active.
    • Calcium (Ca2+) is a strong activator
    of PDH phosphatase, stimulating
    E1 activity.
    • This is particularly important in
    skeletal muscle, where release of
    Ca2+ during contraction stimulates
    the PDH complex and, thereby,
    energy production.
    • Note: Although covalent regulation
    by the kinase and phosphatase is

    Dr. M. Alzaharna 2016


    primary, the complex is also subject
    to product (NADH and acetyl CoA)
    inhibition

    Figure 9.3: Regulation of pyruvate dehydrogenase (PDH) complex.

    Dr. M. Alzaharna 2016

    You might also like