Human Development Day 12: Blood-filled spaces form in

maternal tissue. The chorionic cavity starts

to form.
Day 14: A connecting stalk has formed
between the embryonic disk and chorion.
Chorionic villi, which will be features of a
placenta, start to form.
Days 1-2: The first cleavage furrow
extends between the two polar bodies. Embryonic Development
Later cuts are angled, so cells become Week 2
asymmetrically arranged. Until the eight-
cell stage forms, they are loosely - Development of trophoblast;
organized, with space between them. development of bilaminar embryo,
amnion, yolk sac, sinusoids and
Day 3: After the third cleavage, cells chorion
abruptly huddle to a compacted ball,
which tight junctions among the outer
cells stabilize. Gap junctions formed
along the interior cells enhance
intercellular communication.
Day 4: By 96 hours there is a ball of 16 to
32 cells shaped like a mulberry. It is a
morula. Cells of the surface layer will
function in implantation and will give rise
to a membrane, the chorion.
Day 5: A blastocoel forms in the morula as Week 3
a result surface cell secretion. By the 32- - Gastrulation occurs trilaminar
cell stage, differentiation is occurring in embryonic disc; neurulation;
an inner cell mass that will give rise to the development of somites, CVS,
embryo proper. This embryonic stage is chorionic villi and placenta
the blastocyst.
Day 6-7: Some of the blastocyst’s surface
cells attach themselves to the
endometrium and start to burrow into it.
Implantation has started.

Days 10-11: The yolk sac, embryonic disk,

and amniotic cavity have started to form
from parts of the blastocyst.
 Week 8
- Digits are short and webbed; eyes
are open; ear auricles are visible;
tail disappears; external genital
begin to differentiate

Week 4
- All organs appear (organogenesis);
- Size triples; embryonic folding;
formation of gut
- Formation of pharyngeal arches,
otic placode, lens placode; heart
prominence
- Development of upper and lower
limb buds.

Fetal Development
Fetus
- Developing human between 9
weeks and birth
- Heartbeat is detected at about 5
months
- After 7 months it can survive if born
prematurely

Weeks 5
- Rapid development of brain
Week 6
- Limb development; heart has 4
chambers; neck and trunk begin to
straighten
Week 7
- Regions of limbs are distinct
Week 9 - Abdomen begins to fillout
- Lanugo hairs covers the body
- Neck develops and chin rises from
- Eyelids and eyebrows develop
thorax
- Testes begin to descend
- Eyelids meet and fuse
- External genitalia begin to become 6 months
gender specific
- Decidua degenerates due to less
- Muscular movements occur
blood supply
- Semilunar valves are completed
- Lanugo hairs darken
Week 10 - Surfactant begins to development
- Skin is wrinkled and red
- Cervical flexure is about 15 degrees
- Finger nails appear 7 months
- Eyelids are fused
- Eyelids begin to open
- Bile is secreted
- Skin is slightly wrinkled
- Blood islands are established in the
- Eyelashes are well developed
spleen
- Sulci and gyri begin to appear
Week 11 - Testes are descending
- Termination of splenic
- Nose begins to develop bridge
erythropoiesis
- Cervical flexure is about 8 degrees
- Urine is excreted into the amniotic 8 months
fluid
- Skin is pink and smooth
- Stomach muscles contract
- Fingernails reached the fingertips
- T cells emigrate into bloodstream
- Eyes are capable of pupillary light
Week 12 reflex
- Testes enter the scrotum
- Head is erect
- External ear is forming; yolk sac has 9 months
shrunk
- Toenails reached the tips of toes
- Fetus can respond to skin
- Most lanugo hairs are shed
stimulation
- Placenta weighs 500 g
- Ovaries descend below the pelvic
- Large amounts of surfactant are
rim
secreted
- Blood can coagulate
- Tip of spinal cord at L3
4 months - Myelination of brain begins
- Skin is thin, nostrils are almost
formed
- legs are longer than arms
- Lanugo appear on the head
- Epidermal ridges appear on palms
and fingers
- Fetal movements can belt
5 months
- Epidermal ridges appear on soles
and toes
- Vernix caseosa deposited on skin