DRUG STUDY

Name of the Route, Dosage, & Mechanism of Indications Contraindications/ Side Effects Nursing
Drug Frequency Action Precautions Responsibilities
Generic Name: Route: - Methotrexate - Methotrexate is - Conduct a thorough - Methotrexate -Before administering
- Methotre - IM permeates into typically assessment of the can have side methotrexate, nurses
xate tissues and recommended for patient's medical history, effects, including should assess the
Dosage: undergoes cases of ectopic including any previous nausea, vomiting, patient's medical
Brand Name: - Single conversion into pregnancy where health conditions, abdominal pain, history, including any
- Metoject dose methotrexate the embryo is allergies, or medications fatigue, dizziness, allergies or previous
Frequency: polyglutamate by small, the fallopian they are taking. Ensure lightheadedness, adverse reactions to
Classification: - Once a folylpolyglutamat tube is intact, and that the patient is not changes in bc, methotrexate or
- Anti- week e. Its mode of there is no heavy hemodynamically liver and kidney similar medications.
metaboli action primarily bleeding. It may unstable (severely functions, and -Ensure that the
te hinges on its not be suitable for bleeding or in shock). pulmonary patient has provided
ability to obstruct all ectopic - Confirm the diagnosis of symptoms. informed consent for
enzymes pregnancies, and ectopic pregnancy Patients taking the methotrexate
accountable for the decision to use through various methods, methotrexate treatment,
the creation of methotrexate or including transvaginal should avoid understanding the
nucleotides, pursue surgical ultrasound and serial alcohol and risks and benefits
encompassing intervention beta-human chorionic certain associated with the
dihydrofolate depends on various gonadotropin (beta-hCG) medications that medication.
reductase, factors, including measurements. can interact with -Calculate the correct
thymidylate the size and Methotrexate is typically it. It's important dose of methotrexate
synthase, location of the recommended for to follow your based on the
aminoimidazole ectopic pregnancy, ectopic pregnancies healthcare patient's weight,
caboxamide the patient's detected early, before provider's condition, and
ribonucleotide overall health, and fetal cardiac activity is instructions prescribed regimen.
transformylase the presence of present. carefully. -Nurses should follow
(AICART), and symptoms. - Patients with pre- the prescribed route
amido existing liver or kidney and technique,
phosphoribosyltra conditions may require ensuring proper
nsferase. This more vigilant monitoring, administration.
inhibition of as methotrexate is -If nausea and
nucleotide metabolized by the liver vomiting are
synthesis serves and excreted by the
to impede cell kidneys.
division. - Methotrexate can lead
to bone marrow
suppression, which may
result in decreased white
blood cells, red blood
cells, and platelets.
Monitor blood counts
regularly, especially in
patients with pre-existing
hematologic conditions.
- In some cases, folate
supplementation may be
required to mitigate the
potential side effects of
methotrexate. This
supplementation is
typically prescribed to
reduce the risk of mouth
sores and gastrointestinal
symptoms.
- Patients should be
advised to avoid alcohol
consumption during
methotrexate treatment,
as it can increase the risk
of liver toxicity.
anticipated side
effects, administer
antiemetic
medications as
prescribed to help
manage these
symptoms.
- Regularly monitor
laboratory
parameters,
including complete
blood counts, liver
function tests, and
kidney function tests,
as methotrexate can
affect these systems.
-Accurately
document the
administration of
methotrexate,
including the dose,
route, date, time, any
adverse events, and
the patient's
response.