' i e :

1
Sub.
C

UNIVERSTTY, SALEM

2014

UGUST
145
INAV AKAN
MISSONS AMINATION
(NEW REGULATIONS)
R E E

MRRS D FRSTYEAR
M a x i m u m : 8 0 m a r k s

PAPER I
IOCEMISTRYY

Threr honrs Answer ALL questions

n e c e s s a r y

v w h e r e v e r
(1x10=10)
diagrams
Draw SECTION-A

blood pH by
I.Write essay on: regulation
of (1+9-10)

detail
n
Dis
What is nomal blood pl1? (4x5-20)

renal respiratory butier systcms.

II. Write short notes on:

DNA repair mechanisms

RDA. s o u r c e s and
homeostasis of calcium
4. Oncogenes
5. Hyperuricemia (5x2-10)

III. Answer briefly:

6. Vandenberg reaction
7. Alkaptonuria
serum proteins
8. Normal electrophoretic pattern of
9. Pepsin and trypsin
10. Gamma Aminobutyric acid

SECTION -B
(1x10=10))
I. Write essay on:
in detail. (3+7=10)
11. Structure oftRNA. Discuss process of transcription
II. Write short notes on: (4x5-20)

12. Cyclic AMP

13. Detoxification mechanisms by oxidation and conjugation
14. Urea and creatinine clearance
15. Recombinant DNA technology

IiI. Answer briefly:

5x2-10)
16. Products formed from
tryptophan
17. Two functions of minerals Zinc and
copper
18. Orotic aciduria and Lesch-Nyhan syndrome
19 Two hormones of
20 Fluorosis.
posterior pituitary gland
 S u b . C o d e : 1 0 1 0 1 2 5

s.N114505
M I S S O N S U N I V E R S T T Y , S A L E M

AUGUST
2014
INAYARA M ENAMINATION
MRRS DEGRI (NEWR LATUONS)

RST EAR

PAPER Maximum: 80 marks

BIOCHEMISTRY-

Time: Three hours

Answer ALL queslions
necessary
wherever
Draw diagrams
SECTION - A
(1x10=10)

I. Write essay on: h o m e o s t a s i s

blood glucose
Discuss how (1+9=10)
ucOSe
level?

is maintained in hhumans.
(4x5-20)
I1. Write short notes on:

2. Glycero phospholipids
. RDA, sources. functions of ascorbic acid
4. Heme degradation
5. Ketosis
(5x2=10)
III. Answer briefly:

6. Substrate phosphorylation
7. Pyruvate
dehydrogenase
8. Endoplasmic reticulum
complex
9. Biotin
10. Dietary fibre

SECTION-B
I. Write essay on: (1x10=10)
11. Describe synthesis of cholesterol and add a note on atherosclerosis. (6+4=10)
II. Write short notes on:
12. Isoenzymes as myocardial infarction markers (4x5-20)
13. Sructure and functions of cell membrane
14.
Immunoglobulin
15. Carnitine
-

III. Answer briefly:

16. Von Giereke's disease (5x2=10)
17. BMR
18. Sickle cell
hemoglobin
19, Normal HbAlc value and its
20. Two causes of
fatty liver.
significance

*****
 (.REE E A A M I N A T I O N -FEBR

OND
SINo: MI4006 NEW REGGULATONS)
Maximum: 80 marks

MRRS DEG F I R S T Y E A

PAPERI
R

' A P E R
I
HEMISTRY -
BI
A n s w e r A L L q u e e t i o n s

necessAry

Thre hms ( 1 x 1 0 = 1 0 )

Time: h e r e v e r

w
d i n gS
r FCTDN A
a m s

Dran
of
mctabolism

the (1+5+4}
about

dctail
on: in
I rie rssay D e s c r i b e

(4x5-20)
Cds.

Nme th avmalrc. phenylketonurla

note on
lalane Add a
h
Wrte short notes on: significance.
clinical
its
purines and
of
r a i h w a y

Iron absorption and storage.

4 Tumour markes
(5x2-10)
Homocystinuria.

I . Answer bricfly:
jaundice.
Bochemical findings in a case of obstructive
.What is the normal level of sodium and potassium? myeloma.
reactions.
GNe wo examples ofconjugation syndrome
and multiple
the clectrophoretic pattern
of nephrotic
Draw
10. Mechanism of action of steroid hormones
10

SECTION - B
(1x10=10)
I. Write essay on:
11. Define translation. Discuss in detail about the process f translation.
Add a notle on its inhibitors. (1+7+3)

II. Write short notes on: (4x5-20)

12. Renal regulation of
pH
13. PCR
14. DNA repair mechanism
15. Creatinine clearance

III. Answer briefly:

16. Anion gap 5x2 10)
17. Biochemical
18. Name the
findings in a case of hypothyroidism.
biochemical markers of
19 Name the aminoacids
excreted in
myocardial infarction
urine in
20. Name any four cystinuria
biologically important compounds derived
from glycine.
*****
 : 7005

Srb. Code: 1010125,

RAL
VINAYAKAMISSIONS UNIVERSITY, SALEM
MBBS EGREE EXAMINATION- February 2017
FIRST YEAR
BRAR
y.M.C.

Time Three hours BIOCIEMISTRY PAPERT NDICTER

Maxinmum: 80 marks

Answer ALL questions

raW
diiagrams
wherever necessary
. SECTION- A
Write essay on:
(xi0= 10)
Define enzyme
attecting. d hand its
its general charecteristics. Discuss in detail
dactivity.
enzyme ge factors

I. Write
short notes o11: (4x5 = 20)

emesynthesis and regulation

iiucose ransport mechanisms
RDA. Sources.
ate of
Functions of Ascorbic acid
Fyruvate under aerobic and anerobic conditions
il.Answerbriefly: (5x2= 10
6. Liporopic factors
7. Four
derivatives of cholesterol
8.
isoenzymes of importance in myocardial intarction
9. Ribosomes
0. Antifolate drugs

SECTION - B
I Write essay on: (1x10 = f0)
1. Describe structure, functions of mucopolysaccharides with clinical
mportance.
I rite short notes on:
(4x5 20)
12. GTT and its importance
13. RDA, sources and functions of vitamin K
14. mmunoglobulin G
15. Siructure and functions of cell membrane

I ARSwer briefly:
(5x2 10}
i6. Sickle cell hemoglobin
17. h TCA cycle is considered as
important one in nmetabolism
18 Two high energy compounds
0 Lecithin
ame two giycogen storage disorders with enzyme defect.
 hAD KGREE EXAMUNATION- ***
FIRST YEAR

SOCHEMIST Y FAPER I1
2rks
Time: Three hours Maxim u n: 80 IT

ARSwer AL estjons
( d i n g r a n 1 s s e r e y e teeessay

SECIGNA
(xi0 16;
it ssay On:
S t r u e u e of DNA Discuss n dctail DNA repiiCaiiui
4x5-
i i e short notes on:
1Unction lests
AMP
i1abolic acidosis

Anster briciiy: (5
. Phey!ketonuria
.
KA-Absorpiion cf Îron
F R ciinicai significance
-

.GvE Two ezamples of transamination reactions

1 Aibvmin Giobulin ratio.
-

SECTION -- B

.Writeessay on: (1x10= 0;

1. What is nomal blood urea level? Discuss in detail synthesis of urea. Add a
1 l on metabolic disorders.

i t e short iotes o 4x520

etaxification mechanisms by Oxidation and conjugati.
1.2
3PCR- and its applications
14. Tunor markers
. em pioten C:ectrophoresis principle änd procedure.
kh. Aswer briefly:
(5x2= I
1. Our products derived irom glycine
7 Calcium binding protein
L1 otions -two tyres and e xamples
Ninhydrin test
AT:1 ga
 MID 201

BBS DEGREE EXAMINATION - August

FIRST YEAR

BIOCHEMISTRY- PAPER IT
marks
Maximum : 80
Time Three hours
Answer ALL questions
wherever necessary
Draw diagrams
SECTION - A
(1 x 10 10)
I. Write essay on:
Add a note on urea
and its disposal.
detail the formation of ammonia
in
cycle. 5 20)
(4 x
I1. Write short notes on:
Metabolism of methionine
Structural characteristics of DNA
4. Hyperuricemia
, Discuss glomerular function tests
(5x2 10)
IlI. Answer briefly:
6, Name the tests to be done in hypothyroidism.
7. Name four products derived from Glycine.
8 Define Isoelectric pH of proteins.
9. Write four causes of metabolic acidosis.
Enumerate clinical
T0. What is the enzyme deficient in acute intermittent porphyria?
features.
SECTION- B
I. Write essay on: (1x 10= 10)

11. Describe in detail the replication of DNA in prokaryotes.

IL Write short notes on: (4 x5 20)
12, Respiratory regulation of blood pH
13. Discuss calcium homeostasis.
14. What are the different types of RNA and its functions?
15, Gene therapy.

III. Answer briefly (5 x 2 10)

16 Name four clinical applications of PCR.
17. Name four synthetic nucleotide analogs.
18. Mention four post transcriptional modification.
19. Mention the compounds formed from Tyrosine.
20. What are tumor makers? Give two examples.

*****
 SNo. M17396 Sub. Code

SALLEM
UINIVERSITY,
INAYAKA MISsiONS
st 2017
z01

MBBS DEGREE EXAMINATION-August

FIRST YEAR

BIOCHEMISTRY- PAPER I
marks
Maximum
: 80
Time: Three hours
Answer ALL questions
wherever necessary
Draw diagrams
SECTION - A

(1x10=10)
I. Write essay on: Add a note on
in our body.
the regulation of blood
glucose
in detail about
be
Glucose Tolerance test. 5 20)
(4 x
II. Write short notes on :
2. Oxidative phosphorylation
3. Biochemical functions of Ascorbic acid.
4. Competitive inhibition of enzyme action with exampies.
5. Metabolism in adipose tissue.
(5 x 2 10)
III. Answer briefly:
range of bilirubin and two
causes of conjugate hyper bilirubinemia.
. Keterence
7. Name four acute phase reactants
8. Niemannpick's disease
9. Name four iron containing proteins
10. Ionophores.

SECTION- B
I. Write essay on (1 x 10 10)
11. How will you classify lipoproteins and enumerate the functions of apolipoproteins.
Add a note on metabolism of chylomicrons.

II. Write short notes on: (4 x5 20)

12. What are the biochemical changes in Kwashiokor.
13. Phospholipids
14. Vongierke's disease
15. Structure of hemoglobin which helps in
oxygenation.
IIl. Answer briefly:
16. Biochemical defect in Wilson's disease and
(5 x2 10)
17. FIGLU test
laboratory diagnosis.
18. Mutarotation of glucose and its
19. What are essential fatty acids?
significance
20. Name bile acids.
****
 Course Code .

SI.No. MI7387
INCLUING BIO PHYSICS - PAPER
U M A N PHYSOLOGY

SECTION-A(15X1-15 MARKS)
(Multiple choice questions)
Maximum: 15 marks

Time: Fificen Minutes

Scect the most appropriate answver and answer in the answer sheet ana

Renal plasma flow can be detemmned by measuring the clearance o

A Urca
B PAH
C. Inulin
Crcatinine
ADH dependent water reabsorption takes place nmainly in
A. Collecting duct
B. Proximal convoluted tubule
C.Thick ascending limb of loop of Henle
D. Thin ascending limb of loop of Henle
3. Biood group' O'contains
A. A agglutinogen
B. B agglutinogen
C. C aggiutinogen
D. No aggltinogens

4. The
T-Lymphocytes are processed in
A. Liver
B. Bone marrow
C. Thymus
D. Lymphnode

5. Hormones acting on the cells from which they are produced are called
A. Classical hormones
B. Neurohormones
C. Paracrine hormones
D. Autocrine hormones

feature of following endocrine disorder

Exophthalmos is a

A. Acromegaly
B. Cushing syndrome
C. Grave's disease

D. Myxoedema (p.t.o.)
SI.No: M17005
Sub. Code: 1010125

UNIVERSITY, SALE
NA YAKA MISSIONS 17
MBBS DEGREE EXAMINATION- Februay
FIRST YEAR

BIOCHEMISTRY - PAPERI
Maximum: 80 m a r k s

Time: Three hours

Answer ALL questions
wherever necessary
Draw diagrams
SECTION- A
(1x10= 10)
I. Write essay on:
detall 1actots
Discuss in
general charecteristics.
Define enzyme and its
affecting enzyme activity. (4x5 20)
II. Write short notes on:
2. Hemesynthesis and regulation
3. Glucose transport mechanisms
4. RDA, Sources, Functions of Ascorbic acid
and anerobic conditions
. Fate
of pyruvate under aerobic
(5x2 10)
III. Answer briefly:
6. Lipotropic factors
7. Four derivatives of cholesterol
infarction
8. Isoenzymes of importance in myocardial
9. Ribosomes
10. Antifolate drugs
SECTION -B (1x10 = 10)
I. Write essay on:

11. Describe structure, functions of

mucopolysaccharides with clinical
importance.
(4x5 20)
II Write short notes on:

12. GTT and its importance

vitamin K
13. RDA, sources and functions of
14. Immunoglobulin G
15. Structure and functions of cell membrane
III. Answer briefly: (5x2 10)
16. Sickle cell hemoglobin
17. Why TCA cycle is considered as important one in metabolism
18. Two high energy compounds
19. Lecithin
20. Name two glycogen storage disorders with enzyme defect.
****
 Sub. Code: 1010126

SI.No: M17006
UNIVERSITY,
SALEM
ry 2017
MISSIONS
MAYAKA February
MBBS DEGREE ExAMINATION-
FIRST YEAR

BIOCHEMISTRY- PAPER II
Maximum: 8 0 m a r k s

Time: Three hours

Answer ALL questions
necessary
wherever
Draw diagrams
SECTION - A
(1x10 10)
I. Write essay on:
DNA replication.
DesCribe structure of DNA. Discuss in detail (4x5 200)
II. Write short notes on:
2. Liver function tests
3. Cyclic AMP
4. Metabolic acidosis
5. Gout
(5x2 10)
II. Answer briefly:
6. Phenylketonuria
7. RDA-Absorption of Iron
8. GFR- clinical significance
9. Give two examples of transamination reactions
10. Albumin - Globulin ratio.

SECTION- B
L Write essay on: (1x10 10)
11. What is normal blood urea level? Discuss in detail synthesis of urea. Add a
note on metabolic disorders.

IL Write short notes on:

(4x5 200)
12. Detoxification mechanisms by oxidation and conjugation.
13. PCR- and its applications
14. Tumor markers
15. Serum protein electrophoresis principle and
procedure.
II. Answer briefly:
16. Four products derived from
(5x2 10)
glycine
17. Calcium binding protein
18. Mutations two types and
-

19. Ninhydrin test

examples.
20. Anion gap
****
 MT7389
SALEMM

v *

AMISSIONS
UNIVERSITY,

Ist 2 0 1 7

EXAMINATION- AUBus
sBS DEGREE
First Year
BIOCHEMISTRY- PAPERT
marks
Maximum : 80
Time: Three hours
Answer ALL Questions handed
minutes to be
marks 15
Cdcclion A in the Answer Sheet to it 15
attached
minutes
after 15
OVer the invigilator immediately
to
a n s w e r book
Answer Section B in the
same

Maximum : 65 marks
Time: 2hours 45 minutes SECTION- B
(2 x 15 =30)
I. Write Essays on:

and its sOurces.

substances
**cne
luconeogenisis. Name the Gluconeogenic
Add a note on reciprocal
I S c u s s in detail how Alanine is converted to Glucose.
(2+2+7+4)
regulation of Gluconeogenesis and Glycolysis.
. Discuss in detail the dietary sources, RDA, Synthesis, Transport, storage, active &
1nactive form of Vitamin D. Write about the functions, regulations & deficiency
status of Vitamin D. (1+1+14+1+1+1+1+3+3+2)

II. Write short notes on: (5 x 5 25)

3. Galactosemia (defect, signs & Symptoms, Diagnosis & Treatment) (1+2+1+1)

4. B-Oxidation proper of palmitic acid and its regulation. (2 % +2 )
5. Allosteric and co-valent regulation of enzyme.
(2+3)
6. How haemoglobin is catabolised.
7. Draw the structure of ETC & mention its function.
Enumerate the inhibitionn
of ETC.
(2%+24)
III. Write briefly on:
( x 2 10)
8. Fatty liver
9. Mitochondrial DNA
10. Zellwieger's syndrome
11. Reference range for Glucose
in Fasting & Random in normal & in
12. Definition of Diabetic
Respiratory quotient and its uses
*****
 SI.No. M17390 Course Code: 161021T06

LNAYAKA MISSIONS UNIVERSITY, SALE

MBBS DEGREE MINATION - August 20117
First Year

BIOCHEMISTRY PAPER II -

Time Three hours Maximum : 80 marks

Answer ALL Questions

swer Section A in the Answer Sheet attached to it 15 marks
D e handed overto the invigilator immediately after 15 minutes
u
Answer Section B in the same answer book
Time 2
hours 45 minutes Maximum: 65 marks
SECTION- B
I. Write
Essays on: (2x 15= 30)
Mention the sulphur
containing Aminoacids. Discuss in detail the synthesis and
catabolism of Methionine and
transmethylation reactions.
Add a note onn
Homocystinuria (2+6+4+3)
2. Define pH and its reference range. Discuss in detail the role of buffers and
in kidney
maintaining the physiological pH. Add a note on metabolic acidosis
(2+1+8+4)
II. Write short notes on:
(5 x 5 25)
3. Post
transcriptional modifications
4. Clearance tests
5. Homeostasis of Calcium
6. Albumin
7. Phase II detoxifications reactions
III. Write briefly
on:
8. Blood gas (5 x2 10)
analysis
9. Principle &
10. Fluorimetry
application of PCR
11. Name the anti oxidants
12. Mention
of the body
any 4 tumor markers and in
which carcinoma they are elevated
*****
 Deemed t

vBBS DEGREE EXAMINATION-NoVemb

First Year
BIOCHEMISTRY PAPER I
Maximum: 80marks

Time Three hours

Answer ALL Questions 15
marks-
attached to it 15
CSection
A in the AnswerSheet immediately
after 15
invigilator
nnutes to be handed over to the

minutes answer
book
Section B in the
same
Answer marks
SECTION- B
Maximum : 65
Time 2 hours 45 minutes
(2 x 15 30)
I. Write Essays on:

Explain how many

molecules of A'TP
Describe the process of glycolysis.
(10+5)
condition.
are formed in anaerobic and aerobic
2. Describe sources, biochemical functions,
requirements and deficiency
manifestations of Vitamin A.
(2+5+2+6)
(5 x 5 25)
II Write short notes on

3. Formation of ketone bodies and its chemical significance.

4. What are isoenzymes? Name the isoenzyme forms of Lactate
dehydrogenase and Creatine kinase. What are their chemical significance?
5. What is porphyria? Classify different types of porphyria. Give an account
of acute intermittent porphyria.
6. Define active transport. Explain the different types of active transport with
examples.
7. Components of Electron transport chain (ETC). Sites of ATP formation.
Two inhibitors of ETC.

III. Write briefly on:

5 x 2 10)
8. Dietary fibres.
9. Van den Bergh reaction.
10. Zymogens.
11. Lipoprotic factors.
12. Carnitine.

*****
 S1.No. Ml9006 S A L E M .

FOUNDATION,

VINAYAKA MISSS
SION'S
R E S E A R C H

University)

(Deemed t o be 2018
-
August
A M I N A T I O N

MBBS GREE
First Year

II
BIOCHEMISTRY - PAPER
Maximum: 8 0 marks

Time Three hours

Answer ALL Questions 15 minutes

it 15 marks
-

Answer Sheet
attached to minutes
swer Section A in the after 15
immediately
OC anded over to the invigilator book
answer
Section B in the
same
Answer

BMaximum: 65 marks
SECTION
-

Time: 2 hours 45 minutes

I. Write Essays on: (2 x 15-30)

biochemical
the various
Mention the of aliphatic amino acids. Discuss Glutathione and hyperoxaluria.
names

compounds synthesized from Glycine.

Add a note on

(2+6+5+2) the of new

detail about process
2. Describe the double helix model of DNA. Discuss in
DNA formation. Add a note on RFLP and c DNA.(4+6+3+2)

II Write Short Notes on: (5x 5-25)

3. Renal function test with normal values
4. Repression and rerepression
5. Copper metabolism and disorder
6. Metabolic acidosis and compensation
7. Types and functions of RNA

III Write Briefly On :(5x2=10)

8. Oncogenes
9. ACTH
10. ELISA
11. Free radicals and
damage
12. Nonsense mutation

*****
 Course Code: 161021TU8

SI.No. M21922 ESEARCH FOUNDATION, SALEM.

NAYAKA MISSI
University)
(Deemed to be
October 2019
EXAMINATION-
BBS DEGREE
First Year

BIOCHEMISTRY PAPER II
Maximum: 80marks
Time Three hours

Answer ALL Questions to be

marks -15 minutes
CSection A in the Answer Sheet attached to it 15
after 15 minutes
handed over invigilator immediately
to the
answer b0ok
Answer Section B in the same

marks
Time 2hours 45 minutes SECTION - B Maximum : 65
(2 x 15 = 30)
I. Write essays onn:
. Define translation. Discuss in detail about the steps involved in translation

with diagrams. Add a note on post translational modifications and inhibitors

of translation.
2. What is the normal
pH of Blood? Explain the mechanisms involved in the
maintenance of normal pH.
II. Short notes on:
(5x 5-25)
3. Phenylketonuria
4. Clearance test
5. Laboratory
diagnosis of AIDS.
6. What are tumor markers?
7. Structure of
Classify and applications of tumor markers.
immunoglobulin.
III. Answer
briefly on:
8. Hypothyroidism (5 x210)
9. pH meter
10. Phase II
detoxifications reactions.
11. Laboratory diagnosis obstructive
12. Functions of of jaundice.
copper.

*****
 1 6 1 0 2 1 T O 5

Course
Code :
SI.No M21921
SALEM.

FOUNDATION,

VINAYAKA MISsION'8
ESEARCH

University)
(Deemed to be
2019
October
ENAMINATON
NHBS DFGREE
First Year

BIOCHEMISTRY - PAPERI Maximum 80 marks

Tme Three hou
Anewer AlLL Questions minutes to be
marks -15
to it 15
in the Answer Sheet attached
A immediately after I5
minutess

handed over to the invigilator

answer
book
Answer Scction B in the same

Maximum 6 5 marks
SECTION - B
ime 2 hours 45 minutes

(2 x 15 =
30)
I. Write essays on:
Biochemical functions
Name the sources, form, metabolism, RDA,
active
and deficiency diseases of Vitamin Bi2.
2 Discuss in detail about the B-oxidation of palmitic acid. Add a note on its

regulation and energetie.

II. Short notes on: 5 x5-25)

3. Significance of pentose phosphate pathway.
4. Regulation of enzyme activity by covalent modification.
Protein energy malnutrition.
6. Steps involved in Heme synthesis.
7. Inhibitors of Electron Transport chain.
iII. Answer briefly on
5 x 2 10)
8 Name any iwo
9. Functions and mnarker
glucosaminoglycens and their
functions.
enzyme of mitochondria
10. Name any two
phospholipids and its functions.
11. Biochemical functions of Vitamin B.
12. Specific dynamic action.
 161021T06
Code
Course

S A L E M .

SILNo. M21443 FOUNDATION,

E S E A R C H

VINAYAKA MISSION's
University)

(Deemed to be
2019
- August
E X A M I N A T I O N

MBBS DEGREE
First Year

II
BIOCHEMISTRY - PAPER Maximum : 80
marks

Time Three hours

Answer ALL Questions minutes to be
marks 15 -

attached to it 15
Sheet
Wer Section A in the Answer after 15
minutes
immediately
handed over to the invigilator book
answer
Answer Section B in the same

marks
SECTION - B
Maximum : 65
Time 2 hours 45 minutes
(2 x 15 =
30)
I. Write essays on
inherited disorders of
phenyl alanine metabolised with added
notes on
.How is
tyrosine.

2. How are purine nucleotides catabolised? What are the disorders associated with it
with the investigations for it.

II. Short notes on (5 x 5-25)

3. Creatinine
4. Acid base disorders
5. Enzymes estimation in acute
myocardial infarction
6. PCR
7. Tumour markers

III. Answer briefly on:

8. Mention the name of the tests to (5 x2 10)
asses the synthetic function of liver with normal
valves.
9. Name two radio
isotopes used in diagnosis of
10. Give two
examples for diseases
11. Give two detoxification by conjugation.
examples
12. Write any two of post translational modifications.
tumor markers and
the tumor
associated with them.
*****
 :161021T05
SI.No. M23005 Coursc
Code

SALEM.

VINAYAKA MISSION
ONS
RESEARCH
F O U N D A T I O N ,

University)
(Deemed t o be 2020
-
October
EXAMINA'TION
BBS DEGREE
First Year

BIOCHEMISTRY
PAPER -I marks
Maximum
: 80
Time Three hours
Answer ALL Questions minutes to be
marks
-

15
attached to
it 15
A in the Answer
Sheet after 15
minutes

immediately
d e c t i o n

n a n d e d over to the invigilator answer

book
same

Answer Section
B in the
marks
Maximum : 65
SECTION - B
Time 2 hours 45 minutes 15 3 0 )
(2 x

the
I. Write essays on: Write about
its energetics.
Add a note
on
.Describe citric acid cycle.
nature of the pathway.
Amphibolic functions and
Biochemical

2. Write the sources, daily requirement, A.

manifestations of Vitamin
deficiency
(5 x5 25)
II. Short notes o n :
3. Abnormal haemoglobins functions.
write their
Name them and value
lipoproteins?
4. What are
importance. Write their normal
of diagnostic
5. Name five enzymes

and significance.
malnutrition.
6. Protein energy
phosphorylation.
7. Chemi osmotic theory of oxidative
(5 x 2 10)
III. Answer briefly on:
8. Golgi complex.
chain.
9. Inhibitors of electron transport
write their function
10. Name any two phospholipid and
11. Renal glycosuria
12. Pellagra. *****
 SI.No. M23006
Course Code:161021TO6
VINAYAKA MISSION'S RESEARCH FOUNDATION, SALEM.
(Deemed to be University)

MBBS DEGREE EXAMINATION- October 2020

First Year

BIOCHEMIST- PAPER II

Time Three hours Maximum : 80 marks

Answer ALL Questions

Answer Section A in the Answer Sheet attached to it 15 marks- 15 minutes to be
handed over to the invigilator immediately after 15 minutes
Answer Section B in the same answer book

SECTION - B Maximum : 65 marks

Time: 2 hours 45 minutes
(2 x 15 = 30)
I. Write essays on:

technology. Write its clinical

1. Discuss in detail recombinant DNA
application.
functions of calcium.
2. Write the sources, daily requirement, biochemistry
Add a note on hypocalcaemia.

5x5 25)
II. Short notes on

3. Renal regulation of acid base balance.

4. Transmethylation reactions and its importance.
5. tRNA transfer RNA
-

formed from tyrosine.

6. Biological important compounds
7 Antioxidants
5 x2 10)
II. Answer briefly on:

8. Reverse transcriptase.
9. Creatinine clearance test.
10. Role of insulin in regulation of blood sugar.
l1. Name any two tumour markers and write their importance.
mechanism.
12. Give two examples of detoxification by conjugation
****
 :10119103 II
Course Code
6. M2042
SALEM.
FOUNDATION,
RESEARCH
MISSION'S
INAYAKA University)
(Deemed to be
-

EXAMINATION February 2021

FIRST MBBS DEGREE
BIOCHEMISTRY - II
Maximum: 100 marks
Time: Three hours

Answer ALL Questions

marks
attached for 20
Section A in the Answer Sheet
Answer Scction A
immediately
minutes to be handed over to the invigilator
After 20 answer book provided
Answer Section B in the main
Maximum : 80 marks
SECTION - B
Time: 2 hours 40 mninutes
x 30)
(2 15
I. Long Answer Questions:.
child with mental
one
year old
their
. A consanguineous couple brought children's OP with
and agitated to the
retardation who was hyperactive
There were few hypopigmented
patches around
complaints of tremors and fits. revealed
odour. Blood chemistry
the body and also the child had mousy body lactate
phenyl pyruvate and phenyl
high phenyl alanine levels. Phenyl acetate,
amounts.
were present in the urine in appreciable

Lab report:
Serum phenylalanine levels ->300umol/L (31-75umol/L),
Urine ferric chloride test- positive (blue green colour)
cyanide nitroprusside test- negative.
a. Name the amino acid metabolism that is defective here and the probable
Diagnosis (1+1)
b. Write in detail the catabolic pathway of the amino acid. (4)
c. The name the special products derived from tyrosine (2)
d. Discuss the disorders related to the catabolism of the amino acid in detail (5)
c. Give the reasons for (i) hypopigmented patches and (ii) mousy body odour
(1+1
2.a) What is normal pH of blood?
b) Add a brief note on blood buffers
c) Explain in detail about any 2 mechanisms to maintain pH (3+
d) Add a note on the disorders connected with this

(p
 -(2)

I Shor Answer Questions: 6x

3. What is Gene therapy? Name the vectors used in gcne therapy. What are tho
5 30)
indications & conplcations
of gene therapy?
4 plain why anmmonia is toxic to the brainn?
Ammonia in senm1m
What arc the
causcs of
What are the chnical features observed i
(1+2+1+1)
increased
n
1N7eramonemia?
what is GARA shunt? What are the functions o f GABA? Why thera
convulson in B6 dcficiency?
(2+1+2)
h a t is hemolytic jaundicc? What
obtained
arc its
Causcs? What
(3+1+1)
the LET nroGL
are

A
s0year old male paticnt came with Clo twitching
of muscles. O/. (1+2+2)
22))
"law hand. Trossicu's
Scrum Total Calcum 6 mg/dlL.
sign+, Chovsteks Signt, Biochemical investigatinany+,
ations
a. What are the components which are present in total
b. Name the factors involved in calcium level?
c. Write rich
regulation of serum
calcium level. (1)
sources of calcium in the diet.
8.What are tumor markers? Name (3)
four tumor markers
by them. and the cancer (1)
diagnosed
III. Brief Answer
Questions: (2+3)
9. Inhibitors of protein
synthesis (10 x2 20)
10. What is the
mode of action of the
Gout? drug allopurinol & probenecid in
11. Mention the treating
12. Enumerate theapplication of molecular cloning in
factors that regulate water
and
medicine.
body. electrolyte balance in human
13.
Explain the acid base disturbance
Describe the that is seen
in uncontrolled diabetes
14. The following compensatory
are some
mechanisms that operate in the above mellitus.
Serum Bilirubin of the biochemical condition.
:10 mg% findings in a
ALT: 90 IU/L
AST :80 IUL Conjugated: 8.5 mg% patient.
Urine Bile pigments:++ ALP :40 KA
Bile salts:
Unconjugated: 1.5mg%
1.5mg°%
Feces
What is your ++Urobilinogen:
Stercobilinogen: - (clay coloured) ve -ve units
Blood Coagulation
5. Name the probable diagnosis? time: Prolonged.
a) Molybdenum of Explain.
metalloenzyme each of the
5. b) Manganese following element.
Antioxidants Definition -

and
c) Selenium d) Magnesium
Write the lab classification
Enumerate thefindings of with examples.
primary
principle of hypothyroidism.
this technique. chromatography? Mention clinical
applications or
****
 SI.No. M2340
Course Code :161021 TO6
VINAYAKA MISSION'S M.
RESEARCH FoUNDATION, D
(Deemed to be University)
MBBS DEGREE EXAMINATION - June 2021
First Year

BOICHEMISTRY- PAPER II

Time Three hours Maximum : 80 marks

Answer ALL Questions

Answer Section A in the Answer Sheet attached to it 15 marks - 15 minutes to be

nanded Over to the invigilator immediately after 15 minutes

Answer Section B in the same answer book

Time: 2 hours 45 minutes Maximum : 65 marks

SECTION- B
(2 x 15 = 30)
I. Write essays on:

1. List the parameters used in clinical practice to assess the liver function in

humans. Explain the different types of jaundice. How do you investigate

a case of jaundice ? (4+5+6)
2. Describe the metabolism of phenylalanine and tyrosine Write briefly on
the inborn errors of metabolism associated with it. (8+7)

II. Short notes on: (5 x5 25)

3. Absorption, storage and transport of iron.
4. DNA repair mechanisms.
5. Tumour markers.
6. Renal regulation of blood PH.
7. Recombinant DNA technology.
II. Answer briefly on :
(5 x 2 10)
8. Spliceosome.
9. Mechanism of action of steroid
hormones.
10. Lesch- Nyhan
syndrome.
11. Acute phase proteins in blood.
12. Silent mutation.
****
 SI.No. M2346
Course Code: 10119103- II

RESEARCH FOUNDATION, SALEM.

VINAYAKA MISSION'S

(Deemed to be University)
EXAMINATION -
June 2021
FIRST MBBS DEGREE
BIOCHEMISTRY - PAPERII

Maximum: 100 marks

Time Thrcehours
Answer ALL Questions
attached for 20 marks
Answer Section A in the Ans wer Sheet
immediately Section A
After 20 minutes to be handed over to the invigilator
Answer all the question of Section B in
the main answer book provided

Time: 2 hours 40 minutes SECTION-B Maximum: 80 marks

I. Long Answer Questions (LAQ): (2x 15= 30)

1. An obese lady who had undergone thyroidectomy six months before, reported to
the medical OP with complaints of eramps and spasm of both hands. She had
positive Trosseau's and Chovstek's signs. Her laboratory reports are given
below"
Serum Calcium -4.6 mg%
Serum Phosphate-5.6 mg%
Serum Albumin -4.2 gms%
Serum AIkaline Phosphatase 62 IU/
-

a. Comment on this laboratory results of this case & write the normal levels
of the parameters. (1+2)
b. Give the sources, daily requirement, absorption and functions of calcium
(1+1+1+2)
c. Explain the factors regulating the serum calcium levels (4)
d. Name the disorder that occurs due to the deficiency of calcium& add a brief
on the clinical features of this disorder (1+2)
2. a. Name the plasma proteins and give their normal values.
(2)
b. Name the 2 methods by which you can separate them in the
laboratory (1)
c. Draw the
electrophoretic pattern of normal serum protein electrophoresis (2)
d. Give a detailed account of the functions and clinical significance of albumin
&acute phase proteins (6+4)

(p.t.o)
 -(2)

Questions (SAQ):
Answer
1. Short 6x5 30)
in amino acid transnort
role of glhtathione
33Fxplam Fxplain the
f the formatio1 of specialized products
ot the formation
4 Give an account
of products from
specalized
linical importance.
glycine and their
NamC the vectors used in gene theran
What is Gene therapy' at are th
of gene therapy?
indications & complications
6 What are buffers? Explain the action of diferent blood buffers
in
(1+2+1 1)
blood p" regulation of
7 old was admitted to the medical ward after (2+3)
A 14 vcar girl she
yellowish discolouration of the cye, marked loss of appetite, low
eloped
grade fever
(100 101°F) ausea and occasional vomiting in the last one week. She had
pain
in the right hypochondrium and the urine was highly coloured. She looked noin
and malnourished also. Serum LhTS were done and eak
Total Bilirubin
following were the results
- 8 mg/dl, Direct Bilirubin- 4.8 mg/dl, Serum
Serum ALT- 1210 1UI, Serum ALP - 20 KAU/dl. AST-980 U
a. What is the probable diagnosis? And
justify your answer.
b. What are the common cases of this condition? (11)
c. List out the lab findings in this condition &
add a note on Van (1)
reaction. denBergh
8. Define tumor markers. Enlist the tumour
markers (2-1)
which their levels are increased. along with the tumors in
(1+4)
I1.. Brief Answer Questions (BAQ):
9. Write a brief note on about Meister
(10 x2 20)
acids. cycle, used in the absorption of amino
10.What is a nucleotide? Name
any two
their functions. biologically important nucleotides and
11.Explain non sense mutation and frame shift mutation.
12. What is the normal serum
sodium level? Mention
hyponatremia and their mechanism. any two causes of
13. Name the
and storage
dietary factors promoting iron
4. When a
forms of iron? absorption. What are the transport
person develops
back to normal
level? hypocalcaemia,
how does his body
try to bring it
5.Calculate the creatinine
a) Serum creatinine: 0.8 clearance in a person with following
b) Urine mg/dl Urinary creatinine: I paramete
c)
output in 24 hours:
Calculate the 240 ml. mg/dl.
16. Define
the term Creatinine clearance and
"Deto
Detoxification. Give anyinterpret your
conjugation reactions.
17.Name four examplesresults.
of detoxificationby
any four
involved
18. What is in
diseases related to free
radical injury. Name the enzyme:
the reperfusion
injury.
this method. principle of
colorimetry ne 2 sured
analytes that are by

(aLNa 1246k
SINo. M23 39
VINAY ARA Course Code :16102 T05
MISSION'
ISstON'sS RESEARCH
RESEARCH DATION, SALEM.
(Deemed to be FOUNDATION,
FOUN SALEM.
University)
-
MBRS DEGREE
ENAD
AMINATION July 2021
First Yenr 202
ime Threc hours BIOCHEMISTRY -PAPERI
Maximum 80 marks

ier Answer ALL Questions

Section A in the
heet attached
Answer Sheet - 15 minutes to be
attached to it nat
to t 15D marks
anded over to the invigilator immediately after 15 minutes
Answer Section B in the same answer book
Time :2 hours 45
minutes SECTION - B Maximum:65 marks
I. Write essays on: (2 x 15 30)
.Name the ketone bodies? How are
they formed and utilized in the body?
Add a note on diabetic ketoacidosis.
2. Describe the components and reactions of electron
(1+8+6)
transport chain add a
note on chemiosmotic
theory and inhibitors of ETC. 8+5+2)
II. Short notes on:
5 x5 25)
3. Compare and contrast oxygen dissociation curve of
hemoglobin and
myoglobin.
4. Reverse cholesterol
transport.
5. Enzyme inhibition.
6. Glycated haemoglobin.
7. Active form and metabolic function of
Vitamin D.
III. Answer briefly on: (5 x 2 1
8. Rapaport leubering shunt.
9. Liposomes.
10. Von gierke's disease.
11.Marker enzymes cell organelles.
12. Wilson's disease.
%****