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WEEK 10: BASIC CONCEPT OF COMMUNICABLE DISEASES

TERMINOLOGIES INFECTION: invasion of body tissue by microorganism & their proliferation (main sx: Fever)

CARRIER: person who without apparent sx of disease, harbors and spread specific microorganism

CONTACT: any person or animal known to have been in such association with an infected person/ animal
exposed to infection

COMMUNICABLE PERIOD: etiologic agent may be transferred directly or indirectly from the body of the
infected person to the body of another person

STERILIZATION: destruction of pathogens even the spores

CONTAMINATION: invasion of surface (wound) or article (handkerchief) or matter (water & milk) implies the
presence of undesirable substance which may contain pathogenic microorganism
DISINFECTION: destruction of vitality of pathogens microorganism by chemical or physical means directly
applied
➔ COCURRENT DISINFECTION: ongoing practices that are observed in the care of the client, his supplies,
environment and control microorganism
➔ TERMINAL DISINFECTION: practices to remove pathogens from the client’s belongings and
environment after his illness is no longer communicable.
DISINFECTANT: substance for inanimate objects that destroys pathogens and not spores
ANTISEPTIC: substance intended for persons that inhibit the growth of pathogens but not necessarily destroy
them
BACTERICIDAL: chemical that kills microorganisms
BACTERIOSTATIC: chemical that prevent multiplication but does not kill all forms of microbes
ASEPSIS: absence of disease-producing microorganism; free from infection
➔ MEDICAL ASEPSIS (clean technique): reduced the number and transfer of mo; ex: Handwashing
➔ SURGICAL ASEPSIS (sterile technique): render and keep objects & areas free from pathogens; ex:
handscrubbing
SEPSIS: presence of infection

ETIOLOGY: study of causes

VIRULENCE: vigor with which the organism can grow & multiply; degree or intensity of disease produced

NOSOCOMIAL INFECTION: infections assoc. with the delivery of health care services in a health care facility

OPPORTUNISTIC PATHOGEN: causes disease in a susceptible person

RESIDENT FLORA: mo that are always present in specific areas of body; normally lives on a person’s skin

TRANSIENT FLORA: mo picked up by the skin as a normal activities that can be removed easily.

PATHOGENS: disease producing mo

PATHOGENICITY: ability to produce a disease; the ability of microbes to overcome the defensive powers of host
to induce disease

QUARANTINE: limitation of freedom of movement of such susceptible persons/ animals as have been exposed to
communicable diseases

COLONIZATION: a process by which strains of mo become resident flora, but their presence does not cause
disease

FUMIGATION: any process by which destruction of insects, felas, bugs, etc. and is accomplished by the
employment of gaseous agents

ISOLATION: the separation for the period of communicability of infected persons.

Disease control: reduction of disease incidence, prevalence, morbidity or mortality to a locally acceptable level
as a result of deliberate efforts and continued intervention measures to maintain the reduction

Disease surveillance: ongoing systematic collection, analysis, interpretation, and dissemination of outcome-
specific data for use in the planning, implementation, and evaluation of public health practice
➔ A disease surveillance system includes the functional capacity for data analysis, timely dissemination
of these data to persons who can undertake effective prevention and control activities
Mandatory reporting: obligatory reporting of a condition to local or state health authorities, as required for
notifiable diseases, epidemics or public health events of public health concern

Notifiable disease: disease that, by legal requirements, must be reported to the public health authorities

Public health authority: DOH (specifically the Epidemiology Bureau, Disease Prevention and Control Bureau,
Bureau of Quarantine and International Health Surveillance, Health Emergency Management Bureau, Food and
Drug Administration, government hospitals. Research Institute of Tropical Medicine and other National Reference
Laboratories, and DOH Regional Offices), the local health office (provincial, city or municipality), or any person
directly authorized to act on behalf of the DOH or the local health office;

COMMUNICABLE - An illness due to a specific infectious agent or its toxic products that arises
DISEASE - transmission of that agent directly or indirectly to well person or its products from an infected person,
animal (vector) or inanimate reservoir (e.g. from a food source or contaminated water) to a susceptible
host
- Endogenous or Exogenous
2 TYPES
Contagious disease Infectious disease
- spread by direct contact w/ infectious agents - not only by ordinary contact
causing the disease - requires direct inoculation of organism through
- easily transmitted from 1 person to another a break on the skin or mucous membrane.
through direct or indirect means
CLASSIFICATIONS OF BASED ON OCCURRENCE
DISEASE SPORADIC ENDEMIC EPIDEMIC PANDEMIC
- Intermittent - Continuous - Occurrence is of - Epidemic disease
occurrence of few occurrence - unusually large # that occurs
isolated unrelated throughout a period of of cases in a worldwide
time, of usual number
cases in given relatively short - Simultaneous
of cases in a given
locality locality period of time occurrence of
- Disease occurs - Constantly present in epidemic of same
occasionally population, disease in several
irregularly, no community or country. countries
specific pattern
STD’s, diarrheal diseases, dengue fever, HIV-AIDS, MERS-COV,
Cancers, degenerative PTB, Influenza, different leptospirosis, mumps, SARS
types of pneumonia,,
diseases chicken pox, measles
Schistosomiasis, Malaria,
Filariasis

BASED ON SEVERITY/ DURATION


Acute Disease Chronic disease Sub-acute Disease Latent Disease
- Develops rapidly - Develops more - Intermediate - Causative agent remains
(rapid onset) but slowly but lasts between acute inactive for a time but then
lasts only a short for a long period and chronic becomes active to produce
time - Develops rapidly symptoms of the disease
and has long - an infection held in check by
duration the defensive forces of the
body but activated when
the body resistance is
reduced
Measles, Mumps, TB, Leprosy Bacterial endocarditis
Influenza Chicken pox- Shingles ZosteR

TYPES OF INFECTION RECURRENT REINFECTION SUPERINFECTION AUTOINFECTION


- REAPPEARANCE - after an initial infectious - During the - The infected
OF SYMPTOMS agent has been illness, person is his own
- after infectious eliminated, a NEW additional direct source of
disease has been infection occurs caused by infection occurs re-exposure
treated or - same organism or by by another
subsided another strain of same infectious agent Encephalitis
- renewed species
presence of same
infectious agent covid -19 reinfection of
different strands, influenza
PATTERN OF INFECTION INCUBATION PERIOD PRODROMAL PERIOD ILLNESS PERIOD CONVALSCENT PERIOD
(COURSE OF INFECTION - extends from entry - Extends from the - host experiences - manifestations
PROCESS) of microorganism onset of maximum impact subside
to body nonspecific signs of infectious - S/S start to abate
- to onset of and symptoms to process until the client
nonspecific s/s the appearance of - Specific signs and returns to normal
Body malaise, specific signs and symptoms develop state of health
headache, fever and become
symptoms
evident For outpatient care
Koplik spots in measles
CHAIN OF INFECTION 1. CAUSATIVE AGENT: 2. RESERVOIR 3. PORTAL OF EXIT
Infectious agent - principal habitat in which a pathogen lives, enables a pathogen to
MO THAT PRODUCES DISEASES flourishes and is able to multiply. - infectious leave the reservoir or
- Virus agents: humans, animals or insects, host
- Bacteria environment, inanimate objects (gloves,
- Fungus handkerchief, tissue) RESPI, GUT, GIT, SKIN &
- Parasite MUCOUS MEM.
- Protozoa 2 forms in humans Key portals of exit
1) Acute clinical cases - someone is infected and Alimentary: vomiting,
Three factors is displaying s/s of dse - more likely to be
A. pathogenicity: ability to diagnosed and treated which means that the Diarrhea or biting
produce disease patient's contacts and normal activities will
B. Degree of virulence: normally be restricted Genitourinary: sexual
severity or harmfulness transmission
C. its invasiveness: 2) Carriers - where someone has been colonized
tendency to spread. with an infectious agent but is not unwell; can Respiratory - through
present more of a risk to those around them coughing,
because they do not display any signs or
symptoms of illness Sneezing and talking
4 main types
1) Incubatory carriers - people who are Skin - via skin lesions;
infectious even before their own symptoms start
trans-placental - where
2) Inapparent carriers: able to transmit an transmission is from
infection to others, without ever developing the mother to fetus
infection themselves

3) Convalescent carriers - in the recovery phase


of their illness but who continue to be infectious

4) Chronic carriers - has recovered but who


continues to be a carrier for infection
4. MODE OF TRANSMISSION 5. PORTAL OF ENTRY SUSCEPTIBLE HOST
A. CONTACT - usually this path is as the same as - Final and most
B. AIRBORNE port of exit important link in
C. VEHICLE-BORNE chain of infection
D. VECTOR- BORNE - means by which an infection is - their age - and in
E. TRANSPLACENTAL: AIDS, chicken able to enter a susceptible host particular if they are
pox, german measles very young or very
- inhalation (via the respiratory old
2 main ways tract)
direct transmission: - absorption (via mucous 1) whether there is any
- instantaneous; direct contact membranes such as the eyes) presence of malnutrition
with the infectious agent. - ingestion (via the GI Tract)
or dehydration
Ex: tetanus, glandular fever, - inoculation (as the result of an
respiratory diseases and sexually inoculation injury)
transmitted diseases. - introduction (via the insertion of 2) whether there is any
medical devices) underlying chronic
Indirect transmission disease if the host suffers
- through animate mechanisms from immobility
such as fleas, ticks, flies or
mosquitoes or via inanimate 3) if they are taking any
mechanisms such as food, water, medication which could
biological products or surgical disrupt or suppress their
instruments - can also be immune response
airborne, in which tiny particles
of an infectious agent are carried
4) if they received
by dust or droplets in the air and
immunization
inhaled into the lungs
ANIBIOTIC

SENSITIVE: INTERMEDIATE: RESISTANT:


Organism is inhibited by the Org. are inhi CONTROL Bacteria is on the way to be
serum concentration of the drug MEASURES IN THE SPREAD OF resistant; org are resistant to the
that is achieved using usual INFECTION usually achievable serum drug.
dosage. bited only by the maximum
recommended dosage
CONTROL MEASURES Universal / standard precaution
IN THE SPREAD OF - Avoiding contact with the patient’s bodily fluids
INFECTION ➔ wearing gloves
➔ goggles
➔ face mask
➔ gown
➔ shoe cover.
- Medical instruments should be handled carefully and disposed properly in a sharps container
- Proper handwashing
- Considering all patients are infectious
- Standard precaution go beyond universal precaution regardless of diagnosis
- All personnel protective equipment shall be removed immediately upon leaving the work area.
➔ Used needles and other sharps shall not be sheared, bent, broken, recapped by hand.
- Eating, drinking, smoking, applying cosmetics and handling contact lenses are prohibited
where there is potential occupational exposure.
➔ Food and drinks shall not be stored in refrigerators or cabinets where blood and other
potentially infectious materials are stored.
- All procedures involving blood shall be performed in such a manner as to minimize splashing
HISTORY CENTER FOR DISEASE CONTROL AND PREVENTION
- Est. Jul 1, 1946 (Atlanta, Georgia US)
- Continued to advocate for public health issues & to push for CDC to extend its responsibilities to other
communicable diseases.
- Joseph Mountin: Founder
Edward Anthony Jenner: father of immunology
- producing the very 1st successful vaccine to prevent smallpox; founder of vaccinology in the West in 1796.
CONCEPT OF IMMUNOLOGY
TERMINOLOGIES IMMUNITY: Body’s specific protective response to an invading foreign agent or organism

Immunology- a ➔ NATURAL/INNATE IMMUNITY (Nonspecific): Anatomic and Physiologic Barrier; WBC; Inflammation
division of biology o non-specific response to any foreign invader, regardless of the invader’s composition
concerned with the ANATOMIC AND PHYSIOLOGIC DEFENSES
study of living 1.Intact skin and mucous membranes 6. Eyes:
organisms’ - Body’s first line of defense against - Protected from infection by TEARS which
exemption from microorganism continually wash microorganisms away
harmful agents - Has normal secretions (sweat) that make 7.Gastrointestinal Tract:
skin slightly acidic: Acidity inhibits bacterial - High acidity of the stomach: Normally
Susceptibility: growth prevents bacterial growth
reverse of immunity 2.Resident bacteria: - Resident flora of the large intestines:
and the result of the - Prevent other bacteria from multiplying and prevents the establishment of disease
suppression of use up available nourishment
factors that producing microorganism
3. Nasal Passages:
produces immunity 8. Vagina:
- Moist mucous membrane and cilia traps
- When girl reaches puberty, LACTOBACILLI
microorganism, dusts, foreign materials
Centers for Disease 4.Lungs: ferment sugars in the vaginal secretions
Control and - Have alveolar macrophages (large creating a vaginal pH of 3.5-4.5
Prevention July 1, phagocytes) which are cells that are - This low pH inhibits the growth of many
1946 in Atlanta, responsible to ingest microorganisms and disease-producing microorganisms
Georgia, United foreign particles. 9.Urethra:
States with CDC 5.Oral Cavity: - Urine: Flushing and bacteriostatic action
- Founder Dr. - Sheds mucosal epithelium to rid the mouth keeps bacteria from ascending
Joseph Mounti of colonizers
n - flow of saliva and it’s partially buffering
- continued to action help prevent infection
advocate for
public health
issues and to WBC: Participates both on the natural and acquired immune response
push for CDC to Granulocytes (Granular leukocytes) Agranulocytes
extend its A.Neutrophiles “Polymorphonuclear cells A.Monocytes (Macrophages)
responsibilities (PMN)” - phagocytic cells engulfing, ingesting,
to other - first cells to arrive at the site of inflammation and destroying greater numbers and
communicable quantities of foreign bodies or toxins
- Increased in ACUTE bacterial infection
diseases.
- publishes and B.Lymphocytes:
B.Eosinophiles
frequently - Consisting of B-cells and T-cells that play
- Increased during allergic and parasitic
updates major role in Humoral and Cell-
infections
guidelines on Mediated immune response
caring for
C.Basophiles
patients who - Increased in CHRONIC bacterial and
- Not usually affected by infection
require viral infections
isolation.

INFLAMMATORY RESPONSE
- Inflammation
- Is a local and nonspecific defensive FIVE CHARACTERISTIC SIGNS:
response of tissues to an injurious or Pain (Dolor)
infectious agent Swelling (Tumor)
- It is an adaptive mechanism that: Redness (Rubor)
- Destroys or dilutes the injurious agent Heat (Calor)
- Prevents further spread of injury Impaired function of the part
- Promotes the repair of damaged tissue
➔ ACQUIRED IMMUNITY (Specific):
o Specific immunity develops after birth
o Acquired during life but not present at birth
o Occurs after exposure to an antigen like infectious agent
ACTIVE PASSIVE
- host produces its own antibodies in - Antibodies are produced by another
response to natural antigen source, animal or human.
- Immediate protection
ACTIVE NATURAL
- Recovery from a disease (mumps, PASSIVE NATURAL: 6 mos- 1 year protection
measles, chicken pox) - Transplacental transfer of antibodies
- Lifetime protection - Breastfeeding-colostrum
- Antibodies are formed in the presence - Transfer of IgA “gAtas, lAway, luhA”
of active infection (disease) in the body

ACTIVE ARTIFICIAL PASSIVE ARTIFICIAL: 2-3 weeks protection


- Antigens (vaccines or toxoids) are - Immune serum (antibody) from an
usually administered to the person to animal or another human is injected
stimulate antibody production - Tetanus Ig, Gamma globulin
- All kinds of immunization - Antitoxin, Antiserum Administration
- Many years but not lifelong protection
LYMPHOCYTES
Antibody-Mediated Defenses (B-Cells) “Humoral Cell-Mediated Defenses (T-cells)
(Circulating Immunity)” “Cellular Immunity”
- defenses reside ultimately in the B - occurs through the T-cell system
lymphocytes and are mediated by - On exposure to antigen, the lymphoid
antibodies produced by B cells tissues release large numbers of activated T-
- Defend primarily against the extracellular cells into the lymph system. These T-cells
phases of bacterial and viral infections pass into general circulation
- When Cell-Mediated Immunity is lost
B CELLS: ultimately responsible for the (CD4), as occurs with HIV infection, an
production of antibodies (immunoglobulins) and individual is “defenseless” against most
for Humoral Immunity viral, bacterial and fungal infection
Classes of Immunoglobulin
(Antibody-Mediated Immune Response) Major Group of Tcells
Ig - most abundant immunoglobulin in (Cell Mediated Immune Response)
serum (80% of the total serum
cytotoxic T cell
immunoglobulins) (TC, cytotoxic T lymphocyte, CTL, T-killer
G - Relatively abundant extravascularly cell, cytolytic T cell, CD8+ T-cell or killer T
(interstitial fluid) cell)
- Crosses placenta (natural passive - T lymphocyte (a type of white
immunity of newborn because it blood cell) that kills cancer cells
crosses placental barrier) - cells that are infected particularly
- Assumes major roles in blood- with viruses.
borne and tissue infections T helper cells (Th cells), CD4 cells
- Enhances pha(G)ocytosis - role in adaptive immune system.
- chief Ig in external secretions like - help the activity of other immune
breastmilk, saliva, tears, and cells by releasing T cell cytokines
mucus of the bronchial, (help suppress or regulate
A genitourinary and digestive tracts immune responses)
- major role in secretory immune suppressor T cell
response - blocks the actions of some other
- protective function on mucosal types of lymphocytes, to keep the
immune system from becoming
surfaces exposed to environment
over-active.
transported across mucous
Memory T cells
membrane with secretions
- subset of infection- and cancer-
- largest (Malaki)of the fighting T cells (also known as
immunoglobulins and appears a T lymphocyte) that have
mostly in the intravascular serum previously encountered &
M - rapid protection because it is the responded to their cognate
first antibody noted after antigen antigen
injection in an adult (1stIg class - first proliferated to fight the
produced in primary response to infection.
bacterial & viral infections) - Location: lymphoid organs and
- First Ig to be synthesized by the spleen
neonate
- Mediates the immediate
hypers(E)nsitivity reactions that are
E responsible for the symptoms of
hay fever, asthma and anaphylactic
shock
- Takes part in allergic; combats
parasitic infections.
- located on the surface of B
lymphocytes
D - surface receptors-reaction with
antigen influences lymphocyte
activity
- small amount in serum; biologic
function UNKNOWN.
IMMUNIZATION – IMMUNIZATION
EPI & Updates - vaccines are introduced into the body before the infection sets in.
- promotes health and protects children from disease-causing agents.
VACCINES
- causative agent of a disease so modified as to - These are always antigens, therefore they
be incapable of producing the disease yet at the always induce active immunity when
same time so little changed that it is able, when administered thereby causing the recipient’s
introduced into the body, to elicit production of immune system to react to the vaccine that
specific antibodies against the disease. produces antibodies to fight infection, and are
most useful in the prevention of disease
Expanded Program In cooperation with the World Health Organization (WHO) and UNICEF
on Immunization - to ensure that infants/children and mothers have access to routinely recommended infant/childhood
(EPI) vaccines.
JUL 1976: launched - Vaccination among infants and newborns (0-12 months) against seven vaccine-preventable diseases:
by DOH ➔ Tuberculosis
➔ Poliomyelitis
➔ Diphtheria
➔ Tetanus
➔ Pertussis
➔ Hepatitis
➔ measles.
- Presidential decree No. 996 (September 16, 1976).
➔ “Providing for compulsory basic immunization for infants and children below eight years of age.”
MANDATES
RA No. 10152 “Mandatory Infants and Children EPI Routine Schedule of Immunization:
Health Immunization Act of 2011” - Wednesday: designated immunization day in all
- Signed by President Benigno Aquino III parts of the country.
- July 26, 2010. - Monthly: in a Barangay Health Station (BHS) –
- basic immunization for children under 5 - Quarterly: in far flung areas
including other types that will be determined by
the Secretary of Health.
UPDATES
2012 - Rotavirus and Pneumococcal vaccines 2016 - the Expanded Program on Immunization had a
were introduced in the EPI. transition to become the National Immunization
➔ Immunization will be prioritized among Program (NIP).
the infants of families listed in the ➔ immunizations of other populations such as
National Housing and Targeting System senior citizen immunization, school-age
(NHTS) for Poverty Reduction immunization, and adolescent immunizations.
nationwide.
2018 - there are a total of 13 recommended
2014 - Pneumococcal Conjugate Vaccine 13 vaccinations on the updated childhood immunization
➔ was included in the routine schedule
immunization of EPI ➔ for Filipino children, ages 0 to 18 years old.
➔ It's one less vaccine compared to last year's —
the dengue vaccine was removed
CHILDHOOD
IMMUNIZATION
(2018) SCHED
BCG: 0-2 mons (up
to 6 mons)

The following vaccines are in the 2018 NIP: Recommended Vaccines


- BCG, monovalent Hep B - These are vaccines not included in the NIP
- Pentavalent vaccine (DTwP-Hib-HepB) - Recommended by the Philippines Pediatric Society
- bivalent OPV (PPS), Pediatric Infectious Disease Society of the
- IPV Philippines (PIDSP) and the Philippine Foundation
- PCV for Vaccination (PFV).
- MMR
- MR
- Td
- HPV
VACCINES BCG: Baciilus At birth (w/in 1st 2 mons of 1 Protects from possibility of TB
- Age Calmette life) meningitis & other TB
- Number of Guerin infections
doses Can still be given up to 6mons
- Minimum At birth (NB > 2kgs w/in 24 1 Early start reduces the chance
interval bet. HBV hrs of life) of being infected and becoming
Doses carrier of hepa B
- Reason
Prevents liver cirrhosis & cancer

DTwP-HIB- 6 wks 3 4 wks/ 1 Against Diphteria, Pertussis,


HepB/ month Tetanus, Hepa B, Haemophilus
PENTAVALENT (6, 10. 14) Influenza Type B

IPV/ OPV 6 wks 3 4 wks/ 1 Against Polio


month
(6, 10, 14)
PCV 6 wks 3 4 wks/ 1 Against Pneumonia
month
(6, 10, 14)
ROTAVIRUS 6 wks 2 4 wks/ 1 Against Diarrhea
month
(2nd dose not
later than 32
wks)
INFLUENZA 6 mons 2 4 weeks Against flu viruses.
/1month

MCV1 9 months 1 Prevents death, malnutrition,


MEASLES (but may be given as early and protection from measles
as 6 months of age in cases
of outbreaks as declared
by public health
authorities)

JAPANESE 9 months 2 12-24 months Against Japanese Encephalitis


ENCEPHALITIS *(18yo & virus.
above -1
dose)
MCV2 (MMR) 12 months 2 4 weeks Aagainst measles, mumps, and
MEASLES- /1month rubella virus.
MUMPS-
RUBELLA
Varicella 12 months 2 3 months Against chicken pox.
Vaccine (for children
13yo & above
– 4wks.)

Hepatitis A 12 months 2 6 mons Against Hepatitis A virus.


Vaccine (HAV)

Human 9 yo 9-14 yo: 2 >6months Prevent most genital warts and


Papilloma 15 & up: 3 >0, 2, & most cases of cervical cancer.
virus (HPV) 6months
Vaccine

Meningococcal 9 mons – baby 2 >8 weeks Against meningococcemia.


conjugated 11-12 yo >booster @
vaccine 16yo

Tetanus Toxoid
Immunization
Schedule for
Women

ADMINISTRATION

CHARACTERISTICS
COLD CHAIN AND - Temperature monitoring of vaccines is done in all Vaccine can be stored in Refrigerator
LOGISTICS levels of health facilities to monitor vaccine - Regional – 6 months
Public Health Nurse temperature. - Municipal / City – 3 months
(Cold Chain - Temperature checking is done twice a day early - Main Health Center – 1 month
Manager) in the morning and in the afternoon before going
home. Transport Box: 5 days
- Temperature is plotted every day in monitoring - FEFO (First expiry and first out) vaccine is
chart to monitor break in cold chain. practiced to ensure that all vaccines are utilized
before its expiry date.
Vaccine Wastage - Proper arrangement of vaccines and labelling of
- Wastage is defined as loss by use, decay, erosion vaccines expiry date are done to identify those
or leakage or through wastefulness near to expire vaccines

GENERAL - It is safe and immunologically effective to - Do not give more than one dose of the same
PRINCIPLES administer all EPI vaccines on the same day at vaccine to a child in one session. Give doses of
IN VACCINATION different sites of the body. the same vaccine at the correct intervals.
- The vaccination schedule should not be - Strictly follow the principle of never, ever
restarted from the beginning even if the interval reconstituting the freeze dried vaccine in
between doses exceeded the recommended anything other than the diluent supplied with
interval by months or year. them.
- Giving doses of a vaccine at less than the - If you are giving more than one vaccine, do not
recommended 4 weeks interval may lessen the use the same syringe/needle and do not use the
antibody response. Lengthening the interval same arm or leg for more than one injection.
between doses of vaccines leads to higher - Repeat BCG vaccination if the child does not
antibody levels. develop a scar after the first injection.
- No extra doses must be given to children who - It is safe and effective with mild side effects after
missed a dose of DPT/HB/OPV. The vaccination vaccination. Local reaction, fever, and systematic
must be continued as if no time had elapsed symptoms can result as part of the normal
between doses. immune response.

CONTRAINDICATION - Anaphylaxis or severe hypersensitivity reaction - Do not give live vaccines like BCG to a individuals
TO IMMUNIZATION to a previous dose of vaccine is an absolute who are immunosuppressed due to malignant
contraindication to subsequent doses of vaccine disease (child with AIDS), going therapy with
immunosuppressive agents or radiation.
- Person with a known allergy to a vaccine
component should not be vaccinated. - A child with a sign and symptoms of severe
dehydration
- DPT2 or DPT3 is not given to a child who has
convulsions or shock within 3 days after DPT1. - Fever of 38.5 C and above
Vaccines containing the whole cell pertussis
component should not be given to a children with
an evolving neurological disease (uncontrolled
epilepsy or progressive encephalopathy).

NOT - Allergy or asthma (except if there is a known - Chronic illness such as diseases of heart, lung,
contraindication. allergy to a specific component of vaccine kidney or liver
Infants with these mentioned above) - Stable neurological condition such as cerebral
conditions SHOULD - Minor respiratory tract infection palsy or Down’s Syndrome
be immunized - Diarrhea / vomiting - Premature or low birthweight (vaccination
- Temp. below 38.5 C / low grade fever should not be postponed)
- Family history of adverse reaction following - Recent or imminent surgery
immunization - Malnutrition:
- Family history of convulsions/seizures - History of jaundice at birth
- Known or suspected HIV infection with no signs
and symptoms of AIDS >> Generally, one should be immunized unless the
- Child being breastfed child is so sick that he needs to be hospitalized.
-
>> Note: If parent strongly objects to an
immunization for a sick infant, do not give it. Ask the
mother to comeback when child is well.

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