Active

ingredients

TAZMAN PEPPER™
TAZMAN PEPPER™ AF
To Protect And Calm
Reactive Skin
Direct action on skin discomfort
sensor TRPV1
-
Immediate soothing action on
itching & burning sensations
-
Reduces the appearance
of skin redness
By inhibiting trpvi channel, Tazman Pepper™, decreases
inflammatory markers. It reduces instantly itching and burning
sensations and reduces the appearance of skin redness.

Men should not underestimate the countless harmful factors affecting their skin: shaving,
sweat, UV, pollution, allergens, etc. All these stressful elements provoke the epidermis to
overdrive and leave it no choice but to react! Skin reactivity is a complex inflammatory
process occurring as a result of long-term exposition to external aggressions. Thus,
men need specific and efficient daily skin care protection adapted to their lifestyle to
prevent and reduce skin reactivity.

Tazman Pepper™ is a natural Australian active ingredient extracted from the Tasmanian
pepper berry, specially designed for sensitive skin to protect and reduce skin sensibility
for better skin comfort.

BUSH WARRIOR SPECIES OF THE COLD

MOUNTAINS OF TASMANIA
Origin of Tasmanian pepper berry
The Tasmanian pepper (Tasmannia lanceolata) thrives in the mountains of the South
eastern lands of Australia. It is a hardy species, tolerating cold winter temperature and
surviving on rocky and exposed windy sites. It produces small, round, purple-black
berries floral in aroma. When dried, the berries resemble to black pepper grains in size
and color. It is also called alpine pepper and mountain pepper.

Traditional usage
Australian Aboriginal people were incredibly clever gatherers. Based on thousands of
years of experiences in harsh environments and knowledge passed through generations,
they knew how to exploit the properties of the plants. Early European explorers of the
continent described the diet of the Aborigines to be at least as healthy as in a modern
society. The pepper berry was called ‘Mourao’ by them.

The Tasmanian pepper berries taste slightly sweet in the first second only, followed by
spicy flavor. The biological activity of Tasmanian pepper berry was already exploited by
the Aborigines many centuries ago. It is considered a traditional food in Australia by the
Food Standards Australia New Zealand and is listed in the CODEX.

Composition
The Tasmanian pepper berry contains a powerful active ingredient called polygodial. It
is an anti-inflammatory agent effective to reduce vasodilatation and oedema. Studies
have demonstrated that polygodial calms skin discomforts. It has anti-allergic and
broad antimicrobial activities.

The berry also contains anthocyanins which are free radical scavengers that protect
cells from oxidative damage. The fruit extract has shown to have an antioxidant
power 3X greater than blueberries (TEAC). It also contains rutin, an anti-inflammatory
mediator known to strengthen capillaries. It will have a great impact on reducing the
appearance of dark circles.
THE BURDEN OF LIVING WITH A SENSITIVE SKIN...

During winter time, my skin As a teenager, I remember the first

become even more sensitive. skincare creams that I used: my
My skin itches & turns red. I am skin reddened & tugging... My skin
barely able to shave everyday. could not stand anything!

Sebastian Stephanie

Sensitive skin is vulnerable to external aggressions such as heat and chemical irritants making it more prone to react, causing skin
redness, itching and burning sensations which are manifestations of inflamed skin. The activation of skin discomfort sensor TRPV1
channel, expressed on sensory neurons and keratinocytes, plays an essential role in the initiation and the perpetuation of skin
inflammation.

Heat Sun
Irritants Tazman Pepper™

Skin redness

Epidermis

Keratinocytes

Inflammation IL-8
IL-8
PGE2
Activation Inhibition
TRPV1 PGE2 TRPV1

Fibroblasts IL-1a
Dermis Ca2+ Ca2+ Ca2+
IL-1a

Sensory
Neuron

Normal skin Inflamed skin Skin relief

By targeting TRPV1 channel, Tazman Pepper™ alleviates the skin inflammation for better skin comfort.
INHIBITION OF TRPV1 ACTIVITY
Dosage of IL-1a

Reduction of IL-1a secretion induced by TRPV1 5,0

activation

IL-1α level (pg/ug)

4,5
-115%* -108%*
Test protocol 4,0

3,5
37°C 42°C 37°C
3,0
1h 5 min 24 h Dosage Baseline Heat Heat Heat
of IL-1a (37°C) (42°C) (42°C) (42°C)
Pre-incubation of the control Activation of Incubation of the control by ELISA + +
CPZ 1µM Tazman
or Tazman Pepper™ TRPV1 channel or Tazman Pepper™ Pepper™
Control
by heat 0.05%

CPZ: Capsazepine * p<0.05

Human keratinocytes

By inhibiting TRPV1 channel, the normal level of inflammatory messenger IL-1a is

restored for better control of skin inflammation.

Reduction of PGE2 secretion induced by TRPV1 Dosage of PGE2

activation 300

250

PGE2 level (pg/ug)

200 -60%** -58%*
Test protocol
150

100
37°C 60°C 37°C
50
1h 30 min 24 h Dosage
0
of PGE2 Baseline Heat Heat Heat
Pre-incubation of the control Activation of Incubation of the control by ELISA (37°C) (60°C) (60°C) (60°C)
or Tazman Pepper™ TRPV1 channel or Tazman Pepper™ + +
by heat CPZ 1µM Tazman
Control Pepper™
0.05%

Human keratinocytes CPZ: Capsazepine * p<0.05, ** p<0.01

By controlling the release of the discomfort messenger PGE2 induced by heat it will
help to reduce the skin inflammation.

INFLAMMATION MEDIATORS
MODULATION
Dosage of il-8 induced by il-1a
The presence of inflammatory mediators play a critical role in the development of 2000
IL-8 production (pg/mL)

reactive skin. In vitro experiments were done to demonstrate the efficacy of Tazman 1900
-7%
1800
Pepper™ to reduce cutaneous inflammation. 1700
-29% -29% -34%
1600
1500
Tazman Pepper™ inhibits the release of IL-8 induced by IL-1α. 1400
1300
1200
1100
Tazman Pepper™ dims the inflammatory cascade for optimal calming effect. 1000
IL-1α IL-1α + IL-1α + IL-1α + IL-1α +
0.004 ng/mL DMS Tazman Tazman Tazman
1 µM Pepper™ Pepper™ Pepper™
Control 0.05% 0.1% 0.4%
DMS: Dexamethasone
SOOTHING ACTION
Reduction of itching sensations Effect on itching sensations

100
Test protocol 90

Itching sensations (%)

80 -47%*
- 20 healthy male volunteers with sensitive/reactive skin; 70
60 -79%*
- Application of a 2% Tazman Pepper™ cream or placebo on nasogenian groove; 50
40
- The itching sensations induced by an chemical irritant (capsaicin) were assessed right 30
after the application and up to 5 minutes later. 20
10
0
Tazman Pepper™ results in: Untreated T0 T5 min
• Immediate itching reduction; * p<0.05
• 79% decrease in itching sensations after only 5 minutes.
Placebo Tazman Pepper™

Tazman Pepper™ relieves instantly itching discomfort.

Reduction of burning sensations Effect on burning sensations

100
Test protocol

Burning sensations (%)

90
-33%*
- 20 healthy male volunteers with sensitive/reactive skin; 80
-58%*
- Application of a 2% Tazman Pepper™ cream or placebo on nasogenian groove; 70

- The burning sensations induced by an chemical irritant (capsaicin) were assessed 60

right after the application and up to 5 minutes later. 50

40
Tazman Pepper™ results in: Untreated T0 T5 min
• Fast-relief of burning sensations; * p<0.05
• 58% decrease in burning sensations after only 5 minutes.
Placebo Tazman Pepper™

Tazman Pepper™ provides a fast relief from burning sensations.

It will help reduce razor burns.

Skin redness reduction Reduction of uv-induced erythema

100
Test protocol
Decrease of erythema

95 -9% -17%*
- 20 healthy male and female volunteers older than 18 years 90
(% vs. D0)

- Erythematous induction by UV radiation (1.5 MED) 85

- Application of a cream 2% Tazman Pepper™ or placebo on arm 80
- Erythema was evaluated by colorimetric measurement 75

70
Tazman Pepper™ results in: T 30 min T 24 h

• Fast results after only one application; * p<0.05

• Reduces the appearance of skin redness up to -30% after 30 min; Placebo Tazman Pepper™
• Reduces the appearance of skin redness up to -35% after 24 h.
After
24 h
Tazman Pepper™ reduces UV induced erythema after one application.

Placebo Tazman Pepper™ 2%

Tazman Pepper™ is the best instant soothing natural

active ingredient to calm and protect sensitive skin.
 A C T I V E I N G R E D I E N T S     T A Z M A N P E P P E R ™

Features and benefits

Product
description FEATURES BENEFITS
Extracted from a hardy Perfect for marketing claims
INCI NAME TAZMAN PEPPER™ species endemic to Australia;
Glycerin (1) (and) Water (2) (and)
Alpine pepper berry
Alcohol Denat. (3) (and) Tasmannia
Lanceolata Fruit Extract (4) Target skin discomfort sensor, New mechanism of action to calm reactive and
TRPV1 channel sensitive skin
CAS TAZMAN PEPPER™
56-81-5 (1), 7732-18-5 (2), Proven effective Alleviates appearance of skin redness, the visible
64-17-5 (3), - (4) sign of inflamed skin

EINECS TAZMAN PEPPER™ Fast action Reduces instantly burning and itching sensations
200-289-5 (1), 231-791-2 (2),
200-578-6 (3), - (4)

INCI NAME TAZMAN PEPPER™ AF

Glycerin (1) (and) Water (2) (and)
Tasmannia Lanceolata Fruit/Leaf Soothing after sun gel cream 13.296.01 C139
Extract (3)
INGREDIENTS INCI NAMES %
CAS TAZMAN PEPPER™ AF
56-81-5 (1), 7732-18-5 (2), - (3) A Deionized Water Water 80.35
Chlorphenesin Chlorphenesin 0.30
EINECS TAZMAN PEPPER™ AF
Phenoxyethanol Phenoxyethanol 0.60
200-289-5 (1), 231-791-2 (2), - (3)
Dermofeel™ PA-3* Sodium Phytate (and) Water (and) Alcohol 0.10
APPEARANCE FDC Red 4 Solution 0.1% Water (and) CI 14700 0.50
Pale yellow to red-brown liquid
FDC Yellow 5 Solution 0.1% Water (and) CI 19140 1.50
FORMULATION B Lecigel™ Sodium Acrylates Copolymer (and) Lecithin 1.75
Should be incorporated at the end C Dermofeel™ BGC* Butylene Glycol Dicaprylate (and) Dicaprate 3.00
of the formulation at a temperature
below 40°C. DUB ININ Isononyl Isononanoate 4.00
Myritol 318 Caprylic (and) Capric Triglyceride 3.00
DOSAGE
1-2% Vitapherole E1000 Tocopherol (and) Helianthus Annuus 0.20
(Sunflower) Seed Oil
OPTIMUM pH D Tazman Pepper™ Glycerin (and) Water (and) Alcohol 2.00
3.5-7.5 Denat. (and) Tasmannia Lanceolata Fruit
Extract
APPLICATIONS
- Men care WildPlum Harvest™ Glycerin (and) Water (and) Alcohol 2.00
- After-shave Denat. (and) Terminalia Ferdinandiana Fruit
- Intolerant skin and sensitive skin care Extract (and) Pleiogynium Timorense Fruit
- Reactive skin care Extract (and) Podocarpus Elatus Fruit Extract
- Sun care and after-sun care Melitane™ GL 200 Glycerin (and) Water (and) Dextran (and) 0.50
- Acne-prone care
Acetyl Hexapeptide-1
- Soothing and calming care
- Dermocosmetic care E SG 38235 Fragrance 0.20

COSMOS STATUS pH: 5.0 - 6.0 - Viscosity (Rheo ELV 8, spindle 4, 6 rpm, 3 mn): 50 000 - 80 000 mPa.s
Tazman Pepper™ AF: Registered
CHINA-COMPLIANT *
*Consult us

* Distributed in France by Lucas Meyer Cosmetics.

www.lucasmeyercosmetics.com
info@lucasmeyercosmetics.com
—
This brochure is not intended for consumers and neither this brochure nor any extract thereof shall be used in order to
commercialize products to consumers. No drawing, photograph or other extract derived from this brochure shall be used by
any person without our prior written approval. As well, no claim with respect to the ingredient referred to in this brochure shall
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be made by any person without our prior written approval, even though the claim is set forth in this brochure. The person using
the ingredient referred to in this brochure in the formulation of finished products is solely responsible for ensuring that the use
made of the ingredient, the finished products marketed to consumers, their packaging, labeling and advertising materials and
the claims made with respect to the finished products and the ingredient comply with all applicable laws and regulations. We
hereby disclaim any warranty of suitability of the ingredient referred to in this brochure for any purpose. Any prospective user
of the ingredient shall himself determine the suitability of the ingredient for his intended use and, as the case may be, obtain
the required regulatory approvals for the commercialization of his finished products