DRUG NAME MECHANISM OF ACTION INDICATION/CONTRAINDICATION
RESPONSIBILITIES
GENERIC: Paracetamol Thought to produce analgesia INDICATION:
by inhibiting prostaglandin and Treat mild to moderate pain and reduction of
other substances that sensitize fever. Clinicians can use it for their patients
BRAND NAME: Amcetam pain receptors. Drug may as a single agent for mild to moderate pain
relieve fever through central and in combination with an opioid analgesic
action in the hypothalamic heat- for severe pain.
CLASS: Miscellaneous regulating center.
Analgesics CONTRAINDICATION:
Can cause acute liver failure, which may
require a liver transplant or cause death.
PHARMACOLOGIC: Contraindicated in patients hypersensitive to
Analgesics / Antipyrretics drug. IV form is contraindicated in patients
with severe hepatic impairment.
Use cautiously in patients with any type of
DOSAGE: liver disease, G6PD deficiency, chronic
600 mg q6 x 4 doses more malnutrition, severe hypovolemia or severe
renal impairment.
ROUTE: IV May cause serious, potentially fatal skin
reaction, including SJS, toxic epidermal
necrolysis, and acute generalized
exanthemata’s pustulosis
ADVERSE EFFECT
CNS: agitation (IV), anxiety,
fatigue, headache, insomnia,
pyrexia.
CV: HTN, hypotension,
peripheral edema, periorbital
edema, tachycardia (IV)
GI: nausea, vomiting,
abdominal pain, diarrhea,
constipation (IV)
GU: oliguria
Hematologic: hemolytic
anemia, leukopenia,
neutropenia, pancytopenia,
anemia.
Hepatic: jaundice
Metabolic: hypoalbuminemia,
hypervolemia,
hypomagnesemia
Musculoskeletal: muscle
spasms, extremity pain
Respiratory: abnormal breath
sound, dyspnea, hypoxia,
atelectasis, pleural effusion,
pulmonary edema, stridor,
wheezing
Skin: rash, urticaria; infusion
site pain, pruritus
NURSING
BEFORE: - Check vital signs
especially body temperature for
baseline data. - Assess if the
patient has fever. - Ask pt. if she
has headaches. - Check that the
patient is not taking any other
medication containing
paracetamol. - Check the label
and the dose of the drug that you
will administer. - Inform the
guardian the importance and need
of the drug to him/her.
DURING: - Observe patient’s
rights of drug administration. -
Monitor I&O rates and pattern.
Report any significant changes.
AFTER: - Educate guardian of
the possible adverse reaction of
the drug. - Instruct patient to
notify prescriber if rash and chills
develops. - Document drug’s
name, time, and date of
administration on the patient’s
chart. - Check the pt. VS every 4-
6 hours.
DRUG NAME MECHANISM OF ACTION INDICATION/CONTRAINDICATION ADVERSE EFFECT NURSING
RESPONSIBILITIES