Mechanism of action Thiazide & thiazide like diuretics Side effects / ADRS

D.C.T Indications Hyperuricemia

(NORMAL PHYSIOLOGY) 5 - 10 °
.
N Ci Hyponatremia -
Hypochloremia
N
-

N Ci
A
Gout Hypercalcemia
2K 2K ASE
N - . . .

Uric acid
N K ATP Ci Me n.c.c N Ci
BN
|
' N C
'
a
Ci Hypertension , aoj • •
K
/

N Ci
lz BV BP C
3N N D.C.T
N

Ú
C P.T.H
÷;
N Ci
P. Edema Monotherapy Uric N Ci C
aaaa
'

me
''
- i acid .
•
Uric
CHF OAT
C C THIAZIDE DIURETICS .
.
Cirrhosis M/C dual T x c loop diuretic
Uric
acid
pasa
OAT
acid

N
N
C. Duct
N
C AKI Bru IIIa

K P.C.T K N K azo I -

N
-

2K Pulmonary edema
|
_

aforo N ii. É
-

K ATPASE N N Ci Uric acid -

Hypokalemia
-

Cia n.c.c
H
CHF
_

oiga
-
la
1

's
(
Cirrhosis
Ci -

;
i
'

a
N Ci
BV
AKI _
H
Metabolic alkalosis
Ci
~ 1 2 C
N Ascites N Ci
N eran Cirrhosis
C me C CHF Z
N
C C .
•
Ci
BV
-
C
Glucose K
Thiazide diuretics Thiazides-like diuretics nephrogenic diabetes Insulin H
insipidus Thiazide
like
Hypercalciuria
K S drugsAllergic reaction to Sulfa
Hydrochlorothiazide (HCT2) Chlorthalidone Blood glucose Group of Thiazide-like diuretics
Pancreatic
Osteopenic B - cell Acute interstitial
Hyperglycemia
Metolazone nephritis
ADH
\

Chlorothiazide BV
lz
Ogg
N Ci
(normal) Glucose "
"

É
ATP - sensitive
C
Ha K
µ, K channel É Arthralgias
• . .
.
GLUT ATP
Sulfa-component -
_
C
MI _ C
a
'
Glucose -
"
→
bcz '
Intrarenal
qq.q.fr
.

-
• g. .
hypokalemia A.K.I
a ote
.

Vasodilation
.

Iz
Prostaglandins Rash
"
iii. :&: Eosinophils
'

la
N Ci Insulin
T.P.R Insulin
Z

THIAZIDES
BV
B.P
BF GFR l z l z

P.C.T has more time to reabsorb

N Ci l z

- -
-

Thiazide diuretics | Mechanism of action, indications,

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