Medical Microbiology

Lec-7-

Dr:Rafal Mohammed
• Escherichia coli (E.coli): ‫ألتهاب بالقنوات البوليه‬
• General properties:
‫عصويه‬
• G-ve bacilli
• Non- spores forming.
‫تخمر‬
• Lactose fermenter.
• Motile.
• has many of surface Antigens: O Ags ,H Ags, K
Ags,Fimbrial Ags.
• It considered from normal flora of GIT.
• Producing of vitamin K.
• Mode of transmission: oral -fecal route or contaminated
food or raw meat .

• Virulence factors:
• Adhesion factors : fimbria or pili are important in
adherence to mucosa .
• Toxins: Haemolysin ,Enterotoxins (LT,ST), Cytotoxic
necrotizing factor .
‫ قطع يعتبر صليبه‬٦ ‫فوق ال‬
• Diseases:
• Urinary tract infections (UTI).
• Hemolytic uremic syndrome (HUS). ‫املتالزمة السامه الدميه‬

• Gastroenteritis.
• Pneumonia.
• Klebsiella : ‫ذات الرئه‬
• General properties:
• G-ve bacilli,Non- motile.
• It has three species:
• K.pnemonia:causes pneumonia.
• K.oxytoca.
• K.ozaenae. Lipd poly saccharide

• Capsulated by a large LPS capsule.this capsule

resistance the phagocytosis and important in
development of vaccines.
• Lactose fermenter.
• has many of surface Antigens: O Ags , K Ags .
• produce Urease.
Mode of transmission :
person to person contact.

Virulence factors:
1.LPS capsule.
2. O Ags , K Ags .

Diseases:
Pneumonia.
Septicemia. ‫تسمم الدم‬
Bacterimia.
Otitis media.‫ألتهاب األذن الوسطى‬
• Salmonela: ‫تايفو أيد‬
• General properties:
• G-ve rods.
• Motile with pertrichous flagella.
• Ferment glucose and mannose.
• Aerobic . ‫أحادي‬ ‫أحادي‬

• Produce H2S . ‫كبيرتيت الهايدرو جني‬

• It has four species:
• S.typhi :caused Typhoid fever or Enteric fever.
• S.paratyphi A. ‫سوداء‬

• S. paratyphi B.
• S.Cholerasuis.
• mode of transmission:
• Ingestion of food &water contaminated with
human &animal wastes.
• Virulence factors: ‫فقط ثالثه‬
• Somatic O-Ags.
• Flagellar H-Ags.
• Fimbrial Ag.
• Capsular Ag.
• M-Ag.
• R-Ag.
 • Diseases:
• Enterocolitis
• Bacteremia
• Typhoid fever or Enteric fever.

• Pathogenesis of Typoid fever :

• Pathogenic salmonellae ingested through
contaminated food &drinks and survive in the
gastric acid barrier and invade the mucosa of the
small especially peyer patches and large intestine and
produce toxins. and release of proinflammatory
cytokines which induce an inflammatory reaction.and
causes diarrhea and may lead to ulceration and
destruction of the mucosa. The bacteria can
disseminate from the intestines to blood and caused
bacterimia.
invade
contaminated food &drinks gastric acid barrier mucosa of the small produce toxins and causes diarrhea and
disseminate
blood bacterimia
especially peyer patches proinflammatory cytokines ulceration and destruction
and large intestine of the mucosa
• Symptoms:
• High fever.
• Sever fever.
• Headach.
• Stomach pain.
• Chills.
• Rash.
• Muscle aches
• Rose spots in advanced conditions.
• Diarrhea or constipation.
• Nausea, vomiting .
• Loss of appetite.
• Treatment :
• By antibiotcs such as ciprofloxacin and
fluoroquinolones.
• diagnosis:
• Widal test :its serological test to measurment
for antibodies IgM or IgG that your body
makes against the salmonella bacteria that
causes typhoid fever.
‫دليل على اصابه جديده‬
Note:
• IgM is indicater of presence new infection.
• IgG indicater of presence last infection.
‫دليل على اصابه قديمه‬
• Q5:A 38-year-old-women has a 5-month history of
Sever fever, Stomach pain,Muscle aches ,Loss of
appetite, rose spots on skin:
• 1.what is the name of this infection? Typhoid fever or
Enteric fever.
• 2.What is the agent causing to this
infection?salmonella typhi.
• 3.Numerate the virulence factors of this agent?
Somatic O-Ags.Flagellar H-Ags.Fimbrial Ag.
• 4.Numerate the diseases of this caustive agent?
Typhoid fever or Enteric fever.
• 5. what is best test to diagnosis this infection?Widal
test.
• 6.How treat this infection? By antibiotcs such as
ciprofloxacin and fluoroquinolones.