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Single Injection Reduces Blood Pressure For 6 Months
Single Injection Reduces Blood Pressure For 6 Months
for 6 Months
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A single injection of the investigational antihypertensive agent
zilebesiran (Alnylam Pharmaceuticals) effectively lowered blood
pressure in adults with mild to moderate hypertension for up to 6
months, with what appeared to be an encouraging side-effect
profile, in the phase 2 dose-ranging KARDIA-1 study.
Most hyperkalemia
(https://emedicine.medscape.com/article/240903-overview)
adverse events, which occurred in 6% of patients, were mild, did
not require intervention, and generally resolved with repeat
measurement; none were associated with acute kidney injury
(https://emedicine.medscape.com/article/243492-overview) or
led to study drug discontinuation. The incidence of hypotension
events was low, and no clinically relevant changes in renal or
hepatic function were observed, Bakris reported.