1/31/24, 7:44 PM Insulin Resistance: Symptoms, Causes, Tests, Treatment, and Prevention

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Medically Reviewed by Brunilda Nazario, MD on January 20, 2024 Written by WebMD Editorial Contributors
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3 min read
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What
 Is Insulin Resistance? Suppo
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Insulin resistance is when cells in your muscles, fat, and liver don’t respond well to insulin and can’t use glucose from your blood for
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energy. To make up for it, your pancreas makes more insulin. Over time, your blood sugar levels go up.
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Insulin resistance syndrome includes a group of problems like obesity, high blood pressure, high cholesterol, and type 2 diabetes. It could
affect as many as 1 in 3 Americans. You might also hear it called metabolic syndrome. Pet He
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Symptoms of Insulin Resistance
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You can't tell that you have insulin resistance by how you feel. You'll need to get a blood test that checks your blood sugar levels.
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Likewise, you won’t know if you have most of the other conditions that are part of insulin resistance syndrome (high blood pressure, low
"good" cholesterol levels, and high triglycerides) without seeing your doctor. Wome
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Some signs of insulin resistance include: Lupus

A waistline over 40 inches in men and 35 inches in women Menta

Blood pressure readings of 130/80 or higher Multip

A fasting glucose level over 100 mg/dL
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A fasting triglyceride level over 150 mg/dL
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A HDL cholesterol level under 40 mg/dL in men and 50 mg/dL in women

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Patches of dark, velvety skin called acanthosis nigricans

Risk Factors and Causes of Insulin Resistance

Things that can make this condition more likely include:

Obesity, especially belly fat

Inactive lifestyle

Diet high in carbohydrates

Gestational diabetes

Health conditions like nonalcoholic fatty liver disease and polycystic ovary syndrome
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A family history of diabetes

Smoking

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1/31/24, 7:44 PM Insulin Resistance: Symptoms, Causes, Tests, Treatment, and Prevention

Ethnicity -- it’s more likely if your ancestry is African, Latino, or Native American Subscribe

Age -- it’s more likely after 45

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Hormonal disorders like Cushing’s syndrome and acromegaly
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Medications like steroids, antipsychotics, and HIV medications

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Diagnosis and Tests for Insulin Resistance
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Your doctor will use these things to diagnose insulin resistance:
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Questions. They’ll want to know about your family's medical history.
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Physical exam. They’ll weigh you and check your blood pressure.
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Blood tests. You might get:
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Fasting plasma glucose test. This test measures your blood sugar after you haven’t eaten for at least 8 hours.
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Oral glucose tolerance test. First, you'll take the fasting glucose test. Then you'll drink a sugary solution. Two hours after that, you'll
take another blood test. Diabet
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Hemoglobin A1c test. This blood test shows your average blood sugar level for the past 2 to 3 months. Doctors use it to diagnose
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prediabetes or diabetes. If you have diabetes, it helps show whether it's under control. You may need to take the test again to
confirm the results. Eczem
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How Insulin Resistance Progresses to Type 2 Diabetes
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When you have insulin resistance, your pancreas makes extra insulin to make up for it. For a while, this will work and your blood sugar
levels will stay normal.
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Over time, though, your pancreas won’t be able to keep up. If you don’t make changes in the way you eat and exercise, your blood sugar Wome
levels will rise until you have prediabetes. Your doctor will look for these blood test results:
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Fasting plasma glucose test: 100-125 Menta

Oral glucose tolerance test: 140-199 after the second test Multip
A1c results of 5.7% to 6.4%
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If you aren’t able to manage prediabetes, you’ll be diagnosed with type 2 diabetes when your test levels reach: Pain M

Fasting plasma glucose test: 126 or higher

Oral glucose tolerance test: 200 or higher after the second test

A1c results of 6.5% or above

Insulin Resistance Treatment and Prevention

You can take steps to reverse insulin resistance and prevent type 2 diabetes:

Exercise. Go for at least 30 minutes a day of moderate activity (like brisk walking) 5 or more days a week. If you're not active now,
work up to that.

Get to a healthy weight. If you're not sure what you should weigh or how to reach a weight loss goal, ask your doctor. You may also
want to talk with a nutritionist and a certified personal trainer.

Eat a healthy diet. Think fruits, vegetables, whole grains, nuts, beans, fish, legumes, and other lean protein.
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Take medications. Your doctor may prescribe a medication called metformin (Fortamet, Glucophage, Glumetza, Riomet) to help
keep your blood sugar in check.

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1/31/24, 7:44 PM Insulin Resistance: Symptoms, Causes, Tests, Treatment, and Prevention

Complications of Insulin Resistance Subscribe

If metabolic syndrome goes untreated, it could lead to:

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Severe high blood sugar

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 ARTICLES: Insulin Resistance | Insulin Resistance Diet | Foods That Control Blood Sugar
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