Homework # 2

KCHM 412- Organic Reactions Mechanisms

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1. For each reaction below identify the electrophile and nucleophile in the reactants

2. Mechanisms of nucleophilic substitution at aliphatic sp2 carbons involve two steps:

(1) addition of the nucleophile to the carbonyl group and (2) elimination of some other group
attached to that carbon. Give examples for each step?

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3: Write step-by-step mechanisms for each of the following transformations:

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TsO H2N
NH3 S
S + TsOH
O

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 O

MgBr O C
O C N
H3O

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