Grade: 12

Subject: LIFE SCIENCE

Name of assessment: PART B: CASE STUDY 1
Date: 8 FEBRUARY 2024
Student Name:
Time started:
Time ended:
Number of pages uploaded:
(including the cover pages)

INVIGILATOR DECLARATION
This form is to be completed and signed by the invigilator of this assessment and must
be uploaded along with the completed assessment into the submission box on Moodle.

I _______________________________________________, confirm that this

assessment was written:
1. Under uninterrupted supervision.
2. Within the specified time limit.
3. Without access to Moodle, notes, textbooks, internet research or any other
resources, unless specified as allowed for during the test.
4. Without a cell phone in the vicinity of the exam / test venue.
5. Without any assistance from another person, including myself.
6. Without any prior tips / coaching towards the specific questions of the test
from me.

Notes:

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Signature: _________________________________
 LIFE SCIENCE
CASE STUDY 1
GRADE 12
8 FEBRUARY 2024

QUESTION PAPER
Time: 1 hour Total: 50 marks
Examiner: T. Wallace Moderator: N. Jansen van Vuuren

Student Name and Surname:

Read these instructions carefully:

1. This paper consists of a question paper of 8 pages (including the Invigilator’s
Declaration and this cover page). There is also a Source Booklet which consists of 9
pages. Check that your test/exam paper is complete.
2. Read the information and questions carefully.
3. This is a fill in paper. Please answer all the questions in the spaces provided.
4. No typed scripts will be allowed. They must be hand-written in blue or black ink.
5. It is in your own interest to write legibly and to present your work neatly.
6. Make sure you upload your test in the CORRECT submission box. There will be a
submission box for both Part A and Part B.
7. Be sure to scan all pages clearly before saving and uploading your test/exam –
incomplete or unreadable tests may not be updated after the submission box has
closed.
8. Ensure that the signed Invigilator’s Declaration and this cover page are scanned in
with your test/exam.
9. Save your work according to the following naming convention:
Surname_Firstname_Test Name_Date
10. Please note that should you access the course content on Moodle during this
test/exam you will receive zero. Consulting Google for definitions, diagrams or
any other information during this test/exam will also result in zero. Both are
considered cheating and will carry negative consequences.

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QUESTION 1 [26]

Read through sources A – D in the source booklet and then answer the
questions that follow.

1.1. Is Edward’s syndrome caused by a chromosomal mutation or gene (2)

mutation? Give a reason for your answer.

_______________________________________________________

_______________________________________________________

1.2. There are three genotypic forms (or types) of this syndrome.

1.2.1 During which phase of meiosis would the most common type of (1)
Edward’s Syndrome arise if it is caused by non-disjunction of
chromosomes?

_______________________________________________________

_______________________________________________________

1.2.2 Draw and label a diagram of a cell in this abnormal phase of meiosis (10)
but only use 6 chromosomes (one pair being number 18) in your
diagram. On your diagram make sure to show the non-dis-junction

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1.2.3 During which process in meiosis would a partial trisomy 18 occur? (1)

_______________________________________________________

1.3 Source D states that ultrasound is one form of diagnosing Edward’s (2)
syndrome in a foetus. A pregnancy ultrasound is a test that uses
high-frequency sound waves to image the developing baby and can
help monitor normal fetal development and screen for any potential
problems. Name two features a doctor looks for when trying to
diagnose whether a foetus has this disorder.

_______________________________________________________

_______________________________________________________

_______________________________________________________

1.4 Karyotyping is listed as another diagnostic method. An amniocentesis

would be required to extract foetal cells from the amniotic fluid. The
DNA would be extracted from these few cells and it would be
replicated so that the technician could work with a larger sample.

1.4.1 Give the full name of the process used to make more copies of the (1)
DNA.

_______________________________________________________

1.4.2 The cells are induced to undergo mitosis and then the process is (1)
arrested (stopped) and the nuclear material used to make a
karyotype. During which phase of mitosis is the DNA used to make
the karyotype?

_______________________________________________________

1.4.3 If a woman has had a pregnancy where she had lost the fetus due to (2)
Trisomy 18, would you recommend that she has an amniocentesis to
determine whether the fetus in her next pregnancy has the disorder?
Give TWO well explained reasons for your answer.

_______________________________________________________

_______________________________________________________

_______________________________________________________

_______________________________________________________

_______________________________________________________

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1.5 Study the three karyotypes given in Source B.

1.5.1 Which karyotype shows Edwards syndrome? (1)

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1.5.2 Is this a karyotype of a male or a female? (1)

_______________________________________________________
1.6 Identify the disorder shown in one of the other karyotypes in Source (1)
B.

_______________________________________________________

1.7 Describe how maternal age influences the risk of conceiving a baby (3)
with Trisomy 18 and compare this to the effect of maternal age on
conceiving a baby with XXY.

_______________________________________________________

_______________________________________________________

_______________________________________________________

(26)

QUESTION 2 [15]

Ready through sources E – F in the source booklet and then answer the
questions that follow.

2.1 DNA profiling uses variations called STRs.

2.1.1 What does the abbreviation STR stand for? (2)

_______________________________________________________

2.1.2 Define an STR. (2)

_______________________________________________________

2.1.3 Identify the STR in the following sequence. (1)

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2.1.4 How many repeats are there for the STR sequence in 2.1.3? (1)

_______________________________________________________

2.2 Provide the importance of using the technique, polymerase chain (1)
reaction.

_______________________________________________________

_______________________________________________________
2.3 Read Source G and H before answering the questions.

2.3.1 If Mark Dixie had been arrested and released without charge for a (3)
separate offence BEFORE the murder, could the police still have
caught him using the DNA database? Justify your answer.

_______________________________________________________

_______________________________________________________

_______________________________________________________

2.3.2 Craig Herman was identified as a suspect by using familial searching. (2)
Why do you think people might object to this?

_______________________________________________________

_______________________________________________________

2.3.3 How would having a compulsory DNA database with regards to DNA (3)
profiling help to solve these crimes?

_______________________________________________________

_______________________________________________________

_______________________________________________________

(15)

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QUESTION 3 [9]

Ready through sources I – J in the source booklet and then answer the
questions that follow.

3.1 Only a small amount of DNA could be extracted from the (1)
mosquitoes. What process would the scientists have used to
make many copies of this DNA?

_______________________________________________________

3.2 Suggest why using frog genes to replace the missing dinosaur genes (2)
will not result in a viable dinosaur.

_______________________________________________________

_______________________________________________________

3.3 Study the following section of dinosaur DNA.

3.3.1 Use the template strand to write the corresponding mRNA nucleotide (3)
sequence.

_______________________________________________________

_______________________________________________________

_______________________________________________________

3.3.2 Use the mRNA codon table shown below to write down the amino (3)
acids coded for by the mRNA in the correct order.

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 mRNA codon table

_______________________________________________________

_______________________________________________________

_______________________________________________________

(9)
GRAND TOTAL PART B: 50

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