Overview Notes (8) Related Modules

584 Systemic 67
Pathology

FEMALE GENITAL TRACT:PART1

Vulva 00:01:54

. Paget's disease:
Also knoun as xtra mammary paget's disease.
microscopicaly : Preserce of pagets cells.
" Central nuclei with perinuclear halo/ clearing.
Halo/ clearing is due to glycogen fot : PAS{oil red o
positive.
marker : Ch7 positive.
Crically presents as :
erythematous ucerated lesion on ulva, which is pruritic.
Not necessarily associated with malignancy

verma0aaditya @gmail.com

Paget's disease of the valva uwith Paget's ceis

a. condyoma acuminatum :
Cauiower like grouth.
Also called as qenital warts.
Caused by HPV : louw risk HPV l, l.
D
Feedback HPV in carcinogenesis :
" HPV produces tuo proteins, eo q E7.
Eo combines with p53.
ET combines with Rb.
" This causes
inactivation of these tumor Suppressor genes
" Causes cervical
intraepithelial eoplasa, cancerS.

Patiology v40 Manow65.2023

Page 1/8
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Causative
Presence 4. LOoKS TuoLesion
with 3 " Cells
" "
HPE:
Squamous chromophobe
RCC.
Koilocuytes.
columnor
cells. layers
Intrapapilary
hidradenoma wrth Produced
Perinuclear
Resinoid
halo.
nucleus.
embrane.
Thickshous Notes(8)
Similar
myoepitthelial
factors of resinoid
of
contquration
papillary Koilocutes/
Keratin to
cell cells due
intraductal
: Intrapapillary
hidrodenoma
carcinoma layer seen nucleus to
Pathology
HPVpearis.
E4.
acuminatum
Condyloma
Koilocytic Modules
Related
Io, seen, :
18. papilloma and
v4.0 (Scc): over perinuclear
Marrow epithelum
insidethe change.
of which
6.5 the holocutes
2023
is halo
breast. the
layer

of
tal
67

Genital
Female
Tract:Part 1-

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585
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cells rhabdomyosarcoma
!PTAH.
Langerhans
cel
histiocuytosis.
the smal
below
clusters. protrusons.
ceiis
just myogenin.
age. racket 2023 INCO
MARK
seen
Embryonal
habdomyosarcomai
like ot
botryoides., hypocellular. 6.5.
Embryonal
"
rhabdomyosarcoma.
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qrape
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cytoplasmic
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6.5
of patholoay enbryonal
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cutoKeratin vagina <
shows
chldren number celis/ lectron
mieroscopy
of
Marrow sarcoma are
tadpole
IHC
marker
Desmin Patholoty
appearance below the
mostBy
beiow
v4.0 the
as
in :
laye
Cambium
layer:
cels
occupying Hypocellularin
racket
for
seen stain
Pathology marker of Knon layers celis/
epithelum.
Cambium Ceiis
seen eptheium
Lesions Usually Special
Tennis
Also
Gross HPE: The Strap
IHC
67
Pathology
586
Systemic
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Genital
Female
1
-
Part
Tract:
67
can rsk
00:16:29 junction
squamocolumnar
preanancy invasive Higher
membrane
dauahter. and
membrane 2023
Related
Modules during
epithelum. CN): CIN bAsemet 18.
65
in Sreoaaditya@gmail.com between Ko Marrow
mother membrane. HAV carcer.
microscopy
vagina neoplasia basement
vagina: as by
for
of
epithelum
squamous
Knoun ditferentiatecoloured caused
v4.0
cervical Pathoiogy
of exposure
carcinoma intraepitheial
basement coloured l. in
carcnoma aso pnk 6,
HPyalso choange
Stratted
squamous Elandular
StratiHed cancer.
Invasive into
stibesterol cervix
Lesions
of is
(8)
Notes Transitional
2one 2one to the
HP.
by by be development
Caused
cell Normal
histology
:
of
&ndocerica theused pinkin Can koiocutie
Caused
cell clear epitthelum :Endocervix Cervical "oreaKS 67
qlands EctoceNx:
ectocerNox Transitional by
stain
Intact M:
clear Limted
to
Diethyl cancer. CNI:IN Shous
lead PAS " CIN tor
a. Sys
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Overview
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 Tract:
Part-1
Gnnital
Fornaie
67
Neuroendocrine pko. Gardas,
Chromogranin,
Keratinization. Cancer. chromatin
Salt is index),
grade ipepper
High SIL seen seen.
squamouS
and proliferative
carcer
Modules
Related not NSE, b2023
cell pearls lands
cervix, components.
grade cervical
SquaTous
carcinoma i
SCCtumors
Single Marow
LOwSIL Cervical
cancer Adeno
Squamous
Adenocarcinona hilo7
Keratin
scC: cytokeratin of
i prevention
neuroendocrine 0
cancer v4
nolocytosis
Borderline differentiated
i
scC verma0aaditya@gmail.çom Pathoioay
wit h cervical
diftferentiated for
(8)
Notes HC Cervix HPV
for Synaptophysin.
for
by
moderately for
markersmarer
Nomal contrmed carcinoma
heratin
Pearl Vaccines
Cervari.
Pooriy (sc).
cell IHC IHC
Overview
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 Crital
Fornale
67
hyperchroote(H6). aderocarcira
pronnent fract
art
6155cd03aa8ded2c2197d0f6 squamous
the concer,
epthelurn lesion
epitthelurn,
o
hyperchromatic
intraepithelial
thicknesInvasNe at
uterre orce
Eterral
eyen
elassieaton ee
rderrel
HSL.that grade
the carcinorna
the {LSL not Low 2021
of entire membrore
oV3" a/a" siz2e,
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lesion
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Related
Modules kouer
louer
basement large squorous
elearoree
in in celis not proninent qrode
ofdegree iPathokyv4
olcler celiscelis epitheliun. classiAcation
Newer phic, peiorrorphie,
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Atupical plelomor corcer
CerVical
a.
the Atypical
Atypical of Hiah is
to
Invovement the not cornmon
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haeement
otehial T:
:III on Lessnucleus,verynucleus
rnal
CIN ICIN CIN Based most
cervi.
ot
Notes
(8) " " " "
67
Pathology
Systonic
Overview
588 Feedback O
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Overview Notes (8) Related Modules

Paga/a

590 Systemic 67
Pathology

Aderocarcinomoa

Q.A5 year old girtshous the follouwing, what is the most likey
diagnosis?
A Herpes simplex
6. CmV.
C molluscum contaaiosum.
D. Basal cell carcinoma.

Dimpled umbilicated lesions usually seen in molluscum

contagiosum.
HPE:molluscumn bodies in stratum aranubsum

Herpes simplex?
Coudry type Aincusions.
Genital herpes caused by HSV a shous these on
Feedback
D 3m's. mieroscopy
" marqination of
multinucleation
chromayerma0aaditya @gmail.com
molding
" Ground qloss cells.

Pathology 40 Marrow 65 2023

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Overview Notes (8) Related Modules

Pathology v40" Marrw65 2023

67 Fernala Gonital 591

Tract : Part- 1

multinucleation
and molding

Ground glasses in pathology

. HSV a infecton
a. chronic hepattis e infection shous ground glass
hepatocytes.
Cmv

Shous ow's eye incusion with basophilic nuclei

Basal cell carcinoma
Nests of basaloid cels witth peripheral pallisading and
separatioveFHadáaditya @gmail.com
Q.A 33 year old female witth foul smelling vaginal discharqe.
Pap smear shows the following,
Trichomonas vaginalis
" Pear shaped or ovoid lagellate organism
" Patient presents with foul smeling vaginal discharqe and
strawberry cerv

Feedback
D
Trichomonas
vaginolis e

MARK INCOMPILTI